专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012024687A3 BOND-SELECTIVE VIBRATIONAL PHOTOACOUSTIC IMAGING SYSTEM AND METHOD 审中-公开
标题翻译： BOND选择性振动摄影成像系统及方法
公开(公告)号：WO2012024687A3
公开(公告)日：2012-08-09
申请号：PCT/US2011048671
申请日：2011-08-22
申请人： PURDUE RESEARCH FOUNDATION , CHENG JI-XIN , WANG HAN-WEI , STUREK MICHAEL
发明人： CHENG JI-XIN , WANG HAN-WEI , STUREK MICHAEL
IPC分类号： A61B8/12
CPC分类号： A61B5/0095
摘要： An imaging system, including a radiation source configured to output a signal that can non-invasively and selectively cause overtone excitation of molecules based on a predetermined chemical bond, and an ultrasound detector configured to non-invasively detect an acoustic signal generated by vibrational energy caused by the selective overtone excitation of the molecules and further configured to convert the acoustic signal into an image.
摘要翻译：一种成像系统，包括被配置为输出基于预定化学键可以非侵入性地选择性地引起分子的泛音激励的信号的辐射源，以及被配置为非侵入性地检测由振动能产生的声信号的超声波检测器通过分子的选择性泛音激励，并且还被配置为将声信号转换为图像。

2. 发明申请

WO2011109762A1 MICROFLUIDICS SORTER FOR CELL DETECTION AND ISOLATION 审中-公开
标题翻译：用于细胞检测和分离的微流控分离器
公开(公告)号：WO2011109762A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027276
申请日：2011-03-04
申请人： NATIONAL UNIVERSITY OF SINGAPORE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LIM, Chwee, Teck , HAN, Jongyoon , HOU, Han, Wei , BHAGAT, Ali, Asgar , VAN VLIET, Krystyn, J. , LEE, Wong, Cheng
发明人： LIM, Chwee, Teck , HAN, Jongyoon , HOU, Han, Wei , BHAGAT, Ali, Asgar , VAN VLIET, Krystyn, J. , LEE, Wong, Cheng
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12Q1/04 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2300/0864 , B01L2400/0457 , B01L2400/086 , C12Q1/025 , G01N2015/1415 , G01N2015/149
摘要： A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels wherein each channel has a length and a cross-section of a height and a width defining an aspect ratio adapted to isolate diseased blood cells along at least one portion of the cross-section of the channel based on reduced deformability of diseased blood cells as compared to non-diseased blood cells, wherein diseased blood cells flow along a first portion of the channel to a first outlet and non-diseased blood cells flow along a second portion of the channel to a second outlet. The one or more channels can be adapted to isolate cells along portions of the cross-section of the channel based on cell size. In some embodiments, the one or more channels can be spiral channels.
摘要翻译：一种检测血液样本中的一种或多种患病血细胞的方法包括将血液样品引入到包括一个或多个线性通道的微流体装置的至少一个入口中，其中每个通道具有高度的长度和横截面宽度限定适于根据与非病变血细胞相比减少的患病血细胞的可变形性，沿着所述通道的横截面的至少一部分分离患病血细胞，其中患病血液细胞沿第一部分流动通道的第一出口和非患病血液细胞沿着通道的第二部分流动到第二出口。一个或多个信道可以适于基于小区大小来隔离信道横截面的部分。在一些实施例中，一个或多个通道可以是螺旋通道。

3. 发明申请

WO2009035414A1 CHITOSAN CONSTRUCT AND METHOD OF PREPARING THE SAME 审中-公开
标题翻译： CHITOSAN构造及其制备方法
公开(公告)号：WO2009035414A1
公开(公告)日：2009-03-19
申请号：PCT/SG2008/000339
申请日：2008-09-10
申请人： NATIONAL UNIVERSITY OF SINGAPORE , BAI, Renbi , HAN, Wei
发明人： BAI, Renbi , HAN, Wei
IPC分类号： C08L5/08 , C08B37/08 , C08J5/00 , D01D5/24
CPC分类号： C08L5/08 , C08B37/003 , D01D1/02 , D01D5/24 , D01F9/00
摘要： The present invention provides a chitosan construct having a high mechanical strength. The chitosan construct may have a tensile strength > 0.1 MPa. The tensile strength may be 0.1-6 MPa. The chitosan construct may be a fibre. In particular, the chitosan construct may be a hollow fibre. The chitosan construct may be prepared from a chitosan solution having a high chitosan concentration. The chitosan concentration in the chitosan solution may be ≥ 5 wt %. A method of preparing a construct comprising chitosan is also provided. The method comprises the steps of: (i) mixing chitosan and at least one solvent to form a mixture; (ii) evaporating the mixture to form a chitosan solution; and (iii) preparing the construct from the chitosan solution, wherein the construct has a tensile strength of 0.1-6 MPa. The chitosan solution formed in step (ii) may have a chitosan concentration ≥ 5 wt %.
摘要翻译：本发明提供具有高机械强度的壳聚糖结构。壳聚糖构建体的拉伸强度可以> 0.1MPa。拉伸强度可以为0.1-6MPa。壳聚糖构建体可以是纤维。特别地，壳聚糖构建体可以是中空纤维。壳聚糖构建体可以由具有高壳聚糖浓度的壳聚糖溶液制备。壳聚糖溶液中的壳聚糖浓度可以为= 5wt％。还提供了制备包含壳聚糖的构建体的方法。该方法包括以下步骤：（i）将壳聚糖和至少一种溶剂混合以形成混合物; （ii）蒸发混合物以形成壳聚糖溶液; 和（iii）从壳聚糖溶液制备构建体，其中该构造体具有0.1-6MPa的拉伸强度。在步骤（ii）中形成的壳聚糖溶液可具有5重量％的壳聚糖浓度。

4. 发明申请

WO2009035413A1 A CHITOSAN SOLUTION AND METHOD OF PREPARING THE SAME 审中-公开
标题翻译：一种CHITOSAN解决方案及其制备方法
公开(公告)号：WO2009035413A1
公开(公告)日：2009-03-19
申请号：PCT/SG2008/000338
申请日：2008-09-10
申请人： NATIONAL UNIVERSITY OF SINGAPORE , BAI, Renbi , HAN, Wei
发明人： BAI, Renbi , HAN, Wei
IPC分类号： C08B37/08 , C08L5/08
CPC分类号： C08L5/08 , C08B37/003 , D01D1/02 , D01D5/24 , D01F9/00
摘要： The present invention provides a chitosan solution having a high chitosan concentration. The chitosan concentration in the chitosan solution may be > 5 wt %. The chitosan concentration in the chitosan solution may be 8-20 wt %. The chitosan solution may be a chitosan dope solution. The present invention also provides a method of preparing the chitosan solution, wherein the method comprises the steps of: (i) mixing chitosan and at least one solvent to form a mixture; and evaporating the mixture to form a chitosan solution. The solvent may be an acidic solvent.
摘要翻译：本发明提供了壳聚糖浓度高的壳聚糖溶液。壳聚糖溶液中的壳聚糖浓度可以> 5wt％。壳聚糖溶液中的壳聚糖浓度可以为8-20重量％。壳聚糖溶液可以是壳聚糖溶液。本发明还提供一种制备壳聚糖溶液的方法，其中该方法包括以下步骤：（i）将壳聚糖和至少一种溶剂混合以形成混合物; 并蒸发混合物以形成壳聚糖溶液。溶剂可以是酸性溶剂。

5. 发明申请

WO2007070816A3 THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS 审中-公开
标题翻译：噻吩衍生物作为因子XIA抑制剂
公开(公告)号：WO2007070816A3
公开(公告)日：2007-09-07
申请号：PCT/US2006061970
申请日：2006-12-13
申请人： SQUIBB BRISTOL MYERS CO , HAN WEI
发明人： HAN WEI
IPC分类号： C07D333/24 , A61K31/381 , A61K31/416 , A61P7/02 , A61P29/00 , C07D333/28 , C07D409/04
CPC分类号： C07D333/24 , C07D333/28 , C07D409/04
摘要： The present invention provides compounds of Formula (I); or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L 1 , R 3 , and R 11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译：本发明提供了式（I）的化合物; 或其立体异构体，互变异构体，可药用盐，溶剂化物或前药，其中变量A，L 1，R 3，R 11，如本文所定义。式（I）化合物可用作凝血级联和/或接触活化系统的丝氨酸蛋白酶的选择性抑制剂; 例如凝血酶，因子Xa，因子XIa，因子IXa，因子VIIa和/或血浆激肽释放酶。具体而言，它涉及选择性因子XIa抑制剂的化合物。本发明还涉及包含这些化合物的药物组合物以及使用该组合物治疗血栓栓塞性和/或炎症性疾病的方法。

6. 发明申请

WO2007070816A2 THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS 审中-公开
标题翻译： THIOPHENE DERIVATIVES作为因子XIA抑制剂
公开(公告)号：WO2007070816A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/061970
申请日：2006-12-13
申请人： BRISTOL-MYERS SQUIBB COMPANY , HAN, Wei
发明人： HAN, Wei
CPC分类号： C07D333/24 , C07D333/28 , C07D409/04
摘要： The present invention provides compounds of Formula (I); or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L 1 , R 3 , and R 11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译：本发明提供式（I）的化合物; 或其立体异构体，互变异构体，药学上可接受的盐，溶剂化物或前药，其中变量A，L 1，R 3和R 11，如本文所定义。式（I）的化合物可用作凝血级联和/或接触激活系统的丝氨酸蛋白酶的选择性抑制剂; 例如凝血酶，因子Xa，因子XIa，因子IXa，因子VIIa和/或血浆激肽释放酶。特别地，它涉及作为选择性因子XIa抑制剂的化合物。本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。

7. 发明申请

WO2007027454A1 HETEROCYCLIC DIHYDROPYRIMIDINE COMPOUNDS 审中-公开
标题翻译：杂环二氢嘧啶化合物
公开(公告)号：WO2007027454A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/032382
申请日：2006-08-18
申请人： BRISTOL-MYERS SQUIBB COMPANY , HAN, Wei , HU, Zilun
发明人： HAN, Wei , HU, Zilun
IPC分类号： C07D487/04 , A61K31/505 , A61P9/06
CPC分类号： C07D487/04
摘要： Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra rapidly activating delayed rectifier, which have the structure: (Formula I); stereoisomers including enantiomers thereof and diastereomers thereof, or a pharmaceutically acceptable salt thereof, wherein Q is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl or: (Formula II) which is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 3 is a) (Formula III), b) (Formula IV), or c) (Formula V); wherein R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are defined herein. Methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds are also provided.
摘要翻译：可用作钾通道功能抑制剂的新型杂环二氢嘧啶化合物（特别是电压门控K +通道的Kv1亚家族抑制剂，特别是与超快速活化延迟整流剂连接的抑制剂Kv1.5，其结构如下：（式I）其中Q为烷基，取代的烷基，环烷基，取代的环烷基，环杂烷基，取代的环杂烷基或：（式II），其为芳基，取代的芳基，杂芳基或取代的杂芳基 ; R 3是a）（式III），b）（式IV）或c）（式V）; 其中R 1，R 2，R 4，R 5，R 6， R 7，R 8，R 9和R 10在本文中定义。还提供了使用这些化合物预防和治疗心律失常和IKur相关病症的方法，以及含有这些化合物的药物组合物。

8. 发明申请

WO2005048922A3 SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS 审中-公开
公开(公告)号：WO2005048922A3
公开(公告)日：2005-06-02
申请号：PCT/US2004/031774
申请日：2004-09-29
申请人： BRISTOL-MYERS SQUIBB COMPANY , HAN, Wei , HU, Zilun , GUNGOR, Timur
发明人： HAN, Wei , HU, Zilun , GUNGOR, Timur
IPC分类号： C07D241/36 , C07D239/02 , C07D211/36 , C07D211/40 , C07D211/54 , C07D211/06 , C07D401/12 , C07D413/10 , C07D409/02 , A61K31/40 , A61K31/495 , A61K31/505 , A61K31/47 , A61K31/44 , A61P7/02
摘要： The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula (Ia-If) or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono-or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

9. 发明申请

WO2005032468A3 MONOCYCLIC AND BICYCLIC LACTAMS AS FACTOR XA INHIBITORS 审中-公开
公开(公告)号：WO2005032468A3
公开(公告)日：2005-04-14
申请号：PCT/US2004/031857
申请日：2004-09-29
申请人： BRISTOL-MYERS SQUIBB COMPANY , HAN, Wei , QIAO, Jennifer , HU, Zilun
发明人： HAN, Wei , QIAO, Jennifer , HU, Zilun
IPC分类号： C07D409/12 , A61K31/4025 , C07D401/14 , C07D261/20 , C07D215/14 , C07D401/10 , C07D207/24 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4015
摘要： The present application describes monocyclic and bicyclic lactams and derivatives thereof of Formulae (Ia-e); wherein one of one of T 1 and T 2 is carbonyl, thiocarbonyl, or sulfonyl or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

10. 发明申请

WO2012024687A2 BOND-SELECTIVE VIBRATIONAL PHOTOACOUSTIC IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：粘结选择性振动光声成像系统和方法
公开(公告)号：WO2012024687A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/048671
申请日：2011-08-22
申请人： PURDUE RESEARCH FOUNDATION , CHENG, Ji-Xin , WANG, Han-Wei , STUREK, Michael
发明人： CHENG, Ji-Xin , WANG, Han-Wei , STUREK, Michael
IPC分类号： A61B8/12
CPC分类号： A61B5/0095
摘要： An imaging system, including a radiation source configured to output a signal that can non-invasively and selectively cause overtone excitation of molecules based on a predetermined chemical bond, and an ultrasound detector configured to non-invasively detect an acoustic signal generated by vibrational energy caused by the selective overtone excitation of the molecules and further configured to convert the acoustic signal into an image.
摘要翻译：一种成像系统，包括辐射源和超声检测器，所述辐射源被配置为输出可以非侵入式且选择性地引起基于预定化学键的分子的泛音激发的信号，所述超声检测器被配置为无创地检测由分子的选择性泛音激发引起的振动能量产生的声信号，并且还被配置为将声信号转换为图像。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式