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1. 发明申请

WO2006122312A2 METHODS OF TESTING 审中-公开
标题翻译：测试方法
公开(公告)号：WO2006122312A2
公开(公告)日：2006-11-16
申请号：PCT/US2006018575
申请日：2006-05-11
申请人： UNIV PENNSYLVANIA , CHEN ZONGYUAN , WANG JING , MAUK MICHAEL G , BAU HALM H , MALAMUD DANIEL , ABRAMS WILLIAM , NIEDBALA SAMUEL , TANKE HENDRIKUS JOHANNES , CORSTJENS PAUL L A M
发明人： CHEN ZONGYUAN , WANG JING , MAUK MICHAEL G , BAU HALM H , MALAMUD DANIEL , ABRAMS WILLIAM , NIEDBALA SAMUEL , TANKE HENDRIKUS JOHANNES , CORSTJENS PAUL L A M
IPC分类号： G01N33/53
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/022 , B01L2300/0864 , B01L2300/1822 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0672 , B01L2400/0677 , B01L2400/0688 , G01N2035/00158 , Y10T436/143333
摘要： The present invention relates to sample processing using a microfluidic chip. A method for concurrent testing for at least two of RNA, DNA, antibody, and antigen in a sample is described, as are methods for testing for pre-selected pathogens and microfluidic methods.
摘要翻译：本发明涉及使用微流控芯片的样品处理。还描述了用于同时测试样品中RNA，DNA，抗体和抗原中的至少两种的方法，以及用于测试预先选择的病原体和微流体方法的方法。

2. 发明申请

WO2006122310A2 SYSTEM FOR TESTING 审中-公开
标题翻译：测试系统
公开(公告)号：WO2006122310A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/018481
申请日：2006-05-11
申请人： THE TRUSTESS OF THE UNIVERSITY OF PENNSYLVANIA , CHEN, Zongyuan , WANG, Jing , MAUK, Michael, G. , BAU, Haim, H. , MALAMUD, Daniel , ABRAMS, William , NIEDBALA, Samuel , TANKE, Hendrikus, Johannes , CORSTJENS, Paul, L.a.m.
发明人： CHEN, Zongyuan , WANG, Jing , MAUK, Michael, G. , BAU, Haim, H. , MALAMUD, Daniel , ABRAMS, William , NIEDBALA, Samuel , TANKE, Hendrikus, Johannes , CORSTJENS, Paul, L.a.m.
IPC分类号： C12M3/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/022 , B01L2300/0864 , B01L2300/1822 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0672 , B01L2400/0677 , B01L2400/0688 , G01N2035/00158 , Y10T436/143333
摘要： The present invention relates to sample processing using a microfluidic chip. Systems are described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample; and a developer for engaging the port of the cassette, wherein the developer propels the sample from said inlet to said detection zone.
摘要翻译：本发明涉及使用微流控芯片的样品处理。描述的系统包括具有至少一个端口的盒和与检测区流体连通的样品入口，用于与样品中预先选择的RNA序列，DNA序列，抗体或抗原或其混合物（如果存在）相互作用; 以及用于接合盒的端口的显影剂，其中显影剂将样品从所述入口推进到所述检测区。

3. 发明申请

WO2013103360A1 ISOTHERMAL NUCLEIC ACID AMPLIFICATION REACTOR WITH INTEGRATED SOLID STATE MEMBRANE 审中-公开
标题翻译：具有集成固态膜的同位素核酸放大反应器
公开(公告)号：WO2013103360A1
公开(公告)日：2013-07-11
申请号：PCT/US2012/025196
申请日：2012-02-15
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BAU, Haim, H. , ABRAMS, William, R. , GEVA, Eran , MAUK, Michael, G. , LIU, Changchun , MALAMUD, Daniel , QIU, Xianbo
发明人： BAU, Haim, H. , ABRAMS, William, R. , GEVA, Eran , MAUK, Michael, G. , LIU, Changchun , MALAMUD, Daniel , QIU, Xianbo
IPC分类号： G01N33/53
CPC分类号： C12Q1/6844 , B01L3/5023 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/026 , B01L2200/10 , B01L2300/0663 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1827 , B01L2300/1855 , B01L2300/1861 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q1/6806 , C12Q1/703 , C12Q2537/101
摘要： Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium - such as a lateral flow strip - where the user may label and detect the nucleic acids.
摘要翻译：提供了适于分离，扩增和检测可能存在于生物样品中的核酸的装置。在一些实施方案中，这些装置可以在单个室中分离，扩增和检测核酸。在其他实施方案中，所述装置适于分离和扩增反应室中的核酸，此后可将核酸传递至可渗透的介质 - 例如横向流动条 - 其中用户可以标记和检测核酸。

4. 发明申请

WO2007092713A3 MICROFLUIDIC SYSTEM AND METHOD FOR ANALYSIS OF GENE EXPRESSION IN CELL-CONTAINING SAMPLES AND DETECTION OF DISEASE 审中-公开
标题翻译：用于分析含细胞样本中基因表达的微流感系统和方法及疾病的检测
公开(公告)号：WO2007092713A3
公开(公告)日：2008-12-18
申请号：PCT/US2007061352
申请日：2007-01-31
申请人： UNIV PENNSYLVANIA , ZIOBER BARRY L , BAU HAIM H , MAUK MICHAEL G , CHEN ZONGYUAN , WANG JING
发明人： ZIOBER BARRY L , BAU HAIM H , MAUK MICHAEL G , CHEN ZONGYUAN , WANG JING
IPC分类号： B01D11/04 , B01L3/00 , C12M1/30 , C12M3/00 , C12Q1/00 , G01N1/18 , G01N9/30 , G01N15/06 , G01N21/00 , G01N21/75 , G01N31/00 , G01N33/00 , G01N33/48 , G01N33/53 , G01N33/536 , G01N33/543 , G01N33/551 , G01N33/553
CPC分类号： G01N33/574 , B01L3/502761 , B01L7/52 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/1894 , B01L2400/043 , B01L2400/0487 , B01L2400/0677 , C12Q1/6886 , C12Q2600/158 , G01N33/54366 , G01N2333/70503 , G01N2800/52
摘要： Biomarkers for the detection of pre-cancer and cancer cells and a method for their detection at the point of care are disclosed. The system is comprised of an inexpensive, disposable microfluidic cassette for sample preparation; continuous-flow, magnetic-bead assisted cell sorting and cytometry; cell lysis; nucleic acid isolation and amplification, hybridization, quantification, and analysis. Typically, the disposable cassette will be used with a benchtop instrument platform that provides power, control and detection capabilities to the cassette. In one particular embodiment and application of the invention, the cell sorting is based on the selective binding of magnetic beads coated with an MCAP antibody to exfoliated precancerous and cancerous cells contained in saliva. The bead-labeled precancerous and cancerous cells are then separated from other saliva components using a magnetic field. Both labeled and unlabeled cells can be counted using integrated detectors of several types, including cell counters based on impedance measurements, and cytometers based on Coulter particle counter principles. The sorted sub-population of precancerous and cancerous cells are lysed, and the nucleic acids are isolated for gene assays and/or transcription profiling of the sorted sample subpopulation. In one embodiment of the invention, the cassette includes re verse- transcription polymerase chain reaction for nucleic acid detection and a hybridization array for gene identification. The devices, systems, modes of operation, and methods disclosed here are also applicable for cancer and other disease detection in other body fluids.
摘要翻译：公开了用于检测癌前和癌细胞的生物标志物及其在护理时检测的方法。该系统由用于样品制备的廉价的一次性微流控盒组成; 连续流动，磁珠辅助细胞分选和细胞计数; 细胞裂解; 核酸分离和扩增，杂交，定量和分析。通常，一次性盒式磁带将与台式仪器平台一起使用，该平台为磁带提供功率，控制和检测能力。在本发明的一个具体实施方案和应用中，细胞分选基于用MCAP抗体包被的磁珠与包含在唾液中的脱落的癌前和癌细胞的选择性结合。然后使用磁场将珠标记的癌前和癌细胞与其他唾液成分分离。可以使用几种类型的集成检测器（包括基于阻抗测量的细胞计数器）和基于Coulter粒子计数器原理的细胞计数器来计数标记和未标记的细胞。裂解癌前和癌细胞的分选亚群，分离核酸用于分选的样品亚群的基因测定和/或转录谱。在本发明的一个实施方案中，盒包括用于核酸检测的转录聚合酶链反应和用于基因鉴定的杂交阵列。本文公开的装置，系统，操作模式和方法也适用于其他体液中的癌症和其他疾病检测。

5. 发明申请

WO2008076395A2 MECHANICALLY ACTUATED DIAGNOSTIC DEVICE 审中-公开
标题翻译：机械致动诊断装置
公开(公告)号：WO2008076395A2
公开(公告)日：2008-06-26
申请号：PCT/US2007025699
申请日：2007-12-14
申请人： UNIV PENNSYLVANIA , CHEN ZONGYUAN , BAU HAIM H , MAUK MICHAEL G , QIU XIANBO , KWA JASON
发明人： CHEN ZONGYUAN , BAU HAIM H , MAUK MICHAEL G , QIU XIANBO , KWA JASON
IPC分类号： B01D69/04
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/04 , B01L2200/0621 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , G01N33/558 , G01N2333/54 , Y10T137/8593 , Y10T436/25 , Y10T436/2575
摘要： Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system.
摘要翻译：公开了用于在微流体电路内输送流体并对样品执行诊断操作的机械致动装置。还公开了用于通过靠近微流体系统的致动器的运动进行样品分析的相关方法。

6. 发明申请

WO2007092713A2 MICROFLUIDIC SYSTEM AND METHOD FOR ANALYSIS OF GENE EXPRESSION IN CELL-CONTAINING SAMPLES AND DETECTION OF DISEASE 审中-公开
标题翻译：用于分析含细胞样本中基因表达的微流感系统和方法及疾病的检测
公开(公告)号：WO2007092713A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/061352
申请日：2007-01-31
申请人： TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ZIOBER, Barry, L. , BAU, Haim, H. , MAUK, Michael, G. , CHEN, Zongyuan , WANG, Jing
发明人： ZIOBER, Barry, L. , BAU, Haim, H. , MAUK, Michael, G. , CHEN, Zongyuan , WANG, Jing
CPC分类号： G01N33/574 , B01L3/502761 , B01L7/52 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/1894 , B01L2400/043 , B01L2400/0487 , B01L2400/0677 , C12Q1/6886 , C12Q2600/158 , G01N33/54366 , G01N2333/70503 , G01N2800/52
摘要： Biomarkers for the detection of pre-cancer and cancer cells and a method for their detection at the point of care are disclosed. The system is comprised of an inexpensive, disposable microfluidic cassette for sample preparation; continuous-flow, magnetic-bead assisted cell sorting and cytometry; cell lysis; nucleic acid isolation and amplification, hybridization, quantification, and analysis. Typically, the disposable cassette will be used with a benchtop instrument platform that provides power, control and detection capabilities to the cassette. In one particular embodiment and application of the invention, the cell sorting is based on the selective binding of magnetic beads coated with an MCAP antibody to exfoliated precancerous and cancerous cells contained in saliva. The bead-labeled precancerous and cancerous cells are then separated from other saliva components using a magnetic field. Both labeled and unlabeled cells can be counted using integrated detectors of several types, including cell counters based on impedance measurements, and cytometers based on Coulter particle counter principles. The sorted sub-population of precancerous and cancerous cells are lysed, and the nucleic acids are isolated for gene assays and/or transcription profiling of the sorted sample subpopulation. In one embodiment of the invention, the cassette includes re verse- transcription polymerase chain reaction for nucleic acid detection and a hybridization array for gene identification. The devices, systems, modes of operation, and methods disclosed here are also applicable for cancer and other disease detection in other body fluids.
摘要翻译：公开了用于检测癌前和癌细胞的生物标志物及其在护理时检测的方法。该系统由用于样品制备的廉价的一次性微流控盒组成; 连续流动，磁珠辅助细胞分选和细胞计数; 细胞裂解; 核酸分离和扩增，杂交，定量和分析。通常，一次性盒式磁带将与台式仪器平台一起使用，该平台为磁带提供功率，控制和检测能力。在本发明的一个具体实施方案和应用中，细胞分选基于用MCAP抗体包被的磁珠与包含在唾液中的脱落的癌前和癌细胞的选择性结合。然后使用磁场将珠标记的癌前和癌细胞与其它唾液成分分离。可以使用几种类型的集成检测器（包括基于阻抗测量的细胞计数器）和基于Coulter粒子计数器原理的细胞计数器来计数标记和未标记的细胞。裂解癌前和癌细胞的排序亚群，分离核酸用于分选的样品亚群的基因测定和/或转录谱。在本发明的一个实施方案中，盒包括用于核酸检测的转录聚合酶链反应和用于基因鉴定的杂交阵列。本文公开的装置，系统，操作模式和方法也适用于其他体液中的癌症和其他疾病检测。

7. 发明申请

WO2006122310A3 SYSTEM FOR TESTING 审中-公开
标题翻译：测试系统
公开(公告)号：WO2006122310A3
公开(公告)日：2009-06-04
申请号：PCT/US2006018481
申请日：2006-05-11
申请人： TRUSTESS OF THE UNIVERSITY OF , CHEN ZONGYUAN , WANG JING , MAUK MICHAEL G , BAU HAIM H , MALAMUD DANIEL , ABRAMS WILLIAM , NIEDBALA SAMUEL , TANKE HENDRIKUS JOHANNES , CORSTJENS PAUL L A M
发明人： CHEN ZONGYUAN , WANG JING , MAUK MICHAEL G , BAU HAIM H , MALAMUD DANIEL , ABRAMS WILLIAM , NIEDBALA SAMUEL , TANKE HENDRIKUS JOHANNES , CORSTJENS PAUL L A M
IPC分类号： C12M1/34
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/022 , B01L2300/0864 , B01L2300/1822 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0672 , B01L2400/0677 , B01L2400/0688 , G01N2035/00158 , Y10T436/143333
摘要： The present invention relates to sample processing using a microfluidic chip. Systems are described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample; and a developer for engaging the port of the cassette, wherein the developer propels the sample from said inlet to said detection zone.
摘要翻译：本发明涉及使用微流控芯片的样品处理。描述的系统包括具有至少一个端口的盒和与检测区流体连通的样品入口，用于与样品中预先选择的RNA序列，DNA序列，抗体或抗原或其混合物（如果存在）相互作用; 以及用于接合盒的端口的显影剂，其中显影剂将样品从所述入口推进到所述检测区。

8. 发明申请

WO2006122311A9 MICROFLUIDIC CHIP 审中-公开
标题翻译：微流感芯片
公开(公告)号：WO2006122311A9
公开(公告)日：2007-02-15
申请号：PCT/US2006018534
申请日：2006-05-11
申请人： UNIV PENNSYLVANIA , MAUK MICHAEL G , MALAMUD DANIEL , CHEN ZONGYUAN , WANG JING , BAU HAIM H , ABRAMS WILLIAM , NIEDBALA SAMUEL , TANKE HENDRIKUS JOHANNES , CORSTJENS PAUL L A M
发明人： MAUK MICHAEL G , MALAMUD DANIEL , CHEN ZONGYUAN , WANG JING , BAU HAIM H , ABRAMS WILLIAM , NIEDBALA SAMUEL , TANKE HENDRIKUS JOHANNES , CORSTJENS PAUL L A M
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/022 , B01L2300/0864 , B01L2300/1822 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0672 , B01L2400/0677 , B01L2400/0688 , G01N2035/00158 , Y10T436/143333
摘要： The present invention relates to sample processing using a microfluidic chip. The chip contains at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Chips with certain microfluidic features are also described.
摘要翻译：本发明涉及使用微流控芯片的样品处理。该芯片含有至少两个检测区，用于与预先选择的RNA序列，DNA序列，抗体或抗原相互作用以确定其在样品中的存在。还描述了具有某些微流体特征的芯片。

9. 发明申请

WO2006122311A3 MICROFLUIDIC CHIP 审中-公开
公开(公告)号：WO2006122311A3
公开(公告)日：2006-11-16
申请号：PCT/US2006/018534
申请日：2006-05-11
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , MAUK, Michael, G. , MALAMUD, Daniel , CHEN, Zongyuan , WANG, Jing , BAU, Haim, H. , ABRAMS, William , NIEDBALA, Samuel , TANKE, Hendrikus, Johannes , CORSTJENS, Paul, L.a.m.
发明人： MAUK, Michael, G. , MALAMUD, Daniel , CHEN, Zongyuan , WANG, Jing , BAU, Haim, H. , ABRAMS, William , NIEDBALA, Samuel , TANKE, Hendrikus, Johannes , CORSTJENS, Paul, L.a.m.
IPC分类号： C12M1/34 , C12M3/00
摘要： The present invention relates to sample processing using a microfluidic chip. The chip contains at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Chips with certain microfluidic features are also described.

10. 发明申请

WO2008076395A3 MECHANICALLY ACTUATED DIAGNOSTIC DEVICE 审中-公开
公开(公告)号：WO2008076395A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/025699
申请日：2007-12-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , CHEN, Zongyuan , BAU, Haim, H. , MAUK, Michael, G. , QIU, Xianbo , KWA, Jason
发明人： CHEN, Zongyuan , BAU, Haim, H. , MAUK, Michael, G. , QIU, Xianbo , KWA, Jason
IPC分类号： G01N33/00
摘要： Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system.

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