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1. 发明申请

WO2008037413A3 METHOD AND DEVICE FOR BURNING FUELS 审中-公开
标题翻译：方法和设备燃烧燃料
公开(公告)号：WO2008037413A3
公开(公告)日：2008-07-17
申请号：PCT/EP2007008305
申请日：2007-09-25
申请人： HOCHSCHULE KARLSRUHE TECHNIK U , KOHLER HEINZ , POTRECK ANDREAS , TRAUTMANN THOMAS
发明人： KOHLER HEINZ , POTRECK ANDREAS , TRAUTMANN THOMAS
IPC分类号： F23B10/00 , F23B60/00 , F23G5/16 , F23N3/00 , F23N5/00 , F23N5/02
CPC分类号： F23B10/02 , F23B10/00 , F23B60/00 , F23G5/165 , F23G2900/55003 , F23N3/002 , F23N5/003 , F23N5/006 , F23N5/02 , F23N5/022 , Y02E20/328
摘要： The invention relates to a method for burning solid organic fuels in a furnace (1) comprising a first chamber (2) used for the pre-combustion of the fuel (6) and having a primary, regulatable air supply (4), and a second chamber which is connected to the first chamber (3) for the post-combustion of post-combustible reaction products created during the pre-combustion and comprises a secondary regulatable air supply (5) and a detection device (12) at least for detecting the oxygen content in a representative content of post-combustible reaction products, and for detecting a temperature. The primary air supply is regulated by means of a first correcting variable formed by at least one parameter, and the secondary air supply is regulated by means of a second correcting variable formed by at least two parameters.
摘要翻译：（1）与第一室（2）用于燃料的预燃烧连接的炉中固体有机燃料的燃烧的方法，（6），具有伯，可控制的空气供应（4）和第二，与所述第一腔室（3）提出室的形成在预燃nachverbrennbaren反应产物与至少一个次要的，可控的空气供应（5）和检测装置（12），用于检测氧的内容，代表性的内容nachverbrennbaren反应产物后燃烧以及用于检测温度，其中，所述主空气供给通过来调节所形成的至少一个第一校正可变参数和通过形成第二受操纵变量的至少两个参数中的一个的装置中的二次空气供给的。

2. 发明申请

WO2009108803A2 METHODS AND COMPOSITIONS FOR IMMUNOASSAYS 审中-公开
标题翻译：免疫疗法的方法和组合物
公开(公告)号：WO2009108803A2
公开(公告)日：2009-09-03
申请号：PCT/US2009035333
申请日：2009-02-26
申请人： INNEXUS BIOTECHNOLOGY INC , RUSS MICHAEL A , KOHLER HEINZ , KINDT THOMAS J , LIPINSKI CHRISTOPHER A
发明人： RUSS MICHAEL A , KOHLER HEINZ , KINDT THOMAS J , LIPINSKI CHRISTOPHER A
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/57415 , G01N33/5306 , G01N2333/485 , G01N2333/71
摘要： Methods and compositions for immunoassays are provided according to embodiments of the present invention which include contacting an analyte in a sample with an antibody conjugated to an autophilic peptide; and detecting a complex formed by the analyte and the antibody conjugated to an autophilic peptide.
摘要翻译：根据本发明的实施例提供了用于免疫测定的方法和组合物，其包括使样品中的分析物与偶联自亲性肽的抗体接触; 并检测由分析物和与自体肽缀合的抗体形成的复合物。

3. 发明申请

WO2006056365A2 METHOD FOR IDENTIFICATION AND ANALYSIS OF MEASURING VALUES OBTAINED WITH THE AID OF AN ANALYSIS DEVICE FROM A MULTI-COMPONENT MIXTURE OF MATERIALS IN VARIABLE ENVIRONMENTAL CONDITIONS (GLOBAL) 审中-公开
标题翻译： METHOD FOR辨识与分析单元分析从获得的环境条件变化的一种多组分物质混合物的测量的环境（GLOBAL）
公开(公告)号：WO2006056365A2
公开(公告)日：2006-06-01
申请号：PCT/EP2005012357
申请日：2005-11-18
申请人： KARLSRUHE FORSCHZENT , SEIFERT ROLF , KELLER HUBERT , HETZNECKER ALEXANDER , SCHINDLER VOLKER , KOHLER HEINZ , SCHOENAUER ULRICH , FRANK KEVIN
发明人： SEIFERT ROLF , KELLER HUBERT , HETZNECKER ALEXANDER , SCHINDLER VOLKER , KOHLER HEINZ , SCHOENAUER ULRICH , FRANK KEVIN
CPC分类号： G01N33/0034 , G01N33/0006 , G01N33/0047 , G01N2201/129
摘要： Disclosed is a method for analysis of measuring values which are obtained from an environment with the aid of an analysis device from a multi-component mixture of materials, an n-component mixture of materials, thus designated as the target material. The method is used to classify and identify materials and to prove whether the mixture of materials thus analyzed is in fact the target material, and optionally to determine individual concentrations c i with i = 1, , n in variable envinronmental conditions.
摘要翻译：有分析与从多组分混合物，将其简称为由于正组件材料混合物的意图的目标物质的环境中的测定值的分析器所获得的方法，进行说明。的方法用于材料分类/ -Identification从而检测是否它实际上是检查围绕目标物质Steff混合物时，并且可选地，以确定各个浓度c _{I 其中i = 1，... n，其中变量的环境条件。}

4. 发明申请

WO2007137562A3 DEVICE FOR DETERMINING CONSIDERABLY FLUCTUATING CONTENTS OF VOLATILE SUBSTANCES IN LIQUIDS 审中-公开
标题翻译：一种用于确定挥发性物质强烈波动水平在液体中
公开(公告)号：WO2007137562A3
公开(公告)日：2008-02-21
申请号：PCT/DE2007000950
申请日：2007-05-25
申请人： HOCHSCHULE KARLSRUHE , KOHLER HEINZ , HELGET WERNER , WECKENMANN JUERGEN , HOINKIS JAN , SOERENSEN MARTIN , KIENZLER MATTHIAS
发明人： KOHLER HEINZ , HELGET WERNER , WECKENMANN JUERGEN , HOINKIS JAN , SOERENSEN MARTIN , KIENZLER MATTHIAS
IPC分类号： G01N1/40 , G01N33/18
CPC分类号： G01N33/182 , G01N1/40 , G01N1/4044 , G01N1/44 , G01N33/0022 , G01N2001/4066
摘要： The invention relates to, inter alia, a device (1) for determining considerably fluctuating contents of volatile substances in liquids (2), comprising an expulsion area (3) for expelling the compounds from the liquid to the gas phase (4), and a gas phase sensor device (5) for detecting the compounds expelled to the gas phase. According to the invention, a gas access determination agent (6a1, 6b1, 6c1)for determining access to the gas phase sensor device (5) is provided.
摘要翻译：本发明涉及到u。一。用于确定在液体中的挥发性物质水平波动的装置（1）（2），其具有一个驱动输出部分（3），用于排出从液体废物进入气相（4）和气相传感器装置（5），用于检测在气相物质排出，它提供了用于确定到气相传感器装置（5）的气体通路的气体接入判定装置（6AL，6B1，6C1）被提供。

5. 发明申请

WO0034766A3 GAS ANALYSIS APPARATUS 审中-公开
标题翻译：气体分析仪
公开(公告)号：WO0034766A3
公开(公告)日：2000-11-09
申请号：PCT/EP9909501
申请日：1999-12-04
申请人： KARLSRUHE FORSCHZENT , KELLER HUBERT , SEIFERT ROLF , JERGER ARMIN , BECKER FRANK , KOHLER HEINZ
发明人： KELLER HUBERT , SEIFERT ROLF , JERGER ARMIN , BECKER FRANK , KOHLER HEINZ
IPC分类号： G01N33/00 , G01N27/14 , G01N27/12
CPC分类号： G01N27/124
摘要： The invention relates to a gas analysis apparatus comprising a measuring head. Chambers with specifically sensitive semiconductor gas sensors or semiconductor gas sensors of the same kind are located in said measuring head, are covered by a lid and are only released for aeration by means of a hole in said lid. Said design enables reception of gas-specific sensor signal temperature profiles, reduction of the time required for the determination of a corresponding gas component and simultaneous increase in the selectivity of the gas analysis apparatus.
摘要翻译：一种气体分析仪具有测量头，其中具有相似或特定敏感的半导体气体传感器腔室的位置，其由一个盖子覆盖，并且仅用于通风是通过在盖子上的孔释放出来。这种结构允许特定气体传感器信号的温度分布的夹杂物，测定时间为一个相应的气体成分，并在同一时间的缩短增加了气体分析仪的选择性。

6. 发明申请

WO9620277A2 RECOMBINANT MONOCLONAL ANTI-IDIOTYPE ANTIBODY 3H1 SEQUENCES RELATING TO HUMAN CARCINOEMBRYONIC ANTIGEN 审中-公开
标题翻译：重组单克隆抗体抗体3H1与人类纤维蛋白原抗原相关的序列
公开(公告)号：WO9620277A2
公开(公告)日：1996-07-04
申请号：PCT/US9517103
申请日：1995-12-28
申请人： UNIV KENTUCKY , CHATTERJEE MALAYA , KOHLER HEINZ , CHATTERJEE SUNIL K , FOON KENNETH A
发明人： CHATTERJEE MALAYA , KOHLER HEINZ , CHATTERJEE SUNIL K , FOON KENNETH A
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/39 , A61K39/395 , A61K48/00 , A61P35/00 , A61P37/04 , C07K14/535 , C07K14/55 , C07K16/42 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/574 , G01N33/577 , C12N15/13 , A61K39/285 , C12N5/06 , C12N15/86 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/535 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/55 , C07K16/4266 , C07K2319/00 , C12N2799/023
摘要： This invention provides compositions derived from the sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 3H1 and methods for using these compositions.
摘要翻译：本发明提供衍生自编码单克隆抗独特型抗体3H1的可变轻和/或可变重区的序列的组合物和使用这些组合物的方法。

7. 发明申请

WO2009002939A3 AUTOPHILIC ANTIBODIES 审中-公开
标题翻译：自动抗体
公开(公告)号：WO2009002939A3
公开(公告)日：2009-04-23
申请号：PCT/US2008067917
申请日：2008-06-23
申请人： INNEXUS BIOTECHNOLOGY INTERNAT , KOHLER HEINZ , AMICK JEAN , RUSS MICHAEL A
发明人： KOHLER HEINZ , AMICK JEAN , RUSS MICHAEL A
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6843 , C07K2317/732 , C07K2317/734
摘要： Autophilic antibodies including an immunoglobulin component and an autophilic peptide fused thereto are provided according to embodiments of the present invention. Particular autophilic antibodies described herein include a chimeric gamma immunoglobulin heavy chain and autophilic peptide expressed as a fusion protein. Preferably the autophilic peptide is expressed at the C-terminus of the immunoglobulin component. Expression vectors according to embodiments of the present invention for use in generating autophilic antibodies are provided which include a first nucleic acid sequence encoding an autophilic peptide, operably linked to a transcription promoter. In particular embodiments, a second nucleic acid sequence encoding a chimeric heavy chain of an immunoglobulin operably linked to the transcription promoter and connected to the first nucleic acid sequence such that expression of the first and second nucleic acid sequences produces a fusion protein of the chimeric heavy chain and the autophilic peptide.
摘要翻译：根据本发明的实施方案提供了包括免疫球蛋白组分和与其融合的自亲自肽的亲电抗体。本文所述的特定的自亲免疫抗体包括嵌合γ免疫球蛋白重链和表达为融合蛋白的自噬肽。优选地，所述自噬肽在所述免疫球蛋白组分的C末端表达。提供了根据本发明实施方案用于产生自亲免疫抗体的表达载体，其包括编码与转录启动子有效连接的自噬肽的第一核酸序列。在具体实施方案中，编码免疫球蛋白嵌合重链的第二核酸序列，其可操作地连接到转录启动子并与第一核酸序列连接，使得第一和第二核酸序列的表达产生嵌合重链的融合蛋白链和自噬肽。

8. 发明申请

WO2006119291A3 SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE 审中-公开
标题翻译：超敏反应合成和用于检测，预防和治疗疾病
公开(公告)号：WO2006119291A3
公开(公告)日：2009-04-16
申请号：PCT/US2006016844
申请日：2006-04-29
申请人： INNEXUS BIOTECHNOLOGY INTERNAT , KOHLER HEINZ , MULLER SYBILLE , MORGAN ALTON CHARLES JR
发明人： KOHLER HEINZ , MULLER SYBILLE , MORGAN ALTON CHARLES JR
IPC分类号： A61K39/395 , A61K47/48 , C07K16/00 , C07K16/28 , C07K16/30 , C07K16/32 , C07K16/40 , C07K16/46 , C07K17/00 , C07K17/14 , C12P21/08 , G01N33/53 , G01N33/574
CPC分类号： G01N33/92 , A61K41/0042 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/2803 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/40 , C07K2317/73 , G01N2510/00 , G01N2800/323
摘要： Superantibodies having enhanced autophilic, catalytic, and/or membrane- penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. The superantibodies can enhance the potency and expand the targeting range of target antibodies. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed.
摘要翻译：具有增强的自噬性，催化和/或膜穿透性质的超抗体通过可光活化的有机分子与靶免疫球蛋白的亲和基偶联来制备。可光活化的有机分子具有对免疫球蛋白具有亲和性的发色芳烃部分。光解后，有机分子与免疫球蛋白共价连接。优选的有机分子是肽，优选的芳族烃部分是色氨酸残基。可光活化的有机分子不需要携带嘌呤，嘧啶或叠氮基以实现与免疫球蛋白的结合和/或光活化。超抗体可增强靶向抗体的效力并扩大靶向范围。自噬性超抗体可以促进靶细胞的凋亡和/或增强治疗对抗体治疗反应的疾病或病症的患者的治疗功效。这些疾病的示例是动脉粥样硬化和心血管疾病。膜穿透性超抗体可以通过结合细胞内抗半胱天冬酶信号蛋白来预防凋亡。公开了含有超抗体的组合物，以及制备和使用它们的方法。

9. 发明申请

WO02097041A2 FUSION PROTEINS OF BIOLOGICALLY ACTIVE PEPTIDES AND ANTIBODIES 审中-公开
标题翻译：生物活性肽和抗体的融合蛋白
公开(公告)号：WO02097041A2
公开(公告)日：2002-12-05
申请号：PCT/US0216651
申请日：2002-05-29
申请人： IMMPHERON INC , INNEXUS CORP , KOHLER HEINZ , MORGAN CHARLES
发明人： KOHLER HEINZ , MORGAN CHARLES
IPC分类号： A61K39/00 , C07K14/47 , C07K14/77 , C07K16/00 , C07K16/42 , C12N
CPC分类号： C07K14/472 , A61K39/00 , A61K2039/505 , C07K14/77 , C07K16/00 , C07K16/4208 , C07K16/4266 , C07K2319/00
摘要： A fusion protein is made up of (1) an antibody and (2) a peptide having a biological activity such as immuno-stimulatory, membrane transport and homophilic activities wherein the peptide is connected to the antibody at a site that does not interfere with antigen binding of the antibody. The fusion protein is made by the steps of creating a fusion gene including a nucleic acid sequence encoding an antibody and a nucleic acid sequence encoding the peptide, wherein the nucleic acid sequence encoding the peptide is located inside the nucleic acid sequence encoding the antibody at a site wherein, when the fusion is expressed, the fusion protein created thereby comprises the antibody and the peptide, wherein the peptide is connected to the antibody at a site that does not interfere with antigen binding of the antibody, and expressing the fusion gene to create the fusion protein. The peptide may be flanked by loop-forming or conformation-conferring sequences.
摘要翻译：融合蛋白由（1）抗体和（2）具有生物学活性的肽，例如免疫刺激，膜转运和亲和活性组成，其中肽在不干扰抗原的位点连接到抗体抗体的结合。融合蛋白是通过产生包含编码抗体的核酸序列和编码该肽的核酸序列的融合基因的步骤制备的，其中编码该肽的核酸序列位于编码该抗体的核酸序列的内部其中，当融合表达时，由此产生的融合蛋白包含抗体和肽，其中肽在不干扰抗体的抗原结合的位点处连接到抗体，并表达融合基因以产生融合蛋白。肽可以侧接于环形成或构象赋予序列。

10. 发明申请

WO9620219A3 MURINE MONOCLONAL ANTI-IDIOTYPE ANTIBODY 3H1 审中-公开
标题翻译： MURINE单克隆抗体抗体3H1
公开(公告)号：WO9620219A3
公开(公告)日：1996-09-06
申请号：PCT/US9517105
申请日：1995-12-28
申请人： UNIV KENTUCKY , CHATTERJEE MALAYA , KOHLER HEINZ , CHATTERJEE SUNIL K , FOON KENNETH A
发明人： CHATTERJEE MALAYA , KOHLER HEINZ , CHATTERJEE SUNIL K , FOON KENNETH A
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/39 , A61K39/395 , A61K48/00 , A61P35/00 , A61P37/04 , C07K14/535 , C07K14/55 , C07K16/42 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K14/535 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/55 , C07K16/4266 , C07K2319/00 , C12N2799/023
摘要： The present invention provides a monoclonal anti-idiotype antibody 3H1 that escapes immune tolerance and elicits a specific immune response to CEA in mice, rabbits, monkeys, and patients with advanced CEA-associated disease. This invention also provides compositions which can be used in the detection or treatment of CEA-associated tumors mimics a specific epitope on carcinoembryonic antigen and a hybridoma that produces 3H1. 00000
摘要翻译：本发明提供一种单克隆抗独特型抗体3H1，其逃避免疫耐受，并在小鼠，兔，猴和晚期CEA相关疾病患者中引起对CEA的特异性免疫应答。本发明还提供可用于检测或治疗CEA相关肿瘤的组合物，其模拟癌胚抗原上的特异性表位和产生3H1的杂交瘤。 00000

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