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2. 发明申请

WO2009002939A3 AUTOPHILIC ANTIBODIES 审中-公开
标题翻译：自动抗体
公开(公告)号：WO2009002939A3
公开(公告)日：2009-04-23
申请号：PCT/US2008067917
申请日：2008-06-23
申请人： INNEXUS BIOTECHNOLOGY INTERNAT , KOHLER HEINZ , AMICK JEAN , RUSS MICHAEL A
发明人： KOHLER HEINZ , AMICK JEAN , RUSS MICHAEL A
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K19/00 , A61K47/6811 , A61K47/6843 , C07K2317/732 , C07K2317/734
摘要： Autophilic antibodies including an immunoglobulin component and an autophilic peptide fused thereto are provided according to embodiments of the present invention. Particular autophilic antibodies described herein include a chimeric gamma immunoglobulin heavy chain and autophilic peptide expressed as a fusion protein. Preferably the autophilic peptide is expressed at the C-terminus of the immunoglobulin component. Expression vectors according to embodiments of the present invention for use in generating autophilic antibodies are provided which include a first nucleic acid sequence encoding an autophilic peptide, operably linked to a transcription promoter. In particular embodiments, a second nucleic acid sequence encoding a chimeric heavy chain of an immunoglobulin operably linked to the transcription promoter and connected to the first nucleic acid sequence such that expression of the first and second nucleic acid sequences produces a fusion protein of the chimeric heavy chain and the autophilic peptide.
摘要翻译：根据本发明的实施方案提供了包括免疫球蛋白组分和与其融合的自亲自肽的亲电抗体。本文所述的特定的自亲免疫抗体包括嵌合γ免疫球蛋白重链和表达为融合蛋白的自噬肽。优选地，所述自噬肽在所述免疫球蛋白组分的C末端表达。提供了根据本发明实施方案用于产生自亲免疫抗体的表达载体，其包括编码与转录启动子有效连接的自噬肽的第一核酸序列。在具体实施方案中，编码免疫球蛋白嵌合重链的第二核酸序列，其可操作地连接到转录启动子并与第一核酸序列连接，使得第一和第二核酸序列的表达产生嵌合重链的融合蛋白链和自噬肽。

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