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1. 发明申请

WO0121145A8 METHOD FOR COLORING KERATIN FIBERS BY MEANS OF AT LEAST ONE ENZYME OF THE TRANSGLUTAMINASE TYPE 审中-公开
标题翻译：方法转谷氨酰胺酶着色角蛋白纤维的至少一种酶TYPE
公开(公告)号：WO0121145A8
公开(公告)日：2001-07-05
申请号：PCT/EP0008923
申请日：2000-09-13
申请人： HENKEL KGAA , KLEEN ASTRID , HOEFFKES HORST , SAETTLER ANDREA , OTTO RALF
发明人： KLEEN ASTRID , HOEFFKES HORST , SAETTLER ANDREA , OTTO RALF
IPC分类号： A61K8/00 , A61K8/64 , A61K8/66 , A61Q5/06 , A61Q5/10 , C12S3/00 , C12S7/00 , A61K7/13 , A61K7/06
CPC分类号： A61Q5/10 , A61K8/64 , A61K8/645 , A61K8/66 , A61Q5/065
摘要： The invention relates to a method for coloring keratin fibers with dyes and/or pre-dyes. According to the inventive method, (A) at least one enzyme of the transglutaminase type and (B) at least one active substance that has a substrate activity for the enzyme are applied on the fibers. The inventive method substantially improves the color fastness properties, especially the fastness to washing of the colorations obtained with said dyes.
摘要翻译：本发明涉及一种方法，用于染色用染料和/或染料前体的角质纤维，其中施加具有用于酶的底物活性的至少一种活性物质的纤维（A）的转谷氨酰胺酶类型的至少一种酶和（B），使用这种方法，所述的坚牢度性能，特别是洗涤坚牢度，所获得的颜色可以显著改善。

2. 发明申请

WO0121139A2 METHOD FOR RESTRUCTURING KERATIN FIBERS 审中-公开
标题翻译： PROCESS李玉平角蛋白纤维
公开(公告)号：WO0121139A2
公开(公告)日：2001-03-29
申请号：PCT/EP0008924
申请日：2000-09-13
申请人： HENKEL KGAA , KLEEN ASTRID , BRABAENDER OLIVER , SAETTLER ANDREA , HOEFFKES HORST , OTTO RALF
发明人： KLEEN ASTRID , BRABAENDER OLIVER , SAETTLER ANDREA , HOEFFKES HORST , OTTO RALF
IPC分类号： A61K8/64 , A61K8/66 , A61Q5/00 , A61K7/00
CPC分类号： A61K8/66 , A61K8/64 , A61Q5/00
摘要： The invention relates to a method for restructuring keratin fibers. According to the inventive method, (A) at least one enzyme of the transglutaminase type and (B) at least one active substance that has a substrate activity for said enzyme are applied on the fibers. The inventive method allows the restructurization of damaged fibers.
摘要翻译：本发明涉及一种用于角蛋白纤维的重组，其中所述纤维（A）转谷氨酰胺酶类型的至少一种酶和具有用于酶的底物活性的至少一种活性物质（B）被应用。使用这种方法，可以重组损坏纤维。

3. 发明申请

WO0236801A3 EXTRUDED PROTEIN HYDROLYSATE, METHOD FOR PRODUCTION AND USE THEREOF 审中-公开
标题翻译：膨化蛋白水解物，方法及其和使用
公开(公告)号：WO0236801A3
公开(公告)日：2003-04-24
申请号：PCT/EP0112461
申请日：2001-10-27
申请人： HENKEL KGAA , MUELLNER STEFAN , OTTO RALF , WEISS ALBRECHT , STEHR REGINA , MERCK KARIN B , DE GRAAF LEONTIEN A
发明人： MUELLNER STEFAN , OTTO RALF , WEISS ALBRECHT , STEHR REGINA , MERCK KARIN B , DE GRAAF LEONTIEN A
IPC分类号： A23J3/26 , A23L33/18 , A61K8/65 , A61Q19/00 , A61Q19/10 , C11D1/32 , C12P21/06 , B01J19/20
CPC分类号： A23J3/26 , A23L33/18 , A61K8/65 , A61Q19/00 , A61Q19/10 , C11D1/32 , C12P21/06
摘要： The invention relates to a protein hydrolysate, which may be obtained by continuous enzymatic hydrolysis of a protein-containing substrate, whereby the hydrolysis is carried out in an extruder, a method for production of said protein hydrolysate and the use thereof in the production of cosmetics, adhesives, washing agents, foodstuffs, foodstuff additives, cleaning agents, bodycare agents, leather-care products and similar.
摘要翻译：本发明涉及的蛋白水解产物，通过含有底物的蛋白质，其特征在于水解是在挤出机中进行，用于制造这样的蛋白水解产物及其生产化妆品，粘合剂，洗涤剂，食物，食品增补剂，洗涤剂中使用的方法的连续酶促水解得到的像个人护理产品，皮革护理产品。

4. 发明申请

WO2004050884A2 NOVEL NEOMYCIN PHOSPHOTRANSFERASE GENES AND METHOD FOR THE SELECTION OF HIGH-PRODUCING RECOMBINANT CELLS 审中-公开
标题翻译：可供选择的新霉素磷酸转移酶基因和方法高产重组细胞
公开(公告)号：WO2004050884A2
公开(公告)日：2004-06-17
申请号：PCT/EP0313203
申请日：2003-11-25
申请人： BOEHRINGER INGELHEIM PHARMA , ENENKEL BARBARA , SAUTTER KERSTIN , OTTO RALF , FIEDER JUERGEN , BERGEMANN KLAUS
发明人： ENENKEL BARBARA , SAUTTER KERSTIN , OTTO RALF , FIEDER JUERGEN , BERGEMANN KLAUS
IPC分类号： C12N9/12 , C12N15/85 , C12N5/00
CPC分类号： C12N9/1205 , C12Y207/01095
摘要： The invention relates to novel modified neomycin phosphotransferase genes and the use thereof in a selection method for high-producing recombinant cells. The invention also relates to expression vectors containing a modified neomycin phosphotransferase gene and a gene of interest in a functional bond with a heterologous promoter, and a method for producing heterologous gene products by using said expression vectors.
摘要翻译：本发明涉及新颖的改性新霉素磷酸转移基因和用于高生产重组细胞中的选择方法及其使用。此外，本发明提供了含有修饰的新霉素磷酸转移酶基因和感兴趣的基因功能性连接的表达载体涉及含有异源启动子以及使用这些表达载体异源基因产物的方法。

5. 发明申请

WO2006051065A2 USE OF FLOW-CYTROMETRIC ANALYSIS TO OPTIMIZE CELL BANKING STRATEGIES FOR CHO CELLS 审中-公开
标题翻译：流式细胞分析法优化CHO细胞细胞储存策略的应用
公开(公告)号：WO2006051065A2
公开(公告)日：2006-05-18
申请号：PCT/EP2005055784
申请日：2005-11-07
申请人： BOEHRINGER INGELHEIM PHARMA , KAUFMANN HITTO , FIEDER JUERGEN , OTTO RALF
发明人： KAUFMANN HITTO , FIEDER JUERGEN , OTTO RALF
IPC分类号： A01N1/02
CPC分类号： G01N33/56966 , G01N2333/4718
摘要： Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation strategy is needed for each new production cell line, particularly with regard to the desire to establish production processes that are completely devoid of serum or even any animal components and to ensure robust thaw performance for reliable production. Here we describe a novel strategy employing flow cytometric (FC) analysis of Annexin V-stained cells for high-throughput characterization of CHO cell banks. Our data show that this method enables evaluation of a cryopreservation procedure just 6h after thaw.
摘要翻译：从CHO细胞生产生物药物需要生产高质量的母体，工作和后期生产细胞库，部分是在GMP条件下生产。每个新的生产细胞系都需要最佳的冷冻保存策略，特别是关于建立完全没有血清或甚至任何动物成分的生产过程的愿望，并确保可靠生产的强大的解冻性能。在这里，我们描述了一种采用流式细胞术（FC）分析Annexin V染色细胞用于CHO细胞库的高通量表征的新策略。我们的数据显示，这种方法能够在解冻后6小时评估冷冻保存程序。

6. 发明申请

WO02093639A3 ARRANGEMENT AND METHOD FOR DETECTING DEFECTS ON A SUBSTRATE IN A PROCESSING TOOL 审中-公开
标题翻译：用于检测处理工具中基板上的缺陷的布置和方法
公开(公告)号：WO02093639A3
公开(公告)日：2003-03-20
申请号：PCT/EP0205189
申请日：2002-05-10
申请人： INFINEON TECHNOLOGIES AG , SEIDEL TORSTEN , OTTO RALF , SCHUMACHER KARL , SCHEDEL THORSTEN , MARX ECKHARD , HRASCHAN GUENTHER
发明人： SEIDEL TORSTEN , OTTO RALF , SCHUMACHER KARL , SCHEDEL THORSTEN , MARX ECKHARD , HRASCHAN GUENTHER
IPC分类号： G03F1/08 , G03F7/20 , H01L21/00 , H01L21/027 , H01L21/66 , H01L21/677
CPC分类号： H01L21/67225 , G03F7/7065 , H01L21/67271 , H01L21/67288 , H01L22/12
摘要： A processing tool (1) for manufacturing semiconductor devices (2), e.g. a lithography cluster, comprises a device transfer area (8) with an optical sensor (10), preferably a CCD-camera, and an illumination system (11) mounted within, such that a substrate (2) being transferred to or from one of its processing chambers (1a, 1b, 1c) can be scanned during its movement at low resolution. The substrate (2) may be either a semiconductor wafer to be manufactured or a reticle or mask used to perform an exposure on said wafer. The scanning is performed twice, prior and after processing in at least one the processing chambers (1a, 1b, 1c) of the processing tool (1). Both images are compared and optionally subtracted from each other. Defects imposed to the substrate due to contaminating particles only during the present processes with sizes larger than 10 microm are visible on the subtracted image, while defects imposed earlier are diminished as well as structures formed from e.g. a mask pattern below 10 microm. Pattern recognition allows an efficient classification of the defects being just detected in a processing tool (1). Thus, semiconductor device yield and metrology capacity are advantageously increased.
摘要翻译：一种用于制造半导体器件（2）的加工工具（1），例如，光刻簇包括具有光学传感器（10）的装置传送区域（8），优选地是CCD照相机，以及安装在其内的照明系统（11），使得基板（2）被转移到其处理室（1a，1b，1c）可以在其低分辨率的运动期间被扫描。衬底（2）可以是要制造的半导体晶片或用于在所述晶片上进行曝光的掩模版或掩模。在处理工具（1）的至少一个处理室（1a，1b，1c）中处理之前和之后进行两次扫描。两个图像被比较并且可选地相互减去。仅在尺寸大于10微米的本工艺过程中由于污染颗粒而施加到基材上的缺陷在减去的图像上是可见的，而较早施加的缺陷以及由例如形成的结构减少。 10微米以下的掩模图案。模式识别允许在处理工具（1）中刚刚检测到的缺陷的有效分类。因此，有利地增加了半导体器件的产量和计量能力。

7. 发明申请

WO2005019442A2 METHOD FOR RECLONING PRODUCTION CELLS 审中-公开
标题翻译：重新生产细胞的方法
公开(公告)号：WO2005019442A2
公开(公告)日：2005-03-03
申请号：PCT/EP2004009204
申请日：2004-08-17
申请人： BOEHRINGER INGELHEIM PHARMA , ENENKEL BARBARA , FIEDER JUERGEN , OTTO RALF , KRIEG THOMAS
发明人： ENENKEL BARBARA , FIEDER JUERGEN , OTTO RALF , KRIEG THOMAS
IPC分类号： C12N5/02 , C12N5/071 , C12N5/09 , C12N5/10 , C12P21/00
CPC分类号： C12N5/0694 , C12N2500/90 , C12N2502/00 , C12N2502/30 , C12N2510/02
摘要： The invention relates to a novel method for selecting clones and recloning mammal cells that are used in the production of biopharmaceuticals, preferably hamster or mouse myeloma cells, with a high degree of automation and throughput. The invention also relates to methods for depositing and multiplying individual cell clones of the corresponding cells, to methods for producing proteins using cells that are obtained and multiplied by means of individual cell deposition, and to compositions that enable individual cells to be multiplied.
摘要翻译：用于生产生物药物，优选仓鼠或小鼠骨髓瘤细胞的重要的哺乳动物细胞克隆选择和再克隆的新方法，具有高度的自动化和吞吐量。本发明涉及用于沉积和繁殖Einzellzellklonen相应细胞的方法。此外，本发明涉及使用已经通过单细胞沉积获得并繁殖的细胞和允许单细胞扩增的组合物生产蛋白质的方法。

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