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1. 发明申请

WO1997026034A1 METHOD AND APPARATUS FOR MINIMIZING THE RISK OF AIR EMBOLISM IN THE THORACIC CAVITY 审中-公开
标题翻译：用于最小化胸腔积气风险的方法和装置
公开(公告)号：WO1997026034A1
公开(公告)日：1997-07-24
申请号：PCT/US1997000731
申请日：1997-01-14
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , GARRISON, Michi, E. , DONLON, Brian, S.
IPC分类号： A61M05/00
CPC分类号： A61M25/1011 , A61B17/00234 , A61B17/0218 , A61B17/0293 , A61B90/40 , A61B2017/00243 , A61B2090/401 , A61F2/2403 , A61F2/2427 , A61F2/2448 , A61F2/2466 , A61F2/2496 , A61M25/0041 , A61M25/0133
摘要： An instrument delivery member (2) for use in the thoracic cavity and a method for its use, is disclosed. The delivery member (2) has a gas inlet (40) coupled to a sidewall (44) of the instrument delivery member (2). Gas delivered through the inlet (68) passes through the delivery member and out a plurality of gas outlets (38) such that the gas exiting through the gas outlets (38) passes across the through hole (4) of the delivery member (2) to form a gas shield.
摘要翻译：公开了一种用于胸腔的器械传送部件（2）及其使用方法。输送构件（2）具有联接到仪器输送构件（2）的侧壁（44）的气体入口（40）。通过入口（68）输送的气体通过输送构件并排出多个气体出口（38），使得通过气体出口（38）排出的气体穿过输送构件（2）的通孔（4）形成气体屏蔽。

2. 发明申请

WO1996039942A1 LESS INVASIVE DEVICES AND METHODS FOR TREATMENT OF CARDIAC VALVES 审中-公开
标题翻译：较少的入侵设备和治疗心脏瓣膜的方法
公开(公告)号：WO1996039942A1
公开(公告)日：1996-12-19
申请号：PCT/US1996007970
申请日：1996-05-30
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , GARRISON, Michi, E. , DONLON, Brian, S. , DANIEL, S., Christopher , STEVENS, John, H.
IPC分类号： A61B17/00
CPC分类号： A61F2/2427 , A61B17/00234 , A61B17/0218 , A61B17/0293 , A61B90/40 , A61B2017/00243 , A61B2090/401 , A61F2/2403 , A61F2/2448 , A61F2/2466 , A61F2/2496
摘要： Device and methods are provided for less invasive surgical treatment of cardiac valves whereby the need for a gross thoracotomy or median sternotomy is eliminated. In one aspect of this invention, a delivery system (10) for a cardiac valve prosthesis such as an annuloplasty ring (90) or prosthetic valve (262) includes an elongated handle (28) configured to extend into the heart through an intercostal space from outside of the chest cavity, and a prosthesis holder (100) attached to the handle for releasably holding a prosthesis. The prosthesis holder (100) is attached to the handle (28) in such a way that the holder (100), prosthesis (90) and handle (28) have a profile with a height smaller than the width of an intercostal space when the adjacent ribs are unrectrated, preferably less than about 30 mm. In a further aspect, the invention provides a method for repairing or replacing a heart valve which includes the steps of introducing a prosthesis (262) through an intercostal space and through a penetration in a wall of the heart, and securing the prosthesis (262) to an interior wall of the heart, wherein each step is carried out without cutting, removing, or significantly retracting the ribs or sternum.
摘要翻译：为心脏瓣膜的较少侵入性手术治疗提供了装置和方法，因此消除了对大胸廓切开术或中位胸骨切开术的需要。在本发明的一个方面，用于心脏瓣膜假体例如瓣环成形术环（90）或人工瓣膜（262）的输送系统（10）包括细长手柄（28），其配置成通过肋间隙以及附接到手柄上的假体保持器（100），用于可释放地保持假体。假体保持器（100）以使得保持器（100），假体（90）和手柄（28）具有高度小于肋间空间的宽度的轮廓的方式附接到手柄（28），当该相邻的肋是非直立的，优选小于约30mm。在另一方面，本发明提供了一种修复或替换心脏瓣膜的方法，其包括以下步骤：将假体（262）通过肋间空间引入穿过心脏的壁，并固定假体（262）到心脏的内壁，其中每个步骤在不切割，移除或显着缩回肋骨或胸骨的情况下进行。

3. 发明申请

WO1996040347A1 ENDOVASCULAR SYSTEM FOR ARRESTING THE HEART 审中-公开
标题翻译：用于记录心脏的内镜系统
公开(公告)号：WO1996040347A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008078
申请日：1996-05-30
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , VALLEY, Kirsten, L. , SNOW, David, W. , CORVI, Timothy, C. , DONLON, Brian, S. , BOYD, Stephen, W. , FAN, Sylvia, W. , ROTH, Alex, T. , PETERS, William, S. , MUELLER, Richard, J., Jr. , GIFFORD, Hanson, S., III
IPC分类号： A61M29/00
CPC分类号： A61M25/0147 , A61B17/00234 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/2909 , A61B18/1492 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61F2/2427 , A61M1/3621 , A61M1/3653 , A61M1/3659 , A61M25/0023 , A61M25/0028 , A61M25/0032 , A61M25/0041 , A61M25/0054 , A61M25/0125 , A61M25/0152 , A61M25/0155 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M25/1029 , A61M25/1034 , A61M25/1038 , A61M39/0247 , A61M2025/0002 , A61M2025/0004 , A61M2025/0031 , A61M2025/0046 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/105 , A61M2025/1052 , A61M2025/1059 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2205/11 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/125 , A61M2210/127
摘要： Devices and methods are provided for temporarily inducing cardio-plegia arrest in the heart of a patient, and for establishing cardiopulmonary bypass in order to facilitate surgical procedures onthe heart and its related blood vessels. Specifically, a catheterbased system is provided for isolating the heart and coronary blood vessels of a patient from the remainder of the arterial system(850), and for infusing a cardio-plegia agent into the patient's coronary arteries to induce cardio-plegia arrest in the heart. The system includes an endo-aortic partitioning catheter (10) having an expandable balloon (11, 161) at its distal end, which is expanded within the ascending aorta (12, 157) to occlude the aortic lumen between the coronary ostia and the brachio-cephalic artery. Means for centering the catheter tip (330) within the ascending aorta include specially curved shaft configurations (1600), eccentric (710) or shaped (792) occlusion balloons (161, 350), and a steerable catheter tip (145) which may be used separately or in combination. The shaft of the catheter may have a coaxial (106) or multilumen (602) construction.
摘要翻译：提供了设备和方法，用于暂时诱导患者心脏中的心脏停滞，并建立心肺分流术，以促进心脏及其相关血管的外科手术。具体地说，提供一种基于导管的系统，用于将患者的心脏和冠状动脉血管与动脉系统的其余部分（850）隔离，并将心脏 - 焦虑剂注入患者的冠状动脉以诱发心脏 - 心。该系统包括内主动脉分隔导管（10），其在其远端具有可膨胀气囊（11,161），其在升主动脉（12,157）内扩张以阻塞冠状动脉口和臂动脉之间的主动脉腔脑动脉。用于使导管末端（330）在升主动脉内居中的装置包括特殊弯曲的轴构造（1600），偏心（710）或成形（792）阻塞气囊（161,350）以及可导向的导管尖端（145）单独使用或组合使用。导管的轴可以具有同轴（106）或多腔（602）结构。

4. 发明申请

WO1998003213A1 MINIMALLY-INVASIVE DEVICES AND METHODS FOR TREATMENT OF CONGESTIVE HEART FAILURE 审中-公开
标题翻译：微小的入侵装置和治疗心脏失效的方法
公开(公告)号：WO1998003213A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012934
申请日：1997-07-23
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , STEVENS, John, H. , BOLDUC, Lee, R. , BOYD, Stephen, W. , GIFFORD, Hanson, S., III , DONLON, Brian, S. , HOULE, Philip, R. , ROSENMAN, Daniel, C.
IPC分类号： A61M01/14
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0218 , A61B17/0293 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/122 , A61B17/29 , A61B17/2909 , A61B17/3421 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00867 , A61B2017/00907 , A61B2017/00946 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/2912 , A61B2017/2926 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/061 , A61B2090/306 , A61F2/2442 , A61F2/2445 , A61F7/10 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M1/3621 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/027 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366
摘要： A method of treatment of congestive heart failure comprises the steps of introducing an aortic occlusion catheter (26) through a patient's peripheral artery, the aortic occlusion catheter (26) having an occluding member (30) movable from a collapsed position to an expanded position; positioning the occluding member (30) in the patient's ascending aorta; moving the occluding member (30) from the collapsed shape to the expanded shape after the positioning step; introducing cardio-plegia fluid into the patient's coronary blood vessels to arrest the patient's heart; maintaining circulation of oxygenated blood through the patient's arterial system; and reshaping an outer wall of the patient's heart while the heart is arrested so as to reduce the transverse dimension of the left ventricle. The ascending aorta may be occluded and cardio-plegia fluid delivered by means of an occlusion balloon (44) attached to the distal end of an elongated catheter (42) positioned trans-luminal in the aorta from a femoral, subclavian, or other appropriate peripheral artery.
摘要翻译：治疗充血性心力衰竭的方法包括以下步骤：将主动脉闭塞导管（26）引入患者的外周动脉，所述主动脉闭塞导管（26）具有可从折叠位置移动到扩张位置的闭塞构件（30）将所述闭塞构件（30）定位在患者的升主动脉中; 在定位步骤之后将封闭构件（30）从折叠形状移动到扩展形状; 将心血管流体引入患者的冠状动脉血管以阻止患者的心脏; 维持氧合血液循环通过病人的动脉系统; 并在心脏被逮住时重塑患者心脏的外壁，以减小左心室的横向尺寸。上升主动脉可以闭塞，并且通过附接到细长导管（42）的远端的闭塞气囊（44）递送的心脏 - 血液流体，其从主动脉在大腿，锁骨下或其他适当的周边动脉。

5. 发明申请

WO1996040354A1 DEVICES AND METHODS FOR PORT-ACCESS MULTIVESSEL CORONARY ARTERY BYPASS SURGERY 审中-公开
标题翻译：口服多功能手术器械和方法冠状动脉旁路手术
公开(公告)号：WO1996040354A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008244
申请日：1996-05-31
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , BOYD, Stephen, W. , RAPACKI, Alan, R. , VASKA, Matthias , DONLON, Brian, S. , PETERS, Williams, S. , STEVENS, John, H.
IPC分类号： A61M37/00
CPC分类号： A61F7/10 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/2804 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2912 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/320056 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61B2217/005 , A61F2/2427 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： Surgical methods and instruments are disclosed for performing port-access or closed-chest coronary artery bypass (CABG) surgery in multivessel coronary artery disease. In contrast to standard open-chest CABG surgery, which requires a median sternotomy or other gross thoracotomy to expose the patient's heart, post-access CABG surgery is performed through small incisions or access ports made through the intercostal spaces between the patient's ribs, resulting in greatly reduced pain and morbidity to the patient. In situ arterial bypass grafts, such as the internal mammary arteries and/or the right gastroepiploic artery, are prepared for grafting by thoracoscopic or laparoscopic takedown techniques. Free grafts, such as a saphenous vein graft or a free arterial graft, can be used to augment the in situ arterial grafts. The graft vessels are anastomosed to the coronary arteries under direct visualization through a cardioscopic microscope inserted through an intercostal access port. Retraction instruments are provided to manipulate the heart within the closed chest of the patient to expose each of the coronary arteries for visualization and anastomosis. Disclosed are a tunneler and an articulated tunneling grasper for rerouting the graft vessels, and a finger-like retractor, a suction cup retractor, a snare retractor and a loop retractor for manipulating the heart. Also disclosed is a port-access topical cooling device for improving myocardial protection during the port-access CABG procedure. An alternate surgical approach using an anterior mediastinotomy is also described.
摘要翻译：公开了用于在多支冠状动脉疾病中进行门禁或封闭式冠状动脉旁路（CABG）手术的手术方法和手段。与标准的胸腔CABG手术相比，其需要中位胸骨切开术或其他大胸廓切开术来暴露患者的心脏，通过在患者肋骨之间的肋间空间制造的小切口或进入口进行后访问CABG手术，导致大大降低患者的疼痛和发病率。通过胸腔镜或腹腔镜移植技术准备原位动脉旁路移植物，例如乳内动脉和/或右胃腹动脉，用于移植。可以使用自由移植物，例如隐静脉移植物或自由动脉移植物来增加原位动脉移植物。通过插入通过肋间进入端口的心脏显微镜，在直接可视化下将移植血管吻合到冠状动脉。提供收缩器械以操纵患者的封闭的胸部内的心脏以暴露每个冠状动脉用于可视化和吻合。公开了一种用于重新路由移植血管的隧道器和铰接隧道抓紧器，以及用于操纵心脏的手指状牵开器，吸盘牵开器，圈套牵开器和回卷器。还公开了一种用于在端口访问CABG过程期间改善心肌保护的端口访问局部冷却装置。还描述了使用前纵隔切开术的替代手术方法。

6. 发明申请

WO1998002099A1 CORONARY SHUNT AND METHOD OF USE 审中-公开
标题翻译：冠状动脉搭桥及使用方法
公开(公告)号：WO1998002099A1
公开(公告)日：1998-01-22
申请号：PCT/US1997012402
申请日：1997-07-16
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , SNOW, David, W. , ADAMS, Craig, L. , DONLON, Brian, S. , GIFFORD, Hanson, S., III
IPC分类号： A61B17/00
CPC分类号： A61B17/064 , A61B17/0206 , A61B17/0643 , A61B17/11 , A61B17/115 , A61B17/1152 , A61B17/12036 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00243 , A61B2017/00557 , A61B2017/00703 , A61B2017/0641 , A61B2017/1107 , A61B2017/1135 , A61B2017/12127 , A61F2002/30092 , A61F2210/0014
摘要： This invention is a coronary shunt (800B) for occluding both sides of an anastomosis site, and providing a blood flow path across the anastomosis site. The shunt includes two occluding members (802B) sized and configured to occlude the coronary artery. A tether (808) is attached to the coronary shunt, and is used to remove the coronary shunt from the coronary artery before completing the anastomosis.
摘要翻译：本发明是用于闭塞吻合部位两侧的冠状动脉分流器（800B），并且在整个吻合部位提供血流路径。分流器包括两个封闭构件（802B），其尺寸和构造被阻塞冠状动脉。系绳（808）连接到冠状动脉分流器，并用于在完成吻合之前从冠状动脉移除冠状动脉分流。

7. 发明申请

WO1997027807A1 ENDOSCOPIC SUTURING DEVICES AND METHODS 审中-公开
标题翻译：内窥镜装置和方法
公开(公告)号：WO1997027807A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001127
申请日：1997-01-24
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , DANIEL, S., Christopher , DONLON, Brian, S. , GARRISON, Michi, E. , GIFFORD, Hansen, S., III , ROSENMAN, Daniel, C. , PETERS, William, S. , LATHROP, Robert, L., II , CROTHALL, George , MULLIN, James, B. , ANDERSON, Gerald, R. , KITTRELL, Wiley, A.
IPC分类号： A61B17/04
CPC分类号： A61B17/0491 , A61B17/0469 , A61B17/062 , A61B17/0625 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61F2/2409
摘要： The invention provides devices and methods for suture placement while performing less invasive surgical procedures within a body cavity. In an exemplary embodiment, the invention provides for the placement of sutures (24) within the heart (H) or a great vessel that is accessed from outside the closed chest. According to one exemplary method, the patient's heart valve is accessed through an intercostal port (56) in the patient's chest. At least, one needle (26) having a suture (24) is then directed into the annulus while visualizing through the port placement (56) of the needle into the annulus. The needle (26) is then passed through the annulus.
摘要翻译：本发明提供了用于缝合放置的装置和方法，同时在体腔内执行较少侵入性的外科手术。在一个示例性实施例中，本发明提供将缝合线（24）放置在心脏（H）内或从封闭的胸部外部进入的大血管。根据一个示例性方法，患者的心脏瓣膜通过患者胸部的肋间端口（56）进入。至少，具有缝合线（24）的一个针（26）然后被引导到环形空间中，同时通过针的端口放置（56）可视化成环形空间。针（26）然后穿过环。

8. 发明申请

WO1997027799A1 LESS-INVASIVE DEVICES AND METHODS FOR CARDIAC VALVE SURGERY 审中-公开
标题翻译：用于心脏瓣膜手术的无缺陷装置和方法
公开(公告)号：WO1997027799A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001018
申请日：1997-01-23
申请人： HEARTPORT, INC.
发明人： HEARTPORT, INC. , DONLON, Brian, S. , PETERS, William, S. , GARRISON, Michi, E. , ROSENMAN, Daniel, C. , STEVENS, John, H.
IPC分类号： A61B05/00
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0293 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/122 , A61B17/29 , A61B17/2909 , A61B17/3417 , A61B17/3421 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00278 , A61B2017/00575 , A61B2017/00867 , A61B2017/00907 , A61B2017/00946 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/2912 , A61B2017/2926 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/061 , A61B2090/306 , A61F2/2427 , A61F2/2496 , A61F7/10 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M1/3621 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/027 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , Y10S623/902
摘要： Systems and methods are disclosed for performing less invasive surgical procedures within the heart. A method for less invasive repair or replacement of a cardiac valve (216) comprises placing an instrument (290) through an intercostal access port (212) and through a penetration in a wall of a vessel in communication with the heart, advancing the instrument (290) into the heart, using the instrument (290) to perform a surgical intervention on a cardiac valve (216) in the heart under visualization through an intercostal access port. The surgeons hands are kept outside of the chest during each step. The surgical intervention may comprise replacing the cardiac valve with a prosthetic valve, wherein the native valve is removed using a tissue removal instrument (206), the native valve annulus is sized with a specialized sizing device (216), a prosthetic valve is introduced through an intercostal access port (212) and through the penetration in the vessel, and the prosthetic valve is secured at the native valve position, all using instruments positioned through intercostal access ports without placing the hands inside the chest. Systems and devices for performing these procedures are also disclosed.
摘要翻译：公开了用于在心脏内执行较少侵入性外科手术的系统和方法。用于较少侵入性修复或更换心脏瓣膜（216）的方法包括将器械（290）穿过肋间进入口（212）并通过与心脏连通的血管壁穿透，推进器械 290）进入心脏，使用仪器（290）通过肋间进入端口在可视化的心脏内的心脏瓣膜（216）上执行手术干预。在每一步中，外科医生的手都保持在胸前。外科手术可以包括用假性瓣膜替换心脏瓣膜，其中使用组织去除器具（206）去除所述天然瓣膜，所述天然瓣膜通过专门的上浆装置（216）来定尺寸，通过引入人工瓣膜肋间进入口（212），并穿过容器内的穿透，并且人造瓣膜固定在天然瓣膜位置，所有这些都使用通过肋间进入口定位的器械，而不将手放在胸部内。还公开了用于执行这些程序的系统和装置。

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