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1. 发明申请

WO2016191332A3 METHODS, SYSTEMS, AND COMPOSITIONS FOR DETERMINING BLOOD CLOT FORMATION, AND USES THEREOF 审中-公开
标题翻译：用于确定血液成型的方法，系统和组合物及其用途
公开(公告)号：WO2016191332A3
公开(公告)日：2017-03-16
申请号：PCT/US2016033686
申请日：2016-05-22
申请人： HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORP
发明人： INGBER DONALD E , JAIN ABHISHEK , VAN DER MEER ANDRIES D , MICHELSON ALAN DAVID , FRELINGER III ANDREW L
IPC分类号： C12Q1/56 , A61K35/19 , G01N33/48 , G06F19/12
CPC分类号： G01N33/86 , B01L3/5027 , G01N33/5064 , G01N2800/226
摘要： A method is directed to determining a thrombosis function and includes flowing a fluid sample over a surface having a fixed endothelial cell monolayer. The method further includes stimulating the fixed endothelial cell monolayer to induce formation of a clot, the clot being formed via interaction between the fixed endothelial cell monolayer and the fluid sample. In response to the clot formation, the method further includes determining a thrombosis function associated with the fluid sample and the fixed endothelial cell monolayer.
摘要翻译：一种方法涉及确定血栓形成功能，并且包括使流体样品在具有固定的内皮细胞单层的表面上流动。该方法还包括刺激固定的内皮细胞单层以诱导凝块的形成，凝块通过固定的内皮细胞单层和流体样品之间的相互作用而形成。响应于凝块形成，该方法还包括确定与流体样品和固定内皮细胞单层相关的血栓形成功能。

2. 发明申请

WO2016077067A3 MAGNETIC CAPTURE OF A TARGET FROM A FLUID 审中-公开
标题翻译：从流体中捕获一个目标的磁性
公开(公告)号：WO2016077067A3
公开(公告)日：2016-07-28
申请号：PCT/US2015057516
申请日：2015-10-27
申请人： HARVARD COLLEGE
发明人： KANG JOO HUN , INGBER DONALD E , SUPER MICHAEL
IPC分类号： B03C5/00 , B03C1/00
CPC分类号： B03C1/002 , B03C1/01 , B03C1/025 , B03C1/0332 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , C12N1/20
摘要： Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
摘要翻译：本文公开了用于磁性捕获流体中的靶分子（例如微生物）的改进方法。还提供了用于运载本文所述方法的试剂盒和固体基质。在一些实施方案中，本文所述的方法，试剂盒和固体基质针对微生物和微生物相关分子模式（MAMP）（包括例如但不限于微生物的细胞组分，脂多糖的分离和/ （LPS）和/或内毒素）。

3. 发明申请

WO2014014613A3 SELF-ASSEMBLING PEPTIDES, PEPTIDE NANOSTRUCTURES AND USES THEREOF 审中-公开
标题翻译：自组装肽，肽类纳米结构及其用途
公开(公告)号：WO2014014613A3
公开(公告)日：2014-05-01
申请号：PCT/US2013046821
申请日：2013-06-20
申请人： HARVARD COLLEGE
发明人： INGBER DONALD E , ROBERTS KENNY
IPC分类号： C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C07K14/78 , A61K9/1658 , A61K47/48246 , A61K47/64 , C07K14/001
摘要： Provided herein relates to self-assembling peptides and various nanostructures self-assembled from the isolated peptides. In some embodiments, the self-assembling peptides can form a nanostructure, e.g., a nanoparticle or microparticle, for use in various biomedical applications such as drug delivery or tissue engineering. In some embodiments, the nanostructures can comprise an agent, e.g., a biological molecule. The agent can be encapsulated or entrapped in the nanostructures during formation of the nanostructures. Alternatively or additionally, the agent can be integrated directly or indirectly (e.g., via a linker or a conjugation or crosslinking agent) to the self-assembling peptide structure, prior to formation of the nanostructures. In some embodiments where the agent is a peptide-based agent, unitary peptide nanostructures, rather than nanoparticles that are formed and later covalently modified, can be generated.
摘要翻译：本文涉及自组装肽和从分离的肽自组装的各种纳米结构。在一些实施方案中，自组装肽可以形成用于各种生物医学应用如药物递送或组织工程的纳米结构，例如纳米颗粒或微粒。在一些实施方案中，纳米结构可以包含试剂，例如生物分子。在形成纳米结构期间，该试剂可被包封或包埋在纳米结构中。或者或另外，在形成纳米结构之前，可将试剂直接或间接（例如经由接头或共轭或交联剂）整合至自组装肽结构。在其中试剂是基于肽的试剂的一些实施方案中，可以产生单一肽纳米结构，而不是形成和随后共价修饰的纳米颗粒。

4. 发明申请

WO2012118956A3 THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
标题翻译：透明媒体的热管理
公开(公告)号：WO2012118956A3
公开(公告)日：2012-11-08
申请号：PCT/US2012027253
申请日：2012-03-01
申请人： HARVARD COLLEGE , INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
发明人： INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
IPC分类号： H05B3/84
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24J2/0433 , F24J2/20 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译：可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗户。热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。流体可用于加热或冷却窗户面板的表面，以控制跨过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。流体可以使用建筑物中的环境空气进行加热或冷却。可以调节流体的折射率以改变窗口的光学透明性。在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。在其他实施例中，窗口可以着色，阻挡或散射入射光。

5. 发明申请

WO0189788A2 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A2
公开(公告)日：2001-11-29
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B29C
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以为拓扑复杂和改进的微流体系统提供方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

6. 发明申请

WO2015102726A3 A MICROFLUIDIC DEVICE FOR REAL-TIME CLINICAL MONITORING AND QUANTITATIVE ASSESSMENT OF WHOLE BLOOD COAGULATION 审中-公开
标题翻译：用于实时临床监测和全血凝固定量评估的微流体装置
公开(公告)号：WO2015102726A3
公开(公告)日：2015-10-29
申请号：PCT/US2014060956
申请日：2014-10-16
申请人： HARVARD COLLEGE
发明人： JAIN ABHISHEK , WATERHOUSE ANNA , SUPER MIKE , INGBER DONALD E , LESLIE DANIEL C
IPC分类号： G01N33/49 , G01N33/86
CPC分类号： B01L3/50273 , B01L3/502746 , B01L2200/146 , B01L2300/0627 , B01L2300/08 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2400/0478 , B01L2400/084 , G01N33/4905 , G01N33/86 , G06F19/24
摘要： In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.
摘要翻译：根据一个方面，提供了限定多个微通道的微流体凝固评估装置，其中血液样本以基本恒定的流速被驱动通过微通道，并且控制器被配置为结合定时器和压力感测装置，在流动开始时确定第一压力值（或流量值），其中第二压力值大约是所确定的第一压力值的两倍的第一时间（Tpg），以及第二时间（Tpf）压力值约为所确定的第一压力值的（1 + e）倍，并建立预测通道阻塞的对象凝固模型。在另一方面，血液样本以基本上恒定的压力驱动通过微通道，并且控制器被配置为结合定时器和流量检测装置基于流量进行确定。

7. 发明申请

WO2012074588A3 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES 审中-公开
标题翻译：剪切控制释放用于穿透性损伤和溶栓治疗
公开(公告)号：WO2012074588A3
公开(公告)日：2012-10-11
申请号：PCT/US2011049691
申请日：2011-08-30
申请人： HARVARD COLLEGE , INGBER DONALD E , KORIN NETANEL , KANAPATHIPILLAI MATHUMAI
发明人： INGBER DONALD E , KORIN NETANEL , KANAPATHIPILLAI MATHUMAI
IPC分类号： A61K47/48
CPC分类号： A61K38/02 , A61K9/1617 , A61K9/5153 , A61K31/721 , A61K38/49
摘要： The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.
摘要翻译：本发明提供了用于治疗或成像狭窄，狭窄病变，闭塞的管腔，栓塞现象或血栓形成病症的组合物和方法。本发明进一步提供了用于治疗内出血的组合物和方法。

8. 发明申请

WO2015109220A8 PLATELET DECOYS AND USE THEREOF 审中-公开
标题翻译： PLATELET DECOYS及其使用
公开(公告)号：WO2015109220A8
公开(公告)日：2016-03-10
申请号：PCT/US2015011805
申请日：2015-01-16
申请人： HARVARD COLLEGE
发明人： INGBER DONALD E , PAPA ANNE-LAURE
IPC分类号： A61P7/02
CPC分类号： A61K35/19 , A61K31/122 , A61K31/337 , A61K31/37 , A61K31/4365 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/64 , A61K31/704 , A61K31/7068 , A61K38/49 , C12N5/0644 , A61K2300/00
摘要： The invention provides platelet decoys and mimics that can bind to platelet receptor substrate but do not undergo platelet activation. The invention also provides methods of using the platelet decoys for treating, preventing or inhibiting a disease or disorder in subject when platelet activation, aggregation and/or adhesion contributes to the pathology or symptomology of the disease.
摘要翻译：本发明提供血小板诱饵和可以结合血小板受体底物但不经历血小板活化的模拟物。本发明还提供了当血小板活化，聚集和/或粘附有助于疾病的病理学或症状学时，使用血小板诱饵来治疗，预防或抑制受试者的疾病或病症的方法。

9. 发明申请

WO2014210364A3 INTERCONNECT ADAPTOR 审中-公开
标题翻译：互连适配器
公开(公告)号：WO2014210364A3
公开(公告)日：2015-10-29
申请号：PCT/US2014044417
申请日：2014-06-26
申请人： HARVARD COLLEGE
发明人： INGBER DONALD E , HINOJOSA CHRISTOPHER DAVID , LEVNER DANIEL , RESNIKOFF JOSH ISAAC NIELSEN , THOMPSON III GUY
IPC分类号： G01N1/00 , B01J4/00
CPC分类号： B01L3/563 , B01J19/0093 , B01J2219/00813 , B01J2219/00988 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2300/047 , B01L2300/069 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/123 , B01L2300/16 , C12M23/16 , C12M23/40 , C12M29/00
摘要： An interconnect adaptor for connecting a microfluidic device to a fluidic system. The interconnect adapter includes a base substrate and a nozzle array. The base substrate includes a first side and a second side. The nozzle array includes two or more nozzles extending away from the base substrate. Each nozzle includes an opening with a channel extending therefrom. The channels are configured to transport fluid between the microfluidic device and the fluidic system. Each of the nozzles is configured to be inserted into a respective hole in the microfluidic device. In some embodiments, the insertion forms a radially sealed connection between each nozzle and respective hole when the nozzles are inserted a predetermined distance into the respective holes.
摘要翻译：用于将微流体装置连接到流体系统的互连适配器。互连适配器包括基底基板和喷嘴阵列。基底基板包括第一面和第二面。喷嘴阵列包括远离基底基板延伸的两个或更多个喷嘴。每个喷嘴包括具有从其延伸的通道的开口。通道构造成在微流体装置和流体系统之间输送流体。每个喷嘴构造成插入到微流体装置中的相应孔中。在一些实施例中，当喷嘴在相应的孔中插入预定距离时，插入件在每个喷嘴和相应的孔之间形成径向密封的连接。

10. 发明申请

WO2007044642A3 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 审中-公开
标题翻译：用于连续流动的材料组合微流化 - 微磁性分离的装置和方法
公开(公告)号：WO2007044642A3
公开(公告)日：2007-11-15
申请号：PCT/US2006039344
申请日：2006-10-06
申请人： HARVARD COLLEGE , INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
发明人： INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
IPC分类号： B01D35/06
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成化的微流体装置通过施加局部磁场梯度将结合到磁性粒子的材料从一个层流路径拉到另一层流路径。该装置不需要任何清洗步骤即可从流动的生物流体中去除微生物和哺乳动物细胞微制造的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入到一个流动路径中时，它们仍然限于该流动路径。当HGMC被磁化时，磁珠从初始流动路径被拉入收集流中，从而清洁流体。微装置允许大量的珠子和材料同时分选，没有容量限制，不会因为颗粒被去除而失去分离效率，并且可用于从血液和其他生物流体中分离细胞。这种片上分离器可以在医院和实验室以外的地方进行细胞分离。

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