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1. 发明申请

WO2007112114A3 INTEGRATED SYSTEM FOR PROCESSING MICROFLUIDIC SAMPLES, AND METHOD OF USING SAME 审中-公开
公开(公告)号：WO2007112114A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/007513
申请日：2007-03-26
申请人： HANDYLAB, INC. , HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh N. , GANESAN, Karthik , WU, Betty , PHADKE, Nikhil , PARUNAK, Gene , WILLIAMS, Jeff
发明人： HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh N. , GANESAN, Karthik , WU, Betty , PHADKE, Nikhil , PARUNAK, Gene , WILLIAMS, Jeff
IPC分类号： C12M1/34
摘要： This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.

2. 发明申请

WO2005011867A2 PROCESSING PARTICLE-CONTAINING SAMPLES 审中-公开
标题翻译：加工颗粒样品
公开(公告)号：WO2005011867A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/025181
申请日：2004-08-02
申请人： HANDYLAB, INC. , WU, Betty , HANDIQUE, Kalyan , PARUNAK, Gene , KEHRER, Aaron , GANESAN, Karthik
发明人： WU, Betty , HANDIQUE, Kalyan , PARUNAK, Gene , KEHRER, Aaron , GANESAN, Karthik
IPC分类号： B01L3/00
CPC分类号： C12Q1/6806 , B01L3/502707 , B01L3/502738 , B01L3/502753 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , B33Y40/00 , B33Y80/00 , C12Q2523/109 , G01N1/40 , Y10T436/25 , Y10T436/25375
摘要： A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof.
摘要翻译：微流体装置包括用于将含颗粒的液体样品输入到装置中的输入端口，保持构件和压力致动器。保持构件与输入端口连通并且构造成将含有颗粒的液体样品的颗粒与含有流体样品的颗粒的液体的第一部分空间分离。压力执行器将至少一些分离的颗粒与从颗粒分离的液体的第一部分的一部分重新组合。该装置还可以包括从保留构件接收颗粒和液体的裂解室。裂解室热裂解颗粒以释放其内容物。

3. 发明申请

WO2008060604A2 MICROFLUIDIC SYSTEM FOR AMPLIFYING AND DETECTING POLYNUCLEOTIDES IN PARALLEL 审中-公开
标题翻译：用于平行放大和检测多核苷酸的微流控系统
公开(公告)号：WO2008060604A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/024022
申请日：2007-11-14
申请人： HANDYLAB, INC. , HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh, N. , GANESAN, Karthik , WILLIAMS, Jeff
发明人： HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh, N. , GANESAN, Karthik , WILLIAMS, Jeff
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0684 , B01L2300/021 , B01L2300/022 , B01L2300/045 , B01L2300/046 , B01L2300/0861 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2300/1861 , C12Q1/686 , G01N21/6428 , G01N2021/6419 , Y10S435/808 , C12Q2565/629
摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.
摘要翻译：本技术提供了用于检测样品中特别是生物样品中多核苷酸的装置。该技术更特别涉及在微流体通道内对感兴趣的核苷酸进行PCR并检测这些核苷酸的微流体系统。该装置包括被配置为接受多个样品并且可以分别对每个样品或一组或多个样品同时进行PCR的微流控盒。

4. 发明申请

WO2003022442A1 MICROFLUIDIC DEVICES HAVING A REDUCED NUMBER OF INPUT AND OUTPUT CONNECTIONS 审中-公开
标题翻译：具有减少输入和输出连接数量的微流体设备
公开(公告)号：WO2003022442A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/029012
申请日：2002-09-12
申请人： HANDYLAB, INC. , GANESAN, Karthik
发明人： GANESAN, Karthik
IPC分类号： B01L11/00
CPC分类号： G05D7/0617 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/00 , B01L2200/02 , B01L2200/14 , B01L2200/147 , B01L2300/02 , B01L2300/0819 , B01L2300/1827 , B01L2400/0442 , B01L2400/0677 , Y10T137/0318 , Y10T436/12 , Y10T436/2575
摘要： A system and method for reducing the number of input/output connections required to connect a microfluidic substrate to an external controller for controlling the substrate. In one example, a microfluidic processing device is fabricated on a substrate having a plurality of N independently controllable components, (e.g., a resistive heating elements) each having at least two terminals. The substrate includes a plurality of input/output contacts for connecting the substrate to an external controller, and a plurality of leads for connecting the contacts to the terminals of the components. The leads are arranged to allow the external controller to supply control signals to the terminals of the components via the contacts using substantially fewer contacts than the total number of component terminals. For example, in one embodiment, each lead connects a corresponding contact to a plurality of terminals to allow the controller to supply to signals to the terminals without requiring a separate contact for each terminal. However, to assure that the components can each be controlled independently of the others, the leads are also arranged so that each component's terminals are connected to a unique combination of contacts. Thus, the external controller can activate a selected component by supplying control signals to the combination of contacts uniquely associated with that component.
摘要翻译：一种用于减少将微流体衬底连接到用于控制衬底的外部控制器所需的输入/输出连接的数量的系统和方法。在一个实例中，在具有多个N个可独立控制的部件（例如，电阻加热元件）的基板上制造微流体处理装置，每个具有至少两个端子。基板包括用于将基板连接到外部控制器的多个输入/输出触点，以及用于将触点连接到部件的端子的多个引线。引线被布置成允许外部控制器通过使用比组件端子总数少得多的触点经由触点向组件的端子提供控制信号。例如，在一个实施例中，每个引线将对应的触点连接到多个端子，以允许控制器向终端提供信号，而不需要为每个终端单独的接触。然而，为了确保各个部件可以独立于其他部件来控制，引线也被布置成使得每个部件的端子连接到独特的触头组合。因此，外部控制器可以通过向与该组件唯一相关联的联系人的组合提供控制信号来激活所选择的组件。

5. 发明申请

WO2012142516A1 SCANNING REAL-TIME MICROFLUIDIC THERMO-CYCLER AND METHODS FOR SYNCHRONIZED THERMOCYCLING AND SCANNING OPTICAL DETECTION 审中-公开
标题翻译：扫描实时微流控热循环器和同步热循环和扫描光学检测方法
公开(公告)号：WO2012142516A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033667
申请日：2012-04-13
申请人： BECTON, DICKINSON AND COMPANY , GUBATAYAO, Thomas, Catalino , HANDIQUE, Kalyan , GANESAN, Karthik , DRUMMOND, Daniel, M.
发明人： GUBATAYAO, Thomas, Catalino , HANDIQUE, Kalyan , GANESAN, Karthik , DRUMMOND, Daniel, M.
IPC分类号： G01N35/02
CPC分类号： C12Q1/686 , B01L7/52 , B01L9/527 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N35/00693 , G01N35/026 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2035/00366
摘要： Systems and methods for performing simultaneous nucleic acid amplification and detection. The systems and methods comprise methods for managing a plurality of protocols in conjunction with directing a sensor array across each of a plurality of reaction chambers. In certain embodiments, the protocols comprise thermocycling profiles and the methods may introduce offsets and duration extensions into the thermocycling profiles to achieve more efficient detection behavior.
摘要翻译：同时进行核酸扩增和检测的系统和方法。系统和方法包括用于管理多个协议并结合导致传感器阵列跨过多个反应室中的每一个的方法。在某些实施例中，协议包括热循环曲线，并且该方法可以将偏移和持续时间延伸引入热循环曲线以实现更有效的检测行为。

6. 发明申请

WO2003012406A1 METHODS AND SYSTEMS FOR MICROFLUIDIC PROCESSING 审中-公开
标题翻译：用于微流体处理的方法和系统
公开(公告)号：WO2003012406A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/009440
申请日：2002-03-27
申请人： HANDYLAB, INC.
发明人： PARUNAK, Gene , HANDIQUE, Kalyan , WU, Betty , GANESAN, Karthik
IPC分类号： G01N21/29
CPC分类号： B01L3/502738 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2400/0442
摘要： The present invention relates to a system and method for moving samples, such as fluids, within a microfluidic system using a plurality of gas actuators (168, 170, 172) for applying pressure at different locations within the microfluidic. The system includes a substrate (130, 132) which forms a fluid network through which fluid flows, and a plurality of gas actuators (168, 170, 172) integral with the substrate (130, 132). One such actuator (168) is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator (170) is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve (915, 216) is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator.
摘要翻译：本发明涉及一种使用多个气体致动器（168,170,172）在微流体系统内移动诸如流体的样本的系统和方法，所述气体致动器用于在所述微流体系统内的不同位置处施加压力微流体。该系统包括形成流体流过的流体网络的基底（130,132），以及与基底（130,132）一体的多个气体致动器（168,170,172）。一个这样的致动器（168）在第一位置连接到网络，用于提供气体压力以移动网络内的微流体样本。另一气体致动器（170）在第二位置处联接至网络，用于提供气体压力以进一步移动网络内的微流体样本的至少一部分。阀门（915,216）联接到微流体网络上，使得当阀门关闭时，它基本上将第二气体致动器与第一气体致动器隔离。

7. 发明申请

WO2002078845A1 METHODS AND SYSTEMS FOR CONTROL OF MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流控器件的控制方法与系统
公开(公告)号：WO2002078845A1
公开(公告)日：2002-10-10
申请号：PCT/US2002/009439
申请日：2002-03-27
申请人： HANDYLAB, INC.
发明人： HANDIQUE, Kalyan , GANESAN, Karthik , BRAHMASANDRA, Sundaresh, N.
IPC分类号： B01L3/00
CPC分类号： B01L7/52 , B01F13/0071 , B01F13/0079 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00936 , B01J2219/00943 , B01J2219/00945 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/502784 , B01L3/502792 , B01L2200/0605 , B01L2200/0673 , B01L2200/14 , B01L2300/0816 , B01L2400/0442 , B01L2400/0493 , B01L2400/0677 , G01N1/4077 , G01N35/1083 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected n the preferred structure of the provided methods and systems. In particular, the methods are structured into low -level device component control functions, middle-level actuator, control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring (reaction/detectiong1), mixing (mixing 1), heating (heater1, heater2), and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.
摘要翻译：本发明提供了通过一系列确定的配置移动离散微滴来操作的微流体装置的控制方法，控制系统和控制软件。这样的微流体装置优选地以分级和模块化的方式构成，其反映在所提供的方法和系统的优选结构中。特别地，这些方法被构造成低水平的器件部件控制功能，中间级执行器，控制功能和高级微滴控制功能。有利地，可以通过调用执行诸如测量（反应/检测g1），混合（混合1），加热（加热器1，加热器2）等直观任务的微滴控制功能来指示微流体装置来执行预期的反应或分析。向前。该系统优选地是可编程的并且能够容纳由低电压控制并以标准化配置构造的微流体装置。有利地，单个控制系统因此可以通过加载不同的容易理解的微液滴程序来控制许多不同微流体装置中的许多不同反应。

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