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1. 发明申请

WO2009054870A2 INTERGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTING ON MULTIPLE BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于对多种生物样品进行核酸提取和诊断测试的分解设备
公开(公告)号：WO2009054870A2
公开(公告)日：2009-04-30
申请号：PCT/US2008/008640
申请日：2008-07-14
申请人： HANDYLAB, INC. , WILLIAMS, Jeff , WILSON, Kerry , HANDIQUE, Kalyan
发明人： WILLIAMS, Jeff , WILSON, Kerry , HANDIQUE, Kalyan
IPC分类号： C12M1/00 , C12P19/34
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , C12Q1/686 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2035/00881
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
摘要翻译：本文所述的技术一般涉及用于从多个样品，特别是从生物样品中提取多核苷酸的系统，并且另外涉及随后扩增并检测提取的多核苷酸的系统。该技术更具体地涉及对微流体通道内的多个感兴趣的核苷酸样品进行PCR并检测那些核苷酸的微流体系统。

2. 发明申请

WO2008061165A2 MICROFLUIDIC CARTRIDGE AND METHOD OF MAKING SAME 审中-公开
标题翻译：微流控盒及其制造方法
公开(公告)号：WO2008061165A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084730
申请日：2007-11-14
申请人： HANDYLAB, INC. , HANDIQUE, Kalyan , PARUNAK, Gene , HALEY, Cecelia
发明人： HANDIQUE, Kalyan , PARUNAK, Gene , HALEY, Cecelia
CPC分类号： B01L3/502738 , B01L3/5025 , B01L3/502707 , B01L3/502723 , B01L7/52 , B01L2200/0684 , B01L2200/142 , B01L2300/0803 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/14 , B01L2300/1827 , B01L2300/1844 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0694 , C12Q1/6806 , C12Q1/686 , F16K99/0001 , F16K2099/008 , F16K2099/0084
摘要： The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.
摘要翻译：本技术提供了一种微流体底物，其被配置为并行地在多个含有多核苷酸的样品上进行PCR。衬底可以是微流体盒中的单层衬底。还提供了制造包含这种基底的微流控筒的方法。还公开了适用于分离微流体衬底中的PCR室的微流体阀以及制造这种阀的方法。

3. 发明申请

WO2003012406A1 METHODS AND SYSTEMS FOR MICROFLUIDIC PROCESSING 审中-公开
标题翻译：用于微流体处理的方法和系统
公开(公告)号：WO2003012406A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/009440
申请日：2002-03-27
申请人： HANDYLAB, INC.
发明人： PARUNAK, Gene , HANDIQUE, Kalyan , WU, Betty , GANESAN, Karthik
IPC分类号： G01N21/29
CPC分类号： B01L3/502738 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2400/0442
摘要： The present invention relates to a system and method for moving samples, such as fluids, within a microfluidic system using a plurality of gas actuators (168, 170, 172) for applying pressure at different locations within the microfluidic. The system includes a substrate (130, 132) which forms a fluid network through which fluid flows, and a plurality of gas actuators (168, 170, 172) integral with the substrate (130, 132). One such actuator (168) is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator (170) is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve (915, 216) is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator.
摘要翻译：本发明涉及一种使用多个气体致动器（168,170,172）在微流体系统内移动诸如流体的样本的系统和方法，所述气体致动器用于在所述微流体系统内的不同位置处施加压力微流体。该系统包括形成流体流过的流体网络的基底（130,132），以及与基底（130,132）一体的多个气体致动器（168,170,172）。一个这样的致动器（168）在第一位置连接到网络，用于提供气体压力以移动网络内的微流体样本。另一气体致动器（170）在第二位置处联接至网络，用于提供气体压力以进一步移动网络内的微流体样本的至少一部分。阀门（915,216）联接到微流体网络上，使得当阀门关闭时，它基本上将第二气体致动器与第一气体致动器隔离。

4. 发明申请

WO2013067202A1 POLYNUCLEOTIDE SAMPLE PREPARATION DEVICE 审中-公开
标题翻译：多核苷酸样品制备装置
公开(公告)号：WO2013067202A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063091
申请日：2012-11-01
申请人： HANDYLAB, INC.
发明人： HANDIQUE, Kalyan
IPC分类号： F16K99/00
CPC分类号： C12Q1/6806 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2200/0684 , B01L2200/10 , B01L2300/0816 , B01L2400/06 , B01L2400/0677 , F16K99/0036 , F16K2099/0084
摘要： Disclosed herein are devices configured for the amplification and detection of multiple targets from a sample, and methods of using the same. The devices disclosed herein comprise microfluidic cartridges have a first stage (amplification) and a second (detection) stage. The two-stage design of the cartridges enables testing for multiple targets within a sample, i.e., from a single nucleic acid amplification reaction. Methods for the amplification and detection of a plurality of target nucleic acids from a sample are also disclosed herein.
摘要翻译：这里公开了被配置用于从样品中放大和检测多个靶的装置及其使用方法。本文公开的装置包括具有第一阶段（放大）和第二（检测）阶段的微流体盒。盒的两级设计使得能够测试样品内的多个靶，即来自单个核酸扩增反应。本文还公开了用于从样品扩增和检测多种靶核酸的方法。

5. 发明申请

WO2010005444A1 POLYNUCLEOTIDE CAPTURE MATERIALS, AND METHODS OF USING SAME 审中-公开
标题翻译：多核苷酸捕获材料及其使用方法
公开(公告)号：WO2010005444A1
公开(公告)日：2010-01-14
申请号：PCT/US2008/069895
申请日：2008-07-11
申请人： HANDYLAB, INC. , BRAHMASANDRA, Sundaresh, N. , BOUTT, Elizabeth , HANDIQUE, Kalyan
发明人： BRAHMASANDRA, Sundaresh, N. , BOUTT, Elizabeth , HANDIQUE, Kalyan
IPC分类号： G01N33/551
CPC分类号： G01N33/54393
摘要： Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as DNA from such samples. The DNA is captured by polyethyeleneimine (PEI) bound to a surface, such as the surface of magnetic particles. The methods and materials have high efficiency of binding DNA and of release, and thereby permit quantitative determinations.
摘要翻译：用于处理含多核苷酸的生物样品的方法，以及用于从这些样品中捕获多核苷酸分子例如DNA的材料。 DNA被结合到表面的聚乙烯亚胺（PEI）捕获，例如磁性颗粒的表面。所述方法和材料具有高的结合DNA和释放的效率，从而允许定量测定。

6. 发明申请

WO2007112114A3 INTEGRATED SYSTEM FOR PROCESSING MICROFLUIDIC SAMPLES, AND METHOD OF USING SAME 审中-公开
公开(公告)号：WO2007112114A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/007513
申请日：2007-03-26
申请人： HANDYLAB, INC. , HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh N. , GANESAN, Karthik , WU, Betty , PHADKE, Nikhil , PARUNAK, Gene , WILLIAMS, Jeff
发明人： HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh N. , GANESAN, Karthik , WU, Betty , PHADKE, Nikhil , PARUNAK, Gene , WILLIAMS, Jeff
IPC分类号： C12M1/34
摘要： This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a microfluidic cartridge that contains reagents and a network for processing a sample. Also described are methods of using the apparatus.

7. 发明申请

WO2005108620A2 PROCESSING POLYNUCLEOTIDE-CONTAINING SAMPLES 审中-公开
标题翻译：加工含多核苷酸的样品
公开(公告)号：WO2005108620A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/015345
申请日：2005-05-03
申请人： HANDYLAB, INC. , WU, Betty , ALTHAUS, John, S. , BRAHMASANDRA, Sundaresh, N. , HANDIQUE, Kalyan , PHADKE, Nikhil
发明人： WU, Betty , ALTHAUS, John, S. , BRAHMASANDRA, Sundaresh, N. , HANDIQUE, Kalyan , PHADKE, Nikhil
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/5082 , B01L3/565 , B01L7/52 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0442 , B01L2400/0677 , B01L2400/0683 , B01L2400/0694 , C12N15/1006 , C12Q1/6806 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/0036 , F16K99/0044 , F16K2099/0084 , C12Q2565/629
摘要： Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.
摘要翻译：公开了用于处理多核苷酸（例如DNA）的方法和系统。处理区域包括用在第一组条件（例如温度和pH）下重新获得多核苷酸的配体修饰的一个或多个表面（例如，颗粒表面），并在第二组条件（例如较高的温度和/ 或更多的碱性pH）。处理区域可用于例如浓缩样品的多核苷酸和/或来自多核苷酸的分离的扩增反应抑制剂。公开了具有处理区域的微流体装置。

8. 发明申请

WO2005011867A2 PROCESSING PARTICLE-CONTAINING SAMPLES 审中-公开
标题翻译：加工颗粒样品
公开(公告)号：WO2005011867A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/025181
申请日：2004-08-02
申请人： HANDYLAB, INC. , WU, Betty , HANDIQUE, Kalyan , PARUNAK, Gene , KEHRER, Aaron , GANESAN, Karthik
发明人： WU, Betty , HANDIQUE, Kalyan , PARUNAK, Gene , KEHRER, Aaron , GANESAN, Karthik
IPC分类号： B01L3/00
CPC分类号： C12Q1/6806 , B01L3/502707 , B01L3/502738 , B01L3/502753 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , B33Y40/00 , B33Y80/00 , C12Q2523/109 , G01N1/40 , Y10T436/25 , Y10T436/25375
摘要： A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof.
摘要翻译：微流体装置包括用于将含颗粒的液体样品输入到装置中的输入端口，保持构件和压力致动器。保持构件与输入端口连通并且构造成将含有颗粒的液体样品的颗粒与含有流体样品的颗粒的液体的第一部分空间分离。压力执行器将至少一些分离的颗粒与从颗粒分离的液体的第一部分的一部分重新组合。该装置还可以包括从保留构件接收颗粒和液体的裂解室。裂解室热裂解颗粒以释放其内容物。

9. 发明申请

WO2004094986A2 SYSTEM AND METHOD FOR ELECTROCHEMICAL DETECTION OF BIOLOGICAL COMPOUNDS 审中-公开
标题翻译：用于电化学检测生物化合物的系统和方法
公开(公告)号：WO2004094986A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011900
申请日：2004-04-16
申请人： HANDYLAB, INC. , ALTHAUS, John, S. , KYONGHOON, Lee , NAMASIVAYAM, Vijay , BRAHMASANDRA, Sundaresh, N. , HANDIQUE, Kalyan
发明人： ALTHAUS, John, S. , KYONGHOON, Lee , NAMASIVAYAM, Vijay , BRAHMASANDRA, Sundaresh, N. , HANDIQUE, Kalyan
IPC分类号： G01N
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N33/5438 , Y10T436/143333 , C12Q2565/607 , C12Q2563/173
摘要： The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reverisbly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.
摘要翻译：本发明涉及一种用于检测靶多核苷酸的电化学方法。提供了包括电极表面的电极。电极表面包括相对于电极表面反复固定的至少一个探针分子。获得指示相对于电极表面固定的探针分子的量的第一电化学信号。电极表面与包含靶多核苷酸的液体接触。在接触步骤中，相对于电极表面固定的至少一些探针分子与其分离。获得指示相对于电极表面固定的探针分子的量的第二电化学信号。至少部分地基于第一和第二电化学信号确定靶多核苷酸的存在。

10. 发明申请

WO2008060604A2 MICROFLUIDIC SYSTEM FOR AMPLIFYING AND DETECTING POLYNUCLEOTIDES IN PARALLEL 审中-公开
标题翻译：用于平行放大和检测多核苷酸的微流控系统
公开(公告)号：WO2008060604A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/024022
申请日：2007-11-14
申请人： HANDYLAB, INC. , HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh, N. , GANESAN, Karthik , WILLIAMS, Jeff
发明人： HANDIQUE, Kalyan , BRAHMASANDRA, Sundaresh, N. , GANESAN, Karthik , WILLIAMS, Jeff
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0684 , B01L2300/021 , B01L2300/022 , B01L2300/045 , B01L2300/046 , B01L2300/0861 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2300/1838 , B01L2300/1861 , C12Q1/686 , G01N21/6428 , G01N2021/6419 , Y10S435/808 , C12Q2565/629
摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.
摘要翻译：本技术提供了用于检测样品中特别是生物样品中多核苷酸的装置。该技术更特别涉及在微流体通道内对感兴趣的核苷酸进行PCR并检测这些核苷酸的微流体系统。该装置包括被配置为接受多个样品并且可以分别对每个样品或一组或多个样品同时进行PCR的微流控盒。

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