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1. 发明申请

WO2013165531A1 ELECTROCHEMICAL TRANSDERMAL GLUCOSE MEASUREMENT SYSTEM INCLUDING MICROHEATERS AND PROCESS FOR FORMING 审中-公开
标题翻译：电化学超声波葡萄糖测量系统，包括微波炉和成型工艺
公开(公告)号：WO2013165531A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/027126
申请日：2013-02-21
申请人： GEORGETOWN UNIVERSITY
发明人： PARANJAPE, Makarand , NIJDAM, Arend Jasper , KASHTE, Yogesh, Ekanath
IPC分类号： A61B5/05
CPC分类号： C25D13/12 , A61B5/1451 , A61B5/14532 , A61B5/1477 , A61B5/1486 , A61B18/082 , A61B2018/0047 , A61B2018/00577
摘要： A device contains individually controllable sites for electrochemically monitoring an analyte in interstitial fluid of a user. The sites include a conductive pattern attached at a first and second ends thereof to electrode material in a closed-circuit configuration for receiving a first predetermined voltage applied thereto in order to thermally ablate a stratum corneum of a user's skin to access the interstitial fluid and form an open-circuit configuration including first and second portions of the electrode material that are electrically isolated from each other; a sensing area deposited on at least one of the first and second portions of the electrode material; and a measuring component for receiving individual measurement data from the sensing area in response to a second predetermined voltage applied to the open circuit configuration. The individual measurement data is indicative of an amount of the analyte in the interstitial fluid.
摘要翻译：装置包含用于电化学监测使用者间质液中的分析物的单独可控的部位。这些部位包括在其第一端和第二端处以闭合电路结构连接到电极材料的导电图案，用于接收施加到其上的第一预定电压，以便热消除使用者皮肤的角质层以接近间质液并形成包括彼此电隔离的电极材料的第一和第二部分的开路结构; 沉积在电极材料的第一和第二部分中的至少一个上的感测区域; 以及测量部件，用于响应于施加到所述开路结构的第二预定电压从所述感测区域接收各个测量数据。各个测量数据表示组织液中分析物的量。

2. 发明申请

WO2020051587A1 SYSTEMS AND METHODS FOR IDENTIFYING AND ISOLATING INVASIVE SUBPOPULATIONS OF CANCER CELLS IN REAL-TIME 审中-公开
公开(公告)号：WO2020051587A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/050220
申请日：2019-09-09
申请人： GEORGETOWN UNIVERSITY
发明人： WELLSTEIN, Anton , SHARIF, Ghada M. , PARANJAPE, Makarand
IPC分类号： C12Q1/00 , C12M1/34
摘要： Systems and methods for characterizing cancer cells are disclosed. In certain embodiments, the systems and methods involve coating a first chamber with ECM material and adding a first plurality of cells to the first chamber, adding media to a second chamber, and adding a second plurality of cells and media to a third chamber. The first, second, and third chambers are then clipped together to form a chamber array. The chamber array is mounted to an electric cell impedance sensing reader and impedance readouts of cell invasion are collected from the electric array at time intervals. Cells detected to invade into the second chamber are extracted and characterized.

3. 发明申请

WO2018144506A1 HARVESTING CELL-FREE NON-CODING RNAS (CFNCRS) FROM INTERSTITIAL FLUID FOR SENSITIVE BIOMARKERS 审中-公开
公开(公告)号：WO2018144506A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/016083
申请日：2018-01-31
申请人： GEORGETOWN UNIVERSITY
发明人： PARANJAPE, Makarand
IPC分类号： G01N33/50 , C07H21/02 , C12Q1/68 , A61B5/15 , A61B5/1477 , C12N15/113
摘要： A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.

4. 发明申请

WO2015038204A1 BIOSENSOR AND SYSTEM AND PROCESS FOR FORMING 审中-公开
标题翻译：生物传感器和系统及其形成过程
公开(公告)号：WO2015038204A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/041501
申请日：2014-06-09
申请人： GEORGETOWN UNIVERSITY
发明人： PARANJAPE, Makarand , LIU, Yian
IPC分类号： H01L21/335 , B82Y15/00
CPC分类号： G01N27/4146
摘要： A process for forming a carbon nanotube field effect transistor (CNTFET) device includes site-specific nanoparticle deposition on a CNTFET that has one or more carbon nanotubes, a source electrode, a drain electrode, and a sacrificial electrode on a substrate with an interposed dielectric layer. The process includes control of PMMA removal and electrodeposition in order to select nanoparticle size and deposition location down to singular nanoparticle deposition. The CNTFET device resulting in ultra-sensitivity for various bio-sensing applications, including detection of glucose at hypoglycemic levels.
摘要翻译：用于形成碳纳米管场效应晶体管（CNTFET）器件的方法包括在具有一个或多个碳纳米管的CNTFET上的位点特异性纳米颗粒沉积，源电极，漏电极和牺牲电极在具有介电介质的衬底上层。该过程包括控制PMMA去除和电沉积，以便选择纳米颗粒尺寸和沉积位置到单个纳米颗粒沉积。 CNTFET器件对各种生物传感应用产生超灵敏度，包括在低血糖水平检测葡萄糖。

5. 发明申请

WO2014025522A1 CVD FABRICATION OF SINGLE-WALLED CARBON NANOTUBES 审中-公开
标题翻译：单壁碳纳米管的CVD制备
公开(公告)号：WO2014025522A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/051583
申请日：2013-07-23
申请人： GEORGETOWN UNIVERSITY , FONTANA, Marcio
发明人： FONTANA, Marcio , PARANJAPE, Makarand
IPC分类号： C01B31/02 , C01B31/04 , H01G11/36
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/16 , C01B32/162 , C01B2202/02
摘要： The system and method disclosed herein provide a predetermined, variable volume argon-hydrogen gas mixture for a chemical vapor deposition (CVD)-based process, which enables the growth of single-walled carbon nanotube (SWCNT) structures. The exemplary SWCNT structures of this system and method are fabricated with a degree of control over the field emissions produced by the SWCNT and the range of diameters of each of the SWCNTs. Specifically, the predetermined diameter ranges and the field emissions of the SWCNT structure corresponds to a predetermined range of concentrations of the argon-hydrogen mixture and the argon concentration respectively. The defects and the diameter of the SWCNTs typically contribute to field emissions from the SWCNT structures at low applied voltages.
摘要翻译：本文公开的系统和方法提供用于基于化学气相沉积（CVD）的方法的预定的可变容积的氩 - 氢气混合物，其能够生长单壁碳纳米管（SWCNT）结构。该系统和方法的示例性SWCNT结构以对SWCNT产生的场发射和每个SWCNT的直径范围的程度的控制来制造。具体地，SWCNT结构的预定直径范围和场发射分别对应于氩 - 氢混合物浓度和氩浓度的预定浓度范围。 SWCNT的缺陷和直径通常有助于在低施加电压下来自SWCNT结构的场发射。

6. 发明申请

WO2002058847A2 CELL TRANSFORMATION USING A SINGLE CHIP SILICON MICROFABRICATED ARRAY INCORPORATING INTEGRATED MICRO-PIERCING INJECTORS 审中-公开
标题翻译：使用单芯片硅微波炉阵列进行电池转换，并集成微型激光注射器
公开(公告)号：WO2002058847A2
公开(公告)日：2002-08-01
申请号：PCT/US2001/044289
申请日：2001-11-28
申请人： GEORGETOWN UNIVERSITY , PARANJAPE, Makarand , ESRICK, Mark, A. , CURRIE, John, F.
发明人： PARANJAPE, Makarand , ESRICK, Mark, A. , CURRIE, John, F.
IPC分类号： B01L3/00
CPC分类号： C12M23/16 , C12M35/00
摘要： The present invention provides an improved methodology for the introduction of specific molecules into cells, or the removal of material from cells, over the current state of the art. In particular, the invention provides an efficient means for these procedures to be undertaken on a high throughput level using minimally skilled expertise and handling by providing a microfabricated silicon array substrate having a simplified device fabrication strategy, whereby a single device component performs the transformation process rendering a more durable and robust device.
摘要翻译：本发明提供了在现有技术中将特定分子引入细胞或从细胞中除去材料的改进方法。特别地，本发明提供了一种有效的方法，可以使用最低限度的专业知识和处理方式，在高吞吐量水平下进行这些程序，提供具有简化的器件制造策略的微加工硅阵列基板，由此单个器件部件执行转换处理渲染一个更耐用和更健壮的设备。

7. 发明申请

WO2023069778A1 NON-INVASIVE AND PASSIVE TRANSDERMAL DRUG DELIVERY PATCH FOR PARKINSON'S DISEASE 审中-公开
公开(公告)号：WO2023069778A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047589
申请日：2022-10-24
申请人： GEORGETOWN UNIVERSITY
发明人： MOUSSA, Charbel , PARANJAPE, Makarand
IPC分类号： A61M37/00 , A61M5/142
摘要： A flexible drug delivery patch is described for non-invasively delivering macromolecular drugs directly to the circulatory system of a user. The patch includes multiple sealed reservoirs formed therein, the sealed reservoirs containing the macromolecular drugs which are entrapped within one of a dissolvable polymer matrix using one of nanoparticles or nanofibers or a thermo- responsive hydrogel. The macromolecular drugs being released from the sealed reservoirs and the entrapping material by activating one or more electrically addressable microheating units.

8. 发明申请

WO2013063399A1 METHOD AND SYSTEM FOR GENERATING A PHOTO-RESPONSE FROM MOS2 SCHOTTKY JUNCTIONS 审中-公开
标题翻译：用于从MOS2肖特基函数产生照片响应的方法和系统
公开(公告)号：WO2013063399A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/062130
申请日：2012-10-26
申请人： GEORGETOWN UNIVERSITY , PARANJAPE, Makarand , BARBARA, Paola , LIU, Amy , FONTANA, Marcio
发明人： PARANJAPE, Makarand , BARBARA, Paola , LIU, Amy , FONTANA, Marcio
IPC分类号： H01L31/101
CPC分类号： H01L33/005 , H01L31/032 , H01L31/035209 , H01L31/07 , H01L31/1013 , H01L31/18 , H01L33/0041 , H01L33/06 , H01L33/28 , H01L33/40 , Y02E10/50
摘要： Devices incorporating a single to a few-layer MoS 2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.
摘要翻译：结合单层至几层MoS2通道的设备与优化的基板，电介质，接触和电极材料及其构造相结合，分别显示出发光，光电效应和超导性。

9. 发明申请

WO2012082135A1 SYSTEMS AND PROCESS FOR FORMING CARBON NANOTUBE SENSORS 审中-公开
标题翻译：制备碳纳米管传感器的系统和工艺
公开(公告)号：WO2012082135A1
公开(公告)日：2012-06-21
申请号：PCT/US2010/060929
申请日：2010-12-17
申请人： GEORGETOWN UNIVERSITY , PARANJAPE, Makarand , ZHOU, Jianyun
发明人： PARANJAPE, Makarand , ZHOU, Jianyun
IPC分类号： D01F9/12
CPC分类号： B82Y15/00 , B82Y30/00
摘要： A process for forming a functionalized sensor for sensing a molecule of interest includes providing at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; providing a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for a bioreceptors that react with the molecule of interest; and applying a voltage to the third electrode, causing the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.
摘要翻译：用于形成用于感测感兴趣分子的功能化传感器的方法包括提供至少一个单壁或多壁碳纳米管，其具有与衬底接触的第一和第二电极; 在与所述至少一个具有与其接触的第一和第二电极的所述至少一个单壁或多壁碳纳米管的预定距离的基底上提供包括装饰材料的第三电极，其中所述装饰材料对生物感受器具有结合亲和力，与感兴趣的分子; 以及向所述第三电极施加电压，使所述装饰材料在所述至少一个单壁或多壁碳纳米管上形成所述装饰材料的纳米颗粒。

10. 发明申请

WO2018080923A1 NON-INVASIVE PASSIVE INTERSTITIAL FLUID COLLECTOR 审中-公开
标题翻译：非侵入式被动式间隙流体收集器
公开(公告)号：WO2018080923A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/057614
申请日：2017-10-20
申请人： GEORGETOWN UNIVERSITY
发明人： PARANJAPE, Makarand
IPC分类号： A61B5/145 , A61B5/1477 , A61B5/1491
摘要： A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.
摘要翻译：用于无创和无源地接近患者的间质液的微流体装置包括含有多个穿过其中的垂直微通道的基底，其中在多个垂直微通道中的每一个的第一端处形成微加热器用于可控地消融一部分干燥的死亡皮肤细胞以进入组织液; 并且其中在所述多个垂直微通道中的每一个的第二端处是水平微通道，用于接收来自垂直微通道的被访问的间质液并且将所访问的间质液引导至公共收集端口。

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