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1. 发明申请

WO2011162666A1 METHOD OF PREPARING LIQUID MIXTURES 审中-公开
标题翻译：制备液体混合物的方法
公开(公告)号：WO2011162666A1
公开(公告)日：2011-12-29
申请号：PCT/SE2011/050563
申请日：2011-05-05
申请人： GE HEALTHCARE BIO-SCIENCES AB , ANDREI, Catalin , BERG, Mikael , BLANK, Torbjörn , CARREDANO, Enrique , EKSTRÖM, Karl , KARLSSON, Tomas, M. , LYNGÅ, Jan-Erik , NORDBERG, Roger , RODRIGO, Gustav , SANDEGREN, Henrik
发明人： ANDREI, Catalin , BERG, Mikael , BLANK, Torbjörn , CARREDANO, Enrique , EKSTRÖM, Karl , KARLSSON, Tomas, M. , LYNGÅ, Jan-Erik , NORDBERG, Roger , RODRIGO, Gustav , SANDEGREN, Henrik
IPC分类号： G05D11/08 , B01F15/04 , G01N30/34 , G01N30/88 , G05D11/13
CPC分类号： F17D3/00 , G01N30/34 , G05D21/02 , Y10T137/0329
摘要： A method of preparing a mixed liquid flow having predetermined characteristics, including a predetermined value of a first property and a predetermined value of a second property, comprising the steps of: a) providing a first set of at least one liquid flow each having a different first value of the first property; b) providing a second set of at least one liquid flow each having a different second value of the first property; c) providing a third set of at least one liquid flow of solvent; d) combining the provided liquid flows; and e)varying at least one of the liquid flows of the first and second sets and at least one liquid flow of the third set to adjust the first property and the second property to their respective predetermined values in the resulting mixed liquid flow.
摘要翻译：一种制备具有预定特性的混合液流的方法，包括第一特性的预定值和第二特性的预定值，包括以下步骤：a）提供第一组至少一个液体流，每组具有不同的第一财产的第一价值; b）提供第二组至少一个液体流，每个具有第一属性的不同的第二值; c）提供第三组至少一种液体的溶剂流; d）组合提供的液体流; 以及e）改变所述第一和第二组的液体流中的至少一个以及所述第三组的至少一个液体流，以将所述第一特性和所述第二特性调整到所得混合液体流中其各自的预定值。

2. 发明申请

WO2013039449A1 PLASMA PROTEIN FRACTIONATION BY SEQUENTIAL POLYACID PRECIPITATION 审中-公开
标题翻译：通过顺序聚酰亚胺降解的等离子体蛋白质分解
公开(公告)号：WO2013039449A1
公开(公告)日：2013-03-21
申请号：PCT/SE2012/050971
申请日：2012-09-14
申请人： GE HEALTHCARE BIO-SCIENCES AB , VAN ALSTINE, James , BERG, Mikael , KJÖRNING, Johanna , SHANAGAR, Jamil
发明人： VAN ALSTINE, James , BERG, Mikael , KJÖRNING, Johanna , SHANAGAR, Jamil
IPC分类号： C07K1/30
CPC分类号： C07K1/30 , A61K35/16 , C07K1/303 , C07K14/75 , C07K14/76 , C07K16/18
摘要： There is a recognized need for novel, more simplified, approaches to isolation of plasma from whole blood, as well as a need to isolate cell-free plasma fractions containing different plasma proteins. Methods are divulged for use of aqueous phase systems, formed in blood or blood containing solutions via addition of a single polymer at relatively low concentration, to effect isolation (clarification) of plasma proteins from blood cells. Methods are also divulged to replace widely used Cohn-type plasma protein fractionation which is based on sequential addition of up to 40% (v/v) ethanol and other precipitants, with simple sequential addition of a polyacid. The latter results in isolation of plasma protein fractions (i.e. fibrinogen, immunoglobulin, albumin) in sequence similar to that obtained with Cohn Fractionation and therefore may be suitable for use to reduce solvent use and solvent-related process complications in existing plasma protein purification processes. It may also support use of polymeric film based containers in novel solvent free plasma fractionation processes. The methods disclosed may also be suitable for use in smaller scale plasma protein isolation, in research and diagnostic applications. The general methodologies are robust and can function over a broad range of process variables such as temperature and pH.
摘要翻译：公认需要新颖，更简化的方法来分离全血中的血浆，以及需要分离含有不同血浆蛋白的无细胞血浆级分。泄漏方法用于通过加入相对低浓度的单一聚合物在血液或含血液中形成的水相体系，以实现血细胞从血细胞中分离（澄清）血浆蛋白。也渗透方法代替广泛使用的Cohn型血浆蛋白分离，其基于连续添加高达40％（v / v）乙醇和其它沉淀剂，以简单的顺序加入多酸。后者导致血浆蛋白质部分（即纤维蛋白原，免疫球蛋白，白蛋白）的分离，其顺序类似于用Cohn分级法获得的，因此可能适用于减少现有血浆蛋白纯化过程中的溶剂使用和溶剂相关的过程并发症。它还可以支持在无溶剂溶剂分级过程中使用基于聚合物膜的容器。所公开的方法也可适用于研究和诊断应用中较小规模的血浆蛋白分离。一般方法是稳健的，并且可以在宽范围的过程变量（例如温度和pH）上起作用。

3. 发明申请

WO2007114762A1 METHOD OF SEPARATION OF DEOXYRIBONUCLEIC ACIDS 审中-公开
标题翻译：脱氧核糖酸的分离方法
公开(公告)号：WO2007114762A1
公开(公告)日：2007-10-11
申请号：PCT/SE2007/000302
申请日：2007-03-29
申请人： GE HEALTHCARE BIO-SCIENCES AB , BERG, Mikael , BLOM, Hans , LEMMENS, Raf
发明人： BERG, Mikael , BLOM, Hans , LEMMENS, Raf
IPC分类号： C12N15/10 , A61K48/00 , B01D15/32
CPC分类号： C12N15/101 , B01D15/166 , B01D15/327
摘要： The present invention relates to a method of separating nucleic acids from a liquid, which comprises providing a mobile phase comprising nucleic acids and a first salt, which forms lyotropic ions when dissolved; passing said mobile phase across a hydrophobic interaction chromatography (HIC) matrix to adsorb deoxyribonucleic acid(s); passing an eluent across said matrix to desorb one or more deoxyribonucleic acid(s), which eluent comprises the first salt as well as an increasing gradient provided by a second salt, which second salt forms less lyotropic ions when dissolved than the first salt; and isolating at least one fraction comprising separated deoxyribonucleic acid(s).
摘要翻译：本发明涉及从液体中分离核酸的方法，其包括提供包含核酸和第一盐的流动相，其在溶解时形成溶致离子; 将所述流动相通过疏水相互作用层析（HIC）基质以吸附脱氧核糖核酸; 将洗脱液通过所述基质以解吸一种或多种脱氧核糖核酸，该洗脱液包含第一盐以及由第二盐提供的增加的梯度，当第二盐在溶解时比第二盐形成更少的溶致离子; 并分离至少一个包含分离的脱氧核糖核酸的级分。

4. 发明申请

WO2020002713A1 METHOD IN BIOPROCESS PURIFICATION SYSTEM 审中-公开
公开(公告)号：WO2020002713A1
公开(公告)日：2020-01-02
申请号：PCT/EP2019/067643
申请日：2019-07-01
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： HYCKENBERG, Key , SKOGLAR, Helena , MALMQUIST, Gunnar , CARLSTEN, Mikael , LUNDQVIST, Roger , ANDERSSON, Dan , MATHIASSON, Linda , MATTSSON, Lars , SENDABO, Sara , BERG, Mikael
IPC分类号： C12M1/36 , C12P21/00 , C12Q3/00 , G06N20/00
摘要： The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a p re- determined range.

5. 发明申请

WO2018153743A3 METHODS AND SYSTEMS FOR ADAPTING PATHLENGTH AND/OR WAVELENGTH OF A UV-ABSORBANCE CELL IN A CHROMATOGRAPHY SYSTEM 审中-公开
公开(公告)号：WO2018153743A3
公开(公告)日：2018-08-30
申请号：PCT/EP2018/053659
申请日：2018-02-14
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： BLOM, Hans , BERG, Mikael , EHRING, Hanno , MATHIASSON, Linda , SKOGLAR, Helena , CHMIELOWSKI, Rebecka
IPC分类号： G01N30/42 , B01D15/18 , G01N30/88 , G01N30/74
摘要： The present invention relates to a method for determining operational status of a chromatography column (1; 39, 47, 59; 107, 109, 111, 113), comprising detecting a feed signal (21; 201) representative of the composition of a feed material provided to the inlet of the column; detecting the UV absorbance in the feed material, detecting an effluent signal (23; 203, 205, 207, 209) representative of the composition of the effluent from the column; and using the feed signal and the effluent signal to determine operational status of the column. The feed signal is generated using a first UV detector having a first UV cell pathlength operating at a first UV wavelength and the effluent signal is generated using a second UV detector having a second UV cell pathlength operating at a second UV wavelength. The method further comprising determining a first threshold value based on the detected UV absorbance in the feed material, and selecting the first UV cell pathlength and/or first UV wavelength based on the first threshold value.

6. 发明申请

WO2018153743A2 METHOD FOR ADAPTING UV CELL PATHLENGTH IN A CHROMATOGRAPHY SYSTEM 审中-公开
公开(公告)号：WO2018153743A2
公开(公告)日：2018-08-30
申请号：PCT/EP2018/053659
申请日：2018-02-14
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： BLOM, Hans , BERG, Mikael , EHRING, Hanno , MATHIASSON, Linda , SKOGLAR, Helena , CHMIELOWSKI, Rebecka
IPC分类号： G01N30/42 , B01D15/18
摘要： The present invention relates to a method for determining operational status of a chromatography column (1; 39, 47, 59; 107, 109, 111, 113), comprising detecting a feed signal (21; 201) representative of the composition of a feed material provided to the inlet of the column; detecting the UV absorbance in the feed material, detecting an effluent signal (23; 203, 205, 207, 209) representative of the composition of the effluent from the column; and using the feed signal and the effluent signal to determine operational status of the column. The feed signal is generated using a first UV detector having a first UV cell pathlength operating at a first UV wavelength and the effluent signal is generated using a second UV detector having a second UV cell pathlength operating at a second UV wavelength. The method further comprising determining a first threshold value based on the detected UV absorbance in the feed material, and selecting the first UV cell pathlength and/or first UV wavelength based on the first threshold value.

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