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1. 发明申请

WO2012082061A1 METHOD FOR PREDICTING THE CONDUCTIVITY OF A LIQUID MIXTURE 审中-公开
标题翻译：用于预测液体混合物电导率的方法
公开(公告)号：WO2012082061A1
公开(公告)日：2012-06-21
申请号：PCT/SE2011/051513
申请日：2011-12-15
申请人： GE HEALTHCARE BIO-SCIENCES AB , CARREDANO, Enrique
发明人： CARREDANO, Enrique
IPC分类号： B01F15/00 , G01N27/06 , G01N27/26 , G01N30/34
CPC分类号： G06F19/70 , B01D15/12 , G01N27/06 , G01N27/4166 , G01N30/34
摘要： In a method of preparing a liquid solution by mixing ingredients according to a predetermined recipe, wherein at least one pair of species of the liquid solution is derived from a weak electrolyte and corresponds to an acid-base pair, the conductivity of the liquid solution is predicted by: (i) for each pair of species derived from a weak electrolyte, solving a respective equilibrium equation to calculate the actual molar concentration of each such species at equilibrium in the liquid solution, (ii) calculating for each ionic species of said plurality of species the molar conductivity by the formula: Λ = Λo –Κ x Sqrt(c) wherein Λ is the molar conductivity, Λo is the molar conductivity at infinite dilution, c is the concentration, and K is the coefficient, and wherein K and Λo are predetermined values for K and Λo for each ionic species, (iii) calculating the conductivity κ for each ionic species by the formula: κ = c x Λ and (iv) adding up the conductivities determined in step (iii) for the different ionic species to obtain a predicted conductivity of the liquid solution. A computer program product comprises instructions for causing a computer to perform the method steps.
摘要翻译：在通过根据预定配方混合成分制备液体溶液的方法中，其中至少一对液体溶液来自弱电解质并对应于酸碱对，液体溶液的电导率为通过以下方式预测：（i）对于来自弱电解质的每对物种，求解各自的平衡方程式以计算液体溶液中平衡时每种这样的物质的实际摩尔浓度，（ii）计算所述多个的物质摩尔电导率由下式计算：？ =？o - ？ x Sqrt（c）其中是摩尔电导率，ωo是无限稀释时的摩尔电导率，c是浓度，K是系数，其中K和αo是每种离子物质的K和αo的预定值，（iii）计算电导率对于每个离子物质，通过下式： = c x？和（iv）将不同离子物质的步骤（iii）中确定的电导率相加以获得液体溶液的预测电导率。计算机程序产品包括用于使计算机执行方法步骤的指令。

2. 发明申请

WO2004039765A1 USE OF UREA VARIANTS AS AFFINITY LIGANDS 审中-公开
标题翻译：使用尿素变量作为亲属关系
公开(公告)号：WO2004039765A1
公开(公告)日：2004-05-13
申请号：PCT/SE2003/001434
申请日：2003-09-12
申请人： AMERSHAM BIOSCIENCES AB , AXÉN, Andreas , BAUMANN, Herbert , CARREDANO, Enrique , GRÖNBERG, Anna , STEENSMA, Elles
发明人： AXÉN, Andreas , BAUMANN, Herbert , CARREDANO, Enrique , GRÖNBERG, Anna , STEENSMA, Elles
IPC分类号： C07C275/00
CPC分类号： C07C275/30 , C07C275/28 , C07C275/32 , C07D207/16 , C08G71/02 , G01N33/6854
摘要： The present invention relates to an IgG-binding compound, which more specifically has affinity for human IgGs of k-type and functional derivatives thereof. More specifically, the compound according to the invention comprises an N,N-alkylated urea moiety located between an aromatic part and another part, which is a linear or cyclic substituted or unsubstituted aliphatic group. The compound binds to a pocket-shaped binding site present on all human IgG k-Fabs, which site is located between the two domains (CH1 and CL) of its constant part. Accordingly, the compound according to the invention is a ligand for human IgGs of k-type, and consequently, the invention also relates to a separation matrix for affinity chromatography, which matrix comprises said compound, as well as to other uses of the compound.
摘要翻译：本发明涉及更具体地对k型及其功能性衍生物的人IgG具有亲和性的IgG结合化合物。更具体地，根据本发明的化合物包含位于芳族部分和另一部分之间的N，N-烷基化脲部分，其是线性或环状取代或未取代的脂族基团。该化合物结合存在于所有人IgG k-Fab上的口袋状结合位点，该位点位于其恒定部分的两个结构域（CH1和CL）之间。因此，根据本发明的化合物是k型人IgG的配体，因此，本发明还涉及用于亲和层析的分离基质，该基质包含所述化合物，以及该化合物的其它用途。

3. 发明申请

WO2011162666A1 METHOD OF PREPARING LIQUID MIXTURES 审中-公开
标题翻译：制备液体混合物的方法
公开(公告)号：WO2011162666A1
公开(公告)日：2011-12-29
申请号：PCT/SE2011/050563
申请日：2011-05-05
申请人： GE HEALTHCARE BIO-SCIENCES AB , ANDREI, Catalin , BERG, Mikael , BLANK, Torbjörn , CARREDANO, Enrique , EKSTRÖM, Karl , KARLSSON, Tomas, M. , LYNGÅ, Jan-Erik , NORDBERG, Roger , RODRIGO, Gustav , SANDEGREN, Henrik
发明人： ANDREI, Catalin , BERG, Mikael , BLANK, Torbjörn , CARREDANO, Enrique , EKSTRÖM, Karl , KARLSSON, Tomas, M. , LYNGÅ, Jan-Erik , NORDBERG, Roger , RODRIGO, Gustav , SANDEGREN, Henrik
IPC分类号： G05D11/08 , B01F15/04 , G01N30/34 , G01N30/88 , G05D11/13
CPC分类号： F17D3/00 , G01N30/34 , G05D21/02 , Y10T137/0329
摘要： A method of preparing a mixed liquid flow having predetermined characteristics, including a predetermined value of a first property and a predetermined value of a second property, comprising the steps of: a) providing a first set of at least one liquid flow each having a different first value of the first property; b) providing a second set of at least one liquid flow each having a different second value of the first property; c) providing a third set of at least one liquid flow of solvent; d) combining the provided liquid flows; and e)varying at least one of the liquid flows of the first and second sets and at least one liquid flow of the third set to adjust the first property and the second property to their respective predetermined values in the resulting mixed liquid flow.
摘要翻译：一种制备具有预定特性的混合液流的方法，包括第一特性的预定值和第二特性的预定值，包括以下步骤：a）提供第一组至少一个液体流，每组具有不同的第一财产的第一价值; b）提供第二组至少一个液体流，每个具有第一属性的不同的第二值; c）提供第三组至少一种液体的溶剂流; d）组合提供的液体流; 以及e）改变所述第一和第二组的液体流中的至少一个以及所述第三组的至少一个液体流，以将所述第一特性和所述第二特性调整到所得混合液体流中其各自的预定值。

4. 发明申请

WO2011037530A1 METHOD AND SYSTEM FOR PREPARATION OF LIQUID MIXTURES 审中-公开
标题翻译：液体混合物的制备方法和系统
公开(公告)号：WO2011037530A1
公开(公告)日：2011-03-31
申请号：PCT/SE2010/051023
申请日：2010-09-23
申请人： GE HEALTHCARE BIO-SCIENCES AB , BLANK, Torbjörn , CARREDANO, Enrique , EKSTRÖM, Karl , LYNGÅ, Jan-Erik , NORDBERG, Roger , PETERS, Mike , RODRIGO, Gustav , SANDEGREN, Henrik , STACK, Lisa
发明人： BLANK, Torbjörn , CARREDANO, Enrique , EKSTRÖM, Karl , LYNGÅ, Jan-Erik , NORDBERG, Roger , PETERS, Mike , RODRIGO, Gustav , SANDEGREN, Henrik , STACK, Lisa
IPC分类号： G05D11/02 , B01F15/04 , G01N30/34 , G05D11/08 , B01D15/16 , G01N30/88
CPC分类号： B01D15/166 , B01F15/0022 , B01F15/00227 , G01N30/34 , G01N2030/347 , G05D11/132
摘要： A method for preparing a liquid flow having pre-defined characteristics by mixing liquid flows of at least two different component stock solutions with each other comprises the steps of determining a selected property value for one or more of the stock solutions by sensing, in a flow of each stock solution separately, at least one characteristic related to the property value for the stock solution, and based on the determined property value or values, mixing the stock solution flows in mixing ratios giving the desired mixed liquid flow. A system for carrying out the method comprises sensor means and a control unit, wherein the control unit is arranged to evaluate the characteristics sensed by the sensor means and provide relative ratios of stock solutions required to obtain a mixed liquid flow having the pre-defined characteristics.
摘要翻译：通过混合至少两种不同组分原料溶液的液体流相互混合制备具有预定特性的液体流的方法包括以下步骤：通过在流体中感测来确定一种或多种储备溶液的选定的特性值分别存储与储备溶液的特性值相关的至少一个特征，并且基于所确定的特性值或值，以提供所需混合液体流的混合比混合储备液流。用于执行该方法的系统包括传感器装置和控制单元，其中控制单元布置成评估由传感器装置感测到的特性，并提供获得具有预定特性的混合液流所需的储备溶液的相对比例。

5. 发明申请

WO2009131524A1 PREPARATION OF LIQUID MIXTURES 审中-公开
标题翻译：液体混合物的制备
公开(公告)号：WO2009131524A1
公开(公告)日：2009-10-29
申请号：PCT/SE2009/050399
申请日：2009-04-20
申请人： GE HEALTHCARE BIO-SCIENCES AB , BJÖRKESTEN, Lennart , CARREDANO, Enrique , MALMQUIST, Gunnar , RODRIGO, Gustav , STAFSTRÖM, Nils
发明人： BJÖRKESTEN, Lennart , CARREDANO, Enrique , MALMQUIST, Gunnar , RODRIGO, Gustav , STAFSTRÖM, Nils
IPC分类号： G01N30/34 , B01D15/12 , B01J39/00 , B01J41/00
CPC分类号： B01D15/12 , B01D15/166 , B01D15/361 , G01N30/34 , G01N2030/347
摘要： A method of determining the relative component proportions of at least one each of: a buffer; an acid or a base; a solvent; and optionally a salt, for providing a liquid mix- ture of pre-defined pH and ionic strength, wherein the relative component proportions are determined using the equation of Debye-Hckel, wherein the ion size parameter α in the Debye-Hckelequation is determined as the weighted mean ion size of all species contributing to the ionic strength of the liquid mixture, and wherein the ionic strength of each species is used as weighting parameter. The present method is also applicable in a method of providing a liquid mixture. Further there is provided a buffer preparation device.
摘要翻译：一种确定缓冲器中的至少一个的相对分量比例的方法; 酸或碱; 溶剂; 和任选的盐，用于提供预定义的pH和离子强度的液体混合物，其中相对组分比例使用Debye-Hckel等式确定，其中Debye-Hckelequation中的离子尺寸参数a被确定为有助于液体混合物的离子强度的所有物质的加权平均离子尺寸，并且其中每种物质的离子强度用作加权参数。本方法也适用于提供液体混合物的方法。此外，提供了一种缓冲液制备装置。

6. 发明申请

WO2007004954A1 [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELCTIVE ADSORPTION OF IGG 审中-公开
标题翻译： [1,2,4]三唑并[1,5-A]吡嗪衍生物作为阴离子吸附剂的色谱吸附剂
公开(公告)号：WO2007004954A1
公开(公告)日：2007-01-11
申请号：PCT/SE2006/000808
申请日：2006-06-29
申请人： GE HEALTHCARE BIO-SCIENCES AB , ALTERMAN, Mathias , AXÉN, Andreas , CARREDANO, Enrique , GRÖNBERG, Anna , ZOU, Jinyu
发明人： ALTERMAN, Mathias , AXÉN, Andreas , CARREDANO, Enrique , GRÖNBERG, Anna , ZOU, Jinyu
IPC分类号： C07D487/04 , B01D15/38 , B01J20/289
CPC分类号： B01J20/3255 , B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3244 , C07D487/04
摘要： The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula (I) and its corresponding enol-form, wherein X represents O, S, or NH; R 1 represents H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, Ar, -C(O)NHR 3 , -C(O)-R 3 or halo; R 2 represents H, C 1-3 alkyl or halo; R 3 represents H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
摘要翻译：本发明涉及用于选择性吸附IgG的色谱吸附剂，其包含下式（I）及其相应的烯醇式，其中X代表O，S或NH; R 1表示H，C 1-6烷基，C 1-6 - 烷氧基，C 1-6 - 烷氧基 -C 1-6烷基，Ar，-C（O）NHR 3，-C（O）-R 3或卤素; R 2表示H，C 1-3烷基或卤素; R 3表示H，C 1-6烷基，C 1-6烷氧基，C 1-6 - 烷氧基 -C 1-6烷基或Ar; n表示0,1,2或3; Y表示载体。本发明还涉及生产所述吸附剂的方法及其通过亲和层析分离物质的用途。

7. 发明申请

WO2004039843A1 IMMUNOGLOBULIN G BINDING POCKET 审中-公开
公开(公告)号：WO2004039843A1
公开(公告)日：2004-05-13
申请号：PCT/SE2003/001435
申请日：2003-09-12
申请人： AMERSHAM BIOSCIENCES AB , AXÉN, Andreas , BAUMANN, Herbert , CARREDANO, Enrique
发明人： AXÉN, Andreas , BAUMANN, Herbert , CARREDANO, Enrique
IPC分类号： C07K16/18
CPC分类号： C08G71/02 , C07D207/16 , G01N33/6854
摘要： The present invention relates to a human IgG binding pocket comprised of a first interacting surface, which originates from an IgG k light chain, and a second interacting surface, which originates from an IgG heavy chain, which amino acids are strictly conserved between human IgGs of k-type. The invention also embraces an isolated and purified polypeptide, which comprises said binding pocket. Further, the invention relates to various methods of using the novel binding pocket, such as in screening for identification of chemical entities capable of selective binding thereof, and in other experimental and/or virtual methods for design and/or identification of chemical entities capable of selective binding thereof.
摘要翻译：本发明涉及由来自IgG k轻链的第一相互作用表面和源自IgG重链的第二相互作用表面组成的人IgG结合口袋，所述第一相互作用表面来自IgG重链，所述氨基酸在人IgG之间严格保守 k型。本发明还包括分离和纯化的多肽，其包含所述结合口袋。此外，本发明涉及使用新型结合口袋的各种方法，例如在筛选鉴定能够选择性结合化学物质的实验和/或虚拟方法中用于设计和/或鉴定能够选择性结合。

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