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1. 发明申请

WO2007031620B1 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于METRONIDAZOLE的皮肤发泡及其生产乳液
公开(公告)号：WO2007031620B1
公开(公告)日：2007-06-21
申请号：PCT/FR2006002037
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40
CPC分类号： A61K9/122 , A61K9/0014 , A61K9/107
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 70-81 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass% metronidazole, (d) 4-10 mass % mineral oil, (e) 0.5-20 mass% surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0.1-5 mass % preservative agent and (h) 0-5 mass % metronidazole absorption promoter. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：本发明涉及相对于其组合物的总质量以质量百分数表示的以下组分的乳液：（a）70-81质量％的水，（b）0.1-5质量％的乳液水相胶凝剂，（c）0.75-2质量％甲硝唑，（d）4-10质量％矿物油，（e）0.5-20质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0.1-5质量％％防腐剂和（h）0-5质量％甲硝唑吸收促进剂。还公开了可从所述乳液获得的基于甲硝唑的泡沫及其用途。

2. 发明申请

WO2007031621B1 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于甲基咪唑的皮肤病学泡沫和用于其生产的乳液
公开(公告)号：WO2007031621B1
公开(公告)日：2007-06-21
申请号：PCT/FR2006002038
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/107 , A61K9/122
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 72-76 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass % metronidazole, (d) 5-10 mass % mineral oil, (e) 0.5-10 mass % surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0-4 mass % metronidazole (c) absorption promoter and (h) 0.1-5 mass % preservative agent selected from a group consisting of methylparabene, propylparabene, phenoxyethanol and the mixture thereof. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：（a）72-76质量％的水，（b）乳液含水相的0.1-5质量％胶凝剂，以及（b）（c）0.75-2质量％甲硝唑，（d）5-10质量％矿物油，（e）0.5-10质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0-4质量％甲硝唑（c）吸收促进剂和（h）0.1-5质量％防腐剂，其选自甲基对苯二甲酸，丙基对苯二甲酸，苯氧基乙醇及其混合物。还公开了由所述乳液得到的基于甲硝唑的泡沫及其用途。

3. 发明申请

WO2007031621A3 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于METRONIDAZOLE的皮肤发泡及其生产乳液
公开(公告)号：WO2007031621A3
公开(公告)日：2007-05-03
申请号：PCT/FR2006002038
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/107 , A61K9/122
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 72-76 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass % metronidazole, (d) 5-10 mass % mineral oil, (e) 0.5-10 mass % surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0-4 mass % metronidazole (c) absorption promoter and (h) 0.1-5 mass % preservative agent selected from a group consisting of methylparabene, propylparabene, phenoxyethanol and the mixture thereof. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：本发明涉及相对于其组合物的总质量以质量百分比表示的以下组分的乳液：（a）72-76质量％的水，（b）0.1-5质量％的乳液水相胶凝剂，（c）0.75-2质量％甲硝唑，（d）5-10质量％矿物油，（e）0.5-10质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0-4质量％％甲硝唑（c）吸收促进剂和（h）0.1-5质量％的选自对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，苯氧基乙醇及其混合物的防腐剂。还公开了可从所述乳液获得的基于甲硝唑的泡沫及其用途。

4. 发明申请

WO2007031620A3 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于甲基咪唑的皮肤病学泡沫和用于其生产的乳液
公开(公告)号：WO2007031620A3
公开(公告)日：2007-05-03
申请号：PCT/FR2006002037
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40
CPC分类号： A61K9/122 , A61K9/0014 , A61K9/107
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 70-81 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass% metronidazole, (d) 4-10 mass % mineral oil, (e) 0.5-20 mass% surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0.1-5 mass % preservative agent and (h) 0-5 mass % metronidazole absorption promoter. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：（a）70-81质量％的水，（b）乳液含水相的0.1-5质量％胶凝剂，以及（b）（c）0.75-2质量％甲硝唑，（d）4-10质量％矿物油，（e）0.5-20质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0.1-5质量％防腐剂和（h）0-5质量％甲硝唑吸收促进剂。还公开了由所述乳液得到的基于甲硝唑的泡沫及其用途。

5. 发明申请

WO2009069006A3 FOAM CONTAINING BENZOYL PEROXIDE 审中-公开
标题翻译：含有过氧化苯甲酰的泡沫
公开(公告)号：WO2009069006A3
公开(公告)日：2009-11-12
申请号：PCT/IB2008003908
申请日：2008-12-01
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , SCHUZ DAVID , KEYNAN RITA , BERMAN TAL , DANZIGER JORGE
发明人： TAMARKIN DOV , FRIEDMAN DORON , SCHUZ DAVID , KEYNAN RITA , BERMAN TAL , DANZIGER JORGE
IPC分类号： A61K9/12 , A61K8/04 , A61K31/19 , A61K31/7056 , A61K47/12
CPC分类号： A61K33/40 , A61K8/046 , A61K8/38 , A61K9/0014 , A61K9/122 , A61K31/19 , A61K31/7056 , A61K47/12 , A61Q19/008
摘要： The present invention relates to foamable compositions for treating acne comprising benzoyl peroxide; to a therapeutic kit comprising such compositions; and to a method of treating acne using such compositions.
摘要翻译：本发明涉及用于治疗痤疮的可发泡组合物，其包含过氧化苯甲酰; 涉及包含这种组合物的治疗试剂盒; 并涉及使用这种组合物治疗痤疮的方法。

6. 发明申请

WO2009007785A3 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：WO2009007785A3
公开(公告)日：2009-06-04
申请号：PCT/IB2007004683
申请日：2007-11-14
申请人： FOAMIX LTD , BERMAN TAL , TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , SCHUZ DAVID
发明人： BERMAN TAL , TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , SCHUZ DAVID
IPC分类号： A61K9/113 , A61K9/12
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独或与其它浮游剂组合包含凡士林; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）表面活性剂和除淀粉或改性淀粉酯以外的聚合物，其中表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

7. 发明申请

WO2007054818A3 FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：可燃性车辆及其药用组合物
公开(公告)号：WO2007054818A3
公开(公告)日：2008-10-23
申请号：PCT/IB2006003519
申请日：2006-05-09
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/12 , A61K47/10 , A61K47/38
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

8. 发明申请

WO2007119099A3 APPARATUS AND METHOD FOR RELEASING A MEASURE OF CONTENT FROM A PLURALITY OF CONTAINERS 审中-公开
标题翻译：释放大量容器内容的测量装置和方法
公开(公告)号：WO2007119099A3
公开(公告)日：2008-05-02
申请号：PCT/IB2006003705
申请日：2006-09-12
申请人： FOAMIX LTD , EINI MEIR , FRIEDMAN DORON , TAMARKIN DOV , SCHUZ DAVID
发明人： EINI MEIR , FRIEDMAN DORON , TAMARKIN DOV , SCHUZ DAVID
IPC分类号： B65D83/68 , B67D7/70
CPC分类号： B65D83/68 , B05B11/3084
摘要： A dispenser head for use with a plurality of containers, each of the containers having a hollow stem through which contents are dispensed when the stem is activated, includes (a) a flow guide structured and positioned to receive a plurality of pressurized containers; (b) a plurality of flow conduits disposed within the flow guide, each of the plurality of flow conduits comprising an inlet and an outlet and each said inlet capable of engagement with a respective container stem; and (c) an actuator connected to the flow guide, wherein the actuator is structured and positioned to allow simultaneous flow communication between each of the plurality of flow conduits and a respective hollow stem, allowing substantially contemporaneously dispensing and/or combining of the content from a plurality of containers.
摘要翻译：一种用于多个容器的分配器头，每个容器具有中空杆，当所述杆被致动时通过所述中空杆分配内装物，所述分配头包括：（a）构造并定位成容纳多个加压容器的流动引导件; （b）设置在所述流动引导件内的多个流动管道，所述多个流动管道中的每一个包括入口和出口，并且每个所述入口能够与相应的容器杆接合; 和（c）连接到流动引导件的致动器，其中所述致动器被构造和定位成允许所述多个流动管道中的每一个与相应的中空杆之间的同时流动连通，从而允许基本上同时分配和/或组合所述内容物多个容器。

9. 发明申请

WO2006003481A2 OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM 审中-公开
标题翻译： OLEAGOOUS PHARMACEUTICAL和COSMETIC FOAM
公开(公告)号：WO2006003481A2
公开(公告)日：2006-01-12
申请号：PCT/IB2004004464
申请日：2004-12-16
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/00 , A61L9/04 , A61Q90/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from the group consisting of: a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1 % to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括选自以下的至少一种溶剂：疏水性溶剂，硅油，软化剂，助溶剂及其混合物，其中溶剂的浓度为约70％至约96.5 至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

10. 发明申请

WO2009072007A3 CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF 审中-公开
标题翻译：载体，配方，用于配制用于外用药物的不稳定活性剂的方法及其用途
公开(公告)号：WO2009072007A3
公开(公告)日：2009-11-12
申请号：PCT/IB2008003932
申请日：2008-12-08
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX , SHIFRIN HELEN
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX , SHIFRIN HELEN
IPC分类号： A61K9/12 , A61K8/04 , A61K31/65 , A61K47/06 , A61K47/14 , A61P31/04
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.
摘要翻译：本公开教导了用于局部施用四环素抗生素的独特制剂，其中四环素抗生素保持稳定。

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