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1. 发明申请

WO2007054818A3 FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：可燃性车辆及其药用组合物
公开(公告)号：WO2007054818A3
公开(公告)日：2008-10-23
申请号：PCT/IB2006003519
申请日：2006-05-09
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/12 , A61K47/10 , A61K47/38
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：吸湿性药物组合物包括至少一种浓度足以提供至少0.9的Aw值的吸湿物质和抗感染剂。起泡药物载体包括约50％至约98％的选自多元醇和PEG的极性溶剂; 0％至约48％的第二极性溶剂; 约0.2重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种聚合物; 和以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

2. 发明申请

WO2006003481A2 OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM 审中-公开
标题翻译： OLEAGOOUS PHARMACEUTICAL和COSMETIC FOAM
公开(公告)号：WO2006003481A2
公开(公告)日：2006-01-12
申请号：PCT/IB2004004464
申请日：2004-12-16
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/00 , A61L9/04 , A61Q90/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from the group consisting of: a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1 % to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括选自以下的至少一种溶剂：疏水性溶剂，硅油，软化剂，助溶剂及其混合物，其中溶剂的浓度为约70％至约96.5 至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

3. 发明申请

WO2009072007A3 CARRIERS, FORMULATIONS, METHODS FOR FORMULATING UNSTABLE ACTIVE AGENTS FOR EXTERNAL APPLICATION AND USES THEREOF 审中-公开
标题翻译：载体，配方，用于配制用于外用药物的不稳定活性剂的方法及其用途
公开(公告)号：WO2009072007A3
公开(公告)日：2009-11-12
申请号：PCT/IB2008003932
申请日：2008-12-08
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX , SHIFRIN HELEN
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX , SHIFRIN HELEN
IPC分类号： A61K9/12 , A61K8/04 , A61K31/65 , A61K47/06 , A61K47/14 , A61P31/04
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.
摘要翻译：本公开教导了用于局部施用四环素抗生素的独特制剂，其中四环素抗生素保持稳定。

4. 发明申请

WO2007085902A3 FOAMABLE COMPOSITION COMBINING A POLAR SOLVENT AND A HYDROPHOBIC CARRIER 审中-公开
标题翻译：组合极性溶剂和疏水性载体的可发泡组合物
公开(公告)号：WO2007085902A3
公开(公告)日：2007-11-29
申请号：PCT/IB2006004119
申请日：2006-07-19
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/12 , A61K8/04 , A61K9/107
CPC分类号： A61K8/046 , A61K8/31 , A61K8/34 , A61K8/345 , A61K8/361 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/46 , A61K8/4913 , A61K8/4973 , A61K8/86 , A61K8/891 , A61K8/922 , A61K8/925 , A61K9/122 , A61Q19/00
摘要： The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.
摘要翻译：本发明涉及可发泡载体或化妆品或药物组合物，其包含：（1）浓度为10重量％至70重量％的有机载体，其中所述有机载体同时包含：（i）至少一种疏水有机载体，和（ii）至少一种极性溶剂; （2）至少一种表面活性剂; （3）水; 和（4）至少一种浓度为全部组合物的3重量％至25重量％的液化或压缩气体推进剂。本发明进一步提供了治疗，缓解或预防哺乳动物受试者病症的方法，其包括将上述组合物施用于患病目标部位。

5. 发明申请

WO2007099396A2 ANTIBIOTIC KIT AND COMPOSITION AND USES THEREOF 审中-公开
标题翻译：抗生物工具包及其组合物及其用途
公开(公告)号：WO2007099396A2
公开(公告)日：2007-09-07
申请号：PCT/IB2006003975
申请日：2006-06-07
申请人： FOAMIX LTD , FRIEDMAN DORON , BESONOV ALEX , TAMARKIN DOV , EINI MEIR
发明人： FRIEDMAN DORON , BESONOV ALEX , TAMARKIN DOV , EINI MEIR
CPC分类号： A61K9/122 , A61K9/0014 , A61K9/107
摘要： The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2 % to about 50 % by weight, a surface- active agent, about 0.01 % to about 5 % by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3 % to about 25 % by weight of the total composition.
摘要翻译：本发明涉及提供安全有效剂量的抗生素的治疗试剂盒，其包括气溶胶包装组件，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口，其中所述加压产品包括可发泡组合物，其包含：抗生素; 选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，有机极性溶剂，软化剂及其混合物的有机载体，表面活性剂，约0.01％至约5重量％的至少一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物添加剂，水; 和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

6. 发明申请

WO2008110872A3 FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES 审中-公开
标题翻译：包含一个或多个通道代理，化学试剂，氮氧化物和相关试剂及其用途的可燃组合物和试剂盒
公开(公告)号：WO2008110872A3
公开(公告)日：2009-06-25
申请号：PCT/IB2007004522
申请日：2007-06-22
申请人： FOAMIX LTD , TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , BERMAN TAL , BESONOV ALEX
发明人： TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , BERMAN TAL , BESONOV ALEX
IPC分类号： A61K9/00 , A61K9/12 , A61K31/44 , A61K31/506 , A61K31/55
CPC分类号： A61K9/0014 , A61K9/122 , A61K9/1274 , A61K31/44 , A61K31/506 , A61K31/55 , A61K47/12 , A61K47/26 , A61K47/34 , A61K47/38
摘要： The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
摘要翻译：本发明涉及可发泡治疗组合物，其包含：（a）治疗有效浓度的至少一种选自通道剂，胆碱能药和一氧化氮供体的活性剂; 和（b）可发泡载体，包括：i。约50％至约98％的选自水的溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂及其混合物; II。 0％至约48％的选自水的第二溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂，助溶剂，渗透增强剂及其混合物; III。表面活性剂; IV。约0重量％至约5重量％的至少一种聚合物; 和v。浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述组合物容纳在容器中并且基本上是可流动的，并且其在释放时膨胀以形成可破坏的泡沫; 并且其中所述可发泡载体被选择以产生良好至优异质量的泡沫。本发明进一步提供治疗，减轻或预防哺乳动物受试者病症的方法，包括将所述组合物施用于受影响的靶位点。

7. 发明申请

WO2007023396A3 VASOACTIVE KIT AND COMPOSITION AND USES THEREOF 审中-公开
标题翻译： VASOACTIVE KIT AND COMPOSITION及其用途
公开(公告)号：WO2007023396A3
公开(公告)日：2008-03-20
申请号：PCT/IB2006003525
申请日：2006-05-08
申请人： FOAMIX LTD , FRIEDMAN DORON , BESONOV ALEX , TAMARKIN DOV , EINI MEIR
发明人： FRIEDMAN DORON , BESONOV ALEX , TAMARKIN DOV , EINI MEIR
IPC分类号： A61K9/12 , A61K8/04 , A61K8/67 , A61K9/00 , A61K31/07 , A61K31/202 , A61K31/203 , A61K31/506 , A61K36/00 , A61L9/04 , A61M11/00 , A61M11/02 , A61Q19/00 , B65D83/14
CPC分类号： A61Q7/00 , A61K8/046 , A61K8/06 , A61K8/064 , A61K8/494 , A61K8/4953 , A61K8/671 , A61K8/73 , A61K8/97 , A61K9/0014 , A61K9/122 , A61K9/7015 , A61K31/07 , A61K31/202 , A61K31/203 , A61K31/506 , A61K36/14 , A61K36/17 , A61K36/185 , A61K36/24 , A61K36/48 , A61K36/53 , A61K36/704 , A61K36/71 , A61K2800/70 , A61Q17/005 , A61Q19/00 , B65D83/48 , A61K2300/00
摘要： The present invention relates to a therapeutic kit to provide a safe and effective dosage of a vasoactive agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: a vasoactive agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface- active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及提供安全有效剂量的血管活性剂的治疗试剂盒，其包括气溶胶包装组件，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口，其中所述加压产品包括可发泡组合物，其包含：血管活性剂; 选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，有机极性溶剂，软化剂及其混合物的有机载体，表面活性剂，约0.01％至约5重量％的至少一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物添加剂，水; 和液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

8. 发明申请

WO2007102052A3 FOAM CONTAINING UNIQUE OIL GLOBULES 审中-公开
标题翻译：包含独特油类的泡沫
公开(公告)号：WO2007102052A3
公开(公告)日：2008-01-03
申请号：PCT/IB2006004170
申请日：2006-09-14
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , BESONOV ALEX , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , BESONOV ALEX , EINI MEIR
IPC分类号： A61K8/04 , A61K8/06 , A61K8/14 , A61K9/00 , A61K9/107 , A61K9/12 , A61K9/127 , A61K31/00 , A61K47/06 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/046 , A61K8/06 , A61K8/062 , A61K8/068 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/73 , A61K8/731 , A61K8/86 , A61K8/97 , A61K9/0014 , A61K9/0034 , A61K9/006 , A61K9/122 , A61K2800/21 , A61K2800/413 , A61Q19/00 , B82Y5/00
摘要： The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water emulsion composition includes: an oil globule system, selected from the group consisting of oil bodies; and sub-micron oil globules, about 0.1 % to about 5% by weight of an agent, selected from the group consisting of a surface-active agent, having an HLB value between 9 and 16; and a polymeric agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.
摘要翻译：本发明提供一种用于给予皮肤，体表，体腔或粘膜表面的发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。可发泡水包油乳液组合物包括：油球系统，其选自油体; 和亚微米级油球，约0.1％至约5％重量的选自HLB值在9和16之间的表面活性剂的试剂; 和聚合物剂，以及总组合物重量的约3％至约25％浓度的液化或压缩气体推进剂，加入水和任选的成分以使总质量达到100％。当从气溶胶容器释放时，可发泡组合物形成适合局部给药的膨胀泡沫。

9. 发明申请

WO2005076697A2 COSMETIC AND PHARMACEUTICAL FOAM WITH SOLID MATTER 审中-公开
标题翻译：化学和药物泡沫与固体物质
公开(公告)号：WO2005076697A2
公开(公告)日：2005-08-25
申请号：PCT/IB2005001227
申请日：2005-02-04
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/00 , A61K9/10 , A61K9/12 , A61K47/38 , A61L9/04
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/19 , A61K8/25 , A61K8/27 , A61K8/29 , A61K9/10 , A61K9/12 , A61K47/38 , A61Q17/04 , A61Q19/008
摘要： A foamable composition includes about 2 to about 30% by weight solid particles; about 2 to about 75% by weight hydrophobic solvent; about 10 to about 85% by weight water; about 0.1 % to about 5% by weight surface-active agent; about 0.1 % to about 5 wt% by weight stabilizer/gelling agent; and a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical administration.
摘要翻译：可发泡组合物包含约2至约30重量％的固体颗粒; 约2至约75％重量的疏水性溶剂; 约10至约85重量％的水; 约0.1％至约5％重量的表面活性剂; 约0.1重量％至约5重量％的稳定剂/胶凝剂; 以及在容器中的液化或压缩气体推进剂，其在释放时提供适于局部施用的可破裂泡沫。

10. 发明申请

WO2009007785A3 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：WO2009007785A3
公开(公告)日：2009-06-04
申请号：PCT/IB2007004683
申请日：2007-11-14
申请人： FOAMIX LTD , BERMAN TAL , TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , SCHUZ DAVID
发明人： BERMAN TAL , TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , SCHUZ DAVID
IPC分类号： A61K9/113 , A61K9/12
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独或与其它浮游剂组合包含凡士林; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）表面活性剂和除淀粉或改性淀粉酯以外的聚合物，其中表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

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