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1. 发明申请

WO2009087578A2 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 审中-公开
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：WO2009087578A2
公开(公告)日：2009-07-16
申请号：PCT/IB2009/005005
申请日：2009-01-08
申请人： FOAMIX LTD. , TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , ZLATKIS, Ella , SCHUZ, David , BERMAN, Tal
发明人： TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , ZLATKIS, Ella , SCHUZ, David , BERMAN, Tal
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61Q19/00
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to a composition that provides to a subject at least one sensation for a sustained period of time following application to the skin. The composition includes (a) at least one sensation or sensation modifying agent, comprising one or more of a cooling agent, a warming agent, a relaxing or soothing agent, and a stimulating or refreshing agent; (b) a foamable carrier; and (c) a propellant having a concentration about 3% to about 45% by weight of the total composition. The composition is stored in an aerosol container and upon release expands to form a non-crackling short term stable foam.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地，本发明涉及一种组合物，其在施用于皮肤后向受试者提供至少一种持续持续时间的感觉。组合物包括（a）至少一种感觉或感觉改性剂，其包含一种或多种冷却剂，加温剂，缓和或舒缓剂，以及刺激或清爽剂; （b）可发泡载体; 和（c）具有按总组合物重量计约3％至约45％的浓度的推进剂。将组合物储存在气溶胶容器中并且在释放时膨胀以形成非裂纹短期稳定的泡沫。

2. 发明申请

WO2008152444A2 COMPOSITIONS WITH MODULATING AGENTS 审中-公开
标题翻译：具有调节剂的组合物
公开(公告)号：WO2008152444A2
公开(公告)日：2008-12-18
申请号：PCT/IB2007/004628
申请日：2007-11-29
申请人： FOAMIX LTD. , TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , BERMAN, Tal , SCHUZ, David
发明人： TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , BERMAN, Tal , SCHUZ, David
CPC分类号： A61K9/0014 , A61K9/122 , A61K47/10 , A61K47/14
摘要： The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless compostition and foam.
摘要翻译：本发明涉及无水组合物和作为载体的泡沫体，其中活性药物或化妆品在添加时稳定或稳定化或其不稳定性受到调节剂的存在的阻碍。药物或化妆品组合物和泡沫体包括：无水溶剂，调节剂和一种或多种活性药物或化妆品。本发明还涉及给予无水组合物和泡沫的治疗方法。

3. 发明申请

WO2009098595A2 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 审中-公开
标题翻译：基于非水性可泡沫PETROLATUM的药物和化妆品组合物及其用途
公开(公告)号：WO2009098595A2
公开(公告)日：2009-08-13
申请号：PCT/IB2009/005032
申请日：2009-02-04
申请人： FOAMIX LTD. , TAMARKIN, Dov , FRIEDMAN, Doron , ZIV, Enbal , EINI, Meir , BERMAN, Tal , DANZIGER, Jorge , KEYNAN, Rita , SCHUZ, David
发明人： TAMARKIN, Dov , FRIEDMAN, Doron , ZIV, Enbal , EINI, Meir , BERMAN, Tal , DANZIGER, Jorge , KEYNAN, Rita , SCHUZ, David
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明还提供了治疗，缓解或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。

4. 发明申请

WO2009007785A2 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非醇性可发泡医药乳胶组合物及其使用方法及其用途
公开(公告)号：WO2009007785A2
公开(公告)日：2009-01-15
申请号：PCT/IB2007/004683
申请日：2007-11-14
申请人： FOAMIX LTD. , BERMAN, Tal , TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , SCHUZ, David
发明人： BERMAN, Tal , TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , SCHUZ, David
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的不含酒精的可发泡药物乳剂组合物包含浓度为约0.5重量％至约49重量％的润滑剂; 至少一种多活性剂; 浓度为约0.5重量％至约15重量％水; 有效量的在乳剂组合物中具有溶解度的活性药剂; 和至少一种液体或压缩气体推进剂，其浓度为全部组合物的约3重量％至约25重量％其中所述润滑剂单独包含凡士林或与其他油性剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中两种乳化剂的HLB值之间存在约4个或更多单元的差异，或者在化学性质上存在显着差异或两个乳化器的结构; （b）表面活性剂和泡沫辅助剂或助表面活性剂，其中表面活性剂的HLB接近油相所需的HLB; （c）表面活性剂和液体蜡，其中表面活性剂的HLB接近油相所需的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合剂，其中表面活性剂的HLB接近油相所需的HLB; （e）聚合物试剂和泡沫辅助剂或共表面活性剂，其可协作以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由HLB接近油相所需HLB的酯的混合物组成; 上述任一种的组合，并且其中组合物基本可流动，将其储存在加压容器中，并在释放时膨胀形成易碎泡沫。

5. 发明申请

WO2008110872A2 FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES 审中-公开
标题翻译：包含一个或多个通道代理，化学试剂，氮氧化物和相关试剂及其用途的可燃组合物和试剂盒
公开(公告)号：WO2008110872A2
公开(公告)日：2008-09-18
申请号：PCT/IB2007/004522
申请日：2007-06-22
申请人： FOAMIX LTD. , TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , BERMAN, Tal , BESONOV, Alex
发明人： TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , BERMAN, Tal , BESONOV, Alex
IPC分类号： A61K9/00 , A61K9/12 , A61K31/506 , A61K31/44 , A61K31/55
CPC分类号： A61K9/0014 , A61K9/122 , A61K9/1274 , A61K31/44 , A61K31/506 , A61K31/55 , A61K47/12 , A61K47/26 , A61K47/34 , A61K47/38
摘要： The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
摘要翻译：本发明涉及可发泡治疗组合物，其包含：（a）治疗有效浓度的至少一种选自通道剂，胆碱能药和一氧化氮供体的活性剂; 和（b）可发泡载体，包括：i。约50％至约98％的选自水的溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂及其混合物; II。 0％至约48％的选自水的第二溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂，助溶剂，渗透增强剂及其混合物; III。表面活性剂; IV。约0重量％至约5重量％的至少一种聚合物; 和v。浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述组合物容纳在容器中并且基本上是可流动的，并且其在释放时膨胀以形成可破坏的泡沫; 并且其中所述可发泡载体被选择以产生良好至优异质量的泡沫。本发明进一步提供治疗，减轻或预防哺乳动物受试者病症的方法，包括将所述组合物施用于受影响的靶位点。

6. 发明申请

WO2009069006A2 FOAM CONTAINING BENZOYL PEROXIDE 审中-公开
标题翻译：含有过氧化苯甲酰的泡沫
公开(公告)号：WO2009069006A2
公开(公告)日：2009-06-04
申请号：PCT/IB2008/003908
申请日：2008-12-01
申请人： FOAMIX LTD. , TAMARKIN, Dov , FRIEDMAN, Doron , SCHUZ, David , KEYNAN, Rita , BERMAN, Tal , DANZIGER, Jorge
发明人： TAMARKIN, Dov , FRIEDMAN, Doron , SCHUZ, David , KEYNAN, Rita , BERMAN, Tal , DANZIGER, Jorge
CPC分类号： A61K33/40 , A61K8/046 , A61K8/38 , A61K9/0014 , A61K9/122 , A61K31/19 , A61K31/7056 , A61K47/12 , A61Q19/008
摘要： The present invention relates to foamable compositions for treating acne comprising benzoyl peroxide; to a therapeutic kit comprising such compositions; and to a method of treating acne using such compositions.
摘要翻译：本发明涉及用于治疗痤疮的可发泡组合物，其包括过氧化苯甲酰; 涉及包含这种组合物的治疗试剂盒; 以及使用这种组合物治疗痤疮的方法。

7. 发明申请

WO2009090558A2 POLOXAMER FOAMABLE PHARMACEUTICAL COMPOSITIONS WITH ACTIVE AGENTS AND/OR THERAPEUTIC CELLS AND USES 审中-公开
标题翻译：具有活性药剂和/或治疗细胞和用途的透氧剂可发泡药物组合物
公开(公告)号：WO2009090558A2
公开(公告)日：2009-07-23
申请号：PCT/IB2009/005012
申请日：2009-01-14
申请人： FOAMIX LTD. , TAMARKIN, Dov , BESONOV, Alex , BERMAN, Tal , SCHUZ, David , GAZAL, Elana
发明人： TAMARKIN, Dov , BESONOV, Alex , BERMAN, Tal , SCHUZ, David , GAZAL, Elana
IPC分类号： A61K9/00 , A61K9/12 , A61K47/10 , A61K8/04 , A61K8/90 , A61Q19/00 , A61K31/196 , A61K31/60
CPC分类号： A61K9/122 , A61K8/046 , A61K8/90 , A61K9/06 , A61K9/107 , A61K31/19 , A61K31/196 , A61K31/506 , A61K31/522 , A61K31/60 , A61K31/7056 , A61K47/10 , A61K47/36 , A61Q19/00
摘要： Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1 % to about 15% by weight; wherein when the Poloxamer is between about 0.1 % to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.
摘要翻译：提供了用于其使用的药物或化妆品组合物和方法，其包含水和表面活性剂聚合物体系，其包含浓度为约0.1重量％至约15重量％的泊洛沙姆; 其中当泊洛沙姆为约0.1％至约5％泊洛沙姆时。组合物还可以包含含有非离子表面活性剂或包含非表面活性剂聚合物或多糖和活性剂的支持剂的支持剂，其中泊洛沙姆能够将组合物在输送到身体表面时固定。还提供治疗细胞组合物及其用途。

8. 发明申请

WO2009090495A2 OIL AND LIQUID SILICONE FOAMABLE CARRIERS AND FORMULATIONS 审中-公开
标题翻译：油和液体硅氧烷泡沫载体和配方
公开(公告)号：WO2009090495A2
公开(公告)日：2009-07-23
申请号：PCT/IB2008/003939
申请日：2008-12-08
申请人： FOAMIX LTD. , TAMARKIN, Dov , SHIFRIN, Helen , KEYNAN, Rita , ZIV, Enbal , BERMAN, Tal , SCHUZ, David
发明人： TAMARKIN, Dov , SHIFRIN, Helen , KEYNAN, Rita , ZIV, Enbal , BERMAN, Tal , SCHUZ, David
IPC分类号： A61K9/12 , A61K47/10 , A61K47/14
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01 % to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译：公开了适用于外部施用的无水可发泡药物组合物。该组合物包含至少一种液化或压缩气体推进剂的可发泡载体。可发泡载体包含至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01重量％至约25重量％的至少一种表面活性剂，所述表面活性剂单独或与泡沫辅助剂组合; 和按重量计约0％至约5％的至少一种聚合物试剂或与泡沫佐剂组合; 和它们的混合物。进一步描述了包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。

9. 发明申请

WO2008038140A2 POLYPROPYLENE GLYCOL FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：聚丙烯甘油可动态汽车及其药用组合物
公开(公告)号：WO2008038140A2
公开(公告)日：2008-04-03
申请号：PCT/IB2007/003463
申请日：2007-06-07
申请人： FOAMIX LTD. , FREIDMAN, Doron , TAMARKIN, Dov , FEIMAN, Naomi , SCHUZ, David , BERMAN, Tal
发明人： FREIDMAN, Doron , TAMARKIN, Dov , FEIMAN, Naomi , SCHUZ, David , BERMAN, Tal
CPC分类号： A01N25/16 , A01N53/00 , A61K8/046 , A61K8/86 , A61K9/0014 , A61K9/12 , A61K9/122 , A61Q5/006 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/02 , A61Q19/06 , A01N2300/00 , A01N25/04 , A01N25/02 , A01N25/30 , A01N49/00 , A01N59/12
摘要： The present invention teaches a foamable pharmaceutical carrier comprising polypropylene glycol (PPG) alkyl ether, a surface-active agent water and a liquefied hydrocarbon gas propellant; and pharmaceutical compositions thereof. The present invention further teaches a foamable pharmaceutical carrier comprising polypropylene glycol (PPG) alkyl ether, a surface-active agent, and a liquefied hydrocarbon gas propellant; and pharmaceutical compositions thereof.
摘要翻译：本发明教导了包含聚丙二醇（PPG）烷基醚，表面活性剂水和液化烃气体推进剂的可发泡药物载体; 及其药物组合物。本发明进一步教导了包含聚丙二醇（PPG）烷基醚，表面活性剂和液化烃气体推进剂的可发泡药物载体; 及其药物组合物。

10. 发明申请

WO2010125470A2 FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS COMPRISING APROTIC POLAR SOLVENTS AND USES THEREOF 审中-公开
标题翻译：包含APROTIC极性溶剂的可燃性车辆和药物组合物及其用途
公开(公告)号：WO2010125470A2
公开(公告)日：2010-11-04
申请号：PCT/IB2010/001126
申请日：2010-04-28
申请人： FOAMIX LTD. , TAMARKIN, Dov , SCHUZ, David , BERMAN, Tal , HAZOT, Yohan
发明人： TAMARKIN, Dov , SCHUZ, David , BERMAN, Tal , HAZOT, Yohan
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A61K8/046 , A61K8/46 , A61K9/0014 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/38 , A61K2800/31 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
摘要翻译：本发明教导了包含非质子极性溶剂的可发泡药物和化妆品组合物; 泡沫组合物及其用途。

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