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1. 发明申请

WO2011013009A4 NON SURFACTANT HYDRO-ALCOHOLIC FOAMABLE COMPOSITIONS, BREAKABLE FOAMS AND THEIR USES 审中-公开
标题翻译：非表面活性剂含水醇 - 可发泡组合物，可破裂泡沫及其用途
公开(公告)号：WO2011013009A4
公开(公告)日：2011-06-23
申请号：PCT/IB2010002241
申请日：2010-07-29
申请人： FOAMIX LTD , TAMARKIN DOV , ZIV ENBAL , HAZOT YOHAN , SCHUZ DAVID
发明人： TAMARKIN DOV , ZIV ENBAL , HAZOT YOHAN , SCHUZ DAVID
IPC分类号： C11D7/22
CPC分类号： A61K31/7056 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K47/10 , A61K47/38
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent- free foamable compositions.
摘要翻译：包含短链醇，水，聚合物，脂肪醇或脂肪酸或脂肪醇和脂肪酸及推进剂的组合的基本上不含表面活性剂的可发泡组合物。基本上不含表面活性剂的可发泡组合物，其包含水，聚合物，脂肪醇或脂肪酸和推进剂。一种使用基本上不含表面活性剂的可发泡组合物的治疗方法。

2. 发明申请

WO2010076658A3 APPARTUS AND METHOD FOR RELEASING A MEASURED AMOUNT OF CONTENT FROM A CONTAINER 审中-公开
标题翻译：附图和用于从容器中释放测量的量的方法
公开(公告)号：WO2010076658A3
公开(公告)日：2010-12-02
申请号：PCT/IB2009007991
申请日：2009-12-31
申请人： FOAMIX LTD , EINI MEIR , SCHUZ DAVID
发明人： EINI MEIR , SCHUZ DAVID
IPC分类号： B65D83/16
CPC分类号： B65D83/205 , B65D83/48
摘要： Apparatuses for delivering a predetermined quantity of content from a pressurized container are provided. The apparatuses include (a) a container (12) capable of housing a pressurized gas and a content, the container including a valve in fluid communication with the content; (b) a release assembly (8) for releasing content from the container, where the release assembly is in fluid communication with the valve; and (c) a rotatable assembly (1), where the rotatable assembly includes a wheeled actuator (2) having a plurality of sides (4) and angles (5). The wheeled actuator of the apparatus is positioned for engagement with the release assembly. Engagement of the wheeled actuator with the release assembly moves the release assembly from a first closed position to a second open position. In some embodiments, the apparatus includes one or more wheeled switches. Methods for delivering and applying a predetermined quantity of content from a pressurized container are also provided.
摘要翻译：提供了用于从加压容器输送预定量内容物的装置。所述设备包括：（a）能够容纳加压气体和内容物的容器（12），所述容器包括与所述内容物流体连通的阀; （b）用于从容器中释放内容物的释放组件（8），其中释放组件与阀流体连通; 和（c）可旋转组件（1），其中可旋转组件包括具有多个侧面（4）和角（5）的轮式致动器（2）。设备的轮式致动器定位成与释放组件接合。轮式致动器与释放组件的接合将释放组件从第一关闭位置移动到第二打开位置。在一些实施例中，该装置包括一个或多个轮式开关。还提供了从加压容器输送和施加预定量内容物的方法。

3. 发明申请

WO2010041141A3 OIL-BASED FOAMABLE CARRIERS AND FORMULATIONS 审中-公开
标题翻译：基于油基的可动态载体和配方
公开(公告)号：WO2010041141A3
公开(公告)日：2010-06-17
申请号：PCT/IB2009007184
申请日：2009-10-06
申请人： FOAMIX LTD , TAMARKIN DOV , SCHUZ DAVID , HAZOT YOHAN , GAZAL ELANA
发明人： TAMARKIN DOV , SCHUZ DAVID , HAZOT YOHAN , GAZAL ELANA
IPC分类号： A61K9/12 , A61K8/04 , A61K31/65 , A61K47/06 , A61K47/14 , A61P31/04
CPC分类号： A61K9/122 , A61K9/0014 , A61K31/65 , A61K47/06 , A61K47/14 , A61K47/24
摘要： A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译：公开了一种适用于外部和内部给药的无水可发泡载体和药物组合物。组合物是单相的，包括至少一种液体油; 和甘油酯。进一步描述包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。

4. 发明申请

WO2009098595A3 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 审中-公开
标题翻译：基本上不含水的可发泡油基药物和化妆品组合物及其用途
公开(公告)号：WO2009098595A3
公开(公告)日：2009-11-12
申请号：PCT/IB2009005032
申请日：2009-02-04
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , ZIV ENBAL , EINI MEIR , BERMAN TAL , DANZIGER JORGE , KEYNAN RITA , SCHUZ DAVID
发明人： TAMARKIN DOV , FRIEDMAN DORON , ZIV ENBAL , EINI MEIR , BERMAN TAL , DANZIGER JORGE , KEYNAN RITA , SCHUZ DAVID
IPC分类号： A61K9/12 , A61K8/04 , A61K47/06
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂以及添加和不添加活性剂的稳定的基本上非水，非醇，非硅酮，可发泡载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明进一步提供了治疗，缓解或预防有需要的哺乳动物受试者病症的方法，其包括将上述组合物施用于所述哺乳动物受试者的患病靶位点。

5. 发明申请

WO2009090558A2 POLOXAMER FOAMABLE PHARMACEUTICAL COMPOSITIONS WITH ACTIVE AGENTS AND/OR THERAPEUTIC CELLS AND USES 审中-公开
标题翻译：具有活性药剂和/或治疗细胞和用途的透氧剂可发泡药物组合物
公开(公告)号：WO2009090558A2
公开(公告)日：2009-07-23
申请号：PCT/IB2009/005012
申请日：2009-01-14
申请人： FOAMIX LTD. , TAMARKIN, Dov , BESONOV, Alex , BERMAN, Tal , SCHUZ, David , GAZAL, Elana
发明人： TAMARKIN, Dov , BESONOV, Alex , BERMAN, Tal , SCHUZ, David , GAZAL, Elana
IPC分类号： A61K9/00 , A61K9/12 , A61K47/10 , A61K8/04 , A61K8/90 , A61Q19/00 , A61K31/196 , A61K31/60
CPC分类号： A61K9/122 , A61K8/046 , A61K8/90 , A61K9/06 , A61K9/107 , A61K31/19 , A61K31/196 , A61K31/506 , A61K31/522 , A61K31/60 , A61K31/7056 , A61K47/10 , A61K47/36 , A61Q19/00
摘要： Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1 % to about 15% by weight; wherein when the Poloxamer is between about 0.1 % to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.
摘要翻译：提供了用于其使用的药物或化妆品组合物和方法，其包含水和表面活性剂聚合物体系，其包含浓度为约0.1重量％至约15重量％的泊洛沙姆; 其中当泊洛沙姆为约0.1％至约5％泊洛沙姆时。组合物还可以包含含有非离子表面活性剂或包含非表面活性剂聚合物或多糖和活性剂的支持剂的支持剂，其中泊洛沙姆能够将组合物在输送到身体表面时固定。还提供治疗细胞组合物及其用途。

6. 发明申请

WO2008020268A3 APPARATUS AND METHOD FOR RELEASING A MEASURED AMOUNT OF CONTENT FROM A CONTAINER 审中-公开
标题翻译：从容器中释放测量的内容物的装置和方法
公开(公告)号：WO2008020268A3
公开(公告)日：2008-08-21
申请号：PCT/IB2006004290
申请日：2006-04-18
申请人： FOAMIX LTD , EINI MEIR , TAMARKIN DOV , FRIEDMAN DORON
发明人： EINI MEIR , TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： B65D83/14
CPC分类号： B65D83/36 , A45D34/04 , A45D2200/057 , A45D2200/1018 , B65D83/285 , B65D83/303 , B65D83/54
摘要： Apparatus and method for delivering a predetermined quantity of content (14) from a pressurized container include a container (10) for housing a pressurized gas (12) and a content (14); a valve (26) for releasing content from the container (10); a metering chamber (16) in fluid communication with the container (10) and the valve (26) and having an upper wall and a lower wall, the metering chamber (16) defining a volume proportionate to a predetermined quantity of content (14) to be delivered; and a movable partition (28) comprising a seal (30) positioned in the chamber (16) and capable of moving from a first resting position to a second sealing position, the sealing position sealing fluid communication of the chamber (16) with the valve (26). When the valve (26) is opened to deliver content (14) from the container (10), the movable partition (28) moves from a first resting position to a second sealing position.
摘要翻译：用于从加压容器输送预定量的内容物（14）的装置和方法包括用于容纳加压气体（12）和内容物（14）的容器（10）; 用于从容器（10）释放内容物的阀（26）; 与容器（10）和阀（26）流体连通并具有上壁和下壁的计量室（16），所述计量室（16）限定与预定量的内容物成比例的容积（14）交付; 以及可移动分隔件（28），其包括定位在所述腔室（16）中并且能够从第一静止位置移动到第二密封位置的密封件（30），所述密封位置密封所述腔室（16）与所述阀（26）。当阀（26）打开以从容器（10）输送内容物（14）时，可移动分隔件（28）从第一静止位置移动到第二密封位置。

7. 发明申请

WO2008075207A2 ANTI-INFECTION AUGMENTATION FOAMABLE COMPOSITIONS AND KIT AND USES THEREOF 审中-公开
标题翻译：抗感染AUGMENTATION可发泡组合物和试剂盒及其用途
公开(公告)号：WO2008075207A2
公开(公告)日：2008-06-26
申请号：PCT/IB2007004459
申请日：2007-04-04
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
CPC分类号： A61K31/137 , A61K9/0034 , A61K9/122 , A61K31/415 , A61K47/12 , A61K47/18
摘要： Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti- infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
摘要翻译：抗感染性可发泡组合物和试剂盒包括可发泡载体; 治疗安全有效的抗感染剂浓度; 选自角质层分离剂和皮肤渗透促进剂组成的组中的增强剂; 和推进剂。将组合物容纳在容器中并且在释放时可膨胀以形成易碎泡沫。选择发泡载体以在增塑剂和抗感染剂的存在下产生良好或优异的质量的泡沫。描述了治疗，缓解或预防皮肤，体腔或粘膜表面疾病的方法，其中所述疾病涉及作为其病因之一的真菌，细菌或病毒感染。

8. 发明申请

WO2007072216A3 KIT AND COMPOSITION OF IMIDAZOLE WITH ENHANCED BIOAVAILABILITY 审中-公开
标题翻译：咪唑唑的组合物和增强的生物利用度
公开(公告)号：WO2007072216A3
公开(公告)日：2008-05-08
申请号：PCT/IB2006003974
申请日：2006-01-24
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
IPC分类号： A61K9/12 , A61K9/00 , A61K31/415 , A61K31/4164 , A61K31/496 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38 , A61L9/04 , A61M11/00 , A61P31/10
CPC分类号： A61M11/04 , A01N25/16 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/496 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38
摘要： A composition and therapeutic kit provide a therapeutic azole with increased solubility. The kit includes an aerosol packaging assembly containing a container accommodating a pressurized product and an outlet capable of releasing the pressurized product as a foam. The pressurized product includes a foamable composition including: i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：组合物和治疗试剂盒提供治疗性唑，溶解度增加。该试剂盒包括含有容纳加压产品的容器和能够释放作为泡沫的加压产品的出口的气溶胶包装组件。加压产品包括可发泡组合物，其包括：i。治疗性唑，其中唑在发泡之前在组合物中的溶解度小于发泡后唑类在组合物中的溶解度; II。选自浓度为约2重量％至约50重量％的至少一种选自疏水性有机载体，共溶剂，软化剂及其混合物的有机载体; III。表面活性剂; IV。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。

9. 发明申请

WO2007039825A3 SACCHARIDE FOAMABLE COMPOSITIONS 审中-公开
标题翻译： SACCHARIDE可发泡组合物
公开(公告)号：WO2007039825A3
公开(公告)日：2008-03-06
申请号：PCT/IB2006003628
申请日：2006-05-09
申请人： FOAMIX LTD , TAMARKIN DOV , BESONOV ALEX , FRIEDMAN DORON
发明人： TAMARKIN DOV , BESONOV ALEX , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K47/10 , A61K47/38
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface- active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种可发泡组合物，其含有用于治疗各种疾病的糖类，包括：水，糖类，约0.2％至约5％重量的表面活性剂，至少约0.01％至约5％一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物，以及以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

10. 发明申请

WO2007102052A2 FOAM CONTAINING UNIQUE OIL GLOBULES 审中-公开
标题翻译：包含独特油类的泡沫
公开(公告)号：WO2007102052A2
公开(公告)日：2007-09-13
申请号：PCT/IB2006/004170
申请日：2006-09-14
申请人： FOAMIX LTD. , TAMARKIN, Dov , FRIEDMAN, Doron , BESONOV, Alex , EINI, Meir
发明人： TAMARKIN, Dov , FRIEDMAN, Doron , BESONOV, Alex , EINI, Meir
CPC分类号： A61K8/046 , A61K8/06 , A61K8/062 , A61K8/068 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/73 , A61K8/731 , A61K8/86 , A61K8/97 , A61K9/0014 , A61K9/0034 , A61K9/006 , A61K9/122 , A61K2800/21 , A61K2800/413 , A61Q19/00 , B82Y5/00
摘要： The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water emulsion composition includes: an oil globule system, selected from the group consisting of oil bodies; and sub-micron oil globules, about 0.1 % to about 5% by weight of an agent, selected from the group consisting of a surface-active agent, having an HLB value between 9 and 16; and a polymeric agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.
摘要翻译：本发明提供一种用于给予皮肤，体表，体腔或粘膜表面的发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。可发泡水包油乳液组合物包括：油球系统，其选自油体; 和亚微米级油球，约0.1％至约5％重量的选自HLB值在9和16之间的表面活性剂的试剂; 和聚合物剂，以及总组合物重量的约3％至约25％浓度的液化或压缩气体推进剂，加入水和任选的成分以使总质量达到100％。当从气溶胶容器释放时，可发泡组合物形成适合局部给药的膨胀泡沫。

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