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1. 发明申请

WO2009069006A2 FOAM CONTAINING BENZOYL PEROXIDE 审中-公开
标题翻译：含有过氧化苯甲酰的泡沫
公开(公告)号：WO2009069006A2
公开(公告)日：2009-06-04
申请号：PCT/IB2008/003908
申请日：2008-12-01
申请人： FOAMIX LTD. , TAMARKIN, Dov , FRIEDMAN, Doron , SCHUZ, David , KEYNAN, Rita , BERMAN, Tal , DANZIGER, Jorge
发明人： TAMARKIN, Dov , FRIEDMAN, Doron , SCHUZ, David , KEYNAN, Rita , BERMAN, Tal , DANZIGER, Jorge
CPC分类号： A61K33/40 , A61K8/046 , A61K8/38 , A61K9/0014 , A61K9/122 , A61K31/19 , A61K31/7056 , A61K47/12 , A61Q19/008
摘要： The present invention relates to foamable compositions for treating acne comprising benzoyl peroxide; to a therapeutic kit comprising such compositions; and to a method of treating acne using such compositions.
摘要翻译：本发明涉及用于治疗痤疮的可发泡组合物，其包括过氧化苯甲酰; 涉及包含这种组合物的治疗试剂盒; 以及使用这种组合物治疗痤疮的方法。

2. 发明申请

WO2017029647A1 TETRACYCLINE MANAGEMENT OF EGFR INHIBITOR ASSOCIATED DERMATOSES 审中-公开
标题翻译： EGFR抑制剂相关衍生物的四环素管理
公开(公告)号：WO2017029647A1
公开(公告)日：2017-02-23
申请号：PCT/IB2016/054989
申请日：2016-08-19
申请人： EINI, Meir , SHIRVAN, Mitchell , KEYNAN, Rita , BERMAN, Tal , SCHUZ, David
发明人： EINI, Meir , SHIRVAN, Mitchell , KEYNAN, Rita , BERMAN, Tal , SCHUZ, David
IPC分类号： A61K31/65 , A61K45/06 , A61P17/00 , A61K9/00
CPC分类号： A61K31/65 , A61K9/0014 , A61K9/06 , A61K9/12 , A61K45/06 , A61K47/06 , A61K47/24 , A61K47/44
摘要： Methods of treatment and dosage regimes using a composition comprising a tetracycline antibiotic in treating or alleviating a disorder including EGFRI associated rash, EGFRI associated rash related symptoms, a tetracycline antibiotic responsive EGFRI associated rash related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. EGFRI associated rash bacteria associated disorders and other superficial infections, including skin infections are provided.
摘要翻译：使用包含四环素抗生素的组合物在治疗或缓解包括EGFRI相关性皮疹，EGFRI相关的皮疹相关症状，四环素抗性反应性EGFRI相关性皮疹相关病症，由细菌引起的皮肤病和四环素的疾病中的治疗方法和剂量方案提供了抗生素反应性皮脂腺病，P.EGFRI相关的皮疹细菌相关疾病和其他浅表感染，包括皮肤感染。

3. 发明申请

WO2009098595A3 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 审中-公开
标题翻译：基本上不含水的可发泡油基药物和化妆品组合物及其用途
公开(公告)号：WO2009098595A3
公开(公告)日：2009-11-12
申请号：PCT/IB2009005032
申请日：2009-02-04
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , ZIV ENBAL , EINI MEIR , BERMAN TAL , DANZIGER JORGE , KEYNAN RITA , SCHUZ DAVID
发明人： TAMARKIN DOV , FRIEDMAN DORON , ZIV ENBAL , EINI MEIR , BERMAN TAL , DANZIGER JORGE , KEYNAN RITA , SCHUZ DAVID
IPC分类号： A61K9/12 , A61K8/04 , A61K47/06
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂以及添加和不添加活性剂的稳定的基本上非水，非醇，非硅酮，可发泡载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明进一步提供了治疗，缓解或预防有需要的哺乳动物受试者病症的方法，其包括将上述组合物施用于所述哺乳动物受试者的患病靶位点。

4. 发明申请

WO2009090558A2 POLOXAMER FOAMABLE PHARMACEUTICAL COMPOSITIONS WITH ACTIVE AGENTS AND/OR THERAPEUTIC CELLS AND USES 审中-公开
标题翻译：具有活性药剂和/或治疗细胞和用途的透氧剂可发泡药物组合物
公开(公告)号：WO2009090558A2
公开(公告)日：2009-07-23
申请号：PCT/IB2009/005012
申请日：2009-01-14
申请人： FOAMIX LTD. , TAMARKIN, Dov , BESONOV, Alex , BERMAN, Tal , SCHUZ, David , GAZAL, Elana
发明人： TAMARKIN, Dov , BESONOV, Alex , BERMAN, Tal , SCHUZ, David , GAZAL, Elana
IPC分类号： A61K9/00 , A61K9/12 , A61K47/10 , A61K8/04 , A61K8/90 , A61Q19/00 , A61K31/196 , A61K31/60
CPC分类号： A61K9/122 , A61K8/046 , A61K8/90 , A61K9/06 , A61K9/107 , A61K31/19 , A61K31/196 , A61K31/506 , A61K31/522 , A61K31/60 , A61K31/7056 , A61K47/10 , A61K47/36 , A61Q19/00
摘要： Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1 % to about 15% by weight; wherein when the Poloxamer is between about 0.1 % to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.
摘要翻译：提供了用于其使用的药物或化妆品组合物和方法，其包含水和表面活性剂聚合物体系，其包含浓度为约0.1重量％至约15重量％的泊洛沙姆; 其中当泊洛沙姆为约0.1％至约5％泊洛沙姆时。组合物还可以包含含有非离子表面活性剂或包含非表面活性剂聚合物或多糖和活性剂的支持剂的支持剂，其中泊洛沙姆能够将组合物在输送到身体表面时固定。还提供治疗细胞组合物及其用途。

5. 发明申请

WO2018234865A1 STABLE TOPICAL TETRACYCLINE COMPOSITIONS 审中-公开
公开(公告)号：WO2018234865A1
公开(公告)日：2018-12-27
申请号：PCT/IB2018/000767
申请日：2018-06-19
申请人： FOAMIX PHARMACEUTICALS LTD. , HAZOT, Yohan , BERMAN, Tal , ZAILER, Jana , AMSALEM, Orit , SCHUZ, David , LONDON-DRORI, Anat
发明人： HAZOT, Yohan , BERMAN, Tal , ZAILER, Jana , AMSALEM, Orit , SCHUZ, David , LONDON-DRORI, Anat
IPC分类号： A61K9/00 , A61K9/12
CPC分类号： A61K9/0014 , A61K9/122
摘要： Provided herein are compositions and methods for treating skin disorders, e.g., acne and/or rosacea. In some embodiments, the compositions may comprise carriers which are suitable for stabilizing an unstable active agent, e.g., a tetracycline antibiotic.

6. 发明申请

WO2010125470A2 FOAMABLE VEHICLE AND PHARMACEUTICAL COMPOSITIONS COMPRISING APROTIC POLAR SOLVENTS AND USES THEREOF 审中-公开
标题翻译：包含APROTIC极性溶剂的可燃性车辆和药物组合物及其用途
公开(公告)号：WO2010125470A2
公开(公告)日：2010-11-04
申请号：PCT/IB2010/001126
申请日：2010-04-28
申请人： FOAMIX LTD. , TAMARKIN, Dov , SCHUZ, David , BERMAN, Tal , HAZOT, Yohan
发明人： TAMARKIN, Dov , SCHUZ, David , BERMAN, Tal , HAZOT, Yohan
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A61K8/046 , A61K8/46 , A61K9/0014 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/38 , A61K2800/31 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
摘要翻译：本发明教导了包含非质子极性溶剂的可发泡药物和化妆品组合物; 泡沫组合物及其用途。

7. 发明申请

WO2009090495A3 OIL AND LIQUID SILICONE FOAMABLE CARRIERS AND FORMULATIONS 审中-公开
标题翻译：油和液体硅胶可发泡载体和配方
公开(公告)号：WO2009090495A3
公开(公告)日：2009-11-12
申请号：PCT/IB2008003939
申请日：2008-12-08
申请人： FOAMIX LTD , TAMARKIN DOV , SHIFRIN HELEN , KEYNAN RITA , ZIV ENBAL , BERMAN TAL , SCHUZ DAVID
发明人： TAMARKIN DOV , SHIFRIN HELEN , KEYNAN RITA , ZIV ENBAL , BERMAN TAL , SCHUZ DAVID
IPC分类号： A61K9/12 , A61K8/04 , A61K47/06 , A61K47/14 , A61K47/24
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01 % to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译：公开了一种适用于外用的无水可发泡药物组合物。组合物包括可发泡载体至少一种液化或压缩气体推进剂。可发泡载体包括至少一种液体油; 至少一种硅氧烷和至少一种至少一种稳定剂; 其中所述稳定剂选自约0.01％至约25％重量的至少一种表面活性剂单独或与泡沫佐剂组合; 和约0％至约5％重量的至少一种聚合物单体或与泡沫佐剂组合; 及其混合物。进一步描述包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。

8. 发明申请

WO2009098595A2 SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 审中-公开
标题翻译：基于非水性可泡沫PETROLATUM的药物和化妆品组合物及其用途
公开(公告)号：WO2009098595A2
公开(公告)日：2009-08-13
申请号：PCT/IB2009/005032
申请日：2009-02-04
申请人： FOAMIX LTD. , TAMARKIN, Dov , FRIEDMAN, Doron , ZIV, Enbal , EINI, Meir , BERMAN, Tal , DANZIGER, Jorge , KEYNAN, Rita , SCHUZ, David
发明人： TAMARKIN, Dov , FRIEDMAN, Doron , ZIV, Enbal , EINI, Meir , BERMAN, Tal , DANZIGER, Jorge , KEYNAN, Rita , SCHUZ, David
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译：本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。制剂可以含有其中基本上可混溶的溶剂。本发明还提供了治疗，缓解或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。

9. 发明申请

WO2009087578A2 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 审中-公开
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：WO2009087578A2
公开(公告)日：2009-07-16
申请号：PCT/IB2009/005005
申请日：2009-01-08
申请人： FOAMIX LTD. , TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , ZLATKIS, Ella , SCHUZ, David , BERMAN, Tal
发明人： TAMARKIN, Dov , EINI, Meir , FRIEDMAN, Doron , ZLATKIS, Ella , SCHUZ, David , BERMAN, Tal
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61Q19/00
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to a composition that provides to a subject at least one sensation for a sustained period of time following application to the skin. The composition includes (a) at least one sensation or sensation modifying agent, comprising one or more of a cooling agent, a warming agent, a relaxing or soothing agent, and a stimulating or refreshing agent; (b) a foamable carrier; and (c) a propellant having a concentration about 3% to about 45% by weight of the total composition. The composition is stored in an aerosol container and upon release expands to form a non-crackling short term stable foam.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地，本发明涉及一种组合物，其在施用于皮肤后向受试者提供至少一种持续持续时间的感觉。组合物包括（a）至少一种感觉或感觉改性剂，其包含一种或多种冷却剂，加温剂，缓和或舒缓剂，以及刺激或清爽剂; （b）可发泡载体; 和（c）具有按总组合物重量计约3％至约45％的浓度的推进剂。将组合物储存在气溶胶容器中并且在释放时膨胀以形成非裂纹短期稳定的泡沫。

10. 发明申请

WO2008110872A3 FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES 审中-公开
标题翻译：包含一个或多个通道代理，化学试剂，氮氧化物和相关试剂及其用途的可燃组合物和试剂盒
公开(公告)号：WO2008110872A3
公开(公告)日：2009-06-25
申请号：PCT/IB2007004522
申请日：2007-06-22
申请人： FOAMIX LTD , TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , BERMAN TAL , BESONOV ALEX
发明人： TAMARKIN DOV , EINI MEIR , FRIEDMAN DORON , BERMAN TAL , BESONOV ALEX
IPC分类号： A61K9/00 , A61K9/12 , A61K31/44 , A61K31/506 , A61K31/55
CPC分类号： A61K9/0014 , A61K9/122 , A61K9/1274 , A61K31/44 , A61K31/506 , A61K31/55 , A61K47/12 , A61K47/26 , A61K47/34 , A61K47/38
摘要： The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
摘要翻译：本发明涉及可发泡治疗组合物，其包含：（a）治疗有效浓度的至少一种选自通道剂，胆碱能药和一氧化氮供体的活性剂; 和（b）可发泡载体，包括：i。约50％至约98％的选自水的溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂及其混合物; II。 0％至约48％的选自水的第二溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂，助溶剂，渗透增强剂及其混合物; III。表面活性剂; IV。约0重量％至约5重量％的至少一种聚合物; 和v。浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述组合物容纳在容器中并且基本上是可流动的，并且其在释放时膨胀以形成可破坏的泡沫; 并且其中所述可发泡载体被选择以产生良好至优异质量的泡沫。本发明进一步提供治疗，减轻或预防哺乳动物受试者病症的方法，包括将所述组合物施用于受影响的靶位点。

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