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1. 发明申请

WO2004032791A3 METHOD AND APPARATUS FOR SELECTIVE MATERIAL DELIVERY VIA AN INTRA-RENAL CATHETER 审中-公开
标题翻译：通过内镜导管选择性材料输送的方法和装置
公开(公告)号：WO2004032791A3
公开(公告)日：2004-07-01
申请号：PCT/US0329744
申请日：2003-09-22
申请人： FLOWMEDICA INC , GOODSON HARRY B IV , ELKINS JEFFREY M , PATEL SAMIR R , VALENCIA AURELIO , ABOYTES RICARDO , BALL CRAIG A , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
发明人： GOODSON HARRY B IV , ELKINS JEFFREY M , PATEL SAMIR R , VALENCIA AURELIO , ABOYTES RICARDO , BALL CRAIG A , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
IPC分类号： A61B20060101 , A61F20060101 , A61F2/06 , A61M25/00 , A61M25/01 , A61M25/04 , A61M25/10 , A61M25/14 , A61M29/02
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports (212, 214) that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique location along an abdominal aortic wall.
摘要翻译：两个肾递送构件具有两个远端口（212,214），其适于通过其沿着腹主动脉壁的独特位置处的相应肾口位于两个肾动脉内。

2. 发明申请

WO2004026371A3 METHOD AND APPARATUS FOR SELECTIVE DRUG INFUSION VIA AN INTRAAORTIC FLOW DIVERTER DELIVERY CATHETER 审中-公开
标题翻译：通过流体流量输送管选择性药物输注的方法和装置
公开(公告)号：WO2004026371A3
公开(公告)日：2004-09-02
申请号：PCT/US0329743
申请日：2003-09-22
申请人： FLOWMEDICA INC , VALENCIA AURELIO , ABOYTES RICARDO , ELKINS JEFFREY M , GOODSON HARRY B IV , PATEL SAMIR R , BALL CRAIG A , GREENAN TREVOR M , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
发明人： VALENCIA AURELIO , ABOYTES RICARDO , ELKINS JEFFREY M , GOODSON HARRY B IV , PATEL SAMIR R , BALL CRAIG A , GREENAN TREVOR M , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
IPC分类号： A61M20060101 , A61M25/00
CPC分类号： A61M25/1002 , A61M25/00 , A61M25/0074 , A61M25/0082 , A61M25/04 , A61M29/02 , A61M39/06 , A61M2025/0073 , A61M2025/1052
摘要： A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要翻译：局部肾递送系统包括流动隔离组件和局部注射组件。在一种模式中的流动隔离组件适于仅沿着沿着主动脉壁的外周隔离部分流动区域，使得在其中注入的流体被维持以基本上流入肾动脉。描述了各种类型的流动隔离组件和局部注射组件。

3. 发明申请

WO2004030718A3 METHOD AND APPARATUS FOR INTRA AORTIC SUBSTANCE DELIVERY TO A BRANCH VESSEL 审中-公开
标题翻译：用于内部物质输送到分支机构的方法和装置
公开(公告)号：WO2004030718A3
公开(公告)日：2004-08-19
申请号：PCT/US0329995
申请日：2003-09-22
申请人： FLOWMEDICA INC , PATEL SAMIR R , VALENCIA AURELIO , ABOYTES RICARDO , GOODSON IV HARRY B , ELKINS JEFFREY M , BALL CRAIG A , GREENAN TREVOR M , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
发明人： PATEL SAMIR R , VALENCIA AURELIO , ABOYTES RICARDO , GOODSON IV HARRY B , ELKINS JEFFREY M , BALL CRAIG A , GREENAN TREVOR M , KESTEN RANDY J , KRAMER ANDREW K , PAYNE SAM G , PESOTCHINSKY SOPHIA , ROSENTHAL MICHAEL H
IPC分类号： A61M20060101 , A61M5/31 , A61M25/00 , A61M37/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta (10) in a manner that flows bi-laterally into each of two renal arteries (12, 14) via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly (50) includes two injection members, each having an injection port (58) that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals.
摘要翻译：肾流系统以一定方式将一定体积的流体药剂注入腹主动脉（10）内的一个位置，该方式通过沿着腹主动脉壁的相应间隔开的气道双向流入两个肾动脉（12,14）中的每一个。局部注射组件（50）包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口（58）。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。

4. 发明申请

WO2004034767A8 APPARTUS AND METHOD FOR INSERTING AN INTRA-AORTA CATHETER THROUGH A DELIVERY SHEATH 审中-公开
标题翻译：通过输送管插入入口导管的方法和方法
公开(公告)号：WO2004034767A8
公开(公告)日：2004-07-01
申请号：PCT/US0329585
申请日：2003-09-22
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON HARRY B IV , MAGUIRE MARK A , VALENCIA AURELIO , PATEL SAMIR R
发明人： ELKINS JEFFREY M , GOODSON HARRY B IV , MAGUIRE MARK A , VALENCIA AURELIO , PATEL SAMIR R
IPC分类号： A61M25/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.
摘要翻译：导引器系统将局部给予患者的肾系统治疗。近端联接器组件联接到导引器鞘，其将多个装置同时输送到与第一和第二肾动脉口相关联的腹主动脉内的位置。耦合器组件具有布置成允许多个耦合器件的平滑可滑动接合而没有实质干涉的分支腔的网络。第一分支腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引鞘，并且基本上与鞘的纵向轴线对准。一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组分与另一装置结合引入导引鞘中。提供了新的插入装置来协调多个装置的耦合。

5. 发明申请

WO2004034767A3 CATHETER SYSTEM FOR RENAL THERAPY 审中-公开
标题翻译：用于肾功能治疗的导管系统
公开(公告)号：WO2004034767A3
公开(公告)日：2005-12-29
申请号：PCT/US0329585
申请日：2003-09-22
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON HARRY B IV , MAGUIRE MARK A , VALENCIA AURELIO , PATEL SAMIR R
发明人： ELKINS JEFFREY M , GOODSON HARRY B IV , MAGUIRE MARK A , VALENCIA AURELIO , PATEL SAMIR R
IPC分类号： A61M25/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system (350) delivers therapy locally to a renal system in a patient. A proximal coupler assembly (360) is coupled to an introducer sheath (376) that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly (360) has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath (376) and is substantially aligned with a longitudinal axis of the sheath (376). One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath (376 ) in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.
摘要翻译：引导器系统（350）将治疗局部递送到患者的肾脏系统。近端联接器组件（360）联接到导引器鞘（376），其将多个装置同时传送到与第一和第二肾动脉口相关联的腹主动脉内的位置。耦合器组件（360）具有布置成允许多个耦合器件的平滑可滑动接合而不产生实质干涉的分支腔的网络。第一分支管腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引器鞘（376）并且基本上与护套（376）的纵向轴线对准。一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组分与另一装置结合引入导引鞘（376）。提供了新的插入装置来协调多个装置的耦合。

6. 发明申请

WO2007041031A2 RENAL INFUSION SYSTEMS AND METHODS 审中-公开
标题翻译：肾输入系统和方法
公开(公告)号：WO2007041031A2
公开(公告)日：2007-04-12
申请号：PCT/US2006037025
申请日：2006-09-21
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
发明人： ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
IPC分类号： A61M31/00 , A61F2/958 , A61M20060101 , A61M25/00 , A61M29/00 , A61M29/02 , A61M37/00 , A61N1/362
CPC分类号： A61M25/00 , A61M25/0068 , A61M25/0074 , A61M25/008 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0057 , A61M2025/0183 , A61M2025/0681 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2025/1095 , A61M2029/025 , A61M2210/127
摘要： Systems, devices, and methods for delivering treatment to the renal arteries are provided. Exemplary systems include a delivery catheter having a distal bifurcation, an introducer assembly comprising an introducer sheath in operative association with a Y-hub, wherein Y-hub includes a first port for receiving the delivery catheter and a second port for receiving a second catheter, and a constraint assembly for holding the distal bifurcation of the delivery catheter in a low-profile configuration when it is advanced distally beyond the introducer sheath.
摘要翻译：提供了用于向肾动脉输送治疗的系统，装置和方法。示例性系统包括具有远侧分叉的输送导管，包括与Y轴可操作地相关联的导引器鞘的导引器组件，其中Y轴包括用于接收输送导管的第一端口和用于接收第二导管的第二端口，以及约束组件，用于当输送导管远端分叉超过导引器鞘时，将输送导管的远端分叉保持在低轮廓构造中。

7. 发明申请

WO2007044907A3 VASCULAR SHEATH WITH VARIABLE LUMEN CONSTRUCTION 审中-公开
标题翻译：血管结构可变的血管鞘
公开(公告)号：WO2007044907A3
公开(公告)日：2007-09-07
申请号：PCT/US2006040094
申请日：2006-10-11
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
发明人： ELKINS JEFFREY M , GOODSON HARRY B , BALL CRAIG A , VALENCIA AURELIO , PATEL SAMIR R , HEKMAT NEEMA
IPC分类号： A61M25/00 , A61F2/06
CPC分类号： A61M25/0662 , A61F2/07 , A61F2002/065 , A61M25/0668 , A61M2025/0024 , A61M2025/0183 , A61M2025/0188 , A61M2025/0681
摘要： A system for delivering a renal treatment and a peripheral treatment includes a renal catheter, a peripheral catheter, and an introducer sheath having first and second lumens. The first lumen is configured to receive the renal catheter and is sized to extend from a patient insertion site to a femoral or iliac artery location near or distal to a patient aortic branch. The second lumen is configured to receive the peripheral catheter and is sized to extend from the patient insertion site to an opposite femoral or iliac artery location near or distal to the patient aortic branch. A method of delivering a renal treatment and a peripheral treatment includes positioning an introducer sheath in an iliac artery, advancing a renal catheter and a peripheral catheter through the introducer sheath, where the renal catheter is separated from the peripheral catheter within the introducer sheath by a flap.
摘要翻译：用于递送肾脏治疗和外周治疗的系统包括肾导管，外周导管和具有第一腔和第二腔的导入器鞘。第一内腔被构造成接收肾导管并且被设定尺寸以从患者插入部位延伸到患者主动脉分支附近或远端的股骨或髂动脉位置。第二内腔构造成接收外围导管并且尺寸被设计为从患者插入部位延伸到患者主动脉分支附近或远端的相对的股骨或髂动脉位置。递送肾脏治疗和外周治疗的方法包括将导引鞘定位在髂动脉中，推进肾导管和外周导管穿过导引鞘，其中肾导管与导引鞘内的外周导管分隔开皮瓣。

8. 发明申请

WO2004107965A2 SYSTEMS AND METHODS FOR PERFORMING BI-LATERAL INTERVENTIONS OR DIAGNOSIS IN BRANCHED BODY LUMENS 审中-公开
标题翻译：在分支体内实施双向干预或诊断的系统和方法
公开(公告)号：WO2004107965A2
公开(公告)日：2004-12-16
申请号：PCT/US2004008573
申请日：2004-03-19
申请人： FLOWMEDICA INC , PATEL SAMIR , GOODSON HARRY B IV , ELKINS JEFFREY M , BALL CRAIG A , MATHUR VANDANA S
发明人： PATEL SAMIR , GOODSON HARRY B IV , ELKINS JEFFREY M , BALL CRAIG A , MATHUR VANDANA S
IPC分类号： A61B20060101 , A61F20060101 , A61F2/06 , A61M25/00 , A61M25/01 , A61M25/04 , A61M25/10 , A61M25/14 , A61M29/02 , A61B
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination del ivery/interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.
摘要翻译：分叉输送组件提供从患者的主体空间或内腔延伸的第一和第二分支腔的双向通路。一个或多个介入装置与输送组件组合以用于输送到一个或两个分支腔。双侧肾支架置入或栓塞保护程序是使用组合式/介入装置组件进行的。流体也可以从组件注入或吸出。分叉导管具有位于一个分叉分支上的第一流体端口，位于分叉的第二分支上的第二流体端口和位于第一和第二端口定位的位于腔静脉内的第三流体端口在第一和第二肾静脉内双侧。

9. 发明申请

WO2006036944A3 SYSTEMS AND METHODS FOR BI-LATERAL GUIDEWIRE CANNULATION OF BRANCHED BODY LUMENS 审中-公开
标题翻译：分支机体的双向导向装置的系统和方法
公开(公告)号：WO2006036944A3
公开(公告)日：2006-11-02
申请号：PCT/US2005034543
申请日：2005-09-26
申请人： FLOWMEDICA INC , ELKINS JEFFREY M , GOODSON IV HARRY B , VALENCIA AURELIO , ABOYTES RICHARD , PATEL SAMIR R
发明人： ELKINS JEFFREY M , GOODSON IV HARRY B , VALENCIA AURELIO , ABOYTES RICHARD , PATEL SAMIR R
IPC分类号： A61M29/00
CPC分类号： A61M25/0172 , A61M25/01 , A61M25/0105 , A61M25/0662 , A61M25/09
摘要： A system and method is provided that is adapted to allow for rapid cannulation of a guidewire into a branch lumen extending from a main lumen in a body of a patient, and in particular into two renal arteries extending from an abdominal aorta wall. A dual lumen catheter shaft delivers first and second pre-shaped guidewires to the location of the renal arteries in the aorta, such that the first and second pre-shaped guidewires self-cannulate within the renal arteries. Additional guidewires and/or interventional devices may be incorporated into the system and method for use with the catheter shaft, or over the two pre-shaped guidewires, to meet a particular need for a particular patient or intended procedure.
摘要翻译：提供了一种系统和方法，其适于允许将导丝快速插入到从患者体内的主腔延伸的分支腔中，特别是从腹主动脉壁延伸的两个肾动脉中。双腔导管轴将第一和第二预形状导丝导管到主动脉中肾动脉的位置，使得第一和第二预成形导丝在肾动脉内自我插管。另外的引导线和/或介入装置可以并入系统中，以及与导管轴一起使用的方法，或者在两个预成形导丝上，以满足特定患者或预期程序的特定需要。

10. 发明申请

WO2005112980A2 BI-LATERAL LOCAL RENAL DELIVERY FOR TREATING CONGESTIVE HEART FAILURE AND FOR BNP THERAPY 审中-公开
标题翻译：用于治疗顽固性心脏衰竭和BNP治疗的双向局部肾移植
公开(公告)号：WO2005112980A2
公开(公告)日：2005-12-01
申请号：PCT/US2005017034
申请日：2005-05-13
申请人： FLOWMEDICA INC , GOODSON HARRY BURT IV , PATEL SAMIR R , BALL CRAIG A , ELKINS JEFFREY M
发明人： GOODSON HARRY BURT IV , PATEL SAMIR R , BALL CRAIG A , ELKINS JEFFREY M
IPC分类号： A61K38/17 , A61K38/22 , A61M25/00 , A61M25/04
CPC分类号： A61M25/0041 , A61K38/2242 , A61M25/0054 , A61M25/04 , A61M2025/0681 , A61M2210/1085
摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.
摘要翻译：本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。本发明包括用于肾脏药物递送的装置和使用方法。

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