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1. 发明申请

WO2009023766A1 IN VIVO TRANSPORTATION OF SILICONE GEL FOR USE IN BREAST RECONSTRUCTION AND AUGMENTATION 审中-公开
标题翻译：用于乳腺重建和补充的硅胶凝胶运输
公开(公告)号：WO2009023766A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/073132
申请日：2008-08-14
申请人： FLODESIGN, INC. , PRESZ, JR., Walter , KOWALSKI III, Stanley , LIPKENS, Bart , HALEY, Matthew
发明人： PRESZ, JR., Walter , KOWALSKI III, Stanley , LIPKENS, Bart , HALEY, Matthew
IPC分类号： A61F2/12
CPC分类号： A61F2/12 , A61B90/02 , A61M5/14593
摘要： An evacuated breast implant shell is surgically implanted into the body. One end of a fill tube is attached to a valve on the shell, while the other end of the fill tube is attached to an output port of a pump. The pump includes a container that seals around a pre-filled silicone breast implant containing an amount of silicone gel to be transported to the shell in the body. A rubber diaphragm is located on a lower surface of a pressure chamber. An input port on the top portion of the pressure chamber connects to a source of compressed air. The rubber diaphragm is expanded by the compressed air flowing into the pressure chamber, which causes the diaphragm to press on the implant in the container and forces trie silicone gel in the implant to flow out of the implant and into the implant.
摘要翻译：将抽真空的乳房植入物外壳手术植入体内。填充管的一端连接到壳体上的阀，而填充管的另一端附接到泵的输出端口。泵包括一个容器，该容器围绕预先填充的硅橡胶植入物进行密封，所述植入物含有一定量的硅凝胶以被运输到体内的壳体。橡胶隔膜位于压力室的下表面。压力室顶部的输入端口连接到压缩空气源。橡胶隔膜通过流入压力室的压缩空气膨胀，这导致隔膜压在容器中的植入物上，并迫使植入物中的硅胶凝胶流出植入物并进入植入物。

2. 发明申请

WO2009021111A1 FLOW IMPROVEMENTS FOR DELIVERY OF BIOMATERIALS 审中-公开
标题翻译：用于输送生物材料的流程改进
公开(公告)号：WO2009021111A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/072468
申请日：2008-08-07
申请人： FLODESIGN, INC. , LIPKENS, Bart , PRESZ, JR., Walter M. , KOWALSKI III, Stanley
发明人： LIPKENS, Bart , PRESZ, JR., Walter M. , KOWALSKI III, Stanley
IPC分类号： A61M37/00
CPC分类号： A61M5/3134 , A61M5/34 , A61M5/347
摘要： A delivery system for an aqueous solution of a biomaterial or a mixture of a biomaterial and a biocompatible fluid lubricant includes a syringe and a needle or a needle and catheter combination. A contoured nozzle connects the syringe to the needle and reduces the required plunger force to expel the solution from the needle. An ultrasonic transducer generates acoustic pressure pulses and waves in the solution. The acoustic radiation force of the acoustic field aligns the particles within the solution in the direction of the syringe axis and facilitates expulsion. Also, the acoustic radiation force changes the shape of the biomaterial into oblong shapes, thereby reducing the required expulsion force. Further, the vibratory excitation of the biomaterial by the ultrasonic field facilitates expulsion of the solution. Large pressure pulses may deliver droplets of the solution from the needle opening.
摘要翻译：用于生物材料的水溶液或生物材料和生物相容性流体润滑剂的混合物的递送系统包括注射器和针或针和导管组合。成型的喷嘴将注射器连接到针上，并减少所需的柱塞力以将溶液从针排出。超声波换能器在溶液中产生声压脉冲和波。声场的声辐射力使溶液中的颗粒沿着注射器轴线的方向排列，并促进排出。此外，声辐射力将生物材料的形状改变成长方形，从而减少所需的排出力。此外，通过超声波场的生物材料的振动激发有利于溶液的排出。大的压力脉冲可以从针孔处传送溶液的液滴。

3. 发明申请

WO2009009381A1 FLOW IMPROVEMENTS FOR DELIVERY OF BIOMATERIALS AND DRUGS THROUGH A HYPODERMIC NEEDLE 审中-公开
标题翻译：生物膜和药物通过一种超生物针头递送的流程改进
公开(公告)号：WO2009009381A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069044
申请日：2008-07-02
申请人： FLODESIGN, INC. , LIPKENS, Bart , PRESZ, Walter, M. JR , KOWALSKI III, Stanley
发明人： LIPKENS, Bart , PRESZ, Walter, M. JR , KOWALSKI III, Stanley
IPC分类号： A61M31/00
CPC分类号： A61M5/3134 , A61M5/20 , A61M5/282 , A61M2005/3131 , A61M2005/3139
摘要： A delivery system for an aqueous solution of a biomaterial and a drug includes a syringe and a needle. A contoured nozzle connects the syringe to the needle and reduces the required plunger force to expel the solution from the needle. An ultrasonic transducer generates acoustic pressure pulses and waves in the solution. The acoustic radiation force of the acoustic field aligns the particles within the solution in the direction of the syringe axis and facilitates expulsion. Also, the acoustic radiation force changes the shape of the biomaterial and drug into oblong shapes, thereby reducing the required expulsion force. Further, the vibratory excitation of the biomaterial and drug by the ultrasonic field facilitates expulsion of the solution. Large pressure pulses may deliver droplets of the solution from the needle opening. A sensor may be used for feedback control to allow for constant force operation of the system.
摘要翻译：用于生物材料和药物的水溶液的递送系统包括注射器和针。成型的喷嘴将注射器连接到针上，并减少所需的柱塞力以将溶液从针排出。超声波换能器在溶液中产生声压脉冲和波。声场的声辐射力使溶液中的颗粒沿着注射器轴线的方向排列，并促进排出。此外，声辐射力将生物材料和药物的形状改变成长方形，从而减少所需的排出力。此外，通过超声波场的生物材料和药物的振动激发有利于溶液的排出。大的压力脉冲可以从针孔处传送溶液的液滴。传感器可用于反馈控制，以允许系统的恒定力操作。

4. 发明申请

WO2018200830A1 EXPANDED BED AFFINITY CELL SELECTION 审中-公开
公开(公告)号：WO2018200830A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029594
申请日：2018-04-26
申请人： LIPKENS, Bart , TOSTOES, Rui , CHITALE, Kedar C. , ROSS-JOHNSRUD, Benjamin , PRESZ, JR., Walter M. , SALOIO, Jack
发明人： LIPKENS, Bart , TOSTOES, Rui , CHITALE, Kedar C. , ROSS-JOHNSRUD, Benjamin , PRESZ, JR., Walter M. , SALOIO, Jack
IPC分类号： G01N33/537 , C12N13/00 , G01N30/46 , G01N33/543
摘要： Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

5. 发明申请

WO2017193085A1 ACOUSTOPHORETIC CLARIFICATION OF PARTICLE-LADEN NON-FLOWING FLUIDS 审中-公开
标题翻译：对粒状非流动性液体的透明膜清除
公开(公告)号：WO2017193085A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031425
申请日：2017-05-05
申请人： FLODESIGN SONICS, INC. , LIPKENS, Bart , PRESZ JR, Walter, M. , CHITALE, Kedar , HATTEN, Daniel , BODNAR, Nathaniel , GHOSHAL, Goutam
发明人： LIPKENS, Bart , PRESZ JR, Walter, M. , CHITALE, Kedar , HATTEN, Daniel , BODNAR, Nathaniel , GHOSHAL, Goutam
IPC分类号： B01D43/00 , B01D21/28 , B01D49/00 , B01D51/08 , C12N3/00 , G01N1/40
CPC分类号： C12N13/00 , B01D21/283 , B01D51/08 , C12N1/02
摘要： Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
摘要翻译：公开了用于从不流动的主流体中分离颗粒的声泳装置。这些装置包括基本透声的透明容器和分离单元，容器放置在分离单元内。分离单元中的超声换能器在容器内产生平面或多维声驻波，捕集设置在非流动流体内的颗粒并使它们聚结或结块，然后由于浮力或重力而分离。

6. 发明申请

WO2009151428A2 CONTROLLED-UNAIDED SURGE AND PURGE SUPPRESSORS FOR FIREARM MUZZLES 审中-公开
标题翻译：用于灭火器的控制消除冲击和冲击抑制器
公开(公告)号：WO2009151428A2
公开(公告)日：2009-12-17
申请号：PCT/US2008/010806
申请日：2008-09-17
申请人： FLODESIGN, INC. , PRESZ, Walter, M., JR , WERLE, Michael, J. , LIPKENS, Bart
发明人： PRESZ, Walter, M., JR , WERLE, Michael, J. , LIPKENS, Bart
IPC分类号： F41A21/30
CPC分类号： F41A21/30 , F41A21/34
摘要： A Controlled Unaided Surge and Purge (CUSPS) suppressor for firearms uses the blast and plume characteristics inherent to the ballistic discharge process to develop a new two-step controlled surge and purge system centered around advanced mixer-ejector concepts. The blast surge noise is reduced by controlling the flow expansion, and the flash effects are reduced by controlling inflow and outflow gas purges. In the preferred embodiment, suppressor vent holes are convergently contoured to better reduce the blast surge. Preferably a two-stage supersonic mixer/ejector system, in combination with adjacent vent holes in the suppressor housing and a divergent entrance nozzle, is used to control or eliminate the external Mach disk, while rapidly mixing and diluting the propellant with purged gases. A diffuser downstream of the mixer/ejector system further increases ejector performance and pumping. The pumped gases are used to self-clean and cool the CUSPS suppressor.
摘要翻译：用于枪支的受控的无人值守浪涌和清除（CUSPS）抑制器使用弹道放电过程固有的爆炸和羽流特性，开发以先进的混合器 - 喷射器概念为中心的新的两步控制的浪涌和净化系统。通过控制流量膨胀来减少爆炸浪涌噪声，并通过控制流入和流出气体清除来减少闪光效应。在优选实施例中，抑制器通气孔趋于一致的轮廓以更好地减少鼓风浪涌。优选地，两级超音速混合器/喷射器系统与抑制器壳体中的相邻通气孔和扩散入口喷嘴组合用于控制或消除外部马赫盘，同时用吹扫气体快速混合和稀释推进剂。混合器/喷射器系统下游的扩散器进一步增加喷射器性能和泵送。抽吸气体用于自我清洁和冷却CUSPS抑制剂。

7. 发明申请

WO2011084118A1 CONTROLLED-UNAIDED SURGE AND PURGE SUPPRESSORS FOR FIREARM MUZZLES 审中-公开
标题翻译：用于灭火器的控制消除冲击和冲击抑制器
公开(公告)号：WO2011084118A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/000036
申请日：2010-01-06
申请人： FLODESIGN, INC. , PRESZ, Walter, M. JR. , WERLE, Michael, J. , LIPKENS, Bart , GAWENCKI, Jason
发明人： PRESZ, Walter, M. JR. , WERLE, Michael, J. , LIPKENS, Bart , GAWENCKI, Jason
IPC分类号： F41A21/30 , F41A21/34
CPC分类号： F41A21/30 , F41A21/34
摘要： A Controlled Unaided Surge and Purge Suppressor (1000) for firearms uses the blast and plume characteristics inherent to the ballistic discharge process to develop a new two-step controlled surge and purge system centered around advanced mixer-ejector concepts. The blast surge noise is reduced by- controlling the flow expansion, and the flash effects are reduced by controlling inflow and outflow gas purges. In the preferred embodiment, the blast surge is mitigated via a slotted mixer nozzle (1002); a first expansion chamber (1004); a generally "wagon-wheel" shaped blast baffle (1006) with a vent hole; a series of alternating baffles (1012A-F), with vent holes, strategically located along the suppressor's inner wall surface; a second expansion chamber (1014); and an exit opening (1016). This preferred embodiment contains no "outside" vent holes (i.e. throughbores) which extend through the suppressor's outer or longitudinal wall (1001). Instead of ingesting ambient air through such throughbores and mixing the air with the muzzle gases, the preferred embodiment ingests and mixes chamber gases and contaminants with the muzzle gases while allowing fluid flow through and out the suppressor (1000). It too though can control or eliminate the Mach disk.
摘要翻译：用于火器的受控无人值守浪涌和清除抑制器（1000）使用弹道排放过程固有的爆破和羽流特性，开发以先进搅拌器 - 喷射器概念为中心的新的两步控制浪涌和净化系统。通过控制流量膨胀来减少爆炸浪涌噪声，并通过控制流入和流出气体清除来减少闪光效应。在优选实施例中，通过开槽混合器喷嘴（1002）减轻冲击浪涌; 第一膨胀室（1004）; 具有通气孔的通常为“车轮”形的鼓风挡板（1006）; 一系列交替挡板（1012A-F），具有通风孔，沿着抑制器的内壁表面策略地定位; 第二膨胀室（1014）; 和出口（1016）。该优选实施例不包含延伸穿过抑制器的外壁或纵壁（1001）的“外”通气孔（即通孔）。代替通过这种通孔吸入环境空气并将空气与枪口气体混合，优选实施例将腔室气体和污染物与枪口气体混合，同时允许流体流过和流出抑制器（1000）。它也可以控制或消除马赫盘。

8. 发明申请

WO2017019916A1 ACOUSTIC AFFINITY SEPARATION 审中-公开
标题翻译：声音亲近分离
公开(公告)号：WO2017019916A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044586
申请日：2016-07-28
申请人： FLODESIGN SONICS , LIPKENS, Bart , GILMANSHIN, Rudolf , PRESZ, Walter M. , MASI, Louis , KENNEDY, III, Thomas J.
发明人： LIPKENS, Bart , GILMANSHIN, Rudolf , PRESZ, Walter M. , MASI, Louis , KENNEDY, III, Thomas J.
IPC分类号： G01N33/543 , B01D43/00
CPC分类号： C12N13/00 , A61K2039/545 , C07K16/2851 , C12M35/04 , C12M47/02 , G01N30/462 , G01N30/72 , G01N30/96 , G01N33/54313 , G01N2030/027
摘要： Methods and systems for separating a first biomaterial from a second biomaterial can use functionalized material retained in a liquid-filled chamber at locales within an acoustic standing wave field. A culture suspension containing the first biomaterial and the second biomaterial flows into the liquid-filled chamber and at least portions of the first biomaterial with features complementary to the functionalized material becomes bound to the functionalized material while other portions of the culture suspension containing the second material pass through the chamber. The portion of the first biomaterial bound to the functionalized material is subsequently released from the liquid filled chamber.
摘要翻译：用于从第二生物材料分离第一生物材料的方法和系统可以使用保持在充满液体的腔室中的功能化材料在声驻波场内的区域。包含第一生物材料和第二生物材料的培养悬浮液流入液体填充的室，并且具有与官能化材料互补的特征的第一生物材料的至少部分变得与官能化材料结合，而含有第二材料的培养悬浮液的其它部分通过房间。与功能化材料结合的第一生物材料的部分随后从充满液体的室中释放。

9. 发明申请

WO2011159957A2 PHONONIC CRYSTAL DESALINATION SYSTEM AND METHOD OF USE 审中-公开
公开(公告)号：WO2011159957A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040787
申请日：2011-06-16
申请人： FLODESIGN SONICS, INC. , RIETMAN, Edward, A. , LIPKENS, Bart
发明人： RIETMAN, Edward, A. , LIPKENS, Bart
IPC分类号： C02F1/44 , C02F1/34 , C02F1/58
CPC分类号： C02F1/441 , B01D63/06 , B01D63/065 , B01D2311/26 , B01D2313/24 , B01D2313/36 , B01D2321/2075 , C02F1/34 , C02F1/36 , C02F2201/002 , Y02A20/131
摘要： Disclosed herein are systems and methods for desalination of salt water based on an engineered acoustic field that causes constructive and destructive interference at pre- computed spatial positions. The engineered acoustic field can cause high-pressure and low-pressure regions where desalination membranes are located. The induced pressure from the acoustic field can force pure water through the membranes leaving ionic and dissolved molecular species behind.
摘要翻译：本文公开了基于工程化声场对盐水进行海水淡化的系统和方法，其在预先计算的空间位置处引起建构性和相消干涉。工程声场可以引起脱盐膜所在的高压和低压区域。来自声场的诱发压力可以迫使纯水通过膜离开离子和溶解的分子物质。

10. 发明申请

WO2018183968A1 SEPARATION USING ANGLED ACOUSTIC WAVES 审中-公开
公开(公告)号：WO2018183968A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025578
申请日：2018-03-30
申请人： LIPKENS, Bart , DIONNE, Jason , PRESZ, Walter M., JR. , CHITALE, Kedar C. , ROSS-JOHNSRUD, Benjamin
发明人： LIPKENS, Bart , DIONNE, Jason , PRESZ, Walter M., JR. , CHITALE, Kedar C. , ROSS-JOHNSRUD, Benjamin
IPC分类号： G01N29/02
摘要： Methods and systems for separating material from a host fluid use an acoustophoresis device. These methods and systems can deflect material (e.g., a second fluid, cells, beads or other particles, exosomes, viruses, oil droplets) in host fluid streams at high flow rates.

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