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    • 2. 发明申请
    • FLOW IMPROVEMENTS FOR DELIVERY OF BIOMATERIALS
    • 用于输送生物材料的流程改进
    • WO2009021111A1
    • 2009-02-12
    • PCT/US2008/072468
    • 2008-08-07
    • FLODESIGN, INC.LIPKENS, BartPRESZ, JR., Walter M.KOWALSKI III, Stanley
    • LIPKENS, BartPRESZ, JR., Walter M.KOWALSKI III, Stanley
    • A61M37/00
    • A61M5/3134A61M5/34A61M5/347
    • A delivery system for an aqueous solution of a biomaterial or a mixture of a biomaterial and a biocompatible fluid lubricant includes a syringe and a needle or a needle and catheter combination. A contoured nozzle connects the syringe to the needle and reduces the required plunger force to expel the solution from the needle. An ultrasonic transducer generates acoustic pressure pulses and waves in the solution. The acoustic radiation force of the acoustic field aligns the particles within the solution in the direction of the syringe axis and facilitates expulsion. Also, the acoustic radiation force changes the shape of the biomaterial into oblong shapes, thereby reducing the required expulsion force. Further, the vibratory excitation of the biomaterial by the ultrasonic field facilitates expulsion of the solution. Large pressure pulses may deliver droplets of the solution from the needle opening.
    • 用于生物材料的水溶液或生物材料和生物相容性流体润滑剂的混合物的递送系统包括注射器和针或针和导管组合。 成型的喷嘴将注射器连接到针上,并减少所需的柱塞力以将溶液从针排出。 超声波换能器在溶液中产生声压脉冲和波。 声场的声辐射力使溶液中的颗粒沿着注射器轴线的方向排列,并促进排出。 此外,声辐射力将生物材料的形状改变成长方形,从而减少所需的排出力。 此外,通过超声波场的生物材料的振动激发有利于溶液的排出。 大的压力脉冲可以从针孔处传送溶液的液滴。