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1. 发明申请

WO2005061088A1 POWDER FORMATION BY ATMOSPHERIC SPRAY-FREEZE DRYING 审中-公开
标题翻译：由大气喷雾干燥形成的粉末
公开(公告)号：WO2005061088A1
公开(公告)日：2005-07-07
申请号：PCT/CA2004/002160
申请日：2004-12-20
申请人： FINLAY, Warren, H. , WANG, Zhaolin
发明人： FINLAY, Warren, H. , WANG, Zhaolin
IPC分类号： B01J2/04
CPC分类号： B01J2/04 , A61K9/1623 , A61K9/1682 , F26B5/065 , Y10T436/25
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
摘要翻译：公开了一种制造热敏药用粉末的方法。将原始药物溶解在悬浮液中，悬浮在悬浮液中，该悬浮液通过雾化喷嘴喷雾并在冷气相或液氮中在冷冻室或气套中同时雾化（用于冷却目的）。颗粒在大气压下在具有出口过滤器的下游流体流中冷冻干燥，从而除去截留在冷冻颗粒上或内部的水分。该系统适用于形成其他粉末。

2. 发明申请

WO2003011882A1 4'-SUBSTITUTED LEUCOMYCINS 审中-公开
标题翻译： 4'-取代的胆固醇
公开(公告)号：WO2003011882A1
公开(公告)日：2003-02-13
申请号：PCT/US2002/023878
申请日：2002-07-26
申请人： ENANTA PHARMACEUTICALS, INC. , OR, Yat, Sun , PHAN, Ly, Tam , WANG, Zhaolin , JIAN, Tianying
发明人： OR, Yat, Sun , PHAN, Ly, Tam , WANG, Zhaolin , JIAN, Tianying
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： There are described novel 4'-substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.
摘要翻译：描述了新颖的4'-取代的16元大环内酯和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。还描述了通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物以及制备这些化合物的方法来治疗细菌感染的方法。

3. 发明申请

WO2014014650A1 POWDER FEEDING APPARATUS 审中-公开
标题翻译：粉末送料装置
公开(公告)号：WO2014014650A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/049001
申请日：2013-07-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY , SIMONS, John K. , WANG, Zhaolin
发明人： SIMONS, John K. , WANG, Zhaolin
IPC分类号： B65G65/48
CPC分类号： B65D88/546 , B05C1/0826 , B65G65/4881
摘要： Powder feeding apparatuses (100; 200) and methods. The powder feeding apparatus (100; 200) can include first and second cylindrical rollers (106, 107; 206, 207) adjacent to each other and spaced apart by a gap (108; 208). The first roller(106; 206) can rotate intermittently and independently of the second roller(107; 207). The second roller can rotate intermittently and independently of the first roller. Powder from a hopper (102; 202) is fed through the gap as one or both rollers rotate. The powder feeding method may include a method of feeding powder by intermittently and alternately advancing a first and second roller to dispense powder from the hopper.
摘要翻译：粉末供给装置（100; 200）和方法。粉末供给装置（100; 200）可以包括彼此相邻并由间隙（108; 208）隔开的第一和第二圆柱形辊（106,107; 206,207）。第一辊（106; 206）可以间歇地旋转并独立于第二辊（107,207）旋转。第二辊可以间歇地旋转并且独立于第一辊。当一个或两个辊旋转时，来自料斗（102; 202）的粉末通过间隙进给。粉末输送方法可以包括通过间歇地并交替地推进第一和第二辊以从料斗分配粉末来供给粉末的方法。

4. 发明申请

WO2004050152A1 DEVICE AND METHOD FOR DEAGGLOMERATION OF POWDER FOR INHALATION 审中-公开
标题翻译：用于吸入粉末去除粉末的装置和方法
公开(公告)号：WO2004050152A1
公开(公告)日：2004-06-17
申请号：PCT/CA2003/001859
申请日：2003-11-28
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , FINLAY, Warren , WANG, Zhaolin
发明人： FINLAY, Warren , WANG, Zhaolin
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/003 , A61M15/0021 , A61M2202/064 , A61M2206/16
摘要： A device and method for deagglomerating powder agglomerates for inhalation. The device includes an inlet (20) connected to a chamber (40) and to a powder source for supplying the chamber with powder agglomerates and a flow of gas that define a swirling fluid flow inside the chamber. The device also includes an outlet (22) connected to the chamber for inhalation such that the swirling fluid flow in the chamber can exit from the chamber as a longitudinal fluid flow that is directed along a longitudinal axis (X) of the outlet, and a secondary fluid flow that is directed away from the longitudinal axis of the outlet. A mesh (28) in the outlet prevents powder agglomerates above a predetermined size from traversing the mesh, and reduces the secondary fluid flow relative to the longitudinal fluid flow exiting from the chamber to thereby reduce powder deposition in a mouth and throat of a user.
摘要翻译：用于吸入的粉末团聚体的分散装置和方法。该装置包括连接到室（40）的入口（20）和用于向室提供粉末团聚体的粉末源和在室内限定旋流流体流的气流。该装置还包括连接到用于吸入的腔室的出口（22），使得腔室中的旋转流体流动可以作为沿着出口的纵向轴线（X）引导的纵向流体流动从腔室排出，并且远离出口的纵向轴线的次级流体流动。出口处的网状物（28）防止超过预定尺寸的粉末团聚体穿过网眼，并且相对于从腔室流出的纵向流体流减少二次流体流动，从而减少用户口腔和喉部中的粉末沉积。

5. 发明申请

WO2010135340A2 DRY POWDER INHALERS 审中-公开
标题翻译：干粉吸入器
公开(公告)号：WO2010135340A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035280
申请日：2010-05-18
申请人： 3M INNOVATIVE PROPERTIES COMPANY , HODSON, Peter D. , STEIN, Stephen W. , CHIOU, Herbert C. , WANG, Zhaolin , ROBISON, Thomas S. , DOMROESE, Michael K. , WALBURG, Blake D.
发明人： HODSON, Peter D. , STEIN, Stephen W. , CHIOU, Herbert C. , WANG, Zhaolin , ROBISON, Thomas S. , DOMROESE, Michael K. , WALBURG, Blake D.
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译：干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内，载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。

6. 发明申请

WO2005065241A2 SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS 审中-公开
标题翻译：用于葡萄糖生物传感器的SMMR（小分子代谢报告物）
公开(公告)号：WO2005065241A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043087
申请日：2004-12-23
申请人： ARGOSE, INC. , BELLOTT, Emile, M. , BU, Dongsheng , CHILDS, James, J. , LAMBERT, Christopher, R. , NIENABER, Hubert, A. , SHI, Shirley, J. , WANG, Zhaolin , WORKMAN, Jerome, J., Jr. , ZELENCHUK, Alex, R.
发明人： BELLOTT, Emile, M. , BU, Dongsheng , CHILDS, James, J. , LAMBERT, Christopher, R. , NIENABER, Hubert, A. , SHI, Shirley, J. , WANG, Zhaolin , WORKMAN, Jerome, J., Jr. , ZELENCHUK, Alex, R.
IPC分类号： A61K49/00 , C07F5/02 , C07F7/18
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1856 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo , advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内监测葡萄糖，有利地在皮肤上。

7. 发明申请

WO2003072016A3 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
公开(公告)号：WO2003072016A3
公开(公告)日：2003-09-04
申请号：PCT/US2002/036882
申请日：2002-11-19
申请人： BECTON, DICKINSON AND COMPANY , HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
发明人： HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
IPC分类号： A61K9/14
摘要： A method of preparing a pharmaceutical composition is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35 and about 300m, and/or the powder comprises dried particles having an average mean diameter of between about 35m and about 300m. Compositions made by the above methods, and methods of using the compositions, are also described.

8. 发明申请

WO2012027823A1 HEAT EXCHANGER USING NON-PURE WATER FOR STEAM GENERATION 审中-公开
标题翻译：热交换器使用非纯水进行蒸汽发生
公开(公告)号：WO2012027823A1
公开(公告)日：2012-03-08
申请号：PCT/CA2011/000342
申请日：2011-03-30
申请人： NATERER, Greg , WANG, Zhaolin , SECNIK, Edward
发明人： NATERER, Greg , WANG, Zhaolin , SECNIK, Edward
IPC分类号： B01J7/00 , C01B3/06 , F22B1/06 , F22B1/18 , F22B37/26 , F22B7/02 , F28D7/10 , C02F1/04
CPC分类号： F22B1/06 , B01D1/0047 , B01D1/0058 , C01B3/045 , C01B3/08 , C01B13/0203 , C02F1/001 , C02F1/16 , F22B27/165 , F22B37/265 , F28D3/02 , F28D7/106 , F28D21/0001 , Y02E60/364 , Y02W10/37
摘要： A process and a device are described for producing high purity and high temperature steam from non-pure water which may be used in a variety of industrial processes that involve high temperature heat applications. The process and device may be used with technologies that generate steam using a variety of heat sources, such as, for example industrial furnaces, petrochemical plants, and emissions from incinerators. Of particular interest is the application in a thermochemical hydrogen production cycle such as the Cu-Cl Cycle. Non-pure water is used as the feedstock in the thermochemical hydrogen production cycle, with no need to adopt additional and conventional water pre-treatment and purification processes. The non-pure water may be selected from brackish water, saline water, seawater, used water, effluent treated water, tailings water, and other forms of water that is generally believed to be unusable as a direct feedstock of industrial processes. The direct usage of this water can significantly reduce water supply costs.
摘要翻译：描述了用于从非纯水生产高纯度和高温蒸汽的方法和装置，其可用于涉及高温热应用的各种工业过程中。该方法和装置可以与使用各种热源产生蒸汽的技术一起使用，例如工业炉，石油化工厂和来自焚化炉的排放物。特别感兴趣的是在热化学氢生产循环中的应用，例如Cu-Cl循环。非纯水用作热化学氢生产循环中的原料，不需要采用额外的和常规的水预处理和纯化方法。非纯水可以选自微咸水，盐水，海水，废水，废水处理水，尾矿水和其他形式的水，通常被认为不能用作工业过程的直接原料。直接使用这种水可以显着降低供水成本。

9. 发明申请

WO2012027822A1 THERMOCHEMICAL REACTORS AND PROCESSES FOR HYDROLYSIS OF CUPRIC CHLORIDE 审中-公开
标题翻译：热化学反应器和氯化铜水解的方法
公开(公告)号：WO2012027822A1
公开(公告)日：2012-03-08
申请号：PCT/CA2011/000341
申请日：2011-03-30
申请人： NATERER, Greg , DAGGUPATI, Venkata , GABRIEL, Kamiel S. , WANG, Zhaolin , GRAVELSINS, Robert J.
发明人： NATERER, Greg , DAGGUPATI, Venkata , GABRIEL, Kamiel S. , WANG, Zhaolin , GRAVELSINS, Robert J.
IPC分类号： C01B3/06 , B01J19/00 , B01J4/00 , C01B7/01 , C01G3/06
CPC分类号： B01J8/18 , B01J8/0035 , B01J8/0055 , B01J8/02 , B01J8/1827 , B01J8/1836 , B01J8/1872 , B01J8/44 , B01J2208/00212 , B01J2208/00752 , C01B3/08 , C01B13/0203 , C01G3/05 , C01G3/06 , Y02E60/36
摘要： A thermochemical reactor (4) and associated processes are disclosed. The reactor (4) and processes are used to conduct reactions relating to the hydrolysis of cupric chloride (CuCl2) within any one of the five-, four- and three-step Cu-Cl cycles. The reactor (4) comprises a reaction chamber (22) including a first zone (24) configured to conduct a spray operation and a second zone (26) configured to conduct a fluidized, fixed and/or moving bed operation. The first zone (24) includes a first inlet (28) configured to introduce a first reactant and an additional inlet (30) configured to introduce an additional reactant. A distributor (34) is configured to introduce the additional reactant to the second zone (26). One or more product outlets (44, 46) for communication with the reaction chamber (22) are provided.
摘要翻译：公开了一种热化学反应器（4）和相关工艺。反应器（4）和方法用于进行与五 - ，四 - 和三步Cu-Cl循环中任何一个中氯化铜（CuCl 2）的水解有关的反应。反应器（4）包括反应室（22），其包括构造成进行喷射操作的第一区域（24）和构造成进行流化，固定和/或移动床操作的第二区域（26）。第一区域（24）包括构造成引入第一反应物和被配置成引入另外的反应物的附加入口（30）的第一入口（28）。分配器（34）被配置为将附加的反应物引入第二区域（26）。提供了用于与反应室（22）连通的一个或多个产品出口（44,46）。

10. 发明申请

WO2003043574A3 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
公开(公告)号：WO2003043574A3
公开(公告)日：2003-05-30
申请号：PCT/US2002/036883
申请日：2002-11-19
申请人： BECTON, DICKINSON AND COMPANY , HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
发明人： HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
IPC分类号： A61K9/14
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

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