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1. 发明申请

WO2007059005A2 LATERAL SIDE PORTED NEEDLE 审中-公开
标题翻译：侧面侧针
公开(公告)号：WO2007059005A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/043926
申请日：2006-11-13
申请人： AMGEN INC. , HWANG, C., Robin , AKERS, Michael , PANDEY, Ajit
发明人： HWANG, C., Robin , AKERS, Michael , PANDEY, Ajit
IPC分类号： A61M5/32
CPC分类号： A61M5/3291
摘要： A needle for delivering a fluid to a body includes a shaft having a proximal end, a distal end, and a hollow bore that extends from the proximal end to the distal end. The proximal end is configured to place a fluid reservoir in fluid communication with the hollow bore, and the distal end is configured to penetrate the body. The needle may include at least two groups of side apertures in the shaft, each group of side apertures including at least two laterally aligned side apertures to provide fluid communication between the hollow bore and an exterior of the shaft. Alternatively, the needle may include at least one group of laterally aligned side apertures, the laterally aligned side apertures being positioned at least about 4.5 mm from the proximal end of the needle to permit sub-dermal delivery of fluid.
摘要翻译：用于将流体输送到主体的针包括具有近端，远端和从近端延伸到远端的中空孔的轴。近端构造成使流体储存器与中空孔流体连通，并且远端构造成穿透身体。针可以包括轴中的至少两组侧孔，每组侧孔包括至少两个侧向对准的侧孔，以在中空孔和轴的外部之间提供流体连通。或者，针可以包括至少一组侧向对准的侧孔，横向对准的侧孔定位成距离针的近端至少约4.5mm，以允许液体的皮下递送。

2. 发明申请

WO03072016A2 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
标题翻译：颗粒形式的药物组合物
公开(公告)号：WO03072016A2
公开(公告)日：2003-09-04
申请号：PCT/US0236882
申请日：2002-11-19
申请人： BECTON DICKINSON CO , HWANG C ROBIN , SULLIVAN VINCENT J , HUANG JUAN , WANG ZHAOLIN , MIKSZTA JOHN A , MONTGOMERY DAVID B , FORD BRANDI
发明人： HWANG C ROBIN , SULLIVAN VINCENT J , HUANG JUAN , WANG ZHAOLIN , MIKSZTA JOHN A , MONTGOMERY DAVID B , FORD BRANDI
IPC分类号： A61J3/02 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/18 , A61K9/19 , A61K9/22 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/28 , A61K39/00 , A61K39/145 , A61K47/26 , A61K47/36 , A61K48/00 , A61P31/12 , A61K
CPC分类号： A61K9/1694 , A61K9/0019 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61K9/1652 , A61K9/1688 , A61K47/26
摘要： A method of preparing a pharmaceutical composition is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35 and about 300m, and/or the powder comprises dried particles having an average mean diameter of between about 35m and about 300m. Compositions made by the above methods, and methods of using the compositions, are also described.
摘要翻译：描述了制备药物组合物的方法，其包括（1）使治疗剂的液体制剂雾化以产生雾化制剂; （2）冷冻所述雾化制剂以形成固体颗粒; 和（3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。描述了另一种方法，其包括（1）雾化治疗剂的液体制剂以产生雾化制剂; （2）冷冻所述雾化制剂以形成固体颗粒; 和（3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均直径为约35至约300μm的液滴，和/或所述粉末包含平均直径为约35μm至约300μm的干燥颗粒。还描述了通过上述方法制备的组合物以及使用组合物的方法。

3. 发明申请

WO2003043574A3 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
公开(公告)号：WO2003043574A3
公开(公告)日：2003-05-30
申请号：PCT/US2002/036883
申请日：2002-11-19
申请人： BECTON, DICKINSON AND COMPANY , HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
发明人： HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
IPC分类号： A61K9/14
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

4. 发明申请

WO2003043574A2 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
标题翻译：颗粒形式的药物组合物
公开(公告)号：WO2003043574A2
公开(公告)日：2003-05-30
申请号：PCT/US2002/036883
申请日：2002-11-19
申请人： BECTON, DICKINSON AND COMPANY , HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
发明人： HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
IPC分类号： A61K
CPC分类号： A61K9/1694 , A61K9/0019 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61K9/1652 , A61K9/1688 , A61K47/26
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.
摘要翻译：描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）在大气压下干燥所述固体颗粒以产生粉末，其中所述干燥在振动，内部，机械搅拌或其组合的存在下进行。描述了另一种方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末; 其中所述雾化制剂包含平均直径为约35μm至约300μm的液滴，和/或所述粉末包含平均直径为约35μm至约300μm的干燥颗粒。还描述了通过上述方法制备的组合物以及使用组合物的方法。

5. 发明申请

WO2007059005A3 LATERAL SIDE PORTED NEEDLE 审中-公开
标题翻译：侧面侧针
公开(公告)号：WO2007059005A3
公开(公告)日：2007-07-05
申请号：PCT/US2006043926
申请日：2006-11-13
申请人： AMGEN INC , HWANG C ROBIN , AKERS MICHAEL , PANDEY AJIT
发明人： HWANG C ROBIN , AKERS MICHAEL , PANDEY AJIT
IPC分类号： A61M5/32
CPC分类号： A61M5/3291
摘要： A needle (10) for delivering a fluid to a body includes a shaft (14) having a proximal end (16) , a distal end (12) , and a hollow bore (18) that extends from the proximal end (16) to the distal end (12) . The proximal end (16) is configured to place a fluid reservoir in fluid communication with the hollow bore, and the distal end is configured to penetrate the body. The needle (10) may include at least two groups of side apertures (22) in the shaft, each group of side apertures including at least two laterally aligned side apertures to provide fluid communication between the hollow bore and an exterior of the shaft. Alternatively, the needle may include at least one group of laterally aligned side apertures, the laterally aligned side apertures being positioned at least about 4.5 mm from the proximal end of the needle to permit sub-dermal delivery of fluid.
摘要翻译：用于将流体输送到主体的针（10）包括具有近端（16），远端（12）和从近端（16）延伸到中空孔（18）的中空孔（18）的轴（14）远端（12）。近端（16）构造成使流体储存器与中空孔流体连通，并且远端构造成穿透身体。针（10）可以包括轴中的至少两组侧孔（22），每组侧孔包括至少两个侧向对齐的侧孔，以在中空孔和轴的外部之间提供流体连通。或者，针可以包括至少一组侧向对准的侧孔，横向对准的侧孔定位成距离针的近端至少约4.5mm，以允许液体的皮下递送。

6. 发明申请

WO2003072016A3 PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM 审中-公开
公开(公告)号：WO2003072016A3
公开(公告)日：2003-09-04
申请号：PCT/US2002/036882
申请日：2002-11-19
申请人： BECTON, DICKINSON AND COMPANY , HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
发明人： HWANG, C., Robin , SULLIVAN, Vincent, J. , HUANG, Juan , WANG, Zhaolin , MIKSZTA, John, A. , MONTGOMERY, David, B. , FORD, Brandi , WILLS, Anjana, Bhuta
IPC分类号： A61K9/14
摘要： A method of preparing a pharmaceutical composition is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising (1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; (2) freezing said atomized formulation to form solid particles; and (3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35 and about 300m, and/or the powder comprises dried particles having an average mean diameter of between about 35m and about 300m. Compositions made by the above methods, and methods of using the compositions, are also described.

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