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1. 发明申请

WO2009039626A1 ENHANCED DRUG DELIVERY WITH ORIENTABLE PARTICLES 审中-公开
标题翻译：使用方便的颗粒加强药物输送
公开(公告)号：WO2009039626A1
公开(公告)日：2009-04-02
申请号：PCT/CA2008/001672
申请日：2008-09-23
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , FINLAY, Warren, H. , MARTIN, Andrew, Robert , ORSZANSKA, Helena , THOMPSON, Richard
发明人： FINLAY, Warren, H. , MARTIN, Andrew, Robert , ORSZANSKA, Helena , THOMPSON, Richard
IPC分类号： A61K47/46 , A61M15/00 , A61M16/00 , A61P11/00
CPC分类号： A61M15/02 , A61K9/0009 , A61K9/0078 , A61M2202/064 , A61M2205/0244 , A61M2205/3317
摘要： Small airway deposition of orientable drug particles in the lung due to interception is increased through alignment of these particles with an externally applied force such as a magnetic field. Drug particles in one embodiment are made magnetically responsive by loading them with magnetic nanoparticles. Elongated particles have a natural tendency to align parallel to the direction of flow through an airway, and therefore also parallel to airway walls; accordingly, alignment with a magnetic field to any other orientation increases interception, with a maximum increase for alignment perpendicular to airway walls. By positioning a magnetic field across a specific site within the lung, for example in the area of a tumor, the increase in deposition by interception allows localized targeting of inhaled drug particles to that area.
摘要翻译：通过这些颗粒与外部施加的力（例如磁场）的对准，增加了通过拦截导致的可取向药物颗粒在肺中的小气道沉积。一个实施方案中的药物颗粒通过用磁性纳米颗粒加载而被制成磁性响应。细长的颗粒具有平行于通过气道的流动方向平行排列并因此也平行于气道壁的自然趋势; 因此，与任何其它方向的磁场对准增加截取，垂直于气道壁的对准最大增加。通过将磁场定位在肺内的特定部位（例如在肿瘤区域中），通过截取的沉积增加允许将吸入的药物颗粒定位到该区域。

2. 发明申请

WO2005102428A1 ENHANCED DRUG DELIVERY FOR INHALED AEROSOLS 审中-公开
标题翻译：用于吸入气溶胶的增强药物输送
公开(公告)号：WO2005102428A1
公开(公告)日：2005-11-03
申请号：PCT/CA2005/000616
申请日：2005-04-22
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , FINLAY, Warren, H. , GRGIC, Biljana
发明人： FINLAY, Warren, H. , GRGIC, Biljana
IPC分类号： A61M15/00
CPC分类号： A61M15/0085 , A61M2016/0039
摘要： A combination of a delivery device and a dose adjustment means for delivering an aerosol drug to an individual. The device includes a dosing module (12) for providing an aerosol drug dose, an inhalation air module (14) connected to the dosing module for receiving the aerosol drug dose and mixing air with the aerosol drug dose for providing a delivered dose of the aerosol drug dose, and a mouthpiece (16) connected to the inhalation air module (14) for supplying the delivered dose to the individual. The dose adjustment means allows for the aerosol drug dose to be adjusted for ensuring that a desired amount of the drug dose reaches the lungs of the individual. Adjustement of the dose is based on the morphological characteristics of the individual’s mouth-throat region obtained from magnetic resonance imaging (MRI), computed tomography (CT) or other non-invasive scanning techniques.
摘要翻译：输送装置和用于将气溶胶药物递送给个体的剂量调节装置的组合。该装置包括用于提供气溶胶药物剂量的计量模块（12），连接到计量模块的吸入空气模块（14），用于接收气溶胶药物剂量并将空气与气溶胶药物剂量混合以提供递送剂量的气溶胶药物剂量和连接到吸入空气模块（14）的接口（16），用于将递送的剂量提供给个体。剂量调节装置允许调整气溶胶药物剂量以确保所需量的药物剂量达到个体的肺。剂量的调整是基于从磁共振成像（MRI），计算机断层扫描（CT）或其他非侵入性扫描技术获得的个体喉部区域的形态学特征。

3. 发明申请

WO2010060200A1 BACTERIOPHAGE COMPOSITIONS FOR TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：用于治疗细菌感染的微生物组合物
公开(公告)号：WO2010060200A1
公开(公告)日：2010-06-03
申请号：PCT/CA2009/001696
申请日：2009-11-26
申请人： FINLAY, Warren, H. , DENNIS, Jonathan, J. , ORSZANSKA, Helena , SEED, Kimberley, D. , LYNCH, Karlene, Heather
发明人： FINLAY, Warren, H. , DENNIS, Jonathan, J. , ORSZANSKA, Helena , SEED, Kimberley, D. , LYNCH, Karlene, Heather
IPC分类号： C12N15/33 , A61K35/76 , A61K47/26 , A61K9/72 , A61P31/04 , C12N7/00
CPC分类号： A61K35/76 , A61K9/0075 , C12N2795/00032 , Y10S977/704 , Y10S977/773 , Y10S977/795 , Y10S977/904
摘要： A respirable composition for treatment of a bacterial infection includes one or more active bacteriophages in combination with a pharmaceutically acceptable respirable carrier. The composition includes a carbohydrate carrier, and is prepared as fine powder. In another aspect, bacteriophages are provided in a liquid carrier for administration by nebulization. In one aspect, the bacteriophages have anti-bacterial activity against one or more species or strains of Burkholderia cepacia complex (BCC) bacteria. The invention further relates to the use of a BCC bacteriophage to treat a BCC infection, in particular in an individual suffering from cystic fibrosis.
摘要翻译：用于治疗细菌感染的可呼吸组合物包括与药学上可接受的可呼吸载体组合的一种或多种活性噬菌体。该组合物包括碳水化合物载体，并且制备成细粉末。另一方面，在液体载体中提供噬菌体以通过雾化进行给药。一方面，噬菌体对一种或多种洋葱伯克霍尔德菌（BCC）细菌的物种或菌株具有抗菌活性。本发明还涉及BCC噬菌体用于治疗BCC感染的用途，特别是在患有囊性纤维化的个体中。

4. 发明申请

WO2004101040B1 ADD-ON SPACER DESIGN CONCEPT FOR DRY-POWDER INHALERS 审中-公开
标题翻译：添加剂干粉设计理念
公开(公告)号：WO2004101040B1
公开(公告)日：2005-01-20
申请号：PCT/CA2004000737
申请日：2004-05-14
申请人： UNIV ALBERTA , FINLAY WARREN H , MATIDA EDGAR A , LANGE CARLOS F
发明人： FINLAY WARREN H , MATIDA EDGAR A , LANGE CARLOS F
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M2209/02
摘要： A spacer, for disposition between a user's mouth and a medicament inhaler outlet, has a hollow body defining an elongate internal chamber (10) with a diffuser portion (8) having a spacer inlet (9) adapted to engage the inhaler outlet in communication with the internal chamber, the diffuser portion extending axially outwardly from the spacer inlet; a buffer portion (6) extending axially from the diffuser portion; and a nozzle portion (7) having a spacer outlet (5) adapted to engage the user's mouth in communication with the internal chamber, the nozzle portion extending axially inwardly from the buffer portion.
摘要翻译：用于在使用者的嘴和药物吸入器出口之间的配置的间隔件具有限定细长的内部腔室（10）的中空体，该腔室具有扩散器部分（8），该扩散器部分具有适于与吸入器出口相接合的间隔物入口（9）所述内部腔室，所述扩散器部分从所述间隔件入口轴向向外延伸; 缓冲部分（6），其从所述扩散部分轴向延伸; 以及喷嘴部分（7），其具有适于接合使用者与内部腔室连通的间隔件出口（5），所述喷嘴部分从缓冲部分轴向向内延伸。

5. 发明申请

WO2004050152A1 DEVICE AND METHOD FOR DEAGGLOMERATION OF POWDER FOR INHALATION 审中-公开
标题翻译：用于吸入粉末去除粉末的装置和方法
公开(公告)号：WO2004050152A1
公开(公告)日：2004-06-17
申请号：PCT/CA2003/001859
申请日：2003-11-28
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , FINLAY, Warren , WANG, Zhaolin
发明人： FINLAY, Warren , WANG, Zhaolin
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/003 , A61M15/0021 , A61M2202/064 , A61M2206/16
摘要： A device and method for deagglomerating powder agglomerates for inhalation. The device includes an inlet (20) connected to a chamber (40) and to a powder source for supplying the chamber with powder agglomerates and a flow of gas that define a swirling fluid flow inside the chamber. The device also includes an outlet (22) connected to the chamber for inhalation such that the swirling fluid flow in the chamber can exit from the chamber as a longitudinal fluid flow that is directed along a longitudinal axis (X) of the outlet, and a secondary fluid flow that is directed away from the longitudinal axis of the outlet. A mesh (28) in the outlet prevents powder agglomerates above a predetermined size from traversing the mesh, and reduces the secondary fluid flow relative to the longitudinal fluid flow exiting from the chamber to thereby reduce powder deposition in a mouth and throat of a user.
摘要翻译：用于吸入的粉末团聚体的分散装置和方法。该装置包括连接到室（40）的入口（20）和用于向室提供粉末团聚体的粉末源和在室内限定旋流流体流的气流。该装置还包括连接到用于吸入的腔室的出口（22），使得腔室中的旋转流体流动可以作为沿着出口的纵向轴线（X）引导的纵向流体流动从腔室排出，并且远离出口的纵向轴线的次级流体流动。出口处的网状物（28）防止超过预定尺寸的粉末团聚体穿过网眼，并且相对于从腔室流出的纵向流体流减少二次流体流动，从而减少用户口腔和喉部中的粉末沉积。

6. 发明申请

WO2006130943A1 RESPIRABLE DRIED POWDER FORMULATION COMPRISING DRUG LOADED NANOPARTICLES 审中-公开
标题翻译：包含药物加载纳米颗粒的耐受性干粉配方
公开(公告)号：WO2006130943A1
公开(公告)日：2006-12-14
申请号：PCT/CA2005/001306
申请日：2005-08-26
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , FINLAY, Warren , ORSZANSKA, Helena
发明人： FINLAY, Warren , ORSZANSKA, Helena
IPC分类号： A61K9/19 , A61P35/00 , A61K47/26 , A61K9/72 , A61K9/14 , A61K9/12 , A61J3/02 , A61K31/704
CPC分类号： A61K9/0073 , A61K9/50 , A61K31/704
摘要： A pharmaceutical formulation for administration by aerosol inhalation to the lung and comprising spray-freeze dried powder comprising nanoparticles loaded with at least one active principle is described herein. The powder provides for rapid maximum airway surface liquid concentrations of the active principle upon dissolution of the powder in the airway surface liquid following deposition of the powder throughout the tracheobronchial region.
摘要翻译：本文描述了用于通过气雾剂吸入给予肺并且包含喷雾冷冻干燥粉末的药物制剂，其包含负载有至少一种活性成分的纳米颗粒。该粉末在粉末沉积在整个气管支气管区域中后，在粉末溶解在气道表面液体中时，可提供活性成分的快速最大气道表面液体浓度。

7. 发明申请

WO2004101040A1 ADD-ON SPACER DESIGN CONCEPT FOR DRY-POWDER INHALERS 审中-公开
标题翻译：添加剂干粉设计理念
公开(公告)号：WO2004101040A1
公开(公告)日：2004-11-25
申请号：PCT/CA2004/000737
申请日：2004-05-14
申请人： UNIVERSITY OF ALBERTA , FINLAY, Warren, H. , MATIDA, Edgar, A. , LANGE, Carlos, F.
发明人： FINLAY, Warren, H. , MATIDA, Edgar, A. , LANGE, Carlos, F.
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M2209/02
摘要： A spacer, for disposition between a user's mouth and a medicament inhaler outlet, has a hollow body defining an elongate internal chamber (10) with a diffuser portion (8) having a spacer inlet (9) adapted to engage the inhaler outlet in communication with the internal chamber, the diffuser portion extending axially outwardly from the spacer inlet; a buffer portion (6) extending axially from the diffuser portion; and a nozzle portion (7) having a spacer outlet (5) adapted to engage the user's mouth in communication with the internal chamber, the nozzle portion extending axially inwardly from the buffer portion.
摘要翻译：用于在使用者的嘴和药物吸入器出口之间的配置的间隔件具有限定细长的内部腔室（10）的中空体，该腔室具有扩散器部分（8），该扩散器部分具有适于与吸入器出口相接合的间隔物入口（9）所述内部腔室，所述扩散器部分从所述间隔件入口轴向向外延伸; 缓冲部分（6），其从所述扩散部分轴向延伸; 以及喷嘴部分（7），其具有适于接合使用者与内部腔室连通的间隔件出口（5），所述喷嘴部分从缓冲部分轴向向内延伸。

8. 发明申请

WO2005061088A1 POWDER FORMATION BY ATMOSPHERIC SPRAY-FREEZE DRYING 审中-公开
标题翻译：由大气喷雾干燥形成的粉末
公开(公告)号：WO2005061088A1
公开(公告)日：2005-07-07
申请号：PCT/CA2004/002160
申请日：2004-12-20
申请人： FINLAY, Warren, H. , WANG, Zhaolin
发明人： FINLAY, Warren, H. , WANG, Zhaolin
IPC分类号： B01J2/04
CPC分类号： B01J2/04 , A61K9/1623 , A61K9/1682 , F26B5/065 , Y10T436/25
摘要： A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
摘要翻译：公开了一种制造热敏药用粉末的方法。将原始药物溶解在悬浮液中，悬浮在悬浮液中，该悬浮液通过雾化喷嘴喷雾并在冷气相或液氮中在冷冻室或气套中同时雾化（用于冷却目的）。颗粒在大气压下在具有出口过滤器的下游流体流中冷冻干燥，从而除去截留在冷冻颗粒上或内部的水分。该系统适用于形成其他粉末。

9. 发明申请

WO2005025342A1 TREATMENT OF MAINSTREAM SMOKE CONSTITUENTS BY USE OF OXYGEN STORAGE AND DONOR METAL OXIDE OXIDATION CATALYST 审中-公开
标题翻译：使用氧气储存和金属氧化物氧化催化剂处理主要烟雾成分
公开(公告)号：WO2005025342A1
公开(公告)日：2005-03-24
申请号：PCT/CA2004/001684
申请日：2004-09-15
申请人： ROTHMANS, BENSON & HEDGES INC. , FINLAY, Warren , SNAIDR, Stanislav, M. , CHAPMAN, Steve, G. , KACZMAREK, Peter, P. , BECKER, E., Robert , HUNSICKER, Robert, A. , AYRES, George
发明人： FINLAY, Warren , SNAIDR, Stanislav, M. , CHAPMAN, Steve, G. , KACZMAREK, Peter, P. , BECKER, E., Robert , HUNSICKER, Robert, A. , AYRES, George
IPC分类号： A24B15/28
CPC分类号： D21H21/14 , A24B15/28 , A24B15/282 , A24B15/286 , A24B15/287 , A24B15/288 , A24D1/02 , B01D53/8634 , B01D53/8668 , B01J23/63 , B01J29/06 , B01J29/088 , B01J29/126 , B01J37/0045 , B01J37/0221 , B01J2229/18 , B01J2229/20 , B01J2229/42
摘要： The use of a treatment composition for a cigarette to reduce at least one constituent of mainstream smoke from a burning cigarette, the treatment composition comprising, in combination, an oxygen storage and donor metal oxide oxidation catalyst and an essentially non-combustible finely divided porous particulate adjunct.
摘要翻译：使用用于香烟的处理组合物从燃烧的香烟中减少主流烟雾的至少一种成分，所述处理组合物组合物包含储氧和供体金属氧化物氧化催化剂和基本上不可燃的细碎多孔颗粒附件。

10. 发明申请

WO2003088771A1 A LOW IGNITION PROPENSITY CIGARETTE HAVING OXYGEN DONOR METAL OXIDE IN THE CIGARETTE WRAPPER 审中-公开
标题翻译：在烟灰包装机中具有氧化钕金属氧化物的低点火专用香烟
公开(公告)号：WO2003088771A1
公开(公告)日：2003-10-30
申请号：PCT/CA2003/000581
申请日：2003-04-22
申请人： ROTHMANS, BENSON & HEDGES, INC. , FINLAY, Warren , SNAIDR, Stanislav, M.
发明人： FINLAY, Warren , SNAIDR, Stanislav, M.
IPC分类号： A24D1/02
CPC分类号： A24D1/025 , A24D1/02
摘要： The invention relates to a low ignition propensity cigarette having a self-extinguishing cigarette wrapper which is capable of self-extinguishing the cigarette. The cigarette wrapper comprises an oxygen storage and donor metal oxide to support and maintain free-burn of the self-extinguishing cigarette while retaining the low ignition propensity property of the self-extinguishing cigarette wrapper. The invention further relates to a low sidestream smoke cigarette having low ignition propensity properties. The wrapper has a composition which reduces sidestream smoke from a burning cigarette and comprises in combination, an oxygen storage and donor metal oxide catalyst and an essentially non-combustible finely divided porous particulate adjunct for the catalyst. The sidestream smoke reducing composition reduces porosity of the wrapper to render the cigarette as self-extinguishable. The oxygen storage and donor metal oxide catalyst is in an amount which supports free burn of the cigarette while retaining the self-extinguishing property of the cigarette wrapper.
摘要翻译：本发明涉及一种具有能自熄灭香烟的自熄性香烟包装纸的低点火性香烟。香烟包装纸包括氧气储存器和供体金属氧化物，以支持和保持自熄性香烟的自由燃烧，同时保持自熄性香烟包装纸的低点燃倾向性能。本发明还涉及具有低点燃倾向性能的低侧流烟雾香烟。包装物具有减少来自燃烧香烟的侧流烟的组合物，其组合包括氧储存和供体金属氧化物催化剂以及用于催化剂的基本上不可燃的细碎多孔颗粒添加剂。侧流烟雾减少组合物减少包装纸的孔隙率，使香烟自熄。储氧和供体金属氧化物催化剂的量足以支撑香烟的自由燃烧，同时保持香烟包装纸的自熄性。

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