专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010094659A1 AMINE OR AMINO ALCOHOLS AS GLYT1 INHIBITORS 审中-公开
标题翻译：胺或氨基醇作为GLYT1抑制剂
公开(公告)号：WO2010094659A1
公开(公告)日：2010-08-26
申请号：PCT/EP2010/051877
申请日：2010-02-16
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , MARTY, Hans-Peter , NARQUIZIAN, Robert , PINARD, Emmanuel , STALDER, Henri
发明人： KOLCZEWSKI, Sabine , MARTY, Hans-Peter , NARQUIZIAN, Robert , PINARD, Emmanuel , STALDER, Henri
IPC分类号： A61P25/28 , A61K31/16 , A61P25/18 , C07C215/30 , C07C215/68 , C07C217/70 , C07C233/43 , C07C237/30 , C07C317/32 , C07D213/30 , C07D213/34 , C07D213/61 , C07D277/28 , C07D305/06 , C07D307/20
CPC分类号： A61K31/16 , C07C215/30 , C07C215/68 , C07C217/70 , C07C233/43 , C07C237/30 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/46 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/71 , C07D213/73 , C07D239/26 , C07D277/28 , C07D305/06 , C07D307/12 , C07D307/20 , C07D309/06 , C07D309/12 , C07D333/20 , C07D335/02 , C07D405/12
摘要： The invention relates to the use of compounds of formula (I), wherein the substituents are described in the description and claims, for the preparation of medicaments for the treatment of psychoses, dysfunction in memory and learning, schizophrenia, dementia, attention deficit disorders or Alzheimer's disease.
摘要翻译：本发明涉及式（I）化合物的用途，其中取代基在描述和权利要求书中描述，用于制备用于治疗精神病药，记忆障碍和学习功能障碍的药物，精神分裂症，痴呆，注意力缺陷障碍或阿尔茨海默氏病。

2. 发明申请

WO2010020548A1 GLYT1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： GLYT1受体拮抗剂
公开(公告)号：WO2010020548A1
公开(公告)日：2010-02-25
申请号：PCT/EP2009/060316
申请日：2009-08-10
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , NARQUIZIAN, Robert , PINARD, Emmanuel
发明人： KOLCZEWSKI, Sabine , NARQUIZIAN, Robert , PINARD, Emmanuel
IPC分类号： C07D405/04 , A61P25/18 , A61P25/28 , A61K31/40 , A61K31/4025 , C07D305/08 , C07D231/14 , C07D241/42 , C07D319/18 , C07D333/54 , C07D498/08 , C07D295/13 , C07D491/107
CPC分类号： C07D305/08 , C07D231/14 , C07D241/42 , C07D295/033 , C07D319/18 , C07D333/54 , C07D491/107 , C07D498/16
摘要： The present invention relates to a compound of the general formula (I) wherein R 1 /R 2 are independently from each other lower alkyl, or form together with the N-atom to which they are attached a heterocyclic group, selected from pyrrolidine, piperidine, piperazine, 4-methyl-piperazine, 4-cyclopropyl-piperazine, thiomorpholine, morpholine, 1-(3-oxa-8-aza- bicyclo[3.2.1]oct-8-yl or 1-(2-oxa-6-aza-spiro[3.3]hept-6-yl; X is a bond, -CH 2 - or -O-; Ar 1 is aryl or heteroaryl, which are unsubstituted or substituted by one or two substituents selected from halogen, lower alkyl, lower alkoxy, or lower alkyl substituted by halogen; Ar 2 is aryl or heteroaryl, which are unsubstituted or substituted by one, two or three substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, S-lower alkyl, benzyl or phenyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to their corresponding enantiomers and/or optical isomers thereof. It has surprisingly been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GIyT-1), and that they have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1 / R 2彼此独立地为低级烷基，或与它们所连接的N-原子一起形成杂环基，其选自吡咯烷，哌啶，哌嗪，4-甲基 - 哌嗪，4-环丙基 - 哌嗪，硫代吗啉，吗啉，1-（3-氧杂-8-氮杂 - 双环[3.2.1]辛-8-基或1-（2-氧杂-6-氮杂 - 螺[3.3]庚-6-基; X是键，-CH 2 - 或-O-; Ar 1是未取代的或被一个或两个选自卤素，低级烷基，低级烷氧基，或被卤素取代的低级烷基; Ar 2是未取代的或被1,2或3个选自卤素，低级烷基，低级烷氧基，羟基，被卤素取代的低级烷基，被卤素取代的低级烷氧基，S 或低级烷基，苄基或苯基;或药学上可接受的酸加成盐，与外消旋混合物或其相应的能力其分子量和/或光学异构体。惊奇地发现通式（I）的化合物是甘氨酸转运蛋白1（GlyT-1）的良好抑制剂，并且它们对甘氨酸转运蛋白2（GlyT-2）抑制剂具有良好的选择性。

3. 发明申请

WO2011161008A1 QUINOLIZIDINE AND INDOLIZIDINE DERIVATIVES 审中-公开
标题翻译：喹诺酮和吲哚来啶衍生物
公开(公告)号：WO2011161008A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060077
申请日：2011-06-17
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , PINARD, Emmanuel
发明人： KOLCZEWSKI, Sabine , PINARD, Emmanuel
IPC分类号： C07D455/02 , C07D471/04 , A61K31/437 , A61K31/4375 , A61P25/00
CPC分类号： C07D455/02 , C07D471/04
摘要： The present invention relates to a compound of general formula I-A or I-B wherein X is a bond or a CH 2 - group; R 1 , R 2 and R 3 are independently from each other hydrogen, lower alkoxy, lower alkyl substituted by halogen or S-lower alkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer thereof. It has been found that the compounds of general formulas I-A and I-B are good inhibitors of the glycine transporter 1 (GlyT-1), and that they have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors, suitable in the treatment of neurological and neuropsychiatric disorders.
摘要翻译：本发明涉及通式I-A或I-B的化合物，其中X为键或CH2-基; R 1，R 2和R 3彼此独立地为氢，低级烷氧基，被卤素或S-低级烷基取代的低级烷基; 或其药学上可接受的酸加成盐，或其相应的对映异构体和/或其旋光异构体。已经发现，通式IA和IB的化合物是甘氨酸转运蛋白1（GlyT-1）的良好抑制剂，并且它们对甘氨酸转运蛋白2（GlyT-2）抑制剂具有良好的选择性，适用于治疗神经和神经精神障碍。

4. 发明申请

WO2010086251A1 AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS 审中-公开
标题翻译：作为GLYT-1抑制剂的α-亚氨基 - 和异丁烯酰胺取代的哌啶
公开(公告)号：WO2010086251A1
公开(公告)日：2010-08-05
申请号：PCT/EP2010/050551
申请日：2010-01-19
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , PINARD, Emmanuel , STALDER, Henri
发明人： KOLCZEWSKI, Sabine , PINARD, Emmanuel , STALDER, Henri
IPC分类号： C07D211/56 , C07D401/04 , C07D401/12 , C07D405/04 , C07D417/10 , A61K31/445 , A61K31/4525 , A61K31/4535 , A61K31/4545
CPC分类号： C07D407/04 , A61K31/451 , C07D211/56 , C07D213/56 , C07D221/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D417/10
摘要： The present invention relates to a compound of general formula (I) wherein R 1 is hydrogen, lower alkyl, CD 3 , -(CH 2 ) n -CHO, -(CH 2 ) n -O-lower alkyl, -(CH 2 ) n -OH, -(CH 2 ) n -cycloalkyl or is heterocycloalkyl; R 2 is hydrogen, halogen, hydroxy, lower alkyl, di-lower alkyl, -OCH 2 -O-lower alkyl, or lower alkoxy; or the piperidin ring form together with R 2 a spiro ring, selected from 4-aza-spiro[2.5]oct-6-yl; Ar is aryl or heteroaryl, which are optionally substituted by one, two or three substituents, selected from halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl, lower alkoxy, S-lower alkyl, heteroaryl, heterocycloalkyl, or by phenyl optionally substituted by R', and R' is halogen, lower alkyl, lower alkoxy or lower alkoxy substituted by halogen, or is heteroaryl; R is lower alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted by one or two R'; n is 0, 1 2 or 3; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer thereof. Furthermore, the present invention relates to pharmaceutical compositions containing the compounds of formula I and to their use in the treatment of neurological and neuropsychiatric disorders.
摘要翻译：本发明涉及通式（I）的化合物，其中R1是氢，低级烷基，CD3， - （CH2）n-CHO， - （CH2）nO-低级烷基， - （CH2）n-OH， - （ CH2）n-环烷基或杂环烷基; R2是氢，卤素，羟基，低级烷基，二低级烷基，-OCH2-O-低级烷基或低级烷氧基; 或哌啶环与R2一起形成选自4-氮杂 - 螺[2.5]辛-6-基的螺环; Ar是芳基或杂芳基，其任选被一个，两个或三个选自卤素，低级烷基，被卤素取代的低级烷基，被卤素取代的低级烷氧基，环烷基，低级烷氧基，S-低级烷基，杂芳基，杂环烷基，或被R'任意取代的苯基，R'是卤素，低级烷基，低级烷氧基或被卤素取代的低级烷氧基，或是杂芳基; R是低级烷基，环烷基，杂环烷基，芳基或杂芳基，其中芳基和杂芳基任选被一个或两个R'取代; n为0，1 2或3; 或其药学上可接受的酸加成盐，或其相应的对映异构体和/或其旋光异构体。此外，本发明涉及含有式I化合物的药物组合物及其在治疗神经和神经精神障碍中的用途。

5. 发明申请

WO2011095434A1 TETRAHYDRO-PYRAN DERIVATIVES AGAINST NEUROLOGICAL ILLNESSES 审中-公开
标题翻译：四氢吡喃衍生物对抗神经病学
公开(公告)号：WO2011095434A1
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051179
申请日：2011-01-28
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , PINARD, Emmanuel
发明人： KOLCZEWSKI, Sabine , PINARD, Emmanuel
IPC分类号： A61K31/351 , A61K31/4025 , A61K31/439 , A61K31/4412 , A61K31/4433 , C07D309/14 , C07D407/04 , A61P29/00 , A61P25/00
CPC分类号： A61K31/351 , A61K9/2018 , A61K9/4858 , A61K31/4025 , A61K31/439 , A61K31/4412 , A61K31/4433 , C07D309/14 , C07D405/04
摘要： The present invention relates to a compound of general formula (I) wherein X is -O- or -CH 2- ; X' is -O- or -CH 2- ; with the proviso that one of X or X' is always -O- and the other is -CH 2- . It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GIyT-1) and therefore they may be used for the treatment of schizophrenia, psychoses and other neurological conditions, including pain.
摘要翻译：本发明涉及通式（I）的化合物，其中X是-O-或-CH 2 - ; X'是-O-或-CH 2 - ; 条件是X或X'中的一个总是-O-，另一个是-CH 2 - 。已经发现通式（I）的化合物是甘氨酸转运蛋白1（GlyT-1）和因此它们可用于治疗精神分裂症，精神病和其他神经病症，包括疼痛。

6. 发明申请

WO2011161006A1 AMIDO-TROPANE DERIVATIVES 审中-公开
标题翻译： AMIDO-TROPANE衍生物
公开(公告)号：WO2011161006A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060073
申请日：2011-06-17
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , PINARD, Emmanuel
发明人： KOLCZEWSKI, Sabine , PINARD, Emmanuel
IPC分类号： C07D451/02 , A61K31/46 , A61P25/00
CPC分类号： C07D451/02 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K9/4866
摘要： The present invention relates to a compound of general formula (I) wherein R 1 , R 2 and R 3 are independently from each other hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by halogen or S-lower alkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GlyT-1), and that they have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. The compounds may be used in the treatment of neurological and neuropsychiatric disorders.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1，R 2和R 3彼此独立地为氢，低级烷基，低级烷氧基，环烷基，被卤素或S-低级烷基取代的低级烷基; 或其药学上可接受的酸加成盐，或其相应的对映异构体和/或其旋光异构体。已经发现通式（I）的化合物是甘氨酸转运蛋白1（GlyT-1）的良好抑制剂，并且它们对甘氨酸转运蛋白2（GlyT-2）抑制剂具有良好的选择性。该化合物可用于治疗神经和神经精神障碍。

7. 发明申请

WO2011023667A1 CARBOCYCLIC GLYT1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CARBOCYCLIC GLYT1受体拮抗剂
公开(公告)号：WO2011023667A1
公开(公告)日：2011-03-03
申请号：PCT/EP2010/062281
申请日：2010-08-24
申请人： F. HOFFMANN-LA ROCHE AG , KOLCZEWSKI, Sabine , PINARD, Emmanuel
发明人： KOLCZEWSKI, Sabine , PINARD, Emmanuel
IPC分类号： C07C233/79 , C07C235/62 , C07C323/62 , C07D205/04 , C07D207/06 , C07D211/08 , C07D307/06 , C07D335/02 , C07D487/10 , C07D295/135 , A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4453 , A61K31/495
CPC分类号： A61K31/166 , A61K31/397 , A61K31/40 , A61K31/4453 , A61K31/495 , A61K31/5375 , C07C233/79 , C07C235/62 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/06 , C07D207/10 , C07D207/12 , C07D211/38 , C07D211/46 , C07D295/12 , C07D295/20 , C07D309/14 , C07D335/02 , C07D487/10
摘要： The present invention relates to the use of a compound of general formula (I) wherein R 1 /R 2 are independently from each other hydrogen, lower alkyl, -CH 2 ) o -cycloalkyl for o being 0 or 1, or are benzyl or heterocycloalkyl; or R 1 and R 2 are together with the N-atom to which they are attached a ring containing -(CH 2 ) 3 -, -(CH 2 ) 4 -, -(CH 2 ) 5 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -, -(CH 2 ) 2 -S-(CH 2 ) 2 -, -(CH 2 ) 2 -NR-(CH 2 ) 2 -, -(CH 2 ) 2 -C(O)-(CH 2 ) 2 -, -(CH 2 ) 2 -CF 2 -(CH 2 ) 2 -, -CH 2 -CHR-(CH 2 ) 2 , -CHR-(CH 2 ) 3 , CHR-(CH 2 ) 2 -CHR-, or is the ring 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester and R is hydroxy, halogen, cycloalkyl, or C(O)O-lower alkyl; X is -(CH 2 ) 4 -, -(CH 2 ) 3 -, -(CH 2 ) 2 - or -CH 2 -; R 3 is S-lower alkyl, CF 3 , OCHF 2 , lower alkoxy, lower alkyl, phenyl, cycloalkyl or halogen; R 4 is CF 3 , lower alkoxy, lower alkyl, halogen and n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomers and/or optical isomers thereof for the manufacture of a medicament for the treatment of psychoses, pain, dysfunction in memory and learning, attention deficit, schizophrenia, dementia disorders or Alzheimer's disease.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1 / R 2彼此独立地是O，O或1的氢，低级烷基，-CH 2）o - 环烷基，或者是苄基或杂环烷基; （CH 2）3 - ， - （CH 2）4 - ， - （CH 2）5 - ， - （CH 2）2 -O-（CH 2）） - ， - （CH 2）2 -S-（CH 2）2 - ， - （CH 2）2 -NR-（CH 2）2 - ， - （CH 2）2 -C（O） - （CH 2）2 -CF 2 - （CH 2）2 - ， - CH 2 -CHR-（CH 2）2，-CHR-（CH 2）3，CHR-（CH 2）2 -CHR-，或环2,6-二氮杂 - 螺[3.3]庚烷-2-羧酸叔丁酯，R是羟基，卤素，环烷基或C（O）O-低级烷基; X是 - （CH 2）4 - ， - （CH 2）3 - ， - （CH 2）2 - 或-CH 2 - ; R3是S-低级烷基，CF3，OCHF2，低级烷氧基，低级烷基，苯基，环烷基或卤素; R4为CF3，低级烷氧基，低级烷基，卤素，n为1或2; 或其药学上可接受的酸加成盐，或其相应的对映体和/或光学异构体，用于制备用于治疗精神病，疼痛，记忆功能障碍和学习，注意力缺陷，精神分裂症，痴呆症或阿尔茨海默病。

8. 发明申请

WO2005014563A1 PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS 审中-公开
标题翻译：具有或取代的苯基的哌嗪及其作为GLYT1抑制剂的用途
公开(公告)号：WO2005014563A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008633
申请日：2004-08-02
申请人： F. HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
IPC分类号： C07D295/192
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula (I) wherein the substituents are described in claim 1. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译：本发明涉及式（I）化合物，其中取代基描述于权利要求1中。该化合物可用于治疗基于甘氨酸摄取抑制剂的疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆症和认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病。

9. 发明申请

WO2012019966A1 1,4,5,6-TETRAHYDRO-PYRIMIDIN-2-YLAMINE COMPOUNDS 审中-公开
标题翻译： 1,4,5,6-四氢吡啶-2-基胺化合物
公开(公告)号：WO2012019966A1
公开(公告)日：2012-02-16
申请号：PCT/EP2011/063498
申请日：2011-08-05
申请人： F. HOFFMANN-LA ROCHE AG , SIENA BIOTECH S.P.A , BANNER, David , GABELLIERI, Emanuele , GUBA, Wolfgang , HILPERT, Hans , HORNSPERGER, Benoit , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , PINARD, Emmanuel , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
发明人： BANNER, David , GABELLIERI, Emanuele , GUBA, Wolfgang , HILPERT, Hans , HORNSPERGER, Benoit , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , PINARD, Emmanuel , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D239/22 , C07D239/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/513 , A61P3/10
CPC分类号： C07D417/12 , A61K31/513 , C07D239/22 , C07D239/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： This invention relates to compounds of the formula wherein R 1 to R 9 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as diabetes, particularly type 2 diabetes, and other metabolic disorders.
摘要翻译：本发明涉及下式化合物或其药学上可接受的盐：其中R 1至R 9如下所述。这些化合物是BACE2抑制剂，可用作治疗和/或预防性治疗诸如糖尿病，特别是2型糖尿病和其它代谢疾病的药物。

10. 发明申请

WO2011069934A1 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS 审中-公开
标题翻译：作为BACE 1和/或BACE 2抑制剂的2-氨基-5,5-二氟-5,6-二氢-4H-氧化物
公开(公告)号：WO2011069934A1
公开(公告)日：2011-06-16
申请号：PCT/EP2010/068912
申请日：2010-12-06
申请人： F. HOFFMANN-LA ROCHE AG , SIENA BIOTECH S.P.A. , BANNER, David , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , PINARD, Emmanuel , POWER, Eoin , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , PINARD, Emmanuel , POWER, Eoin , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D265/08 , C07D413/12 , A61K31/535 , A61K31/5355
CPC分类号： C07D265/08 , C07D413/12
摘要： The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)- phenyl]-amide derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译：本发明涉及具有BACE1和/或其衍生物的式（I）的2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]恶嗪-4-基） - 苯基] BACE2抑制活性，其制备，含有它们的药物组合物及其作为治疗活性物质的用途。本发明的活性化合物可用于例如治疗和/或预防性治疗。阿尔茨海默病和2型糖尿病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式