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1. 发明申请

WO2005014563A1 PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS 审中-公开
标题翻译：具有或取代的苯基的哌嗪及其作为GLYT1抑制剂的用途
公开(公告)号：WO2005014563A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008633
申请日：2004-08-02
申请人： F. HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
IPC分类号： C07D295/192
CPC分类号： C07D239/42 , C07D213/85 , C07D241/20 , C07D251/42 , C07D257/04 , C07D263/32 , C07D271/06 , C07D295/192 , C07D309/12
摘要： The invention relates to compounds of formula (I) wherein the substituents are described in claim 1. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译：本发明涉及式（I）化合物，其中取代基描述于权利要求1中。该化合物可用于治疗基于甘氨酸摄取抑制剂的疾病，例如精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆症和认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病。

2. 发明申请

WO2005023261A1 1-BENZOYL-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES 审中-公开
标题翻译：作为用于治疗心脏病的甘油摄取抑制剂的1-苯甲酰基哌嗪衍生物
公开(公告)号：WO2005023261A1
公开(公告)日：2005-03-17
申请号：PCT/EP2004/009699
申请日：2004-08-31
申请人： F. HOFFMANN-LA ROCHE AG , ALBERATI-GIANI, Daniela , JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
发明人： ALBERATI-GIANI, Daniela , JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
IPC分类号： A61K31/496
CPC分类号： C07D295/16 , A61K31/495 , A61K31/496 , C07D213/56 , C07D213/69 , C07D213/74 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D251/42 , C07D251/48 , C07D257/04 , C07D263/32 , C07D277/30 , C07D295/185 , C07D309/04 , C07D309/20 , C07D333/24 , C07D409/12
摘要： The invention relates to compounds of formula (I) wherein Ar is substituted aryl or unsubstituted or substituted 6-membered heteroaryl, containing one, two or three nitrogen atoms, and wherein the aryl and the heteroaryl groups may be substituted by one or more substituents selected from the group consisting of hydroxy, halogen, CN, (C 1 C 6 )-alkyl, (C 1 -C 6 )-alkyl substituted by halogen, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxy substituted by halogen, NR 7 R 8 , C(O)R 9 or SO 2 R 10 ; R 1 is hydrogen or (C 1 -C 6 )-alkyl; R 2 is halogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl, wherein a hydrogen atom may be replaced by CN, C(O)-R 9 or (C 1 -C 6 )-alkyl, or is (C 2 -C 6 )alkynyl, (C 1 -C 6 )-alkyl substituted by halogen, -(CH 2 ) n -(C 3 -C 7 )-cycloalkyl, -(CH 2 ) n -heterocycloalkyl, -C(O)-R 9 , -(CH 2 ) n -aryl or -(CH 2 ) n -5 or -6membered heteroaryl containing one, two or three heteroatoms, selected from the group consisting of oxygen, sulphur or nitrogen wherein aryl, cycloalkyl, heterocycloalkyl and heteroaryl are unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxy, halogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl substituted by halogen or (C 1 -C 6 ) alkoxy; R 3 , R 4 and R 6 independently from each other are hydrogen, hydroxy, halogen, (C 1 -C 6 )-alkyl or (C 1 -C 6 )-alkoxy; R 5 is NO 2 , CN, C(O)R 9 , SO 2 R 10 or NR 11 R 12 ; R 7 and R 8 independently from each other are hydrogen or (C 1 -C 6 )-alkyl; the other substituents are defined in the claims; and to pharmaceutically acceptable acid addition salts thereof for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译：本发明涉及式（I）化合物，其中Ar是含有一个，两个或三个氮原子的取代的芳基或未取代或取代的6元杂芳基，其中芳基和杂芳基可以被一个或多个选自由羟基，卤素，CN，（C 1 -C 6） - 烷基，被卤素取代的（C 1 -C 6） - 烷基，（C 1 -C 6） - 烷氧基，被卤素取代的（C 1 -C 6） - 烷氧基，NR 7 R 8，C（O）R 9或SO 2 R 10; R 1是氢或（C 1 -C 6） - 烷基; R 2是卤素，（C 1 -C 6） - 烷基，（C 2 -C 6） - 烯基，其中氢原子可以被CN，C（O）-R 9或（C 1 -C 6） - 烷基或（C 2 -C 6）炔基，被卤素， - （CH 2）n - （C 3 -C 7） - 环烷基， - （CH 2）n - 杂环烷基，-C（O）-R 含有一个，两个或三个选自氧，硫或氮的杂原子的（CH 2）n - 芳基或 - （CH 2）n-5或 - （CH 2）n-5或-6元杂芳基，其中芳基，环烷基，杂环烷基和杂芳基是未取代的或被一个或多个选自羟基，卤素，（C 1 -C 6） - 烷基，被卤素或（C 1 -C 6）烷氧基取代的（C 1 -C 6） R 3，R 4和R 6彼此独立地是氢，羟基，卤素，（C 1 -C 6） - 烷基或（C 1 -C 6） - 烷氧基; R 5是NO 2，CN，C（O）R 9，SO 2 R 10或NR 11 R 12; R 7和R 8彼此独立地是氢或（C 1 -C 6） - 烷基; 其它取代基在权利要求中限定; 以及其药学上可接受的酸加成盐，用于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和其他认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病。

3. 发明申请

WO2005023260A1 1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES 审中-公开
标题翻译： 1-（2-氨基苄基） - 哌嗪衍生物作为甘油摄取抑制剂用于治疗心脏病
公开(公告)号：WO2005023260A1
公开(公告)日：2005-03-17
申请号：PCT/EP2004/009665
申请日：2004-08-30
申请人： F. HOFFMANN-LA ROCHE AG , ALBERATI-GIANI, Daniela , JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
发明人： ALBERATI-GIANI, Daniela , JOLIDON, Synese , NARQUIZIAN, Robert , NETTEKOVEN, Matthias, Heinrich , NORCROSS, Roger, David , PINARD, Emmanuel , STALDER, Henri
IPC分类号： A61K31/496
CPC分类号： C07D295/192 , A61K31/495 , A61K31/496 , C07D207/08 , C07D207/12 , C07D207/20 , C07D211/42 , C07D231/12 , C07D233/54 , C07D237/20 , C07D249/08 , C07D257/04 , C07D307/14 , C07D309/14
摘要： A compound of formula (I) wherein the substituents are described in claim 1 for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
摘要翻译：式（I）化合物，其中取代基在权利要求1中描述，用于治疗精神病，疼痛，记忆和学习中的神经变性功能障碍，精神分裂症，痴呆和认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病疾病。

4. 发明申请

WO2006072436A1 [4-(HETEROARYL) PIPERAZIN-1-YL]-(2,5-SUBSTITUTED -PHENYL)METHANONE DERIVATIVES AS GLYCINE TRANSPORTER 1 (GLYT-1) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译：作为用于治疗神经病学和神经病学疾病的甘氨酸运输1（GLYT-1）抑制剂的[4-（异丁基）哌嗪-1-基] - （2,5-取代的苯基）甲酮衍生物
公开(公告)号：WO2006072436A1
公开(公告)日：2006-07-13
申请号：PCT/EP2005/014082
申请日：2005-12-28
申请人： F. HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： A61K31/427 , A61K31/433 , A61P25/28 , C07D277/42 , C07D277/56 , C07D417/12 , C07D285/12 , C07D285/08
CPC分类号： C07D285/08 , C07D277/42 , C07D277/56 , C07D285/135 , C07D417/12
摘要： The present invention relates to compounds of the general formula (I) wherein R 1 is-OR 1’ ,-SR 1’ or is a heterocycloalkyl group; R 1’ is lower alkyl, lower alkyl substituted by halogen or is -(CH 2 ) n -cycloalkyl; R 2 is-S(O) 2 -lower alkyl, -S(O) 2 NH-lower alkyl, NO 2 or CN; X 1 is CR 3 or N; X 2 is CR 3’ or N; R 3 /R 3’ are independently from each other hydrogen, halogen, lower alkyl, CN, NO 2 ,-S(O) 2 -phenyl, -S(O) 2 -lower alkyl, -S(O) 2 -pyridin-2, 3 or 4-yl, phenyl, optionnally substituted by one or two substituents selected from the group consisting of NO 2 or halogen, or is lower alkyl substituted by halogen or is -C(O)-lower alkyl; n is 0, 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GlyT-1). They may be used in the treatment of schizophrenia.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是 - 或 - 1'， - SR 1'或其是杂环烷基 R 1是低级烷基，被卤素取代的低级烷基或是 - （CH 2 CH 2）n - 环烷基; R 2是-S（O）2 - 低级烷基，-S（O）2 NH-低级烷基，NO 2 或CN; X 1是CR 3或N; X 2是CR 3或N; R 3和R 3彼此独立地为氢，卤素，低级烷基，CN，NO 2，-S（O） -S（O）2 - 低级烷基，-S（O）2 - 吡啶基-2,3或4-基 - ，苯基，其选自一个或两个选自NO 2或卤素的取代基，或被卤素取代的低级烷基或-C（O） - 低级烷基; n为0,1或2; 及其药学上可接受的酸加成盐。已经发现通式（I）的化合物是甘氨酸转运蛋白1（GlyT-1）的良好抑制剂。它们可用于治疗精神分裂症。

5. 发明申请

WO2006061135A1 PHENYL-PIPERAZIN METHANONE DERIVATIVES 审中-公开
标题翻译：苯基哌嗪甲酮衍生物
公开(公告)号：WO2006061135A1
公开(公告)日：2006-06-15
申请号：PCT/EP2005/012833
申请日：2005-12-01
申请人： F. HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： C07D277/82 , C07D277/64 , C07D275/04 , C07D263/58 , C07D215/38 , C07D241/44 , A61K31/428 , A61K31/423 , A61K31/47 , A61K31/498 , A61P25/00
CPC分类号： C07D215/38 , C07D241/44 , C07D263/58 , C07D275/04 , C07D277/64 , C07D277/82
摘要： The present invention relates to compounds of the general formula (I) wherein R 1 is the group (A) or (B) or (C) or (D); R 2 is a non aromatic heterocycle, or is OR' or N(R") 2 ; R' is lower alkyl, lower alkyl substituted by halogen or -(CH 2 ) n -cycloalkyl; R" is lower alkyl; R 3 is NO 2 , CN or SO 2 R'; R 4 is hydrogen, hydroxy, halogen, NO 2 , lower alkyl, lower alkyl, substituted by halogen, lower alkoxy, SO 2 R' or C(O)OR"; R 5 /R 6 /R 7 are hydrogen, halogen, lower alkyl or lower alkyl, substituted by halogen; X 1 /X 1’ are CH or N, with the proviso that X 1 /X 1’ are not simultaneously CH; X 2 is O, S, NH or N(lower alkyl); n is 0, l or 2; and to pharmaceutically active acid addition salts and to their use in the treatment of neurological and neuropsychiatric disorders.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是基团（A）或（B）或（C）或（D）; R 2是非芳族杂环，或是OR'或N（R“）2; R'是低级烷基，被卤素取代的低级烷基或 - （CH 3） N 2 - 环烷基; R“是低级烷基; R 3是NO 2，CN或SO 2 R'; R 4是氢，羟基，卤素，NO 2，低级烷基，被卤素取代的低级烷基，低级烷氧基，SO 2 R' 或C（O）OR“; R 5，R 6，R 6和R 7是氢，卤素，低级烷基或低级烷基，被卤素; X 1 / X 1'是CH或N，条件是X 1 / X 1' >不同时为CH; X 2为O，S，NH或N（低级烷基）; n为0,1或2;以及药学活性的酸加成盐及其在治疗中的用途的神经和神经精神障碍。

6. 发明申请

WO2006079467A1 PHENYL METHANONE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER 1 INHIBITORS 审中-公开
标题翻译：苯甲酮衍生物及其作为甘氨酸运输商1抑制剂
公开(公告)号：WO2006079467A1
公开(公告)日：2006-08-03
申请号：PCT/EP2006/000361
申请日：2006-01-17
申请人： F. HOFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： C07D471/04 , C07D217/06 , C07D215/14 , C07D491/04 , A61K31/47 , A61K31/472 , A61K31/519
CPC分类号： C07D471/04 , C07D215/14 , C07D217/06 , C07D491/04
摘要： The present invention relates to compounds of general formula IA or IB. The compounds may be used for the treatment of diseases related to the glycine transporter inhibitor.
摘要翻译：本发明涉及通式IA或IB的化合物。该化合物可用于治疗与甘氨酸转运蛋白抑制剂有关的疾病。

7. 发明申请

WO2006063709A1 BI- AND TRICYCLIC SUBSTITUTED PHENYL METHANONES AS GLYCINE TRANSPORTER I (GLYT-1) INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE 审中-公开
标题翻译：作为治疗阿尔茨海默病的糖蛋白转运蛋白I（GLYT-1）抑制剂的BI-和三聚取代的苯甲醇
公开(公告)号：WO2006063709A1
公开(公告)日：2006-06-22
申请号：PCT/EP2005/012994
申请日：2005-12-05
申请人： F.HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： C07D495/04 , C07D513/04 , C07D487/04 , C07D471/04 , A61K31/4985 , A61K31/4365 , A61K31/437 , A61P25/28
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to compounds of the general formula (I), wherein formula (II) is A or B or C or D or E or F. R 1 is a non aromatic heterocycle, or is OR' or N(R") 2 ; R' is lower alkyl, lower alkyl substituted by halogen or is -(CH 2 ) ri cycloalkyl; R" is lower alkyl; R 2 is NO 2 , CN or SO 2 R"; R 3 is hydrogen, halogen, lower alkyl, lower alkoxy, or lower alkyl substituted by halogen; R 4 is hydrogen, lower alkyl, phenyl substituted by halogen or CF 3 , or is a five or six membered aromatic heterocycle; R 5 /R 6 are hydrogen, halogen, lower alkyl, lower alkoxy, or are lower alkyl or lower alkoxy, substituted by halogen; R 7 is hydrogen or lower alkyl; n is 0, 1 or 2; and to pharmaceutically active acid addition salts for the treatment of neurological and neuropsychiatric disorders.
摘要翻译：本发明涉及通式（I）的化合物，其中式（II）是A或B或C或D或E或F.R 1是非芳族杂环，或OR '或N（R“）2'; R'是低级烷基，被卤素取代的低级烷基，或是 - （CH 2）n N' ; R“为低级烷基; R 2是NO 2，CN或SO 2 R“; R 3是氢，卤素，低级烷基，低级烷氧基或被卤素取代的低级烷基; R 4是氢，低级烷基，被卤素或CF 3 N取代的苯基，或是五或六元芳族杂环 R 5是氢，卤素，低级烷基，低级烷氧基，或被卤素取代的低级烷基或低级烷氧基; R 7， SUP>是氢或低级烷基; n是0,1或2;以及用于治疗神经和神经精神障碍的药学活性的酸加成盐。

8. 发明申请

WO2006072435A1 SULFANYL SUBSTITUTED PHENYL METHANONES AS GLYCINE TRANSPORTER 1 (GLYT-1) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： SULFANYL取代苯甲酸酯作为甘油运输机1（GLYT-1）用于治疗神经病学和神经病学疾病的抑制剂
公开(公告)号：WO2006072435A1
公开(公告)日：2006-07-13
申请号：PCT/EP2005/014081
申请日：2005-12-28
申请人： F.HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： C07D295/18 , C07D213/74 , C07D239/42 , A61K31/506 , A61K31/496 , A61K31/495 , A61P25/28
CPC分类号： C07D213/74 , C07D239/42 , C07D295/192
摘要： The present invention relates to compounds of the general formula (I) wherein R 1 is lower alkyl or lower alkyl substituted by halogen; R 2 is -S(O) 2 -lower alkyl, -S(O) 2 NH-lower alkyl, NO 2 or CN; R 3 is halogen, CN, lower alkyl, lower alkyl substituted by halogen, NO 2 , -C(O)-lower alkyl or S(O) 2 -lower alkyl; X/X 1 are independently from each other CR 4 or N; R 4 is hydrogen or halogen; n is 0, 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (G1yT-1) for the treatment of schizophrenia.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是被卤素取代的低级烷基或低级烷基; R 2是-S（O）2 - 低级烷基，-S（O）2 NH-低级烷基，NO 2 或CN; R 3是卤素，CN，低级烷基，被卤素取代的低级烷基，NO 2 - ， - C（O） - 低级烷基或S（O）2 低级烷基; X / X 1彼此独立地为CR 4或N; R 4是氢或卤素; n为0,1或2; 和其药学上可接受的酸加成盐。已经发现，通式（I）的化合物是用于治疗精神分裂症的甘氨酸转运蛋白1（G1yT-1）的良好抑制剂。

9. 发明申请

WO2006077026A1 2, 5-DISUBSTITUTED PHENYL METHANONE DERIVATIVES AS GLYCINE TRANSPORTER 1 (GLYT-I) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRY DISORDERS 审中-公开
标题翻译： 2，5-取代的苯甲酮衍生物作为甘油运输机1（GLYT-1）抑制剂治疗神经病学和神经缺血性疾病
公开(公告)号：WO2006077026A1
公开(公告)日：2006-07-27
申请号：PCT/EP2006/000127
申请日：2006-01-10
申请人： F.HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： A61K31/4427 , A61K31/4409 , A61K31/397 , A61P25/28 , C07D401/12 , C07D211/46 , C07D207/12 , C07D205/04 , A61K31/40 , A61K31/445
CPC分类号： C07D207/12 , C07D205/04 , C07D211/46 , C07D401/12
摘要： The present invention relates to compounds of the general formula (I) wherein R 1 is -OR 1 , -SR 1 or is a heterocycloalkyl group; R 1 is lower alkyl, lower alkyl substituted by halogen, or is -(CH 2 ) n -cycloalkyl; R 2 is -S(O) 2 -lower alkyl or -S(O) 2 NH-lower alkyl; R 3 is aryl or heteroaryl, which are unsubstituted or substituted by one to three substituents, selected from the group consisting of lower alkyl, lower alkoxy, CN, NO 2 , -C(O)-lower alkyl, -C(O)O-lower alkyl, halogen or lower alkyl substituted by halogen; n is 1 or 2; m is 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. It has been found that the compounds of general formula (I) are good inhibitors of the glycine transporter 1 (GIyT-I).
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是-OR 1，-SR 1或杂环烷基 ; R 1是低级烷基，被卤素取代的低级烷基，或是 - （CH 2 CH 2）n - 环烷基; R 2是-S（O）2 - 低级烷基或-S（O）2 NH-低级烷基; R 3是未取代的或被1至3个选自低级烷基，低级烷氧基，CN，NO 2 - 的取代基取代的芳基或杂芳基， C（O） - 低级烷基，-C（O）O-低级烷基，卤素或被卤素取代的低级烷基; n为1或2; m为1或2; 及其药学上可接受的酸加成盐。已经发现通式（I）的化合物是甘氨酸转运蛋白1（GlyT-I）的良好抑制剂。

10. 发明申请

WO2006082001A1 HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 审中-公开
标题翻译：作为糖蛋白转运蛋白1的保护剂的杂环取代的苯甲醇
公开(公告)号：WO2006082001A1
公开(公告)日：2006-08-10
申请号：PCT/EP2006/000761
申请日：2006-01-30
申请人： F.HOFFMANN-LA ROCHE AG , JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
发明人： JOLIDON, Synese , NARQUIZIAN, Robert , NORCROSS, Roger, David , PINARD, Emmanuel
IPC分类号： C07D209/44 , C07D403/04 , C07D471/04 , C07D209/08 , C07D231/56 , C07D235/06 , C07D417/04 , C07D401/04 , C07D409/04 , C07D487/04 , C07D209/88 , C07D405/04 , C07D491/08 , C07D498/08 , C07D413/04
CPC分类号： C07D471/04 , C07D209/08 , C07D209/44 , C07D209/46 , C07D209/88 , C07D231/56 , C07D235/06 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D491/08
摘要： The present invention relates to compounds of general formula (I) wherein (i) is an aromatic or partially aromatic bicyclic amine, which may contain one or two additional N-atoms, selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h) and to pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明涉及通式（I）的化合物，其中（i）是芳族或部分芳族双环胺，其可以含有一个或两个另外的N-原子，其选自（a），（b），（c），（d），（e），（f），（g），（h）及其药学上可接受的酸加成盐。

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