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1. 发明申请

WO2010069532A1 ANTIBODIES AGAINST HUMAN ANGIOPOIETIN 2 审中-公开
标题翻译：抗体人类抗体2
公开(公告)号：WO2010069532A1
公开(公告)日：2010-06-24
申请号：PCT/EP2009/008930
申请日：2009-12-14
申请人： F. HOFFMANN-LA ROCHE AG , BRINKMANN, Ulrich , GRIEP, Remko Albert , KALUZA, Klaus , KAVLIE, Anita , KLEIN, Christian , REGULA, Joerg Thomas , SCHEUER, Werner
发明人： BRINKMANN, Ulrich , GRIEP, Remko Albert , KALUZA, Klaus , KAVLIE, Anita , KLEIN, Christian , REGULA, Joerg Thomas , SCHEUER, Werner
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti- ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。

2. 发明申请

WO2010040508A9 BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 审中-公开
公开(公告)号：WO2010040508A9
公开(公告)日：2010-04-15
申请号：PCT/EP2009/007182
申请日：2009-10-07
申请人： F. HOFFMANN-LA ROCHE AG , BAEHNER, Monika , BRINKMANN, ULRICH , GEORGES, Guy , GRIEP, Remko, Albert , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , SEEBER, Stefan , THOMAS, Markus
发明人： BAEHNER, Monika , BRINKMANN, ULRICH , GEORGES, Guy , GRIEP, Remko, Albert , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , SEEBER, Stefan , THOMAS, Markus
IPC分类号： C07K16/22 , A61K39/395 , C07K19/00 , C07K16/46 , C07K14/00
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

3. 发明申请

WO2011117329A1 BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 审中-公开
标题翻译： BISPECIFIC，BIVALENT ANTI-VEGF / ANTI-ANG-2 ANTIBODIES
公开(公告)号：WO2011117329A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054504
申请日：2011-03-24
申请人： F. HOFFMANN-LA ROCHE AG , BAEHNER, Monika , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , STUBENRAUCH, Kay-Gunnar , THOMAS, Markus
发明人： BAEHNER, Monika , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , STUBENRAUCH, Kay-Gunnar , THOMAS, Markus
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其制备方法，含有所述抗体的药物组合物及其用途。

4. 发明申请

WO2011003780A1 BI-SPECIFIC DIGOXIGENIN BINDING ANTIBODIES 审中-公开
标题翻译：双特异性抗体结合抗体
公开(公告)号：WO2011003780A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059243
申请日：2010-06-30
申请人： F. HOFFMANN-LA ROCHE AG , BRAMLAGE, Birgit , BRINKMANN, Ulrich , CROASDALE, Rebecca , DILL, Simone , DORMEYER, Wilma , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike , ICKENSTEIN, Ludger Markus , JAHN-HOFMANN, Kerstin , JOHN, Matthias , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
发明人： BRAMLAGE, Birgit , BRINKMANN, Ulrich , CROASDALE, Rebecca , DILL, Simone , DORMEYER, Wilma , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike , ICKENSTEIN, Ludger Markus , JAHN-HOFMANN, Kerstin , JOHN, Matthias , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原是PEG或生物素，最优选地高辛，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有所述抗体及其用途。

5. 发明申请

WO2011003557A1 A COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 审中-公开
标题翻译：复合物与特异性抗体和联合治疗或诊断代谢的二氢吉他宁
公开(公告)号：WO2011003557A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/004051
申请日：2010-07-05
申请人： F. HOFFMANN-LA ROCHE AG , BRINKMANN, Ulrich , CROASDALE, Rebecca , DORMEYER, Wilma , GEORGES, Guy , HAAS, Alexander , HOFFMANN, Eike , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , DORMEYER, Wilma , GEORGES, Guy , HAAS, Alexander , HOFFMANN, Eike , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途，含有所述抗体的药物组合物及其用途。

6. 发明申请

WO2011003996A1 IN VIVO TUMOR VASCULATURE IMAGING 审中-公开
标题翻译：血管成像肿瘤体内
公开(公告)号：WO2011003996A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059858
申请日：2010-07-09
申请人： F. Hoffmann-La Roche AG , DOBOSZ, Michael , KLEIN, Christian , SAM, Johannes , SCHEUER, Werner
发明人： DOBOSZ, Michael , KLEIN, Christian , SAM, Johannes , SCHEUER, Werner
IPC分类号： A61K49/00 , C07K16/28 , C07K16/30
CPC分类号： A61K49/0058
摘要： The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject.
摘要翻译：本发明涉及非侵入性的方法和在受试者中使用的肿瘤脉管系统的体内成像方法，包括检测抗CD31荧光标记的抗体。在另一个方面，本发明涉及非侵入性的方法和在受试者中使用用于抗血管生成剂的治疗功效的体内监测，包括检测标记的抗CD31抗体通过荧光检测。此外，本发明涉及一种用于在本发明中，其包括一个抗CD31荧光标记以及用于近红外荧光成像的抗体来检测抗体在受试者的方法中使用的试剂盒。

7. 发明申请

WO2011138462A1 DIAGNOSTIC METHOD FOR THE DETECTION OF CELLS EX VIVO 审中-公开
标题翻译：用于检测细胞的诊断方法
公开(公告)号：WO2011138462A1
公开(公告)日：2011-11-10
申请号：PCT/EP2011/057400
申请日：2011-05-09
申请人： F. HOFFMANN-LA ROCHE AG , DOBOSZ, Michael , SCHEUER, Werner
发明人： DOBOSZ, Michael , SCHEUER, Werner
IPC分类号： G01N33/574 , A61K39/395 , A61K49/16 , C07K16/18 , C07K16/28
CPC分类号： G01N33/566 , A61K49/0032 , A61K49/0058 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K16/4291 , G01N33/57484 , G01N33/57492
摘要： The present invention relates in essence to a method for detecting a subset of cells with a binding domain which is specific for a target which characterizes said subset of cells, which method comprises detecting, ex vivo, said subset of cells, wherein said binding domain is to be administered to a subject which comprises or is assumed to comprise said subset of cells, prior to the removal of said subset of cells. The present invention also relates to the use of a binding domain as defined herein in a method defined herein. The use of a binding domain as defined herein for the preparation of a diagnostic composition to be used in a method defined herein is also envisaged. In another aspect, the present invention relates to the binding domain as defined herein to be used in a method defined herein. Kits comprising a binding domain as defined herein and means to administer said binding domain to a subject, and, optionally, means to detect said binding domain with a method defined herein, are also disclosed. In another aspect, the present invention relates to the use of a binding domain, preferably a therapeutically effective antibody like for example alemtuzumab, apolizumab, cetuximab, epratuzumab, galiximab, gemtuzumab, ipilimumab, labetuzumab, panitumumab, rituximab, trastuzumab, nimotuzumab, mapatumumab, matuzumab, rhMab ICR62, rhMab B-Ly1 and pertuzumab etc including combinations thereof, for the preparation of a pharmaceutical composition for the treatment of patients disposed to respond favorably to said binding domain as identified by a method defined herein.
摘要翻译：本发明实质上涉及一种用于检测细胞子集的方法，所述结合域具有针对表征所述细胞亚群的靶特异性的结合域，所述方法包括离体检测细胞的所述子集，其中所述结合域为在除去所述细胞子集之前，将其施用于包含或假设包含细胞子集的受试者。本发明还涉及如本文定义的方法中定义的结合结构域的用途。还设想使用如本文所定义的结合结构域来制备用于本文定义的方法中的诊断组合物。在另一方面，本发明涉及如本文所定义的用于本文定义的方法的结合结构域。还公开了包含如本文所定义的结合结构域的试剂盒和将受试者施用所述结合结构域的手段，以及任选地使用本文定义的方法检测所述结合结构域的手段。另一方面，本发明涉及结合结构域，优选治疗有效的抗体，例如阿仑单抗，阿朴替珠单抗，西妥昔单抗，依普珠单抗，加利昔单抗，吉妥单抗，伊曲单抗，拉替珠单抗，帕尼单抗，利妥昔单抗，曲妥珠单抗，尼妥珠单抗， matuzumab，rhMab ICR62，rhMab B-Ly1和pertuzumab等包括其组合，用于制备用于治疗患者的药物组合物，所述药物组合物用于通过本文定义的方法鉴定的所述结合结构域有利地响应。

8. 发明申请

WO2008022746A1 TUMOR THERAPY WITH AN ANTI-VEGF ANTIBODY 审中-公开
标题翻译：肿瘤治疗与抗VEGF抗体
公开(公告)号：WO2008022746A1
公开(公告)日：2008-02-28
申请号：PCT/EP2007/007276
申请日：2007-08-17
申请人： F. HOFFMANN-LA ROCHE AG , FRIESS, Thomas , HASMANN, Max , SCHEUER, Werner
发明人： FRIESS, Thomas , HASMANN, Max , SCHEUER, Werner
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/545 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a method of treating a patient suffering from relapsed HER2 positive cancer with an anti-VEGF antibody during or after treatment with an anti-HER2 antibody. The invention also provides corresponding articles of manufacture.
摘要翻译：本发明提供了在用抗HER2抗体治疗期间或之后用抗VEGF抗体治疗患有复发性HER2阳性癌症的患者的方法。本发明还提供了相应的制造品。

9. 发明申请

WO2012120004A1 IN VIVO SELECTION OF THERAPEUTICALLY ACTIVE ANTIBODIES 审中-公开
标题翻译：在体内选择治疗活性抗体
公开(公告)号：WO2012120004A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/053801
申请日：2012-03-06
申请人： F. HOFFMANN-LA ROCHE AG , DOBOSZ, Michael , SCHEUER, Werner
发明人： DOBOSZ, Michael , SCHEUER, Werner
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0058 , A61K49/0008 , A61K49/0032
摘要： The present invention relates to non-invasive methods of in vivoselecting an antibody against a desired target on the surface of a mammalian cell of a subject by applying near-infrared fluorescence imaging (NIRF) as well as uses of NIRF in such methods. In addition, kits for the use in these methods comprising a panel of potentially therapeutic effective fluorescence labeled antibodies and means for NIRF imaging are provided.
摘要翻译：本发明涉及通过应用近红外荧光成像（NIRF）以及在这些方法中使用NIRF，在受试者的哺乳动物细胞表面上活跃选择抗体的非侵入性方法。此外，提供了用于这些方法的试剂盒，其包含一组潜在治疗有效的荧光标记的抗体和用于NIRF成像的装置。

10. 发明申请

WO2007107329A1 TUMOR THERAPY WITH AN ANTIBODY FOR VASCULAR ENDOTHELIAL GROETH FACTOR AND AN ANTIBODY FOR HUMAN EPITHELIAL GROWTH FACTOR RECEPTOR TYPE 2 审中-公开
标题翻译：肿瘤治疗用于血管内皮细胞因子的抗体和人上皮生长因子受体2型的抗体
公开(公告)号：WO2007107329A1
公开(公告)日：2007-09-27
申请号：PCT/EP2007/002448
申请日：2007-03-20
申请人： F. HOFFMANN-LA ROCHE AG , FRIESS, Thomas , HASMANN, Max , SCHEUER, Werner
发明人： FRIESS, Thomas , HASMANN, Max , SCHEUER, Werner
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： A61K39/39558 , A61K39/3955 , A61K2039/507 , C07K16/22 , C07K16/3015 , C07K16/32 , C07K2317/24
摘要： The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding articles of manufacture and pharmaceutical compositions.
摘要翻译：本发明提供了一种治疗患有先前用抗VEGF抗体治疗失败的患者的乳腺癌疾病的方法，其包括向患者施用治疗有效量的抗HER2抗体，同时继续进行所述抗VEGF抗体治疗。本发明还提供相应的制品和药物组合物。

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