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1. 发明申请

WO2013113663A1 METHOD FOR THE DETECTION OF A BINDING PARTNER OF A MULTISPECIFIC BINDER 审中-公开
标题翻译：用于检测多重绑定的绑定伙伴的方法
公开(公告)号：WO2013113663A1
公开(公告)日：2013-08-08
申请号：PCT/EP2013/051604
申请日：2013-01-29
申请人： F. HOFFMANN-LA ROCHE AG , STUBENRAUCH, Kay-Gunnar , WESSELS, Uwe
发明人： STUBENRAUCH, Kay-Gunnar , WESSELS, Uwe
IPC分类号： G01N33/543
CPC分类号： G01N33/6854 , G01N33/54306 , G01N2333/00
摘要： Herein is reported a method for the detection of free antigen of a multispecific antibody in a sample, whereby the antigen to be detected can be specifically bound by a first binding site of the multispecific antibody, comprising the step of incubating a sample comprising free antigen and multispecific antibody with an anti-idiotypic antibody, which specifically binds to a second binding specificity of the bispecific antibody, which is different from the first binding specificity, whereby the anti-idiotypic antibody is bound to a solid phase.
摘要翻译：本文报道了用于检测样品中多特异性抗体的游离抗原的方法，其中待检测的抗原可以被多特异性抗体的第一结合位点特异性结合，其包括将包含游离抗原和具有抗特异性抗体的多特异性抗体，其特异性结合双特异性抗体的第二结合特异性，其不同于第一结合特异性，由此抗独特型抗体结合固相。

2. 发明申请

WO2009077127A1 DISTINGUISHING ASSAY 审中-公开
标题翻译：鉴别测定
公开(公告)号：WO2009077127A1
公开(公告)日：2009-06-25
申请号：PCT/EP2008/010575
申请日：2008-12-12
申请人： F. HOFFMANN-LA ROCHE AG , STUBENRAUCH, Kay-Gunnar , ZADAK, Markus
发明人： STUBENRAUCH, Kay-Gunnar , ZADAK, Markus
IPC分类号： G01N33/576 , G01N33/68 , G01N33/94
CPC分类号： G01N33/94 , G01N33/6854
摘要： The current invention comprises a method for determining of an antibody against a drug antibody in a sample using an immunoassay comprising a capture drug antibody and a tracer drug antibody, wherein the method comprises providing i) a capture drug antibody, which is the drug antibody conjugated to a solid phase, ii) a tracer drug antibody, which is the drug antibody conjugated to a detectable label, contacting the capture drug antibody separately with i) the sample, ii) the sample, to which the drug antibody in monomeric form has been added, iii) the sample, to which the drug antibody in oligomeric form has been added, and determining an antibody against the drug antibody in the sample by a positive immunoassay in i) and a negative immunoassay in ii) and iii).
摘要翻译：本发明包括使用包含捕获药物抗体和示踪药物抗体的免疫测定来测定样品中抗体的抗体的方法，其中所述方法包括提供i）捕获药物抗体，其为药物抗体缀合的 ii）示踪剂药物抗体，其是与可检测标记缀合的药物抗体，其将捕获药物抗体与i）样品分开接触，ii）样品，单体形式的药物抗体已经 iii）已经加入寡聚形式的药物抗体的样品，并且通过i）中的阳性免疫测定和ii）和iii）中的阴性免疫测定法确定样品中抗体的抗体。

3. 发明申请

WO2006066912A9 DETECTION OF A THERAPEUTIC ANTIBODY IN AN EXPERIMENTAL ANIMAL 审中-公开
标题翻译：在实验动物中检测治疗性抗体
公开(公告)号：WO2006066912A9
公开(公告)日：2007-02-22
申请号：PCT/EP2005013849
申请日：2005-12-22
申请人： HOFFMANN LA ROCHE , LENZ HELMUT , STUBENRAUCH KAY-GUNNAR
发明人： LENZ HELMUT , STUBENRAUCH KAY-GUNNAR
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K16/4283
摘要： The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. A monoclonal antibody directed to a certain epitope that is present on all classes of human immunoglobulin of class G, but not on the immunoglobulin of any experimental animal except on the IgG of chimpanzees was used (MAB-M-R10Z8E9) .
摘要翻译：本发明涉及治疗性抗体领域。它特别涉及实验动物中治疗性抗体的研究。本发明公开了一种检测从实验动物获得的样品中的治疗性抗体的方法，包括以下步骤：a）提供待分析的样品，b）将所述样品与结合治疗性抗体的抗体孵育，所述实验动物的免疫球蛋白，c）任选地使用适于选择性检测总体，活性或抗原结合的治疗性抗体的试剂培养所述样品，以及d）使（b）或（c）中形成的复合物与所述治疗性抗体。（MAB-M-R10Z8E9）使用针对存在于G类人免疫球蛋白的所有类别但不在任何实验动物的免疫球蛋白上的特定表位的单克隆抗体，除了黑猩猩的IgG。

4. 发明申请

WO2005100402A1 ANTI-P-SELECTIN ANTIBODIES 审中-公开
标题翻译：抗P-选择素抗体
公开(公告)号：WO2005100402A1
公开(公告)日：2005-10-27
申请号：PCT/EP2005/003581
申请日：2005-04-05
申请人： F.HOFFMANN-LA ROCHE AG , GRAUS, Yvo , HIMBER, Jacques , JANSEN-MOLENAAR, Miranda , KLING, Dorothee , KOPETZKY, Erhard , PARREN, Paul , REBERS, Frank , STEINER, Beat , STERN, Anne , STREIN, Pamela , STUBENRAUCH, Kay-Gunnar , VAN DE WINKEL, Jan , VAN VUGT, Martine
发明人： GRAUS, Yvo , HIMBER, Jacques , JANSEN-MOLENAAR, Miranda , KLING, Dorothee , KOPETZKY, Erhard , PARREN, Paul , REBERS, Frank , STEINER, Beat , STERN, Anne , STREIN, Pamela , STUBENRAUCH, Kay-Gunnar , VAN DE WINKEL, Jan , VAN VUGT, Martine
IPC分类号： C07K16/28
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译：本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子Clq的抗P-选择蛋白抗体及其变体。这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。

5. 发明申请

WO2012022682A1 ANTI-HUMAN IGG1 ANTIBODY 审中-公开
标题翻译：抗人IGG1抗体
公开(公告)号：WO2012022682A1
公开(公告)日：2012-02-23
申请号：PCT/EP2011/063906
申请日：2011-08-12
申请人： F. HOFFMANN-LA ROCHE AG , ESSIG, Ulrich , KLOSTERMANN, Stefan , KOWALEWSKY, Frank , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf , WESSELS, Uwe
发明人： ESSIG, Ulrich , KLOSTERMANN, Stefan , KOWALEWSKY, Frank , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf , WESSELS, Uwe
IPC分类号： C07K16/42 , G01N33/68
CPC分类号： G01N33/686 , C07K16/4241 , C07K16/4283 , C07K2317/14 , C07K2317/30 , C07K2317/33 , C07K2317/54 , C07K2317/92 , G01N33/6854
摘要： Herein are reported a monoclonal antibody specifically binding to a human IgG1 antibody and not specifically binding to the immunoglobulin of an experimental animal and the use of the antibody in immunoassays.
摘要翻译：本文报道了与人IgG1抗体特异性结合并且不特异性结合实验动物免疫球蛋白的单克隆抗体以及免疫测定中所述抗体的用途。

6. 发明申请

WO2011048043A1 NON-CROSS-REACTIVE ANTI IgG ANTIBODIES 审中-公开
标题翻译：非交叉抗体IgG抗体
公开(公告)号：WO2011048043A1
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065617
申请日：2010-10-18
申请人： F. HOFFMANN-LA ROCHE AG , ESSIG, Ulrich , KLOSTERMANN, Stefan , KOWALEWSKY, Frank , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf , WESSELS, Uwe
发明人： ESSIG, Ulrich , KLOSTERMANN, Stefan , KOWALEWSKY, Frank , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf , WESSELS, Uwe
IPC分类号： G01N33/68 , C07K16/42
CPC分类号： C07K16/4283 , G01N33/6854
摘要： Herein are reported the cell lines DSM ACC3006, DSM ACC3007, and DSM ACC3008, as well as the antibodies obtained from the cell lines and the use of an antibody obtained from the cell lines in an immunoassay. Also are reported antibodies binding to human or chimpanzee IgG and not binding to canine and marmoset IgG and antibodies specifically binding to an IgGl that comprises a kappa light chain constant domain.
摘要翻译：本文报道了细胞系DSM ACC3006，DSM ACC3007和DSM ACC3008，以及从细胞系获得的抗体以及在免疫测定中从细胞系获得的抗体的用途。还报告了结合人或黑猩猩IgG的抗体，并且不结合犬和m猴IgG以及特异性结合包含κ轻链恒定结构域的IgG1的抗体。

7. 发明申请

WO2008031532A1 ANTI-DRUG ANTIBODY ASSAY 审中-公开
标题翻译：抗药物抗体测定
公开(公告)号：WO2008031532A1
公开(公告)日：2008-03-20
申请号：PCT/EP2007/007803
申请日：2007-09-07
申请人： F. HOFFMANN-LA ROCHE AG , ESSIG, Ulrich , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf , WESSELS, Uwe
发明人： ESSIG, Ulrich , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf , WESSELS, Uwe
IPC分类号： G01N33/68 , G01N33/564
CPC分类号： G01N33/6854 , C07K16/065 , C07K16/42 , C07K16/4283 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/52
摘要： The invention provides an antibody binding specifically to Cynomolgus IgG characterized by not binding to Human IgG, and a method for the immunological determination of an immune complex (DA/ADA complex) of a drug antibody (DA) and an antibody against said drug antibody (anti-drug antibody, ADA) in a sample of a monkey species using a double antigen bridging immunoassay.
摘要翻译：本发明提供了特异性结合人IgG的食蟹猴特异性结合的抗体，以及药物抗体（DA）和针对所述药物抗体的抗体的免疫复合物（DA / ADA复合物）的免疫学测定方法抗药物抗体ADA）在使用双抗原桥接免疫测定的猴物种的样品中。

8. 发明申请

WO2006066912A3 DETECTION OF A THERAPEUTIC ANTIBODY IN AN EXPERIMENTAL ANIMAL 审中-公开
标题翻译：在实验动物中检测治疗性抗体
公开(公告)号：WO2006066912A3
公开(公告)日：2006-08-10
申请号：PCT/EP2005013849
申请日：2005-12-22
申请人： HOFFMANN LA ROCHE , LENZ HELMUT , STUBENRAUCH KAY-GUNNAR
发明人： LENZ HELMUT , STUBENRAUCH KAY-GUNNAR
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C07K16/4283
摘要： The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. A monoclonal antibody directed to a certain epitope that is present on all classes of human immunoglobulin of class G, but not on the immunoglobulin of any experimental animal except on the IgG of chimpanzees was used (MAB-M-R10Z8E9) .
摘要翻译：本发明涉及治疗性抗体领域。它特别涉及实验动物中治疗性抗体的研究。本发明公开了一种检测从实验动物获得的样品中的治疗性抗体的方法，包括以下步骤：a）提供待分析的样品，b）将所述样品与结合治疗性抗体的抗体孵育，所述实验动物的免疫球蛋白，c）任选地使用适于选择性检测总体，活性或抗原结合的治疗性抗体的试剂培养所述样品，以及d）使（b）或（c）中形成的复合物与所述治疗性抗体。（MAB-M-R10Z8E9）使用针对存在于G类人免疫球蛋白的所有类别但不在任何实验动物的免疫球蛋白上的特定表位的单克隆抗体，除了黑猩猩的IgG。

9. 发明申请

WO2010072384A1 ANTI-IDIOTYPE ANTIBODY AGAINST AN ANTIBODY AGAINST THE AMYLOID β PEPTIDE 审中-公开
标题翻译：抗抗原抗体对抗AMYLOIDß肽的抗体
公开(公告)号：WO2010072384A1
公开(公告)日：2010-07-01
申请号：PCT/EP2009/009160
申请日：2009-12-18
申请人： F. HOFFMANN-LA ROCHE AG , ESSIG, Ulrich , HOESEL, Wolfgang , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf
发明人： ESSIG, Ulrich , HOESEL, Wolfgang , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf
IPC分类号： C07K16/42
CPC分类号： G01N33/686 , C07K16/4241 , C07K2317/56 , C07K2317/565 , G01N2333/4709 , G01N2469/20
摘要： The current invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is an immunoassay for the determination of an antibody against the amyloid β peptide and for determination of an anti-idiotype antibody binding to an antibody against the amyloid β peptide.
摘要翻译：本发明涉及结合抗Aβ淀粉样蛋白抗体的互补决定区的抗独特型抗体。在一个实施方案中，所述抗体结合与从细胞系DSM ACC2939获得的抗体相同的表位或重叠表位。还报道了用于测定针对淀粉样蛋白β肽的抗体的免疫测定和用于测定结合抗淀粉样蛋白β肽的抗体的抗独特型抗体。

10. 发明申请

WO2007101661A1 ANTI-DRUG ANTIBODY ASSAY 审中-公开
标题翻译：抗药物抗体测定
公开(公告)号：WO2007101661A1
公开(公告)日：2007-09-13
申请号：PCT/EP2007/001935
申请日：2007-03-07
申请人： F.HOFFMANN-LA ROCHE AG , HOESEL, Wolfgang , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf
发明人： HOESEL, Wolfgang , STUBENRAUCH, Kay-Gunnar , VOGEL, Rudolf
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/54353 , G01N33/54393 , G01N33/686
摘要： The invention provides a method for the immunological determination of an antibody against a drug antibody in a sample using a double antigen bridging immunoassay comprising a capture drug antibody and a tracer drug antibody, characterized in that the capture drug antibody is a mixture of said drug antibody conjugated to the solid phase at at least two different antibody sites and the tracer drug antibody is a mixture of said drug antibody conjugated to the detectable label at at least two different antibody sites.
摘要翻译：本发明提供了使用包含捕获药物抗体和示踪药物抗体的双抗原桥接免疫测定免疫测定样品中抗体的抗体的方法，其特征在于捕获药物抗体是所述药物抗体的混合物在至少两个不同抗体位点与固相缀合，示踪药物抗体是在至少两个不同抗体位点缀合至可检测标记的所述药物抗体的混合物。

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