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1. 发明申请

WO2011003996A1 IN VIVO TUMOR VASCULATURE IMAGING 审中-公开
标题翻译：血管成像肿瘤体内
公开(公告)号：WO2011003996A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059858
申请日：2010-07-09
申请人： F. Hoffmann-La Roche AG , DOBOSZ, Michael , KLEIN, Christian , SAM, Johannes , SCHEUER, Werner
发明人： DOBOSZ, Michael , KLEIN, Christian , SAM, Johannes , SCHEUER, Werner
IPC分类号： A61K49/00 , C07K16/28 , C07K16/30
CPC分类号： A61K49/0058
摘要： The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject.
摘要翻译：本发明涉及非侵入性的方法和在受试者中使用的肿瘤脉管系统的体内成像方法，包括检测抗CD31荧光标记的抗体。在另一个方面，本发明涉及非侵入性的方法和在受试者中使用用于抗血管生成剂的治疗功效的体内监测，包括检测标记的抗CD31抗体通过荧光检测。此外，本发明涉及一种用于在本发明中，其包括一个抗CD31荧光标记以及用于近红外荧光成像的抗体来检测抗体在受试者的方法中使用的试剂盒。

2. 发明申请

WO2012120004A1 IN VIVO SELECTION OF THERAPEUTICALLY ACTIVE ANTIBODIES 审中-公开
标题翻译：在体内选择治疗活性抗体
公开(公告)号：WO2012120004A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/053801
申请日：2012-03-06
申请人： F. HOFFMANN-LA ROCHE AG , DOBOSZ, Michael , SCHEUER, Werner
发明人： DOBOSZ, Michael , SCHEUER, Werner
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0058 , A61K49/0008 , A61K49/0032
摘要： The present invention relates to non-invasive methods of in vivoselecting an antibody against a desired target on the surface of a mammalian cell of a subject by applying near-infrared fluorescence imaging (NIRF) as well as uses of NIRF in such methods. In addition, kits for the use in these methods comprising a panel of potentially therapeutic effective fluorescence labeled antibodies and means for NIRF imaging are provided.
摘要翻译：本发明涉及通过应用近红外荧光成像（NIRF）以及在这些方法中使用NIRF，在受试者的哺乳动物细胞表面上活跃选择抗体的非侵入性方法。此外，提供了用于这些方法的试剂盒，其包含一组潜在治疗有效的荧光标记的抗体和用于NIRF成像的装置。

3. 发明申请

WO2011138462A1 DIAGNOSTIC METHOD FOR THE DETECTION OF CELLS EX VIVO 审中-公开
标题翻译：用于检测细胞的诊断方法
公开(公告)号：WO2011138462A1
公开(公告)日：2011-11-10
申请号：PCT/EP2011/057400
申请日：2011-05-09
申请人： F. HOFFMANN-LA ROCHE AG , DOBOSZ, Michael , SCHEUER, Werner
发明人： DOBOSZ, Michael , SCHEUER, Werner
IPC分类号： G01N33/574 , A61K39/395 , A61K49/16 , C07K16/18 , C07K16/28
CPC分类号： G01N33/566 , A61K49/0032 , A61K49/0058 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K16/4291 , G01N33/57484 , G01N33/57492
摘要： The present invention relates in essence to a method for detecting a subset of cells with a binding domain which is specific for a target which characterizes said subset of cells, which method comprises detecting, ex vivo, said subset of cells, wherein said binding domain is to be administered to a subject which comprises or is assumed to comprise said subset of cells, prior to the removal of said subset of cells. The present invention also relates to the use of a binding domain as defined herein in a method defined herein. The use of a binding domain as defined herein for the preparation of a diagnostic composition to be used in a method defined herein is also envisaged. In another aspect, the present invention relates to the binding domain as defined herein to be used in a method defined herein. Kits comprising a binding domain as defined herein and means to administer said binding domain to a subject, and, optionally, means to detect said binding domain with a method defined herein, are also disclosed. In another aspect, the present invention relates to the use of a binding domain, preferably a therapeutically effective antibody like for example alemtuzumab, apolizumab, cetuximab, epratuzumab, galiximab, gemtuzumab, ipilimumab, labetuzumab, panitumumab, rituximab, trastuzumab, nimotuzumab, mapatumumab, matuzumab, rhMab ICR62, rhMab B-Ly1 and pertuzumab etc including combinations thereof, for the preparation of a pharmaceutical composition for the treatment of patients disposed to respond favorably to said binding domain as identified by a method defined herein.
摘要翻译：本发明实质上涉及一种用于检测细胞子集的方法，所述结合域具有针对表征所述细胞亚群的靶特异性的结合域，所述方法包括离体检测细胞的所述子集，其中所述结合域为在除去所述细胞子集之前，将其施用于包含或假设包含细胞子集的受试者。本发明还涉及如本文定义的方法中定义的结合结构域的用途。还设想使用如本文所定义的结合结构域来制备用于本文定义的方法中的诊断组合物。在另一方面，本发明涉及如本文所定义的用于本文定义的方法的结合结构域。还公开了包含如本文所定义的结合结构域的试剂盒和将受试者施用所述结合结构域的手段，以及任选地使用本文定义的方法检测所述结合结构域的手段。另一方面，本发明涉及结合结构域，优选治疗有效的抗体，例如阿仑单抗，阿朴替珠单抗，西妥昔单抗，依普珠单抗，加利昔单抗，吉妥单抗，伊曲单抗，拉替珠单抗，帕尼单抗，利妥昔单抗，曲妥珠单抗，尼妥珠单抗， matuzumab，rhMab ICR62，rhMab B-Ly1和pertuzumab等包括其组合，用于制备用于治疗患者的药物组合物，所述药物组合物用于通过本文定义的方法鉴定的所述结合结构域有利地响应。

4. 发明申请

WO2012119999A1 MEANS AND METHODS FOR IN VIVO TESTING OF THERAPEUTIC ANTIBODIES 审中-公开
标题翻译：治疗性抗体血清检测方法及方法
公开(公告)号：WO2012119999A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/053786
申请日：2012-03-06
申请人： F. Hoffmann-La Roche AG , DOBOSZ, Michael , SCHEUER, Werner
发明人： DOBOSZ, Michael , SCHEUER, Werner
IPC分类号： A61B5/00 , G01N21/64 , A61K49/00
CPC分类号： A61K49/0045 , A61B5/0059 , A61B5/0071 , A61B5/0073 , A61B5/0086 , A61K49/0032 , A61K49/0058 , G01N2800/52
摘要： The present invention provides methods and means for identifying a cancer-patient disposed to respond favourably to a therapeutic antibody as well as methods for in vivo selecting a xenograft tumor model which is most qualified for preclinical testing of a therapeutic antibody. These methods apply near-infrared fluorescence imaging which is an excellent imaging technology because of its simplicity, fast scanning times and non- hazardous radiation.
摘要翻译：本发明提供了用于鉴定被设置为对治疗性抗体有利地响应的癌症患者的方法和手段，以及用于体内选择最适合用于治疗性抗体的临床前测试的异种移植肿瘤模型的方法。这些方法应用近红外荧光成像技术，因为它的简单性，快速的扫描时间和无害的辐射，这是一种出色的成像技术。

5. 发明申请

WO2011012646A3 NON-INVASIVE IN VIVO OPTICAL IMAGING METHOD 审中-公开
公开(公告)号：WO2011012646A3
公开(公告)日：2011-02-03
申请号：PCT/EP2010/060957
申请日：2010-07-28
申请人： F. HOFFMANN-LA ROCHE AG , DOBOSZ, Michael , SCHEUER, Werner , STROBEL, Steffen
发明人： DOBOSZ, Michael , SCHEUER, Werner , STROBEL, Steffen
IPC分类号： A61B3/12 , A61B3/14 , A61B5/00 , G01N33/58 , G01N21/64 , A61K49/00
摘要： The present invention relates to a non-invasive method of determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of a fluorescent analyte which comprises a fluorescent entity and a second entity, in the blood of a subject, comprising or consisting of the steps: (a) directing excitation light of at least one predetermined wavelength onto a delineated region comprising at least a portion of the pupil of said subject, to excite the fluorescent entity, (b) receiving light emitted from said fluorescent analyte with a wavelength distinguishable from the predetermined wavelength of (a), through the eye of said subject, thereby determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of said fluorescent analyte in the blood of said subject. The present invention further relates to a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for use in any one of the preceding methods. The present invention furthermore relates to the use of a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for the preparation of a diagnostic composition which is to be employed in any one of the preceding methods. The present invention furthermore relates to a device for use in any of the methods defined herein.

6. 发明申请

WO2011012646A2 NON-INVASIVE IN VIVO OPTICAL IMAGING METHOD 审中-公开
标题翻译：非侵入式光学成像方法
公开(公告)号：WO2011012646A2
公开(公告)日：2011-02-03
申请号：PCT/EP2010060957
申请日：2010-07-28
申请人： HOFFMANN LA ROCHE , DOBOSZ MICHAEL , SCHEUER WERNER , STROBEL STEFFEN
发明人： DOBOSZ MICHAEL , SCHEUER WERNER , STROBEL STEFFEN
IPC分类号： A61B3/12 , A61B3/14 , A61B5/00 , A61K49/00 , G01N21/64 , G01N33/58
CPC分类号： G01N33/582 , A61B3/1241 , A61B5/0059 , A61B5/14555 , A61B5/415 , A61B5/418 , A61K49/0021 , A61K49/0032 , A61K49/0034 , G01N21/6408 , G01N21/6428
摘要： The present invention relates to a non-invasive method of determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of a fluorescent analyte which comprises a fluorescent entity and a second entity, in the blood of a subject, comprising or consisting of the steps: (a) directing excitation light of at least one predetermined wavelength onto a delineated region comprising at least a portion of the pupil of said subject, to excite the fluorescent entity, (b) receiving light emitted from said fluorescent analyte with a wavelength distinguishable from the predetermined wavelength of (a), through the eye of said subject, thereby determining the presence, quantifying the blood level, and/or monitoring or determining the blood clearance of said fluorescent analyte in the blood of said subject. The present invention further relates to a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for use in any one of the preceding methods. The present invention furthermore relates to the use of a fluorescent analyte or fluorescent label as defined in any one of the preceding claims for the preparation of a diagnostic composition which is to be employed in any one of the preceding methods. The present invention furthermore relates to a device for use in any of the methods defined herein.
摘要翻译：本发明涉及一种在受试者的血液中确定包含荧光实体和第二实体的荧光分析物的存在，量化血液水平和/或监测或确定荧光分析物的血液清除率的非侵入性方法，包括或由以下步骤组成：（a）将至少一个预定波长的激发光引导到包括所述受试者的瞳孔的至少一部分的描绘区域上，以激发荧光实体，（b）接收从所述荧光通过所述受试者的眼睛，可识别具有与（a）的预定波长区分开的波长的分析物，从而确定存在，定量血液水平，和/或监测或确定所述受试者血液中所述荧光分析物的血液清除率。本发明还涉及如前述权利要求中任一项所述的荧光分析物或荧光标记，用于上述任一方法。本发明还涉及如前述权利要求中任一项所述的荧光分析物或荧光标记物在制备用于上述任一方法的诊断组合物中的用途。本发明还涉及用于本文定义的任何方法的装置。

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