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1. 发明申请

WO9416313A3 METHOD AND DEVICE FOR ASSESSING THE SUITABILITY OF BIOPOLYMERS 审中-公开
标题翻译：用于评估生物聚合物适用性的方法和装置
公开(公告)号：WO9416313A3
公开(公告)日：1994-09-29
申请号：PCT/EP9400117
申请日：1994-01-18
申请人： EVOTEC BIOSYSTEMS GMBH , RIGLER RUDOLF , EIGEN MANFRED , HENCO KARSTEN
发明人： RIGLER RUDOLF , EIGEN MANFRED , HENCO KARSTEN
IPC分类号： C12M1/34 , C12Q1/68 , G01N21/64 , G01N27/447 , G01N30/74 , G01N33/483 , G01N33/543 , G01N33/58
CPC分类号： G01N21/6402 , G01N21/6428 , G01N21/6458 , G01N2021/6417 , Y10S435/808 , Y10S436/805 , Y10T436/11
摘要： Disclosed is a method for the identification of one or a small number of molecules, in particular at a dilution of « 1 νM, by using laser-stimulated fluorescence correlation spectroscopy with measurement times of « 500 ms and short diffusion paths for the molecules under analysis, the measurement preferably being carried out on small volumes of « 10-14 litres to measure parameters specific to the material and which can be determined by luminescence measurements on the molecules under investigation. The device preferably used to carry out the method proposed has per se prior art microscope optics which focus the laser light used to stimulate the fluororescence of a highly dilute solution in a small measurement cell and to form an image from the emitted light in the subsequent measurement stage by confocal imaging. The optics used have a large numerical aperture of » 1.2 N.A., the amount of light is limited by an apertured diaphragm confocally disposed in the plane of the object after the objective lens of the microscope, and the measurement cell is positioned at a distance between 0 and 1,000 νm from the viewing lens.

2. 发明申请

WO9535492A3 PROCESS AND DEVICE FOR SELECTIVELY EXTRACTING COMPONENTS FROM COMPLEX MIXTURES 审中-公开
标题翻译：从复合混合物中选择性提取组分的方法和设备
公开(公告)号：WO9535492A3
公开(公告)日：1996-02-08
申请号：PCT/EP9502344
申请日：1995-06-16
申请人： EVOTEC BIOSYSTEMS GMBH , EIGEN MANFRED , RIGLER RUDOLF , HENCO KARSTEN
发明人： EIGEN MANFRED , RIGLER RUDOLF , HENCO KARSTEN
IPC分类号： B01L3/02 , B67D7/70 , C12M1/26 , G01N15/10
CPC分类号： B01L3/0268 , C12M33/07 , G01N15/10 , Y10T436/2575
摘要： The process of the invention facilitates the selective extraction of one or a few molecularly dispersed or cellular components of a system, like molecules, molecule complexes, vesicles, micells, cells, possibly with a relevant volume element V of size 10?-9 1 » 10-18¿ 1, from a larger sample volume. The required component is selectively transferred to another environment by setting the place and time of the extraction by means of a signal correlating the small component to be extracted. The process is particularly suitable for the extraction of rare components, the existence of which can be detected in a previous stage by means of a scanning process. The process is also suitable for the extraction of unidentified components.

3. 发明申请

WO0185991A3 METHOD FOR DETECTING POLYNUCLEOTIDES USING FLUORESCENCE CORRELATION SPECTROSCOPY 审中-公开
标题翻译：通过荧光相关光谱法检测的多核苷酸
公开(公告)号：WO0185991A3
公开(公告)日：2002-12-12
申请号：PCT/EP0105410
申请日：2001-05-11
申请人： GNOTHIS HOLDING SA , RIGLER RUDOLF , FOELDES-PAPP ZENO
发明人： RIGLER RUDOLF , FOELDES-PAPP ZENO
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6816
摘要： The invention relates to a method for detecting polynucleotides on a substrate, whereby the substrate contains a multitude of separate detection regions each accommodating different polynucleotides. The polynucleotides in the detection regions exist, contrary to known DNA chip test formats, in a form that is not bound to the substrate. The invention also relates to a device for implementing said method.
摘要翻译：本发明涉及一种用于在载体上，其中载体包括多个分开的检测区域，每个具有不同的多核苷酸的检测多核苷酸的方法。在检测区域中的多核苷酸是 - 与已知的DNA芯片试验格式 - 在非结合到载体形式。此外，用于执行该方法的设备被公开。

4. 发明申请

WO2009021732A3 METHOD FOR DETERMINING THE FLOW OF A FLUID CLOSE TO A SURFACE OF AN OBJECT IMMERSED IN THE FLUID 审中-公开
标题翻译：用于确定流体接近流体中所存在的物体的表面的流动的方法
公开(公告)号：WO2009021732A3
公开(公告)日：2009-04-23
申请号：PCT/EP2008006671
申请日：2008-08-13
申请人： RIGLER RUDOLF
发明人： RIGLER RUDOLF
IPC分类号： G01P5/22 , G01F1/708 , G01F1/712 , G01P5/26
CPC分类号： G01P5/22 , G01F1/7086 , G01F1/712 , G01P5/26
摘要： The invention relates to a Method for determining the flow of a fluid close to a surface of an object immersed in the fluid by analyzing at least one confocal measurement volume in the fluid, comprising the steps of: focusing light into the at least one confocal volume within the fluid; detecting and determining of at least one optical parameter of at least one particle comprised in the confocal volume; and determining the flow velocity of the fluid based on the determination of the at least one optical parameter using a correlation function, in particular an auto correlation function or a cross correlation function. Furthermore, the invention relates to an object immersed in a fluid and comprising a measuring device for carrying out the method.
摘要翻译：本发明涉及一种通过分析流体中的至少一个共聚焦测量体积来确定接近浸入流体中的物体表面的流体的流动的方法，包括以下步骤：将光聚焦到至少一个共焦体积在流体内检测和确定包含在共焦体积中的至少一个粒子的至少一个光学参数; 以及使用相关函数，特别是自相关函数或互相关函数，基于所述至少一个光学参数的确定来确定所述流体的流速。此外，本发明涉及浸没在流体中并包括用于执行该方法的测量装置的物体。

5. 发明申请

WO2005029153A3 SOLID IMMERSION LENS SPECTROSCOPY AND MICROSCOPE 审中-公开
标题翻译： SOLID-浸没透镜的光谱和显微
公开(公告)号：WO2005029153A3
公开(公告)日：2005-05-19
申请号：PCT/EP2004010302
申请日：2004-09-15
申请人： ZEISS CARL JENA GMBH , BRUNNER ROBERT , DIETRICH MARTIN , RAO RAMACHANDRA , SEROV ALEXANDRE , LASSER THEO , GOESCH MICHAEL , RIGLER RUDOLF
发明人： BRUNNER ROBERT , MARTIN DIETRICH , RAO RAMACHANDRA , SEROV ALEXANDRE , LASSER THEO , GOESCH MICHAEL , RIGLER RUDOLF
IPC分类号： G02B21/02 , G02B21/33
CPC分类号： G02B21/33 , G02B21/02
摘要： The invention relates to a solid immersion lens (SIL) for a microscope, comprising a lens system with a predetermined numerical aperture. The refractive index of the material of the solid immersion lens is selected in such a way that the numerical aperture of the lens system is higher when the solid immersion lens is connected to said lens system.
摘要翻译：它是提供（SIL）用于显微镜用具有预定的数值孔径，其中，所述固体浸没透镜的材料的折射率被选择为使得当物镜系统预羊Teter固体浸没透镜，物镜系统的数值孔径增大的透镜系统的固体lmmersionslinse ，

6. 发明申请

WO03052137A2 EVANESCENCE-BASED MULTIPLEX SEQUENCING METHOD 审中-公开
标题翻译：倏逝BASED多重测序法
公开(公告)号：WO03052137A2
公开(公告)日：2003-06-26
申请号：PCT/EP0214490
申请日：2002-12-18
申请人： GNOTHIS HOLDING SA , RIGLER RUDOLF
发明人： RIGLER RUDOLF
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/501 , C12Q2565/518 , C12Q2521/319 , C12Q2563/107
摘要： The invention relates to a method and a device for an evanescence-based multiplex sequencing of nucleic acid molecules that are immobilized on a support.
摘要翻译：本发明涉及一种方法和用于固定在载体的核酸分子基于消散-多重测序的装置。

7. 发明申请

WO0202795A3 MULTIPLEX SEQUENCING METHOD 审中-公开
标题翻译：多重测序法
公开(公告)号：WO0202795A3
公开(公告)日：2002-07-18
申请号：PCT/EP0107462
申请日：2001-06-29
申请人： GNOTHIS HOLDING SA , RIGLER RUDOLF
发明人： RIGLER RUDOLF
IPC分类号： B01J19/00 , C12M1/42 , C12Q1/00 , C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/501 , C12Q2563/107 , C12Q2521/319 , C12Q2525/107 , C12Q2565/1015
摘要： The invention relates to a method and to a device for the multiplex sequencing of nucleic acid molecules that are immobilized on a substrate.
摘要翻译：本发明涉及用于对固定在载体上的核酸分子进行多重测序的方法和设备。

8. 发明申请

WO0185990A3 METHOD AND DEVICE FOR SEPARATING MARKED BIOPOLYMERS 审中-公开
标题翻译：方法和装置分离TAGGED生物聚合物
公开(公告)号：WO0185990A3
公开(公告)日：2002-05-23
申请号：PCT/EP0105409
申请日：2001-05-11
申请人： GNOTHIS HOLDING S A , RIGLER RUDOLF
发明人： RIGLER RUDOLF
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： C12Q1/6813 , C12Q1/6869 , C12Q2565/125 , C12Q2563/107 , C12Q2537/143
摘要： The invention relates to a method and a device for detecting marked biopolymers, especially nucleic acid fragments in a gel matrix. A parallel separation takes place in a number of microcapillaries that are filled with a gel matrix.
摘要翻译：本发明涉及一种用于检测生物聚合物标记的方法和装置，特别是核酸片段在凝胶基质，其特征在于，一个平行分离成多个微毛细管填充有凝胶基质发生。

9. 发明申请

WO0238806A2 DETECTION OF NUCLEIC ACID POLYMORPHISMS 审中-公开
标题翻译：核酸多态性的检测
公开(公告)号：WO0238806A2
公开(公告)日：2002-05-16
申请号：PCT/EP0113120
申请日：2001-11-13
申请人： GNOTHIS HOLDING SA , RIGLER RUDOLF , EDMAN LARS , FOELDES PAPP ZENO
发明人： RIGLER RUDOLF , EDMAN LARS , FOELDES-PAPP ZENO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2537/163 , C12Q2525/186 , C12Q2563/149 , C12Q2563/107 , C12Q2535/101
摘要： The invention relates to methods that function at an individual molecule level, for characterising nucleotide polymorphisms.
摘要翻译：上有用于表征核苷酸多态性处理单分子水平上的工作方法进行说明。

10. 发明申请

WO0186285A3 DIRECT DETECTION OF INDIVIDUAL MOLECULES 审中-公开
标题翻译：单分子直接检测
公开(公告)号：WO0186285A3
公开(公告)日：2002-04-11
申请号：PCT/EP0105408
申请日：2001-05-11
申请人： GNOTHIS HOLDING SA , RIGLER RUDOLF
发明人： RIGLER RUDOLF
IPC分类号： B01L3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01J3/44 , G01N21/64 , G01N33/53 , C12Q1/68
CPC分类号： G01N21/6452 , B01J2219/00286 , B01J2219/00315 , B01J2219/00414 , B01J2219/00439 , B01J2219/00441 , B01J2219/00511 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B01L3/5027 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01J3/4412 , G01N21/6408 , G01N21/6428 , G01N33/5302 , G01N2021/6417
摘要： The invention relates to a method for directly detecting an analyte in a sample fluid while flowing inside a microchannel, and to a device suited for implementing said method.
摘要翻译：本发明涉及一种用于在微通道流动期间直接检测在样品液体中的分析物的，和用于其的设备的方法。

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