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1. 发明申请

WO2004106534A1 THE ENZYMATIC METHOD OF MAKING 1,2-DIOL DERIVATIVES AND THEIR ESTERS WITH SUCCINE ANHYDRIDE 审中-公开
标题翻译：制备1,2-二醇衍生物的方法及其与无水异氰酸酯的酯化
公开(公告)号：WO2004106534A1
公开(公告)日：2004-12-09
申请号：PCT/KR2004/001313
申请日：2004-06-02
申请人： ENZYTECH, LTD. , HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn , LEE, Tae Im , CHUNG, Sun Ho
发明人： HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn , LEE, Tae Im , CHUNG, Sun Ho
IPC分类号： C12P41/00
CPC分类号： C12P7/62 , C12P7/04 , C12P41/004
摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relates to the process for the preparation of optically active alcohols and their esters which are used as pharmaceutical intermediates by reacting the hydroxyl group stereospecifically by lipase after adding racemic alcohols represented by the general formula 1 and succinic anhydride as an acylating agent to the organic solvent. According to this invention, the primary hydroxyl group of 1,2-diols is transformed by other functional group and the secondary hydroxyl group is esterified stereospecifically with succinic anhydride as an acylating agent. Optically active alcohols and their esters of high optical purity in high yield can be produced by using succinic anhydride as an acylating agent because alcohols can be separated from their esters more easily than those of other conventional methods.
摘要翻译：本发明涉及制备由通式2表示的光学活性醇的新方法及其在方案1中由通式3表示的酯。更详细地说，本发明涉及制备光学活性的方法醇和它们的酯，其通过在将通式1表示的外消旋醇和琥珀酸酐作为酰化剂加入到有机溶剂中之后通过脂肪酶立体特异性地使羟基反应而用作药物中间体。根据本发明，1,2-二醇的伯羟基被其它官能团转变，仲羟基与琥珀酸酐作为酰化剂立体特异性酯化。通过使用琥珀酸酐作为酰化剂可以生产高产率的高光学纯度的光学活性醇及其酯，因为与其它常规方法相比，可以更容易地将醇与其酯分离。

2. 发明申请

WO2004097026A1 THE ENZYMATIC METHOD OF MAKING 1,2-DIOL DERIVATIVES AND THEIR ESTERS 审中-公开
标题翻译：制备1,2-二醇衍生物及其酯的方法
公开(公告)号：WO2004097026A1
公开(公告)日：2004-11-11
申请号：PCT/KR2004/001005
申请日：2004-04-30
申请人： ENZYTECH, LTD. , HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn
发明人： HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn
IPC分类号： C12P41/00
CPC分类号： C12P7/02 , C12P7/62 , C12P41/004
摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 by enzymatic method from racemic alcohols represented by the general formula 1 in scheme 1. In more details, this invention relates to a process for producing optically active alcohols and their esters which are used as pharmaceutical intermediates from alcohols represented by the general formula 1 by stereospecific transesterification of secondary hydroxyl group using lipases as catalyst with acyl donors in organic solvent or with acyl donors only without using organic solvent. According to this invention, optically active alcohols and esters of high optical purity in high yield can be produced by transforming the primary hydroxyl group of 1,2-diols by tosyl group and transesterifying the secondary hydroxyl group stereospecifically by lipase.
摘要翻译：本发明涉及由方案1中通式1表示的外消旋醇通过酶法由制备由通式2表示的光学活性醇及其由通式3表示的酯的新方法。更具体地，本发明涉及一种用于制备光学活性醇及其酯的方法，其通过使用脂肪酶作为催化剂的有机溶剂中的酰基供体的催化剂或仅与酰基供体的立体特异性酯交换作为由通式1表示的醇用作药物中间体不使用有机溶剂。根据本发明，可以通过将1,2-二醇的伯羟基转化成甲苯磺酰基并通过脂肪酶立体特异性酯交换酯化，可以制备高产率的高光学纯度的光学活性醇和酯。

3. 发明申请

WO2012091357A2 COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING 审中-公开
标题翻译：预防呕吐或呕吐的组合物
公开(公告)号：WO2012091357A2
公开(公告)日：2012-07-05
申请号：PCT/KR2011/009908
申请日：2011-12-21
申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION , SEO, Min Hyo , LEE, Sa Won , KIM, Do Hoon
发明人： SEO, Min Hyo , LEE, Sa Won , KIM, Do Hoon
IPC分类号： A61K31/4178 , A61K31/4184 , A61K31/573 , A61P1/08
CPC分类号： A61K31/573 , A61K9/0019 , A61K31/4178 , A61K31/4184 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： Provided is a composition for preventing nausea or vomiting, including a 5-HT 3 receptor antagonist and a corticosteroid, and having a pH adjusted to 3.0-6.0. Provided also is a method for preparing a composition for preventing nausea or vomiting, including: mixing a 5-HT 3 receptor antagonist with a corticosteroid; and adjusting pH of the mixture obtained from the preceding operation to 3.0-6.0.
摘要翻译：本发明提供用于预防恶心或呕吐的组合物，其包含5-HT 3受体拮抗剂和皮质类固醇，并且具有调节至3.0-6.0的pH。还提供了用于制备用于预防恶心或呕吐的组合物的方法，所述方法包括：将5-HT 3受体拮抗剂与皮质类固醇混合; 并将由前述操作获得的混合物的pH调节至3.0-6.0。

4. 发明申请

WO2009041790A1 NOVEL 2,4,5-TRISUBTITUTED-1,3-THIAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 2,4,5- TRISUBSTITUTED-1,3-THIAZOLE DERIVATIVES AS AN EFFECTIVE INGREDIENT 审中-公开
标题翻译：新的2,4,5-三唑-1,3-二噻唑衍生物及其药学上可接受的盐，其制备方法，由包含2,4,5-三唑基-1,3-噻唑衍生物的SPC活性诱发的炎症疾病的治疗剂一个
公开(公告)号：WO2009041790A1
公开(公告)日：2009-04-02
申请号：PCT/KR2008/005726
申请日：2008-09-26
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , AMOREPACIFIC CORPORATION , GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , JEONG, Dae Young , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyoung June , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
发明人： GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , JEONG, Dae Young , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyoung June , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
IPC分类号： C07D277/44 , A61K31/426 , A61P29/00
CPC分类号： C07D277/46 , C07D417/04 , C07D417/12
摘要： Provided are a 2,4,5-trisubstiuted-l,3-thiazole derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent for inflammatory disease induced by sphingosylphosphorylcholine (SPC). The 2,4,5-trisubstiuted-l,3-thiazole derivative of the present invention has been confirmed to have superior inhibition activity against SPC receptor in an animal experiment using human-derived endothelial cells and mice. Thus, a pharmaceutical composition for treating inflammatory disease containing the 2,4,5-trisubstiuted-l,3-thiazole derivative or a pharmaceutically acceptable salt thereof as an effective ingredient may be useful for treating inflammation, itching or skin infection associated with atopic dermatitis or other disease induced by SPC receptor.
摘要翻译：本发明提供由以下化学式1表示的2,4,5-三溴代-1,3-噻唑衍生物，其药学上可接受的盐，其制备方法及其作为治疗剂的有效成分的用途由鞘氨醇磷酰胆碱（SPC）引起的炎性疾病。在使用人源性内皮细胞和小鼠的动物实验中，已证实本发明的2,4,5-三溴代-1,3-噻唑衍生物对SPC受体具有优异的抑制活性。因此，用于治疗含有2,4,5-三溴代-1,3-噻唑衍生物或其药学上可接受的盐作为有效成分的炎性疾病的药物组合物可用于治疗与特应性皮炎相关的炎症，瘙痒或皮肤感染或由SPC受体诱导的其他疾病。

5. 发明申请

WO2010005144A1 PSEUDOLIPID COMPLEX MIXTURE AND A SKIN EXTERNAL APPLICATION COMPOSITION CONTAINING SAME 审中-公开
标题翻译： PSEUDOLIPID复合混合物和含有其的皮肤外用应用组合物
公开(公告)号：WO2010005144A1
公开(公告)日：2010-01-14
申请号：PCT/KR2008/005144
申请日：2008-09-02
申请人： AMOREPACIFIC CORPORATION , KIM, Do Hoon , AN, Eun Jung , HWANG, Jae Sung , SHIN, Hong Ju , PARK, Won Seok , YI, Chang Geun , PARK, Jong Hee , KIM, Jeong Hwan
发明人： KIM, Do Hoon , AN, Eun Jung , HWANG, Jae Sung , SHIN, Hong Ju , PARK, Won Seok , YI, Chang Geun , PARK, Jong Hee , KIM, Jeong Hwan
IPC分类号： A61K8/68
CPC分类号： A61K8/68 , A61K8/361 , A61K8/63 , A61Q19/007
摘要： Provided is a pseudolipid complex mixture comprising a pseudoceramide and a stearic acid and an external skin application composition comprising the same. The complex mixture has improved phase stability and a structure similar to that of the stratum corneum which can retain water and other beneficial materials, and accordingly the composition comprising the same can be used as an external skin application composition having improved moisturization and barrier repair capabilities.
摘要翻译：本发明提供一种假脂质复合物混合物，其包含假花被酰胺和硬脂酸，以及包含其的外用皮肤应用组合物。复合混合物具有改善的相稳定性和类似于可以保留水和其它有益材料的角质层的结构，因此包含其的组合物可以用作具有改善的保湿和阻隔修复能力的外用皮肤施用组合物。

6. 发明申请

WO2010010985A1 MULTI-LAYERED LAMELLAR GRANULE AND SKIN EXTERNAL APPLICATION COMPOSITION CONTAINING SAME 审中-公开
标题翻译：多层蓝宝石颗粒和皮肤外用应用组合物
公开(公告)号：WO2010010985A1
公开(公告)日：2010-01-28
申请号：PCT/KR2008/005143
申请日：2008-09-02
申请人： AMOREPACIFIC CORPORATION , KIM, Do Hoon , AN, Eun Jung , HWANG, Jae Sung , SHIN, Hong Ju , PARK, Won Seok , YI, Chang Geun , PARK, Jong Hee , KIM, Jeong Hwan , KIM, Jin Woong , SEO, Jung A , KIM, Yong Jin , SHIM, Jong Won , KIM, Mi Jin
发明人： KIM, Do Hoon , AN, Eun Jung , HWANG, Jae Sung , SHIN, Hong Ju , PARK, Won Seok , YI, Chang Geun , PARK, Jong Hee , KIM, Jeong Hwan , KIM, Jin Woong , SEO, Jung A , KIM, Yong Jin , SHIM, Jong Won , KIM, Mi Jin
IPC分类号： A61K9/16 , A61K45/00 , A61K9/127
CPC分类号： A61K9/5078 , A61K8/0245 , A61K8/68 , A61K9/0014 , A61K9/10 , A61K2800/412 , A61K2800/614 , A61Q19/007
摘要： Provided are: a multi-layered lamellar granule comprising a nucleating agent, a ceramide-containing artificial stratum corneum lipid lamellar layer which encases the nucleating agent and a polymer layer disposed on the artificial stratum corneum lipid lamellar layer; and an external skin application composition comprising the same. The external skin application composition shows improved moisturizing and barrier repair capabilities when applied to the skin, which can be advantageously used in cosmetics and pharmaceuticals.
摘要翻译：提供：包含成核剂，包含成核剂的含神经酰胺的人造角质层脂质层层和设置在人造角质层脂层上的聚合物层的多层片状颗粒; 和包含其的外用皮肤应用组合物。外用皮肤应用组合物在施用于皮肤时显示改善的保湿和屏障修复能力，其可有利地用于化妆品和药物中。

7. 发明申请

WO2009041789A2 NOVEL 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AS AN EFFECTIVE INGREDIENT 审中-公开
标题翻译：新型3-氯代-5-取代的喹喔啉-2-胺衍生物及其药学上可接受的盐，其制备方法，由含有3-氯代 - 喹啉-2-胺的SPC活性诱导的炎症疾病的治疗剂
公开(公告)号：WO2009041789A2
公开(公告)日：2009-04-02
申请号：PCT/KR2008/005725
申请日：2008-09-26
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , AMOREPACIFIC CORPORATION , GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , PARK, Woo-Kyu , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
发明人： GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , PARK, Woo-Kyu , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Provided are a 3-chloro-5-substiuted-quinoxalin-2-amine derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent for inflammatory disease induced by activity of sphingosyl phosphorylcholine (SPC) receptor. The 3-chloro-5-substiuted-quinoxalin-2-amine derivative of the present invention has been confirmed to have superior inhibition activity against SPC receptor in an animal experiment using human-derived endothelial cells and mice. Thus, a therapeutic agent for inflammatory disease containing the 3- chloro-5-substiuted-quinoxalin-2-amine derivative or a pharmaceutically acceptable salt thereof as an effective ingredient may be useful for treating inflammation, itching or skin infection associated with atopic dermatitis or other disease induced by activity of SPC receptor.
摘要翻译：本发明提供由以下化学式1表示的3-氯-5-取代喹喔啉-2-胺衍生物，其药学上可接受的盐，其制备方法及其作为治疗剂的有效成分的用途由鞘氨醇磷酰胆碱（SPC）受体活性引起的炎性疾病。在使用人源性内皮细胞和小鼠的动物实验中，已经证实本发明的3-氯-5-取代喹喔啉-2-胺衍生物对SPC受体具有优异的抑制活性。因此，含有3-氯-5-取代的喹喔啉-2-胺衍生物或其药学上可接受的盐作为有效成分的炎性疾病治疗剂可用于治疗与特应性皮炎相关的炎症，瘙痒或皮肤感染或其他由SPC受体活性引起的疾病。

8. 发明申请

WO2008127051A1 METHOD FOR DANCE GAME AND THE RECORDING MEDIA THEREIN READABLE BY COMPUTER 审中-公开
标题翻译：用于舞蹈游戏的方法和计算机可读的记录媒体
公开(公告)号：WO2008127051A1
公开(公告)日：2008-10-23
申请号：PCT/KR2008/002084
申请日：2008-04-14
申请人： NURIEN SOFTWARE , KU, Andrew , KIM, Taehoon , KIM, Do Hoon , KIM, Jong Sook , JEONG, KeeSeok , HONG, Hui Jeong
发明人： KU, Andrew , KIM, Taehoon , KIM, Do Hoon , KIM, Jong Sook , JEONG, KeeSeok , HONG, Hui Jeong
IPC分类号： G06Q50/00
CPC分类号： A63F13/814 , A63F13/10 , A63F13/12 , A63F13/46 , A63F13/5375 , A63F2300/8047
摘要： A dance game method and computer-readable storage medium storing instructions for implementing the dance game method is provided. The dance game method arouses a user's interest to feel a sensation of being assimilated with a virtual character dancing according to music.
摘要翻译：提供了一种舞蹈游戏方法和存储用于实现舞蹈游戏方法的指令的计算机可读存储介质。舞蹈游戏方法唤起用户的兴趣，感受到与虚拟角色一起被吸收的感觉，根据音乐跳舞。

9. 发明申请

WO2012087062A2 SUSTAINED-RELEASE POLYMERIC MICROPARTICLES CONTAINING POORLY WATER-SOLUBLE DRUG AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：含有不溶性水溶性药物的可持续释放聚合物微生物及其制备方法
公开(公告)号：WO2012087062A2
公开(公告)日：2012-06-28
申请号：PCT/KR2011/010030
申请日：2011-12-23
申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION , LEE, Sa won , KIM, Do Hoon , KIM, Bong Oh , SEO, Min Hyo
发明人： LEE, Sa won , KIM, Do Hoon , KIM, Bong Oh , SEO, Min Hyo
IPC分类号： A61K9/16 , A61K9/22 , A61K47/14 , A61K47/36
CPC分类号： A61K47/34 , A01N25/28 , A61K9/1635 , A61K9/1647 , A61K9/1694 , A61K31/175 , A61K31/27 , A61K31/436 , A61K31/485 , A61K31/519 , A61K31/554 , A61K31/565 , A61K31/57
摘要： Disclosed are sustained-release polymeric microparticles containing a poorly water-soluble drug and a method for preparing the same.
摘要翻译：公开了含有水难溶性药物的缓释性聚合物微粒及其制备方法。

10. 发明申请

WO2009057847A1 SUSTAINED-RELEASE NANOPARTICLE AND THE COSMETIC COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：持续释放纳米颗粒和含有它们的化妆品组合物
公开(公告)号：WO2009057847A1
公开(公告)日：2009-05-07
申请号：PCT/KR2007/005994
申请日：2007-11-26
申请人： AMOREPACIFIC CORPORATION , KIM, Do Hoon , SHIM, Jongwon , PARK, Chang Man , KIM, Jin Woong , KIM, Junch , KANG, Byung-Young
发明人： KIM, Do Hoon , SHIM, Jongwon , PARK, Chang Man , KIM, Jin Woong , KIM, Junch , KANG, Byung-Young
IPC分类号： A61K8/02
CPC分类号： A61K8/345 , A61K8/11 , A61K2800/412 , A61Q19/00
摘要： The present invention relates to a sustained-release nanoparticle and a cosmetic composition comprising the nanoparticle. Specifically, the present invention relates to a sustained-release nanoparticle that is prepared using phytantriol to inhibit an initial burst release of drugs or active ingredients and slowly release the drugs or active ingredients, and to a cosmetic composition comprising the nanoparticle.
摘要翻译：本发明涉及包含纳米颗粒的缓释纳米颗粒和化妆品组合物。具体地说，本发明涉及使用植物三醇制备抑制药物或活性成分的初始爆发释放并缓慢释放药物或活性成分的缓释纳米颗粒，以及包含纳米颗粒的化妆品组合物。

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