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1. 发明申请

WO2012091357A2 COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING 审中-公开
标题翻译：预防呕吐或呕吐的组合物
公开(公告)号：WO2012091357A2
公开(公告)日：2012-07-05
申请号：PCT/KR2011/009908
申请日：2011-12-21
申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION , SEO, Min Hyo , LEE, Sa Won , KIM, Do Hoon
发明人： SEO, Min Hyo , LEE, Sa Won , KIM, Do Hoon
IPC分类号： A61K31/4178 , A61K31/4184 , A61K31/573 , A61P1/08
CPC分类号： A61K31/573 , A61K9/0019 , A61K31/4178 , A61K31/4184 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： Provided is a composition for preventing nausea or vomiting, including a 5-HT 3 receptor antagonist and a corticosteroid, and having a pH adjusted to 3.0-6.0. Provided also is a method for preparing a composition for preventing nausea or vomiting, including: mixing a 5-HT 3 receptor antagonist with a corticosteroid; and adjusting pH of the mixture obtained from the preceding operation to 3.0-6.0.
摘要翻译：本发明提供用于预防恶心或呕吐的组合物，其包含5-HT 3受体拮抗剂和皮质类固醇，并且具有调节至3.0-6.0的pH。还提供了用于制备用于预防恶心或呕吐的组合物的方法，所述方法包括：将5-HT 3受体拮抗剂与皮质类固醇混合; 并将由前述操作获得的混合物的pH调节至3.0-6.0。

2. 发明申请

WO2011145785A1 OPTICAL MODULE AND FABRICATING METHOD THEREOF 审中-公开
标题翻译：光学模块及其制作方法
公开(公告)号：WO2011145785A1
公开(公告)日：2011-11-24
申请号：PCT/KR2010/006856
申请日：2010-10-07
申请人： HANTECH CO., LTD. , CHOI, Jae-Shik , JOO, Gwan-Chong , KIM, Do-Hoon , KIM, Jung-Taek , KIM, Hyo-Gyeom
发明人： CHOI, Jae-Shik , JOO, Gwan-Chong , KIM, Do-Hoon , KIM, Jung-Taek , KIM, Hyo-Gyeom
IPC分类号： G02B6/43
CPC分类号： G02B6/4249 , G02B6/4202 , G02B6/423 , G02B6/4281
摘要： Provided are an optical module and a method of fabricating the same. An optical fiber block includes an optical fiber array substrate having a plurality of receiving grooves in which optical fibers are respectively disposed, and an optical fiber array cover coupled to an upper surface of the optical fiber array substrate to fix the optical fiber. An optical bench has a plurality of through-holes in which the optical fibers protruding through a surface of the optical fiber block are respectively inserted. The number of the through-holes corresponds to the number of the receiving grooves formed in the optical fiber block. A first surface of the optical bench is fixed to the optical fiber block. An optical device block includes optical devices corresponding respectively to the through-holes formed in the optical bench. The optical device block is fixed to a second surface of the optical bench.
摘要翻译：提供了一种光学模块及其制造方法。光纤块包括具有分别布置有光纤的多个接收槽的光纤阵列基板和耦合到光纤阵列基板的上表面以固定光纤的光纤阵列盖。光学台具有多个通孔，分别插入穿过光纤块表面突出的光纤。通孔的数量对应于在光纤块中形成的接收槽的数量。光台的第一表面固定在光纤块上。光学器件块包括分别对应于形成在光学平台上的通孔的光学器件。光学器件块固定到光学台的第二表面。

3. 发明申请

WO2009041789A3 NOVEL 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMIN 审中-公开
标题翻译：新的3-氯-5-取代的喹喔啉-2-胺衍生物及其药学上可接受的盐，制备治疗由SPC活性引起的炎性疾病包含3-氯-5-取代的喹喔啉-2-胺的方法
公开(公告)号：WO2009041789A3
公开(公告)日：2009-05-14
申请号：PCT/KR2008005725
申请日：2008-09-26
申请人： KOREA RES INST CHEM TECH , AMOREPACIFIC CORP , GONG YOUNG-DAE , CHO HEEYEONG , JEON MOON-KOOK , LEE TAEHO , CHOI GILDON , KONG JAE-YANG , PARK WOO-KYU , HWANG SOON-HEE , KIM JUNG JU , LEE CHANG-HOON , KO JAEYOUNG , NOH MINSOO , HAN EUN SIL , KIM HYUK , YUN JUN-WON , MOH JOO HYUN , KIM DO HOON
发明人： GONG YOUNG-DAE , CHO HEEYEONG , JEON MOON-KOOK , LEE TAEHO , CHOI GILDON , KONG JAE-YANG , PARK WOO-KYU , HWANG SOON-HEE , KIM JUNG JU , LEE CHANG-HOON , KO JAEYOUNG , NOH MINSOO , HAN EUN SIL , KIM HYUK , YUN JUN-WON , MOH JOO HYUN , KIM DO HOON
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Provided are a 3-chloro-5-substiuted-quinoxalin-2-amine derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent for inflammatory disease induced by activity of sphingosyl phosphorylcholine (SPC) receptor. The 3-chloro-5-substiuted-quinoxalin-2-amine derivative of the present invention has been confirmed to have superior inhibition activity against SPC receptor in an animal experiment using human-derived endothelial cells and mice. Thus, a therapeutic agent for inflammatory disease containing the 3- chloro-5-substiuted-quinoxalin-2-amine derivative or a pharmaceutically acceptable salt thereof as an effective ingredient may be useful for treating inflammation, itching or skin infection associated with atopic dermatitis or other disease induced by activity of SPC receptor.
摘要翻译：本发明提供由以下化学式1表示的3-氯-5-取代的喹喔啉-2-胺衍生物，其药学上可接受的盐，其制备方法及其作为有效成分在治疗剂中的用途由鞘氨醇磷酸胆碱（SPC）受体活性诱导的炎性疾病。已证实本发明的3-氯-5-取代的喹喔啉-2-胺衍生物在使用源于人的内皮细胞和小鼠的动物实验中对SPC受体具有优异的抑制活性。因此，含有3-氯-5-取代的喹喔啉-2-胺衍生物或其药学上可接受的盐作为有效成分的炎症性疾病治疗剂可用于治疗与特应性皮炎相关的炎症，发痒或皮肤感染或其他由SPC受体活性诱导的疾病。

4. 发明申请

WO2004106534B1 THE ENZYMATIC METHOD OF MAKING 1,2-DIOL DERIVATIVES AND THEIR ESTERS WITH SUCCINE ANHYDRIDE 审中-公开
标题翻译：制备1,2-二醇衍生物的方法及其与无水异氰酸酯的酯化
公开(公告)号：WO2004106534B1
公开(公告)日：2005-06-16
申请号：PCT/KR2004001313
申请日：2004-06-02
申请人： ENZYTECH LTD , HWANG SOON OOK , KIM DO HOON , RYU HYE YOUN , LEE TAE IM , CHUNG SUN HO
发明人： HWANG SOON OOK , KIM DO HOON , RYU HYE YOUN , LEE TAE IM , CHUNG SUN HO
IPC分类号： C12P7/04 , C12P7/62 , C12P41/00
CPC分类号： C12P7/62 , C12P7/04 , C12P41/004
摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relates to the process for the preparation of optically active alcohols and their esters which are used as pharmaceutical intermediates by reacting the hydroxyl group stereospecifically by lipase after adding racemic alcohols represented by the general formula 1 and succinic anhydride as an acylating agent to the organic solvent. According to this invention, the primary hydroxyl group of 1,2-diols is transformed by other functional group and the secondary hydroxyl group is esterified stereospecifically with succinic anhydride as an acylating agent. Optically active alcohols and their esters of high optical purity in high yield can be produced by using succinic anhydride as an acylating agent because alcohols can be separated from their esters more easily than those of other conventional methods.
摘要翻译：本发明涉及制备由通式2表示的光学活性醇的新方法及其在方案1中由通式3表示的酯。更详细地说，本发明涉及制备光学活性的方法醇和它们的酯，其通过在将通式1表示的外消旋醇和琥珀酸酐作为酰化剂加入到有机溶剂中之后通过脂肪酶立体特异性地使羟基反应而用作药物中间体。根据本发明，1,2-二醇的伯羟基被其它官能团转变，仲羟基与琥珀酸酐作为酰化剂立体特异性酯化。通过使用琥珀酸酐作为酰化剂可以生产高产率的高光学纯度的光学活性醇及其酯，因为与其它常规方法相比，可以更容易地将醇与其酯分离。

5. 发明申请

WO2011122840A3 INHIBITOR FOR MELANIN, AND COSMETIC COMPOSITION CONTAINING SAME 审中-公开
标题翻译：用于梅毒素的抑制剂和含有它们的化妆品组合物
公开(公告)号：WO2011122840A3
公开(公告)日：2012-03-01
申请号：PCT/KR2011002170
申请日：2011-03-30
申请人： AMOREPACIFIC CORP , SHIN HONG JU , KIM DO HOON , KIM JEONG HWAN , KOH HYUN JU , PARK WON SEOK
发明人： SHIN HONG JU , KIM DO HOON , KIM JEONG HWAN , KOH HYUN JU , PARK WON SEOK
IPC分类号： A61K8/34 , A61K8/30 , A61K8/42 , A61Q19/00
CPC分类号： A61K8/44 , A61K8/675 , A61Q19/00 , A61Q19/02
摘要： The present invention relates to an inhibitor for melanin which contains tranexamic acid and niacinamide as active ingredients for inhibiting the formation of melanin cells in the skin, and a cosmetic composition containing the inhibitor for melanin as an active ingredient for relieving liver spots, blemishes, freckles and inflammatory hyperpigmentation, improving skin tone and texture, and skin whitening.
摘要翻译：本发明涉及含有氨甲环酸和烟酰胺作为抑制皮肤黑色素细胞形成的活性成分的黑色素抑制剂，含有黑色素抑制剂作为缓解肝斑，瑕疵，雀斑的活性成分的化妆品组合物和炎性色素沉着过敏，改善肤色和质地，以及皮肤美白。

6. 发明申请

WO2010110545A3 NOVEL HYDROXAMATE DERIVATIVE, A PRODUCTION METHOD FOR THE SAME, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新型羟肟酸衍生物，其生产方法和包含其的药物组合物
公开(公告)号：WO2010110545A3
公开(公告)日：2011-03-24
申请号：PCT/KR2010001656
申请日：2010-03-18
申请人： CHONG KUN DANG PHARM CORP , LEE SUNG SOOK , LEE KYUNG JOO , LEE CHANG SIK , YANG HYUN MO , KIM DO HOON , CHOI DAE KYU , CHOI HO JIN , KIM DAL HYUN , HWANG IN CHANG , KIM MI JEONG , HAN BYEONG HOON
发明人： LEE SUNG SOOK , LEE KYUNG JOO , LEE CHANG SIK , YANG HYUN MO , KIM DO HOON , CHOI DAE KYU , CHOI HO JIN , KIM DAL HYUN , HWANG IN CHANG , KIM MI JEONG , HAN BYEONG HOON
IPC分类号： C07D209/04 , C07D209/08 , C07D209/44
CPC分类号： C07D401/04 , C07D209/08 , C07D209/14 , C07D209/44 , C07D231/56 , C07D235/14 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to a hydroxamate derivative, to an isomer of the hydroxamate derivative and to pharmaceutically acceptable salts, hydrates or solvates of the hydroxamate derivative or the isomer of the hydroxamate derivative, as well as to an application for the same in the production of a pharmaceutical composition, to a pharmaceutical composition containing the same and to a method for the prophylaxis and treatment of medical conditions in which the pharmaceutical composition is employed, and also to a production method for the hydroxamate derivative.
摘要翻译：本发明涉及异羟肟酸酯衍生物，异羟肟酸衍生物的异构体以及异羟肟酸酯衍生物的药学上可接受的盐，水合物或溶剂合物或异羟肟酸衍生物的异构体，以及其用于生产药物组合物，含有该药物组合物的药物组合物，以及预防和治疗其中使用药物组合物的医疗条件的方法，以及用于异羟肟酸衍生物的制备方法。

7. 发明申请

WO2009041790A1 NOVEL 2,4,5-TRISUBTITUTED-1,3-THIAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 2,4,5- TRISUBSTITUTED-1,3-THIAZOLE DERIVATIVES AS AN EFFECTIVE INGREDIENT 审中-公开
标题翻译：新的2,4,5-三唑-1,3-二噻唑衍生物及其药学上可接受的盐，其制备方法，由包含2,4,5-三唑基-1,3-噻唑衍生物的SPC活性诱发的炎症疾病的治疗剂一个
公开(公告)号：WO2009041790A1
公开(公告)日：2009-04-02
申请号：PCT/KR2008/005726
申请日：2008-09-26
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , AMOREPACIFIC CORPORATION , GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , JEONG, Dae Young , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyoung June , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
发明人： GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , JEONG, Dae Young , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyoung June , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
IPC分类号： C07D277/44 , A61K31/426 , A61P29/00
CPC分类号： C07D277/46 , C07D417/04 , C07D417/12
摘要： Provided are a 2,4,5-trisubstiuted-l,3-thiazole derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent for inflammatory disease induced by sphingosylphosphorylcholine (SPC). The 2,4,5-trisubstiuted-l,3-thiazole derivative of the present invention has been confirmed to have superior inhibition activity against SPC receptor in an animal experiment using human-derived endothelial cells and mice. Thus, a pharmaceutical composition for treating inflammatory disease containing the 2,4,5-trisubstiuted-l,3-thiazole derivative or a pharmaceutically acceptable salt thereof as an effective ingredient may be useful for treating inflammation, itching or skin infection associated with atopic dermatitis or other disease induced by SPC receptor.
摘要翻译：本发明提供由以下化学式1表示的2,4,5-三溴代-1,3-噻唑衍生物，其药学上可接受的盐，其制备方法及其作为治疗剂的有效成分的用途由鞘氨醇磷酰胆碱（SPC）引起的炎性疾病。在使用人源性内皮细胞和小鼠的动物实验中，已证实本发明的2,4,5-三溴代-1,3-噻唑衍生物对SPC受体具有优异的抑制活性。因此，用于治疗含有2,4,5-三溴代-1,3-噻唑衍生物或其药学上可接受的盐作为有效成分的炎性疾病的药物组合物可用于治疗与特应性皮炎相关的炎症，瘙痒或皮肤感染或由SPC受体诱导的其他疾病。

8. 发明申请

WO2003040795A1 OPTICAL FIBER ARRAY BLOCK EMBEDDING OPTICAL DEVICE THEREIN 审中-公开
标题翻译：光纤阵列嵌入式光学器件
公开(公告)号：WO2003040795A1
公开(公告)日：2003-05-15
申请号：PCT/KR2002/002063
申请日：2002-11-06
申请人： HANTECH CO., LTD. , JOO, Gwan-Chong , CHOI, Jae-Shik , YANG, Jin-Se , KIM, Sang-Mo , JI, Kwang-Soon , KIM, Eok-Yeun , CHUNG, Ki-Woo , KIM, Eun-Ha , KIM, Do-Hoon , SONG, Kyung-Soo , LEE, Ji-Yeon
发明人： JOO, Gwan-Chong , CHOI, Jae-Shik , YANG, Jin-Se , KIM, Sang-Mo , JI, Kwang-Soon , KIM, Eok-Yeun , CHUNG, Ki-Woo , KIM, Eun-Ha , KIM, Do-Hoon , SONG, Kyung-Soo , LEE, Ji-Yeon
IPC分类号： G02B6/42
CPC分类号： G02B6/2852 , G02B6/3636 , G02B6/4202 , G02B6/4219 , G02B6/4249
摘要： An optical fiber array block includes at least one optical waveguide having an optical fiber zone, and an optical device. An optical signal leakage window is formed at the optical waveguide, and the optical device corresponds to the optical signal leakage window. If the optical signal leakage window is formed at an optical fiber comprising a core and a clad layer, the clad layer is partially removed or is partially connected to the core by means of tan ion implantation technique. Thus, the clad layer has a refractive index that is similar to that of the core.
摘要翻译：光纤阵列块包括至少一个具有光纤区的光波导和光学装置。在光波导处形成光信号泄漏窗，光学装置对应于光信号泄漏窗。如果在包括芯和包层的光纤上形成光信号泄漏窗，则通过棕褐色离子注入技术部分去除或部分地将覆盖层连接到芯。因此，包覆层具有与芯的折射率相似的折射率。

9. 发明申请

WO2012087062A2 SUSTAINED-RELEASE POLYMERIC MICROPARTICLES CONTAINING POORLY WATER-SOLUBLE DRUG AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：含有不溶性水溶性药物的可持续释放聚合物微生物及其制备方法
公开(公告)号：WO2012087062A2
公开(公告)日：2012-06-28
申请号：PCT/KR2011/010030
申请日：2011-12-23
申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION , LEE, Sa won , KIM, Do Hoon , KIM, Bong Oh , SEO, Min Hyo
发明人： LEE, Sa won , KIM, Do Hoon , KIM, Bong Oh , SEO, Min Hyo
IPC分类号： A61K9/16 , A61K9/22 , A61K47/14 , A61K47/36
CPC分类号： A61K47/34 , A01N25/28 , A61K9/1635 , A61K9/1647 , A61K9/1694 , A61K31/175 , A61K31/27 , A61K31/436 , A61K31/485 , A61K31/519 , A61K31/554 , A61K31/565 , A61K31/57
摘要： Disclosed are sustained-release polymeric microparticles containing a poorly water-soluble drug and a method for preparing the same.
摘要翻译：公开了含有水难溶性药物的缓释性聚合物微粒及其制备方法。

10. 发明申请

WO2011021892A3 COMPOSITION FOR SKIN IMPROVEMENT COMPRISING HEXAMIDINES AND RETINOIDS 审中-公开
标题翻译：包含己内酰胺和维甲酸的皮肤改善组合物
公开(公告)号：WO2011021892A3
公开(公告)日：2011-07-07
申请号：PCT/KR2010005541
申请日：2010-08-20
申请人： AMOREPACIFIC CORP , PARK JONG HEE , PARK SHIN YOUNG , SHIN HONG-JU , KIM DO-HOON , YI CHANG-GEUN , PARK WON SEOK , KOH HYUN JU , KIM JEONG-HWAN , KIM HYOUNG JUN
发明人： PARK JONG HEE , PARK SHIN YOUNG , SHIN HONG-JU , KIM DO-HOON , YI CHANG-GEUN , PARK WON SEOK , KOH HYUN JU , KIM JEONG-HWAN , KIM HYOUNG JUN
IPC分类号： A61K31/155 , A61K31/203 , A61P17/08 , A61P17/10
CPC分类号： A61K31/155 , A61K31/203
摘要： Disclosed is herein a composition comprising hexamidines, derivatives thereof, or pharmaceutically acceptable salts thereof; and retinoids, derivatives thereof, or pharmaceutically acceptable salts thereof, as an active ingredient. The composition of the present invention has effects for preventing, improving or treating acne; controlling sebum; pore-controlling; and preventing, improving or treating skin pigmentation. Also, the composition of the present invention could alleviate skin-irritations caused with retinoids by including ceramides.
摘要翻译：本文公开了包含六脒，其衍生物或其药学上可接受的盐的组合物; 和类视黄醇，其衍生物或其药学上可接受的盐作为活性成分。本发明的组合物具有预防，改善或治疗痤疮的作用; 控制皮脂; 孔隙控制; 并预防，改善或治疗皮肤色素沉着。而且，本发明的组合物可以通过包含神经酰胺来缓解由类维生素A引起的皮肤刺激。

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