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1. 发明申请

WO2012024169A2 NON-INVASIVE TREATMENT OF BRONCHIAL CONSTRICTION 审中-公开
标题翻译：非正式协商的协商处理
公开(公告)号：WO2012024169A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/047509
申请日：2011-08-12
申请人： ELECTROCORE LLC , SIMON, Bruce , ERRICO, Joseph , RAFFLE, John , MENDEZ, Steven
发明人： SIMON, Bruce , ERRICO, Joseph , RAFFLE, John , MENDEZ, Steven
IPC分类号： A61N2/04 , A61H1/00 , A61N7/00 , A61N5/06 , A61F7/00 , A61N1/36
CPC分类号： A61N2/002 , A61H23/00 , A61H23/004 , A61H23/02 , A61H23/0236 , A61H31/00 , A61H39/002 , A61H2201/123 , A61H2201/1604 , A61H2201/1609 , A61H2201/165 , A61N1/3601 , A61N1/36014 , A61N1/36114 , A61N1/3758 , A61N1/3787 , A61N1/40 , A61N2/006 , A61N2/02 , A61N5/0603 , A61N5/0622 , A61N5/0625 , A61N7/00 , A61N2005/0605 , A61N2005/063 , A61N2007/0026
摘要： Devices, systems and instructing methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The instructing method for treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.
摘要翻译：公开了用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和指导方法。治疗的指导方法包括将能量非侵入性的脉冲传递给负责平滑肌肉扩张的选定的神经纤维。包括磁和/或电的机械和/或声学以及光学和/或热能的透射能量脉冲刺激所选择的神经纤维。

2. 发明申请

WO2013126176A1 NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE 审中-公开
标题翻译：用于平均静脉注射或感染疾病的神经刺激方法
公开(公告)号：WO2013126176A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/023014
申请日：2013-01-24
申请人： ELECTROCORE LLC , SIMON, Bruce , ERRICO, Joseph P. , RAFFLE, John T.
发明人： SIMON, Bruce , ERRICO, Joseph P. , RAFFLE, John T.
IPC分类号： A61N1/00 , A61N2/00
CPC分类号： A61N1/36021 , A61N2/008
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.
摘要翻译：公开了经皮电磁神经刺激装置，以及使用由装置非侵入性地传送的能量来避免即将发生的医疗攻击的方法。特别地，装置和方法涉及设计成以足以使癫痫发作最小化或避免的信号刺激患者的迷走神经的手持装置。

3. 发明申请

WO2012121750A1 DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT 审中-公开
标题翻译：用于非侵入性电刺激的装置和方法及其对患者的NECK刺激的VAGUS神经刺激的使用
公开(公告)号：WO2012121750A1
公开(公告)日：2012-09-13
申请号：PCT/US2011/049844
申请日：2011-08-31
申请人： ELECTROCORE LLC , ERRICO, Joseph P. , SIMON, Bruce , RAFFLE, John T.
发明人： ERRICO, Joseph P. , SIMON, Bruce , RAFFLE, John T.
IPC分类号： A61N1/00
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15 - 50 bursts per second.
摘要翻译：非侵入式电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。刺激器包括电源，至少一个电极和电极接触的连续导电介质。刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉。电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选以每秒15-50突发重复脉冲串。

4. 发明申请

WO2010110785A1 ELECTRICAL TREATMENT OF BRONCHIAL CONSTRICTION 审中-公开
标题翻译：电力治理
公开(公告)号：WO2010110785A1
公开(公告)日：2010-09-30
申请号：PCT/US2009/038081
申请日：2009-03-24
申请人： ELECTROCORE, INC. , ERRICO, Joseph, P. , PASTENA, James, R. , MENDEZ, Steven , HU, Hecheng , ROSS, Arthur , SIMON, Bruce
发明人： ERRICO, Joseph, P. , PASTENA, James, R. , MENDEZ, Steven , HU, Hecheng , ROSS, Arthur , SIMON, Bruce
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/36114
摘要： Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease wherein the treatment includes stimulating selected nerve fibers responsible for smooth muscle dilation at a selected region within a patient's neck, thereby reducing the magnitude of constriction of bronchial smooth muscle.
摘要翻译：用于治疗与哮喘，过敏反应或慢性阻塞性肺疾病相关的支气管收缩的装置，系统和方法，其中所述治疗包括在患者颈部内的选定区域刺激负责平滑肌扩张的选定神经纤维，从而减少支气管平滑肌肉。

5. 发明申请

WO2009126383A2 METHODS AND APPARATUS FOR ELECTRICAL TREATMENT USING BALLOON AND ELECTRODE 审中-公开
标题翻译：使用气泡和电极进行电解处理的方法和装置
公开(公告)号：WO2009126383A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/036259
申请日：2009-03-06
申请人： ELECTROCORE INC. , SIMON, Bruce , MENDEZ, Steven , HU, Hecheng , DICKERSON, Richard, P. , PASTENA, James, R. , GUO, Puyun
发明人： SIMON, Bruce , MENDEZ, Steven , HU, Hecheng , DICKERSON, Richard, P. , PASTENA, James, R. , GUO, Puyun
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/40 , A61L29/14 , A61L31/14 , A61M25/10 , A61M2025/1093 , A61N1/0517 , A61N1/0519 , A61N1/3601 , A61N1/36014
摘要： The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided having an enclosure within an outer wall formed from an electrically-permeable material to allow for electrical energy to pass from the interior of the enclosure through the outer wall. The device further includes an electrode positioned within the interior of the enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid into the interior of the enclosure such that the electrically conductive fluid couples the electrode with the electrically-permeable section of the outer wall. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. In this manner, the electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.
摘要翻译：本发明提供了用于选择性地向身体组织施加电能的系统，装置和方法。提供了一种装置，其具有由电渗透材料形成的外壁内的外壳，以允许电能从外壳的内部通过外壁。该装置还包括位于外壳内部的电极和耦合到外壳的流体通道，用于将导电流体输送到外壳的内部，使得导电流体将电极与电渗透部分外墙。导电流体允许来自电极的电能通过外壳的流体和外壁，用于治疗患者身上或患者中的组织。以这种方式，电极不直接接触患者的组织，这降低了组织中侧支组织损伤或坏死和/或过度电场的可能性。

6. 发明申请

WO2008033221A2 THERAPEUTIC BONE REPLACEMENT MATERIAL 审中-公开
标题翻译：治疗骨替代材料
公开(公告)号：WO2008033221A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/019023
申请日：2007-08-30
申请人： EBI, L.P. , SIMON, Bruce , SIMON, Joshua
发明人： SIMON, Bruce , SIMON, Joshua
IPC分类号： A61F2/28 , A61K6/00 , A61L27/02 , A61L27/42 , A61L27/54
CPC分类号： A61K6/0625 , A61F2/28 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61L27/025 , A61L27/54 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/604 , A61L2430/02
摘要： A biodegradable bone replacement material for the treatment of bone defects and delivery of antibiotic compounds, particularly for treating bone infections, comprising calcium sulfate hemihydrate, calcium sulfate dihydrate, an antibiotic mixture comprising a tetracycline compound and an ansamycin compound. Preferably, the ratio of calcium sulfate hemihydrate to calcium sulfate dihydrate is from 1:1 to about 3:1. Methods for treating, repairing or augmenting an osseous defect using the bone replacement material are also provided.
摘要翻译：一种可生物降解的骨替代材料，用于治疗骨缺损和递送抗生素化合物，特别是用于治疗骨感染，包括硫酸钙半水合物，硫酸钙二水合物，包含四环素化合物和安莎霉素化合物的抗生素混合物。优选地，半水合硫酸钙与硫酸钙二水合物的比例为1:1至约3:1。还提供了使用骨置换材料治疗，修复或增加骨缺损的方法。

7. 发明申请

WO2007056433A3 METHODS OF TREATING TISSUE DEFECTS 审中-公开
公开(公告)号：WO2007056433A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043443
申请日：2006-11-07
申请人： EBI, L.P. , SIMON, Bruce
发明人： SIMON, Bruce
IPC分类号： A61K35/28 , C12N5/06 , A61N2/00 , A61K38/18 , A61P19/08
摘要： Methods of treating tissue defects, including defects such as bone fractures, vertebrae fusions, and spinal disc repair, using electric or electromagnetic fields and growth factors. In various embodiments, the present invention provides methods for the treatment of a human or other mammal subject in need thereof, by administering electric stimulation and growth factors to stimulate endogeneous stem cells in the subject to facilitate healing. Other embodiments include methods of administering electric stimulation, growth factors, and stem cells to the defect. In various embodiments the amount of growth factor is a subefficacious amount.

8. 发明申请

WO2008109101A2 ANGIOGENESIS INITIATION AND GROWTH 审中-公开
标题翻译：血管发生和发育
公开(公告)号：WO2008109101A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/002921
申请日：2008-03-05
申请人： BIOMET BIOLOGICS, LLC , HIGGINS, Joel, C. , SIMON, Bruce , WOODELL-MAY, Jennifer, E.
发明人： HIGGINS, Joel, C. , SIMON, Bruce , WOODELL-MAY, Jennifer, E.
IPC分类号： A61N1/32 , C12N13/00
CPC分类号： A61K35/19 , A61K35/16 , A61K35/28 , A61K35/35 , A61K38/18 , A61K38/19 , A61K45/06 , A61M37/00 , A61N1/205 , A61N1/326 , A61N2/02 , C12N13/00 , A61K2300/00

9. 发明申请

WO2003072128A3 METHODS AND COMPOSITIONS FOR TREATING BONE OR CARTILAGE DEFECTS 审中-公开
公开(公告)号：WO2003072128A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/005200
申请日：2003-02-21
申请人： EBI, L.P. , SIMON, Bruce
发明人： SIMON, Bruce
IPC分类号： A61K38/30
摘要： Compositions and methods of treating bone and cartilage disorders and defects consisting of applying naturally secreted growth factors to a defect site. Specifically, the present invention provides a method of treating a bone or cartilage defect comprising: culturing a living tissue, preferably skin tissue, so that the tissue secretes a plurality of growth factors; and administering the growth factor to the site of the defect. Compositions comprise a plurality of human growth factors secreted in a culture by living skin tissue. Preferably, the compositions additionally comprise a pharmaceutically-acceptable carrier. The growth factors are released onto a matrix or medium and subsequently processed for introduction to a defect site. In a preferred embodiment, the medium into which the factors are secreted is administered to the site of the defect.

10. 发明申请

WO2003072128A2 METHODS AND COMPOSITIONS FOR TREATING BONE OR CARTILAGE DEFECTS 审中-公开
标题翻译：治疗骨质疏松症的方法和组合物
公开(公告)号：WO2003072128A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005200
申请日：2003-02-21
申请人： EBI, L.P. , SIMON, Bruce
发明人： SIMON, Bruce
IPC分类号： A61K38/30
CPC分类号： A61K38/1841 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/30
摘要： Compositions and methods of treating bone and cartilage disorders and defects consisting of applying naturally secreted growth factors to a defect site. Specifically, the present invention provides a method of treating a bone or cartilage defect comprising: culturing a living tissue, preferably skin tissue, so that the tissue secretes a plurality of growth factors; and administering the growth factor to the site of the defect. Compositions comprise a plurality of human growth factors secreted in a culture by living skin tissue. Preferably, the compositions additionally comprise a pharmaceutically-acceptable carrier. The growth factors are released onto a matrix or medium and subsequently processed for introduction to a defect site. In a preferred embodiment, the medium into which the factors are secreted is administered to the site of the defect.
摘要翻译：治疗骨和软骨病症的组合物和方法以及将天然分泌生长因子应用于缺陷部位组成的缺陷。具体地说，本发明提供了一种治疗骨或软骨缺损的方法，包括：培养活组织，优选皮肤组织，使得组织分泌多种生长因子; 以及将所述生长因子施用于所述缺陷部位。组合物包含由活体皮肤组织分泌在培养物中的多种人生长因子。优选地，组合物另外包含药学上可接受的载体。生长因子释放到基质或培养基上，随后处理以引入缺陷部位。在优选的实施方案中，将分泌因子的培养基施用于缺陷部位。

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