专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012121750A1 DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT 审中-公开
标题翻译：用于非侵入性电刺激的装置和方法及其对患者的NECK刺激的VAGUS神经刺激的使用
公开(公告)号：WO2012121750A1
公开(公告)日：2012-09-13
申请号：PCT/US2011/049844
申请日：2011-08-31
申请人： ELECTROCORE LLC , ERRICO, Joseph P. , SIMON, Bruce , RAFFLE, John T.
发明人： ERRICO, Joseph P. , SIMON, Bruce , RAFFLE, John T.
IPC分类号： A61N1/00
CPC分类号： A61N1/36021 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61N1/0456 , A61N1/0496 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N1/40
摘要： A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15 - 50 bursts per second.
摘要翻译：非侵入式电刺激装置形成可以平行于长神经（例如患者颈部的迷走神经）定向的细长的电场，在患者体内产生期望的生理反应。刺激器包括电源，至少一个电极和电极接触的连续导电介质。刺激装置被配置为产生峰值脉冲电压，该峰值脉冲电压足以在目标神经附近产生生理有效的电场，但是不能基本上刺激位于目标神经附近和患者皮肤之间的其它神经和肌肉。电流以优选五个正弦脉冲的脉冲串通过电极，其中脉冲串内的每个脉冲具有优选200微秒的持续时间，并且优选以每秒15-50突发重复脉冲串。

2. 发明申请

WO2015179744A1 SYSTEMS AND METHODS FOR VAGAL NERVE STIMULATION 审中-公开
标题翻译： VAGAL NERVE刺激的系统和方法
公开(公告)号：WO2015179744A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/032144
申请日：2015-05-22
申请人： ELECTROCORE, LLC
发明人： SIMON, Bruce J. , ERRICO, Joseph P. , RAFFLE, John T.
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61N1/0456 , A61N1/36014 , A61N1/36053 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent disorders in a patient. The devices comprise a handheld device having one or more electrode interfaces for contacting the outer skin surface of a patient, a power source and a signal generator coupled to the electrode/interfaces for applying one or more electrical impulses to a deep nerve within the patient, such as the vagus nerve. The device further comprises a filter situated in series between the signal generator and the electrode/interfaces for filtering out undesired high frequency components of the electrical impulses to create a cleaner, smoother signal. The filter may comprise an electrically conductive medium and/or a low-pass filter between the signal generator and the electrode/interface.
摘要翻译：公开了用于电刺激迷走神经治疗或预防患者疾病的装置，系统和方法。该装置包括具有用于接触患者的外皮表面的一个或多个电极接口的手持式装置，耦合到电极/接口的电源和信号发生器，用于将一个或多个电脉冲施加到患者体内的深部神经，如迷走神经。该装置还包括串联在信号发生器和电极/接口之间的滤波器，用于滤除电脉冲的不期望的高频分量以产生更清洁，更平滑的信号。滤波器可以包括在信号发生器和电极/接口之间的导电介质和/或低通滤波器。

3. 发明申请

WO2015066670A2 NERVE STIMULATOR SYSTEM 审中-公开
标题翻译：神经刺激系统
公开(公告)号：WO2015066670A2
公开(公告)日：2015-05-07
申请号：PCT/US2014/063801
申请日：2014-11-04
申请人： ELECTROCORE, LLC
发明人： SIMON, Bruce J. , ERRICO, Joseph P. , MENDEZ, Steven
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/3605 , A61N1/36153 , A61N1/36171 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3787
摘要： Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves are described. An electrical stimulator is introduced through a to a target location within, adjacent to, or in close proximity with, the carotid sheath. The stimulator has an antenna that allows it to be powered solely by far-field or approximately plane wave electromagnetic radiation, having frequencies in the range of 0.3 to 10 GHz. Electrical impulses are applied through the stimulator to a vagus nerve to stimulate, block or otherwise modulate activity of the nerve and treat the patient's condition. The stimulator uses an adjustable number of fixed voltage (or fixed current) pulses with fixed duration to elicit desired changes in nerve response, the timing of which are controlled by an external power transmitter and controller.
摘要翻译：描述了将电脉冲施加到一个或多个所选择的神经的装置，系统和方法。将电刺激器通过颈部护套内，邻近或紧邻的目标位置引入。刺激器具有允许其仅由具有0.3至10GHz范围内的频率的远场或近似平面波电磁辐射供电的天线。通过刺激器将电脉冲施加到迷走神经以刺激，阻断或以其他方式调节神经的活动并治疗患者的状况。刺激器使用具有固定持续时间的可调数量的固定电压（或固定电流）脉冲，以引起神经反应的所需变化，其时间由外部功率发射器和控制器控制。

4. 发明申请

WO2015138981A1 DEVICES AND METHODS FOR TREATING MEDICAL DISORDERS WITH EVOKED POTENTIALS AND VAGUS NERVE STIMULATION 审中-公开
标题翻译：用于治疗具有诱发电位和VAGUS神经刺激的医疗障碍的装置和方法
公开(公告)号：WO2015138981A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020572
申请日：2015-03-13
申请人： ELECTROCORE, LLC
发明人： SIMON, Bruce J. , ERRICO, Joseph P.
IPC分类号： A61N1/36
CPC分类号： A61N1/0456 , A61N1/36021
摘要： Devices and systems for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.
摘要翻译：用于与诱发电位（EP）的测量结合使用的用于通过无创电刺激迷走神经治疗医学病症（例如偏头痛或其它原发性头痛）或纤维肌痛的装置和系统。该系统包括刺激器，其施加到患者颈部的表面以施加足以刺激颈部迷走神经的电脉冲，用于测量由该刺激引起的EP的头皮电极，反馈或生物反馈电路以改变刺激基于EP特征以及产生EP的其它感觉刺激模式。该系统优选用于优化刺激器的放置，以测试患者是否是使用迷走神经刺激治疗的合适候选者，以及选择优化急性或慢性治疗的刺激参数，例如通过修正EP习惯性缺陷。

5. 发明申请

WO2014074638A1 NON-INVASIVE MAGNETIC OR ELECTRICAL NERVE STIMULATION TO TREAT OR PREVENT DEMENTIA 审中-公开
标题翻译：非侵入式磁刺激或电刺激治疗或预防感染
公开(公告)号：WO2014074638A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068804
申请日：2013-11-06
申请人： ELECTROCORE, LLC
发明人： SIMON, Bruce J. , ERRICO, Joseph P. , RAFFLE, John T.
IPC分类号： A61N1/36 , A61N1/40
CPC分类号： A61N1/40 , A61N1/36014 , A61N1/36025 , A61N1/36053 , A61N2/006 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
摘要翻译：公开了用于治疗或预防痴呆的装置，系统和方法，例如阿尔茨海默氏病。所述方法包括将能量的脉冲非侵入性地传递到选择的神经纤维，特别是迷走神经中的神经纤维，这些神经纤维调节患者的基因座的活性。包括磁能和/或电能的透射能量脉冲刺激所选择的神经纤维，以使得斑马鱼将去甲肾上腺素释放到含有β-淀粉样蛋白的脑区域中。去甲肾上腺素抵消会损害那些区域和颈部神经元的神经炎症，从而阻止或减缓患者疾病进展。

6. 发明申请

WO2015179571A1 NON-INVASIVE NERVE STIMULATION VIA MOBILE DEVICES 审中-公开
标题翻译：非侵入性神经刺激通过移动设备
公开(公告)号：WO2015179571A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031847
申请日：2015-05-20
申请人： ELECTROCORE, LLC
发明人： ERRICO, Joseph P. , MENDEZ, Steven , SIMON, Bruce J.
IPC分类号： A61N1/36
CPC分类号： A61N1/0456 , A61N1/36021 , A61N1/36025
摘要： Devices, systems, and methods are disclosed that allow a patient to self-treat a medical condition, such as a migraine headache,an epileptic seizure, a neurodegenerative disease, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy or the like, by electrical non-invasive stimulation of a vagus nerve. The system can comprise a handheld stimulator which is applied to a surface of the patient's neck, wherein the stimulator comprises or is joined to a mobile device. A camera of the mobile device may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
摘要翻译：公开了允许患者自我治疗诸如偏头痛，癫痫发作，神经变性疾病如痴呆，阿尔茨海默氏病，缺血性卒中，脑震荡综合征，慢性疾病的装置，系统和方法创伤性脑病等，通过电刺激迷走神经的电刺激。该系统可以包括施加到患者颈部表面的手持式刺激器，其中刺激器包括或者连接到移动装置。可以使用移动设备的照相机将刺激器定位和重新定位到患者颈部上的特定位置。该系统还可以包括用于测量刺激器内的可再充电电池的充电的基站。基站和刺激器相对于刺激会话的状态彼此传输数据。

7. 发明申请

WO2014113294A2 MEDICAL SELF-TREATMENT USING NON-INVASIVE VAGUS NERVE STIMULATION 审中-公开
标题翻译：使用非侵入性VAGUS神经刺激的医疗自我治疗
公开(公告)号：WO2014113294A2
公开(公告)日：2014-07-24
申请号：PCT/US2014/011123
申请日：2014-01-10
申请人： ELECTROCORE, LLC
发明人： SIMON, Bruce J. , ERRICO, Joseph P. , RAFFLE, John T.
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/0402 , A61B5/0476 , A61B5/08 , A61B5/4836 , A61N1/0456 , A61N1/37247 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck, as well as a docking station that is used to charge a rechargeable battery within the stimulator. The docking station and stimulator housing transmit data to one another regarding the status of a stimulation session, as well as to a computer program in a patient interface device such as a mobile phone or computer. The interface device in turn communicates with medical record and billing databases contained within other computers, via the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
摘要翻译：公开了允许患者通过对迷走神经的电无刺激性刺激来自我治疗诸如偏头痛头痛的医疗状况的装置，系统和方法。该系统包括施加到患者颈部表面的刺激器，以及用于对刺激器内的可再充电电池充电的对接站。对接站和刺激器壳体相对于刺激会话的状态以及患者接口设备（例如移动电话或计算机）中的计算机程序彼此传输数据。接口设备又通过互联网与包含在其他计算机内的医疗记录和计费数据库通信。该系统旨在解决在医疗专业人员不存在的情况下特别在自我治疗期间出现的问题。

8. 发明申请

WO2016014436A1 MOBILE PHONE FOR STIMULATING THE TRIGEMINAL NERVE TO TREAT DISORDERS 审中-公开
标题翻译：用于刺激触诊神经来治疗疾病的移动电话
公开(公告)号：WO2016014436A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/041195
申请日：2015-07-20
申请人： ELECTROCORE, LLC
发明人： ERRICO, Joseph P. , MENDEZ, Steven , SIMON, Bruce J.
IPC分类号： A61N1/18 , A61N1/24 , A61N1/36
CPC分类号： A61N1/0456 , A61N1/36014
摘要： Devices and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a handheld mobile device, such as a smartphone, that is applied to the surface of the patient's head. One or more electrodes on the mobile device apply electrical impulses transcutaneously through the patient's skin to the targeted nerve to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
摘要翻译：公开了允许患者通过非侵入性电刺激头部神经，特别是眶上，超声波，眶下和精神神经来自我治疗诸如偏头痛和三叉神经痛等医学状况的装置和方法。其孔或附近的孔。该系统包括应用于患者头部表面的诸如智能手机的手持式移动设备。移动装置上的一个或多个电极通过患者的皮肤经皮肤地将电脉冲施加到目标神经，以治疗该疾病。该系统旨在解决在医疗专业人员不存在的情况下特别在自我治疗期间出现的问题。

9. 发明申请

WO2014039569A2 NON-INVASIVE VAGAL NERVE STIMULATION TO TREAT DISORDERS 审中-公开
标题翻译：非侵入性VAGAL神经刺激治疗疾病
公开(公告)号：WO2014039569A2
公开(公告)日：2014-03-13
申请号：PCT/US2013/058079
申请日：2013-09-04
申请人： ELECTROCORE, LLC
发明人： SIMON, Bruce J. , ERRICO, Joseph P. , RAFFLE, John T.
IPC分类号： A61N1/36
CPC分类号： A61N1/395 , A61N1/36014 , A61N1/36053 , A61N2/008 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
摘要翻译：公开了用于治疗主要或至少部分地由脑中的神经递质不平衡驱动的各种疾病和病症的装置，系统和方法，例如哮喘，COPD，抑郁症，焦虑症，癫痫，纤维肌痛等。本发明涉及使用能量源，该能量源包括磁性和/或电能非侵入性或非常接近所选择的神经以暂时刺激，阻断和/或调节选定神经中的信号，使得激活神经通路以释放患者大脑中的抑制性神经递质。

10. 发明申请

WO2013126176A1 NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE 审中-公开
标题翻译：用于平均静脉注射或感染疾病的神经刺激方法
公开(公告)号：WO2013126176A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/023014
申请日：2013-01-24
申请人： ELECTROCORE LLC , SIMON, Bruce , ERRICO, Joseph P. , RAFFLE, John T.
发明人： SIMON, Bruce , ERRICO, Joseph P. , RAFFLE, John T.
IPC分类号： A61N1/00 , A61N2/00
CPC分类号： A61N1/36021 , A61N2/008
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. In particular, the devices and methods involve handheld devices designed to stimulate the vagus nerve of a patient with a signal sufficient to minimize or avert epileptic seizures.
摘要翻译：公开了经皮电磁神经刺激装置，以及使用由装置非侵入性地传送的能量来避免即将发生的医疗攻击的方法。特别地，装置和方法涉及设计成以足以使癫痫发作最小化或避免的信号刺激患者的迷走神经的手持装置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式