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1. 发明申请

WO1998029662A1 A DEVICE FOR GENERATING A PULSATILE FLUID DRUG FLOW 审中-公开
标题翻译：用于产生流体液体流量的装置
公开(公告)号：WO1998029662A1
公开(公告)日：1998-07-09
申请号：PCT/IE1997000090
申请日：1997-12-30
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： F04B43/073
CPC分类号： F04B43/073
摘要： A device (10) for generating a pulsatile fluid drug flow comprises a housing (11) containing an expandable-contractible chamber (12) having an inlet (14) and an outlet (15), a valve (16) associated with the outlet (15) which is actuated by the expansion and contraction of the chamber (12), and means (13, 23) for biasing the chamber (12) to its contracted state. When the inlet (14) is connected to a pressurised fluid drug supply the chamber (12) is expanded by the drug, and this expansion of the chamber (12) actuates the valve (16) to open, thereby allowing release of the drug from the chamber (12), following which the chamber (12) contracts under the influence of the biasing means (13, 23), this contraction in turn actuating the valve (16) to close thereby allowing the chamber (12) to refill. By this mechanism, a constant supply of liquid, such as from an osmotic or elastomeric drug delivery pump, can be converted to a pulsatile flow, which may provide a more suitable delivery of certain drugs.
摘要翻译：用于产生脉动流体药物流的装置（10）包括容纳具有入口（14）和出口（15）的可膨胀收缩室（12）的壳体（11），与出口由室（12）的膨胀和收缩致动的装置（15），以及用于将室（12）偏压到其收缩状态的装置（13,23）。当进口（14）连接到加压流体药物供应时，腔室（12）被药物膨胀，并且腔室（12）的这种膨胀致动阀门（16）打开，从而允许药物从在室（12）之后，腔室（12）在偏置装置（13,23）的影响下收缩，这种收缩又使阀门（16）致动，从而允许腔室（12）再填充。通过这种机制，可以将诸如来自渗透性或弹性体药物输送泵的液体的恒定供应转化为脉动流，这可以提供某些药物的更合适的递送。

2. 发明申请

WO1996004953A1 ORALLY ADMINISTRABLE DELIVERY DEVICE 审中-公开
公开(公告)号：WO1996004953A1
公开(公告)日：1996-02-22
申请号：PCT/IE1995000039
申请日：1995-08-04
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph , KELLY, John, Gerard
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61M31/00
CPC分类号： A61M5/14593 , A61K9/0009 , A61M31/002 , A61M2005/14204
摘要： An orally administrable delivery device (10) comprising a housing (11) with walls of a water-permeable material and having a first chamber (13) adapted to receive an active ingredient, an orifice (15) through which the active ingredient is expelled from the housing (10) under pressure in a liquid form and a second chamber (14) containing two spaced-apart electrodes (16, 17) which form part of an electric circuit which is closed upon ingress of an aqueous ionic solution to the second chamber (14), such that a potential difference is set up between the electrodes (16, 17) and a current flows through the circuit resulting in the generation of a gas at electrode (16), the gas once generated acting on a displaceable membrane (12) to compress the first chamber (13) and expel the active ingredient through the orifice (15) for progressive delivery to the gastrointestinal tract. The electrode (16) forms part of an electric circuit which is closed by the ingress of an electrolyte (the aqueous solution), the circuit allowing controlled generation of gas and, thereby, controlled delivery of the active ingredient to the gastrointestinal tract.
摘要翻译：一种可口服给药装置（10），包括具有透水材料壁的壳体（11），并具有适于接收活性成分的第一腔室（13），活性成分被排出的孔口（15）在液体形式的压力下的壳体（10）和包含两个间隔开的电极（16,17）的第二室（14），其形成电路的一部分，该电路在离子水溶液进入第二室（14），使得在电极（16,17）之间形成电位差，并且电流流过电路，导致在电极（16）产生气体，一旦产生的气体作用在可位移膜上（ 12）以压缩第一室（13）并通过孔口（15）排出活性成分以逐渐递送至胃肠道。电极（16）形成电路的一部分，该电路由电解质（水溶液）的进入封闭，该电路允许控制气体的产生，从而控制活性成分输送到胃肠道。

3. 发明申请

WO1996014026A1 ANALYTE-CONTROLLED LIQUID DELIVERY DEVICE AND ANALYTE MONITOR 审中-公开
标题翻译：分析控制液体输送装置和分析仪监视器
公开(公告)号：WO1996014026A1
公开(公告)日：1996-05-17
申请号：PCT/IE1995000055
申请日：1995-10-27
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph , KELLY, John, Gerard
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61F02/02
CPC分类号： A61M5/14248 , A61B5/14865 , A61B5/6848 , A61K9/0021 , A61K9/7023 , A61M5/14244 , A61M5/1723 , A61M2005/14204 , A61M2005/14268 , A61M2005/1726 , A61M2205/8206 , C07C253/34 , G06F19/00 , Y02A90/26
摘要： A liquid delivery device (40) comprising a housing (41) having a lower surface (51) for application to the skin of a subject and having a reservoir (42) and a gas generation chamber (43) therein separated by a displaceable membrane (45). Gas generated by an electrolytic cell (44) under the control of a microprocessor (46) causes the gas generation chamber (43) to expand and the reservoir (42) to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle (49) extending from the lower surface (51). The delivery needle (49) and a sensor needle (48) both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle (48) has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle (49) is made of platinum-iridium, and a current passes between the needles (48, 49) and a potentiostat circuit (47) according to the amount of glucose detected. A reference electrode (silver/silver chloride) (50) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit (47) is measured by a voltmeter (53) and a signal from the voltmeter (53) is amplified and communicated to the microprocessor (46) which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.
摘要翻译：一种液体输送装置（40），包括具有用于施用到受试者皮肤的下表面（51）的壳体（41），并且具有储存器（42）和气体生成室（43），所述储存器（42）和气体生成室（43） 45）。在微处理器（46）的控制下由电解槽（44）产生的气体使得气体发生室（43）膨胀并且储存器（42）收缩，从而从液体储存器（例如胰岛素）中排出液体药物通过从下表面（51）延伸的中空输送针（49）。输送针（49）和传感器针（48）都从下表面延伸足够的距离，以便当外壳被压靠皮肤时穿过表皮并进入真皮。传感器针（48）具有用于检测被检体血浆中的分析物（例如葡萄糖）的酶涂层。输送针（49）由铂 - 铱制成，并且根据检测到的葡萄糖的量，电流在针（48,49）和恒电位仪电路（47）之间通过。靠在受试者皮肤上的参比电极（银/氯化银）（50）增加了葡萄糖测量的准确度。通过电位计（53）测量通过恒电位仪电路（47）的电流，并且来自电压表（53）的信号被放大并传送到微处理器（46），微处理器（46）基于以下方式确定药物的正确传送速率在受试者血浆中检测到的分析物水平。

4. 发明申请

WO1995032013A1 LIQUID DELIVERY DEVICE 审中-公开
标题翻译：液体输送装置
公开(公告)号：WO1995032013A1
公开(公告)日：1995-11-30
申请号：PCT/IE1995000031
申请日：1995-05-22
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph , KELLY, John, Gerard
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61M05/168
CPC分类号： A61M5/16854 , A61M5/14593 , A61M2005/14204 , G01P13/0066
摘要： A liquid delivery device (10) particularly useful for delivering drugs in a liquid form, comprising a pressure-control chamber (18) having an electrolytic cell (22) therein and a reservoir (17) for the liquid separated from the pressure-control chamber (18) by a displaceable diaphragm (15). When sufficient pressure is generated within the pressure-control chamber (18) and reservoir (19), a second diaphragm (16) is raised to allow liquid to escape from the device, via an opening (26), through an outlet tube (20). The device (10) also includes a compensation chamber (19) which adjusts the rate of flow of the liquid in response to variations in ambient temperature and pressure. There is provided a pressure sensor (21) in the form of a sensor chamber (27) for immediately detecting an interruption in the flow of liquid from the device as an increase in pressure in the outlet tube (20) with respect to the pressure within the compensation chamber (19) and hence the reservoir (17). The means (21) for detecting an interruption in the delivery of liquid does not rely on the increase in pressure occurring as a result of continued gas generation.
摘要翻译：一种液体输送装置（10），特别用于输送液体形式的药物，包括其中具有电解池（22）的压力控制室（18）和用于从压力控制室（18）通过可移动隔膜（15）。当在压力控制室（18）和储存器（19）内产生足够的压力时，升高第二隔膜（16）以允许液体经由开口（26）从装置逸出通过出口管（20））。装置（10）还包括补偿室（19），其响应于环境温度和压力的变化来调节液体的流速。提供了传感器室（27）形式的压力传感器（21），用于立即检测来自装置的液体流动的中断，因为出口管（20）中的压力相对于出口管（20）内的压力增加补偿室（19），因此储存器（17）。用于检测液体输送中断的装置（21）不依赖于由于持续产生气体而产生的压力增加。

5. 发明申请

WO1995003078A1 LIQUID MATERIAL DISPENSER AND VALVE 审中-公开
标题翻译：液体材料分配器和阀
公开(公告)号：WO1995003078A1
公开(公告)日：1995-02-02
申请号：PCT/IE1994000037
申请日：1994-07-15
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61M05/142
CPC分类号： A61M5/142 , A61M2005/14204
摘要： A liquid material dispenser, for use, for example, in dispensing liquid medicine over an extended period of time, which includes a housing (10) enclosing a reservoir (12) for storing the liquid to be dispensed and having an outlet (14) through which the liquid is dispensed, and a connecting passageway (16) between the reservoir and the outlet. Located in the passageway is a diaphragm (18), one side of which defines a pumping chamber (20) and the other side of which defines a pressure control chamber (22). The diaphragm (18) is cyclically displaceable through a pumping stroke for pumping liquid through the outlet (14) and a drawing stroke for drawing liquid from the reservoir (12). Also located in the passageway (16) are a pair of valves (30, 33) which serve, during the drawing stroke, to cause the diaphragm (18) to draw liquid from the reservoir (12) into the pumping chamber (20), and during the pumping stroke, to cause the diaphragm (18) to pump liquid from the pumping chamber (20) through the outlet (14). An electrolytic cell (24) generates gas at suitable times for suitable durations and rates which is supplied to the pressure control chamber (22) to drive the pumping member (18) through the pumping stroke. A vent is used for venting the gas from the pressure control chamber (22) to the atmosphere to drive the pumping member (18) through the drawing stroke. The vent has an inlet vent opening (40) inside the pressure control chamber (22), with the opening (40) being caused to open to end the pumping stroke and to close after a portion of the gas has vented.
摘要翻译：液体材料分配器，用于例如在长时间内分配液体药物，其包括封闭储存器（12）的壳体（10），用于储存待分配的液体并具有出口（14）通过所述液体被分配，以及在所述储存器和所述出口之间的连接通道（16）。位于通道中的是隔膜（18），其一侧限定了泵送室（20），另一侧限定了压力控制室（22）。隔膜（18）通过抽吸冲程循环移位，用于泵送液体通过出口（14）和用于从储存器（12）抽取液体的抽取冲程。还设置在通道（16）中的一对阀（30,33），其在牵引行程中用于使隔膜（18）将液体从储存器（12）抽吸到泵送室（20）中，并且在泵送冲程期间，使隔膜（18）从泵送室（20）泵送液体通过出口（14）。电解槽（24）在合适的时间产生合适的持续时间和速率的气体，其供应给压力控制室（22）以通过泵送冲程驱动泵送构件（18）。通气孔用于将气体从压力控制室（22）排放到大气中以通过牵引行程驱动泵送构件（18）。排气口在压力控制室（22）内具有入口通气口（40），其中开口（40）被打开以结束泵送冲程，并且在气体的一部分排气之后关闭。

6. 发明申请

WO1997009078A1 CHEMICALLY DRIVEN LIQUID DELIVERY PUMPING DEVICE 审中-公开
标题翻译：化学驱动液体输送装置
公开(公告)号：WO1997009078A1
公开(公告)日：1997-03-13
申请号：PCT/IE1996000055
申请日：1996-08-22
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61M05/155
CPC分类号： A61M5/155 , A61M5/1413 , A61M5/142 , A61M5/172
摘要： A liquid delivery pumping device (10) for the delivery of liquids enterally or parenterally comprises a housing (11) including a gas generating chamber (17), wherein a gas is generated intermittently when two reactants, such as the components of an effervescent couple, are caused to react, a pumping chamber (16) for a reciprocating pumping unit (15) operable by the gas and to which chamber (16) the gas is conveyed once generated, the pumping unit (15) forming part of a mechanism which receives and regulates the liquid to be delivered in response to the reciprocation of the pumping unit (15), and means (29-37) for controlling the gas pressure within the pumping chamber (16) to enable controlled reciprocation of the pumping unit. The device (10) provides precisely controlled rates of liquid delivery to a patient irrespective of the viscosity of the liquid to be delivered.
摘要翻译：用于肠内或肠胃外输送液体的液体输送泵送装置（10）包括包括气体发生室（17）的壳体（11），其中当两个反应物（例如泡腾夫妇的组分）引起反应的泵送室（16），用于可由气体操作的往复抽吸单元（15）的泵送室（16），并且一旦产生气体就被输送到该室（16），泵送单元（15）形成接收并且响应于泵送单元（15）的往复运动来调节待输送的液体，以及用于控制泵送室（16）内的气体压力的装置（29-37），以实现泵送单元的可控的往复运动。装置（10）提供精确控制的液体输送速率到患者，而不管待输送的液体的粘度如何。

7. 发明申请

WO1997009025A1 MEDICAMENT CONVERSION SYSTEM 审中-公开
标题翻译：药物转换系统
公开(公告)号：WO1997009025A1
公开(公告)日：1997-03-13
申请号：PCT/IE1996000058
申请日：1996-08-30
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , TSALS, Izrail
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61J01/00
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201
摘要： A system (10) for converting a medicament (12) from a storage form to an administrable form comprises an evacuated medicament container (11), a container (17) for a liquid (18), and means in the form of a hollow needle (19) for establishing communication between said containers (11 and 17) and thereby causing liquid (18) to be drawn by suction from the liquid container (17) to the medicament container (11). By establishing communication between an evacuated container (11) and an unevacuated container (17), there is an instant, reliable and controlled addition of liquid (18) to the medicament (12) from the liquid container (17). The system (10) has particular application to lyophilised medicaments.
摘要翻译：用于将药物（12）从储存形式转化为可施用形式的系统（10）包括抽空的药物容器（11），用于液体（18）的容器（17）和空心针形式的装置（19），用于在所述容器（11和17）之间建立连通，从而使液体（18）从液体容器（17）抽吸到药物容器（11）。通过建立抽真空的容器（11）和未完成的容器（17）之间的连通，从液体容器（17）向液体（12）中立即，可靠和可控地添加液体（18）。系统（10）特别适用于冻干药物。

8. 发明申请

WO1996037245A1 FEEDBACK-CONTROLLED LIQUID DELIVERY DEVICE 审中-公开
标题翻译：反馈控制液体输送装置
公开(公告)号：WO1996037245A1
公开(公告)日：1996-11-28
申请号：PCT/IE1996000029
申请日：1996-05-13
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph
IPC分类号： A61M05/155
CPC分类号： B65D83/625 , A61M5/155 , B01J7/02
摘要： A liquid delivery device (10) for delivering a nutritive liquid (13) to a subject comprises a reservoir (12) for the nutritive liquid connected, in use, to a gas generator (11) for supplying a gas to the reservoir (12) to drive the liquid (13) therefrom. The generator (11) comprises first and second compartments (16, 17), each containing a reactant (19, 20), the compartments (16, 17) being interconnected in a manner which permits the flow, in use, of a reactant (19) from the first compartment (16) to contact the other reactant (20), the reactants in the form of citric acid solution (19) and powdered sodium bicarbonate (20) reacting on contact to generate a gas, wherein an increase in gas pressure within the generator (11) reduces the rate of flow reactant (19) from the first compartment (16), thereby controlling the rate of gas generation by feedback and in turn the rate of liquid delivery. Delivery of liquid from the device (10) can be stopped by clamping a tube (14) leading from the reservoir (12), and the resultant increase in pressure in the reservoir (12) and in the gas generator (11) cuts off the flow of reactant (19) from the first compartment (16) and thereby stops the reaction. Only when the tube (14) is unclamped and there is a resultant decrease in pressure within the reservoir (12) does the flow of reactant recommence. Thus, delivery can be interrupted for periods of 20-30 hours and subsequently recommenced with full effectiveness.
摘要翻译：用于将营养液体（13）输送到受试者的液体输送装置（10）包括用于在使用中连接到用于将气体供应到储存器（12）的气体发生器（11）的营养液体的储存器（12）从而驱动液体（13）。发生器（11）包括第一和第二隔室（16,17），每个隔室包含反应物（19,20），隔室（16,17）以允许使用中的反应物流动的方式相互连接 19）从第一隔室（16）接触另一反应物（20），柠檬酸溶液（19）和粉状碳酸氢钠（20）形式的反应物在接触反应生成气体，其中气体的增加发电机（11）内的压力降低了来自第一隔室（16）的流动反应物（19）的速率，从而通过反馈控制气体产生速率，进而控制液体输送速率。可以通过夹紧从储存器（12）引出的管（14）来停止来自装置（10）的液体的输送，并且所产生的储存器（12）和气体发生器（11）中的压力的增加切断了反应物（19）从第一隔室（16）流出，从而停止反应。只有当管（14）松开并且储存器（12）内压力的降低导致反应物流动重新开始时。因此，交货可以中断20-30小时，随后重新开始全面有效。

9. 发明申请

WO1994023777A1 INTRADERMAL INJECTION DEVICE 审中-公开
标题翻译：内窥镜注射装置
公开(公告)号：WO1994023777A1
公开(公告)日：1994-10-27
申请号：PCT/IE1994000020
申请日：1994-04-07
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph , KELLY, John, Gerard
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED
IPC分类号： A61M05/42
CPC分类号： A61M5/425 , A61M5/282 , A61M5/3298 , A61M5/46
摘要： A device (10) for administering, including self-administering, a metered dose of a liquid medicament (23) intradermally or subcutaneously comprises means (12, 27', 30', 35) for creating a vacuum so as to secure the device (10) to the skin during medicament delivery, means (32) for penetrating one or more skin layers to a desired depth and delivering the medicament and means (12, 27', 30', 35) for releasing the vacuum for removal of the device (10) following medicament delivery. The device (10) can be in the form of a disposable, pre-filled product for once-off use. The device (10) provides a convenient method of medicament delivery for increasing patient compliance.
摘要翻译：一种用于自发施用计量剂量的液体药物（23）皮内或皮下的装置（10），包括用于产生真空以固定装置的装置（12,27'，30'，35）用于在药物输送期间皮肤的装置（32），用于将一个或多个皮肤层穿透到期望的深度并输送药物和装置（12,27'，30'和35），用于释放用于移除装置的真空（10）药物递送后。装置（10）可以是用于一次性使用的一次性预填充产品的形式。装置（10）提供了方便的药物递送方法，以增加患者依从性。

10. 发明申请

WO1993023096A1 LIQUID MATERIAL DISPENSER 审中-公开
标题翻译：液体材料分配器
公开(公告)号：WO1993023096A1
公开(公告)日：1993-11-25
申请号：PCT/IE1993000024
申请日：1993-04-29
申请人： ELAN MEDICAL TECHNOLOGIES LIMITED
发明人： ELAN MEDICAL TECHNOLOGIES LIMITED , GROSS, Joseph
IPC分类号： A61M05/155
CPC分类号： B67D7/0238 , A61M5/14224 , B05B11/00414 , B05B11/0056 , B67D7/72
摘要： A liquid material dispenser for dispensing medicaments includes a housing (2) formed with a reservoir (4) for the liquid to be dispensed, an outlet (6) through which the liquid is to be dispensed, and a connecting passageway (8) between the reservoir (4) and the outlet (6). A diaphragm (12) is located in a cavity (10) in the passageway (8) such that one side of the diaphragm (12) defines a pumping chamber (10a), and the other side defines a control chamber (10b). An electrolytic cell (14) generates a gas which is fed to the control chamber (10b) according to the quantity of electrical current passed through the electrolyte (14c), for driving the diaphragm (12) through forward strokes to pump liquid to the outlet (6); and a slow-acting vent (20) vents the gas from the control chamber (10b) to the atmosphere at a rate lower than that of generation of gas by the electrolytic cell (14), for driving the diaphragm (12) through return strokes to refill the pumping chamber (10a).
摘要翻译：用于分配药物的液体材料分配器包括形成有用于待分配液体的储存器（4）的壳体（2），待分配液体的出口（6）和在其间分配的连接通道（8）储存器（4）和出口（6）。隔膜（12）位于通道（8）中的空腔（10）中，使得隔膜（12）的一侧限定了泵送室（10a），另一侧限定了控制室（10b）。电解池（14）根据通过电解质（14c）的电流量，产生供给到控制室（10b）的气体，用于通过正向冲程驱动隔膜（12）将泵送到出口（6）; 并且缓慢作用的排气口（20）以比由电解槽（14）产生的气体低的速率将气体从控制室（10b）排出到大气中，以通过返回行程驱动隔膜（12）以再填充泵送室（10a）。

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