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1. 发明申请

WO1998024495A1 TWO-PART MEDICAL PRESSURE TRANSDUCER WITH DIAPHRAGM STAND-OFFS 审中-公开
标题翻译：两片医用压力传感器，具有透气式立体声功能
公开(公告)号：WO1998024495A1
公开(公告)日：1998-06-11
申请号：PCT/US1997021699
申请日：1997-11-20
申请人： MEDEX, INC. , BRUNNER, Glenn, D. , PATZER, Charles, R. , SHAH, Nilesh, M.
发明人： MEDEX, INC.
IPC分类号： A61M05/168
CPC分类号： F16M13/02 , A61M5/1413 , A61M5/16854 , A61M2205/12 , F16M11/041 , F16M11/16 , F16M11/22 , F16M13/005 , G01L19/0023
摘要： A medical pressure transducer (10) includes a reusable component (100) with channels (160, 162) to either side of a reusable diaphragm (124), and a disposable dome (200) with mountings wings (230, 232) to either side of a disposable diaphragm (224) and slidably receivable in the channels (160, 162) to mount the dome (200) with the diaphragms (124, 224) in confronting relationship. Stand-off bumps (223) are provided on the wings (230, 232) which cooperate with support surfaces (176) on the reusable component (100) in the channel (160 or 162) to keep the dome and reusable diaphragms (224, 124) sufficiently spaced apart as to minimize deleterious wear thereon when the dome (200) and reusable component (100) are put together and/or taken apart. Dimples (178) may be provided in the support (176) surface to receive the bumps (233) when the diaphragms are in confronting relationship and no longer need to be spaced sufficiently apart. Camming ramps (181, 240) are provided in the channels (100, 162) and on the wings (230, 232) by which to drive the dome diaphragm (224) into the reusable diaphragm (124).
摘要翻译：医疗压力传感器（10）包括具有到可重复使用的隔膜（124）的任一侧的通道（160,162）的可重复使用的部件（100），以及具有安装翼（230,232）到任一侧的一次性圆顶（200）的一次性隔膜（224），并且可滑动地容纳在通道（160,162）中，以使面罩与隔膜（124,224）安装在一起。支撑凸块（223）设置在与通道（160或162）中的可重复使用部件（100）上的支撑表面（176）配合的翼部（230,232）上，以保持圆顶和可重复使用的隔膜 124），当圆顶（200）和可重复使用部件（100）放在一起和/或分开时，足够间隔开以最小化其上的有害磨损。当隔膜处于面对关系并且不再需要相互间隔足够的间隔时，凹部（178）可以设置在支撑（176）表面中以接收凸起（233）。在通道（100,162）和翼（230,232）上设有凸轮斜面181,240，以驱动圆顶隔膜224进入可重复使用的隔膜124。

2. 发明申请

WO1998000186A1 IMPROVED INFUSION APPARATUS 审中-公开
标题翻译：改进的输液装置
公开(公告)号：WO1998000186A1
公开(公告)日：1998-01-08
申请号：PCT/IL1997000218
申请日：1997-06-30
申请人： MEDUN LTD. , TVERSKOY, Grigory, N. , LIPETSKER, Leonid , VORONOV, Evgeny , STRUZER, Roman
发明人： MEDUN LTD.
IPC分类号： A61M05/168
CPC分类号： A61M39/28 , A61M5/16827 , Y10S128/13
摘要： A multi-drug intravenous infusion apparatus which comprises a plurality of vials containing drugs to be provided to a patient; a fluid container containing a fluid to be mixed with said drugs; conduit means for leading drugs from said vials, mixed with fluid from said container, to means for introducing the drugs with said fluid into the patient's body, said conduit means comprising: a main section, a plurality of individual sections, each comprising at least a collapsible portion, connected to said vials and to said main section, a terminal section connected to said main section and to means for introducing the drugs with said fluid into the patient's body, and a fluid section leading fluid from said fluid container to said terminal section; a switching unit comprising a plurality of switches, each one associated with one of said individual sections, wherein each switch is capable of either blocking the drug flow in the associated section by exerting pressure whereby to collapse the collapsible portion thereof or allowing said flow by releasing said collapsible portion; and programmable control means for managing and regulating the operation of the apparatus.
摘要翻译：一种多药物静脉内输注装置，其包括多个容纳有待提供给患者的药物的小瓶; 含有与所述药物混合的流体的流体容器; 用于将来自所述容器的流体与来自所述容器的流体混合的导管药物的导管装置用于将药物与所述流体引入患者体内的装置，所述导管装置包括：主部分，多个单独部分，每个部分至少包括连接到所述小瓶和所述主要部分的可折叠部分，连接到所述主要部分的端子部分和用于将药物与所述流体引入患者体内的装置，以及将流体从所述流体容器引导到所述端子部分的流体部分 ; 开关单元，包括多个开关，每个开关与所述单独部分中的一个相关联，其中每个开关能够通过施加压力来阻塞相关部分中的药物流动，从而通过释放压力来使其可折叠部分折叠或允许所述流动所述可折叠部分; 以及用于管理和调节装置的操作的可编程控制装置。

3. 发明申请

WO1997007842A1 CONTINUOUSLY OPERATING INFUSION DEVICE AND METHOD 审中-公开
标题翻译：连续操作输液装置和方法
公开(公告)号：WO1997007842A1
公开(公告)日：1997-03-06
申请号：PCT/FR1996001297
申请日：1996-08-20
申请人： DEBIOTECH S.A. , NEFTEL, Frédéric , BOUVIER, Bernard
发明人： DEBIOTECH S.A.
IPC分类号： A61M05/168
CPC分类号： A61M5/16827 , A61M5/007
摘要： A continuously operating infusion device has two discrete infusion bottles (12) for at least one fluid to be injected to a patient by means of a tubing, each bottle having means (51) for detecting that the infusion of the fluid contained therein is completed and for controlling fluid flow interruption means (53). The device has an upstream infusion device (10) with two feed tubes (50) connected to a bottle (12) and a downstream infusion device (70) with fluid pumping means (72, 84) connected to the patient by a downstream tube (78) as well as to connector means (54). The device is useful for conducting infusions prior to an imaging procedure by X-ray or NMR scanner.
摘要翻译：连续操作的输注装置具有两个离散输液瓶（12），用于通过管道将至少一种待注射到患者的流体，每个瓶子具有用于检测其中包含的流体的输液完成的装置（51）用于控制流体流动中断装置（53）。所述装置具有上游输注装置（10），其中两个进料管（50）连接到瓶（12）和下游输注装置（70），其中流体泵送装置（72,84）通过下游管连接到患者 78）以及连接器装置（54）。该装置可用于在通过X射线或NMR扫描仪的成像程序之前进行输注。

4. 发明申请

WO1995032014A1 INSTANTANEOUS VOLUME MEASUREMENT SYSTEM AND METHOD FOR NON-INVASIVELY MEASURING LIQUID PARAMETERS 审中-公开
标题翻译：用于非自发测量液体参数的瞬时体积测量系统和方法
公开(公告)号：WO1995032014A1
公开(公告)日：1995-11-30
申请号：PCT/US1995004874
申请日：1995-04-21
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , PACKARD, Warren, J. , PAWLAK, Kenneth, E.
IPC分类号： A61M05/168
CPC分类号： G01F1/00 , A61M5/16809 , A61M5/16886 , G01F1/86
摘要： A non-invasive technique and system is provided for measuring flow of liquid driven by a flexible diaphragm of a membrane pump (18). Flow, pressure and/or temperature of a gas, such as air, used to drive the pump (18) is continuously monitored. Instantaneous volume of liquid being pulled into or out of a chamber of the pump (18) can be calculated from measured values of the gas used to drive the pump (18). Sensors (10, 12 and/or 14) are used to measure values relating to the gas. The sensed parameters are concurrently monitored and continuously determine the amount of gas flowing to and from the diaphragm of the membrane pump (18) utilized to move liquid within a liquid pathway. The measurements may then be used to calculate the instantaneous flow rate of the liquid.
摘要翻译：提供了一种非侵入性技术和系统，用于测量由膜泵（18）的柔性隔膜驱动的液体的流动。连续监测用于驱动泵（18）的气体（例如空气）的流量，压力和/或温度。可以从用于驱动泵（18）的气体的测量值来计算被拉入或流出泵（18）的腔室的瞬时体积。传感器（10,12和/或14）用于测量与气体有关的值。同时监测所感测的参数，并且连续地确定流入和流出用于在液体通路内移动液体的膜泵（18）的隔膜的气体量。然后可以使用测量来计算液体的瞬时流速。

5. 发明申请

WO1993021977A1 FLOW CONTROL DEVICE FOR INFUSION SYSTEMS 审中-公开
标题翻译：用于输液系统的流量控制装置
公开(公告)号：WO1993021977A1
公开(公告)日：1993-11-11
申请号：PCT/FR1993000410
申请日：1993-04-28
申请人： CHRONOTEC S.A.R.L. , TECHSONIC S.A.R.L. , HAUSER, Jean-Luc , GUYOMAR, Daniel , SAUZADE, Jean, Denis
发明人： CHRONOTEC S.A.R.L. , TECHSONIC S.A.R.L.
IPC分类号： A61M05/168
CPC分类号： A61M5/168 , G05D7/06
摘要： A device for controlling the flow of a medicinal substance in an infusion tube by means of a valve comprising a sealing means and a circuit (24) for controlling the position of the sealing means. The valve includes a chamber (10) with an inlet (12) and an outlet (14), a bi-metallic strip (16) arranged within the chamber (10) and secured to one of its walls (18), a ball (20) secured to the bi-metallic strip (16) for partially or entirely sealing off the inlet (12), and a control circuit (24) for controlling the voltages (V1, V2) applied to said strip (16) in order to provided continuous and accurate control of the flow of medicinal substance through the valve.

6. 发明申请

WO1992016247A2 FLOW-CONTROL VALVE SYSTEM 审中-公开
标题翻译：流量控制阀系统
公开(公告)号：WO1992016247A2
公开(公告)日：1992-10-01
申请号：PCT/US1992002294
申请日：1992-03-20
申请人： DEKA PRODUCTS LIMITED PARTNERSHIP
发明人： DEKA PRODUCTS LIMITED PARTNERSHIP , KAMEN, Dean, L. , FAUST, Valentine, L.
IPC分类号： A61M05/168
CPC分类号： F04B43/043 , A61M39/22 , A61M39/26 , A61M2205/128 , F16K31/005
摘要： A valve for controlling intravenous fluid includes a flexible membrane (11), which together with a rigid body (21) forms a valving chamber (29). Two mouths (27, 32) lead into and out of the valving chamber. In one embodiment, a stem (23) having an enlarged portion (15) is attached to the membrane's inner face and extends into the outlet mouth. Fluid pressure on the inner face causes the enlarged portion of the stem to press against a narrower portion (38) of the outlet conduit, thereby preventing flow through the oulet conduit. External pressure on the membrane's outer face causes the enlarged portion of the stem to separate from the outlet conduit's walls, thereby permitting flow through the outlet conduit. In another embodiment, a groove (43) is placed near one of the mouths. The membrane may be pressed against the rigid body and the groove, so as to prevent flow except through the groove and to variably restrict flow through the groove.
摘要翻译：用于控制静脉内流体的阀包括柔性膜（11），其与刚体（21）一起形成阀腔（29）。两口（27,32）进入和离开阀室。在一个实施例中，具有扩大部分（15）的杆（23）附接到膜的内表面并延伸到出口。内表面上的流体压力导致杆的扩大部分压靠出口管道的较窄部分（38），从而防止流过口腔导管。膜的外表面上的外部压力导致杆的扩大部分与出口导管的壁分离，从而允许流过出口导管。在另一个实施例中，凹槽（43）放置在其中一个口附近。膜可以压靠刚性体和凹槽，以防止除了沟槽之外的流动并且可变地限制流过凹槽的流动。

7. 发明申请

WO1997010013A1 METHOD AND ARRANGEMENT FOR DETECTING THE CONDITION OF A BLOOD VESSEL ACCESS 审中-公开
标题翻译：检测血液流通条件的方法和装置
公开(公告)号：WO1997010013A1
公开(公告)日：1997-03-20
申请号：PCT/SE1996001127
申请日：1996-09-11
申请人： GAMBRO AB , HERTZ, Thomas , JÖNSSON, Sven , STERNBY, Jan
发明人： GAMBRO AB
IPC分类号： A61M05/168
CPC分类号： A61M5/16859 , A61M1/16 , A61M1/34 , A61M1/3639 , A61M1/3656 , A61M2205/13 , A61M2205/18 , A61M2205/3331 , A61M2205/3344
摘要： The heart produces a pressure wave which passes via the blood vessel access (1, 14) and is sensed by a pressure detector (4, 15) on the other side of the blood vessel access. The signal obtained comprises interference signals which are separated via a processing arrangement (25) in order to obtain the pulse signal. Absence of the pulse signal indicates a malfunction in the blood vessel access. A blood pump in an extracorporeal blood circuit can be used as a pressure wave generator.
摘要翻译：心产生通过血管通路（1,14）的压力波，并由血管通路另一侧的压力检测器（4,15）感测。获得的信号包括通过处理装置（25）分离以获得脉冲信号的干扰信号。没有脉搏信号表示血管通路的故障。体外血液回路中的血泵可用作压力波发生器。

8. 发明申请

WO1997007843A1 UPSTREAM OCCLUSION DETECTION SYSTEM 审中-公开
标题翻译： UPSTREAM监测系统
公开(公告)号：WO1997007843A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013881
申请日：1996-08-29
申请人： IVAC MEDICAL SYSTEMS, INC.
发明人： IVAC MEDICAL SYSTEMS, INC. , BUTTERFIELD, Robert, D.
IPC分类号： A61M05/168
CPC分类号： A61M5/16859 , A61M2005/16872
摘要： A pumping segment of a fluid line alternately in fluid communication with the upstream and downstream portions of the fluid line connects a fluid supply to a fluid receiver. A pressure sensor located downstream of the segment monitors the pressure during the segment's communication with the upstream and downstream ends. The pressure difference is used to establish a pressure threshold against which the average pressure is compared to determine if an upstream occlusion exists. Should the average pressure fall within a cautionary zone, the pump is reversed to examine the pressure difference once again. Based on the pressure difference during thre reversal, a pressure threshold line may be adjusted thereby adapting to fluid administration conditions.
摘要翻译：交替地与流体管线的上游部分和下游部分流体连通的流体管线的泵送段将流体供应件连接到流体接收器。位于分段下游的压力传感器监测分段与上游和下游端的通信期间的压力。压力差被用于建立压力阈值，使平均压力与之相比较以确定是否存在上游阻塞。如果平均压力落在警戒区内，则泵反转以再次检查压力差。基于反转期间的压力差，可以调节压力阈值线，从而适应流体管理条件。

9. 发明申请

WO1996040328A2 CASSETTE FOR INTRAVENOUS-LINE FLOW-CONTROL SYSTEM 审中-公开
标题翻译：用于静态流量控制系统的CASSETTE
公开(公告)号：WO1996040328A2
公开(公告)日：1996-12-19
申请号：PCT/US1996006622
申请日：1996-05-09
申请人： DEKA PRODUCTS LIMITED PARTNERSHIP
发明人： DEKA PRODUCTS LIMITED PARTNERSHIP , HOULE, Phillip, R. , LARKINS, William, T.
IPC分类号： A61M05/168
CPC分类号： A61M5/14224 , A61M5/1413 , A61M5/16809 , A61M5/16831 , A61M5/16854 , A61M5/16877 , A61M5/36 , A61M5/365 , A61M2005/1402 , A61M2205/12 , A61M2205/128 , A61M2205/35 , A61M2205/8206 , F04B43/043 , F16K31/005 , G01N29/036 , G01N29/12 , G01N2291/02433 , G01N2291/02836
摘要： A cassette for controlling the flow of IV fluid from a patient to a source. The cassette preferably includes, along the fluid passage through the cassette, first and second membrane-based valves (6, 7) on either side of a pressure-conduction chamber (50), and a stopcock-type valve (20). The stopcock valve is preferably located downstream of the second membrane-based valve (7), which is preferably located downstream of the pressure-conduction chamber (50). The stopcock control valve preferably has two rigid cylindrical members (22, 220) with complementary surfaces, wherein one member includes a tapered groove (231) defined on its complementary surface. The two complementary surfaces define a space therebetween, instead of having an interference fit, and a resilient sealing member (25) is disposed in this space. When the first and second rigid members are in an open position with respect to each other, the sealing member defines an aperture (251) through which fluid communication is provided between the fluid-path portions (23, 24) defined respectively by the two rigid members. When the first and second rigid members are in the closed position with respect to each other, the sealing member provides a seal preventing flow between the fluid-path portions. The membrane defining the valving chamber of the second membrane-based valve (7) is preferably large and resilient, so that the valving chamber (75) may provide a supply of pressurized intravenous fluid to the patient, when the valve is closed and the stopcock valve provides a restriction downstream of the valve. The pressure-conduction chamber (50) preferably has a membrane (41) that is stable in the empty-chamber position but relatively unstable in the filled-chamber position.
摘要翻译：用于控制从患者到源的IV流体的流动的盒。所述盒优选地包括沿着通过所述盒的流体通道，在压力传导室（50）的任一侧上的第一和第二膜基阀（6,7）和活塞式阀（20）。活塞阀优选地位于第二膜基阀（7）的下游，其优选位于压力传导室（50）的下游。活塞控制阀优选地具有两个具有互补表面的刚性圆柱形构件（22,220），其中一个构件包括限定在其互补表面上的锥形槽（231）。两个互补表面在它们之间限定了一个空间，而不是具有过盈配合，并且弹性密封件（25）设置在该空间中。当第一和第二刚性构件相对于彼此处于打开位置时，密封构件限定一个孔（251），流体连通被设置在流体通路部分（23,24）之间，分别由两个刚性成员。当第一和第二刚性构件相对于彼此处于关闭位置时，密封构件提供防止流体路径部分之间流动的密封件。限定第二膜基阀（7）的阀室的膜优选是大的和有弹性的，使得当阀关闭时，阀室（75）可以向患者提供加压的静脉内流体供应，并且止动阀阀门在阀门下游提供限制。压力传导室50优选地具有在空腔位置稳定但在填充室位置中相对不稳定的膜41。

10. 发明申请

WO1996039211A1 METHOD AND SYSTEM FOR OBTAINING TARGET INFUSION DOSAGE 审中-公开
标题翻译：用于获取目标输注剂量的方法和系统
公开(公告)号：WO1996039211A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008808
申请日：1996-06-05
申请人： COBE LABORATORIES, INC.
发明人： COBE LABORATORIES, INC. , ELLINGBOE, Bruce, S.
IPC分类号： A61M05/168
CPC分类号： A61M5/16827 , A61M1/361 , A61M1/3664 , A61M5/1723 , A61M2205/366 , A61M2209/082 , Y10S128/03
摘要： A method and system are disclosed for more accurate administration of a composition being infused into a body fluid having formed elements. The improved accuracy is due to a correction factor that corrects for the relative impermeability of the formed elements to the infused composition. In one embodiment, the infusion system is a cardioplegia system in which a controller receives information pertaining to the hematocrit and initial blood potassium concentration and adjusts blood flow rate and crystalloid (KCl) solution flow rate so as to obtain the desired resulting potassium concentration in the cardioplegia. The invention further includes an infusion system that comprises a controller which uses an equation that relates the correction factor to an index of formed elements in the body fluid, such as the hematocrit. The equation is determined empirically from a series of experiments in which the resulting concentration of the substance infused into the body fluid is correlated to a formed element index of the body fluid, such as hematocrit.
摘要翻译：公开了一种方法和系统，用于更精确地施用注入具有形成元件的体液中的组合物。改进的精确度是由于校正因子，其校正了形成的元件对于输注的组合物的相对不渗透性。在一个实施例中，输注系统是心脏停搏系统，其中控制器接收关于血细胞比容和初始血液钾浓度的信息，并且调节血液流速和晶体（KCl）溶液流速，以获得所需的所得钾浓度停搏。本发明还包括输注系统，其包括控制器，该控制器使用将校正因子与体液中形成的元件的指数（例如血细胞比容）相关联的方程式。该方程式是从一系列实验确定的，其中输入体液中的物质的浓度与体液的形成的元素指数（例如血细胞比容）相关。

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