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1. 发明申请

WO2011025957A3 TG-APROTININ FUSION PROTEINS AND MATRICES THEREOF 审中-公开
标题翻译： TG-APROTININ融合蛋白及其基因
公开(公告)号：WO2011025957A3
公开(公告)日：2011-07-07
申请号：PCT/US2010046991
申请日：2010-08-27
申请人： ECOLE POLYTECH , HUBBELL JEFFREY A , FREY PETER , LORENTZ KRISTEN
发明人： HUBBELL JEFFREY A , FREY PETER , LORENTZ KRISTEN
IPC分类号： A61L24/10
CPC分类号： A61L24/106 , A61L24/108 , A61L31/046 , A61L31/047
摘要： Fusion proteins containing a first domain and a second domain, where the first domain contains a crosslinkable substrate domain and the second domain contains a fibrinolysis inhibitor, are provided. In a preferred embodiment, the fibrinolysis inhibitor is a protease inhibitor, preferably, aprotinin. The fusion protein optionally contains a degradable site between the fist domain and the second domain. In a preferred embodiment, the crosslinkable substrate domain is a transglutaminase substrate domain, more preferably a Factor XIIIa substrate domain. Also provided is a method for decreasing the degradation of a fibrin matrix, and supplemented fibrin matrices with reduced degradation rates. The method includes covalently crossHnking a fusion protein containing a fibrinolysis inhibitor to the matrix. The supplemented fibrin matrices contain lower concentrations of a fibrinolysis inhibitor covalently bound to the matrix, compared to the concentration of unbound fibrinolysis inhibitor required to achieve the same reduction in degradation of the fibrin matrix.
摘要翻译：提供了含有第一结构域和第二结构域的融合蛋白，其中第一结构域含有可交联的底物结构域，第二结构域含有纤维蛋白溶解抑制剂。在优选的实施方案中，纤维蛋白溶解抑制剂是蛋白酶抑制剂，优选抑肽酶。融合蛋白任选地包含第一结构域和第二结构域之间的可降解位点。在优选的实施方案中，可交联底物结构域是转谷氨酰胺酶底物结构域，更优选因子XIIIa底物结构域。还提供了降低纤维蛋白基质降解的方法，以及降低降解速率的补充的纤维蛋白基质。该方法包括将含有纤维蛋白溶解抑制剂的融合蛋白共价交叉到基质上。与实现纤维蛋白基质降解相同的降低所需的未结合的纤维蛋白溶解抑制剂的浓度相比，补充的纤维蛋白基质含有较低浓度的与基质共价结合的纤维蛋白溶解抑制剂。

2. 发明申请

WO8807096A3 EPITAXIAL INSTALLATION 审中-公开
标题翻译：外来安装
公开(公告)号：WO8807096A3
公开(公告)日：1988-10-06
申请号：PCT/EP8800188
申请日：1988-03-10
申请人： SITESA SA , DAN JEAN PIERRE , BONI EROS DE , FREY PETER , IFANGER JOHANN
发明人： DAN JEAN-PIERRE , DE BONI EROS , FREY PETER , IFANGER JOHANN
IPC分类号： C30B25/02 , C30B25/12 , C30B25/14 , C30B25/16 , C30B35/00 , H01L21/205
CPC分类号： C30B25/02 , C30B25/12 , C30B25/14 , C30B35/00
摘要： Epitaxial installation with at least one reaction chamber (10) of a dielectrical material, provided with a gas inlet in the cover area and a gas outlet in the floor area, a gas mixer (100) connected to the gas inlet of the reaction chamber (10), for the introduction of reaction and circulation gases, a rotatable graphite support (50), disposed in the reaction chamber between the gas inlet and gas outlet, tapering towards the gas inlet and in the form of a polyhedron, for supporting several wafers (70), an induction heater (510, 512), essentially surrounding the reaction chamber (10), for the indirect heating of the wafer support (50), a device for transporting the wafer support (50) from a charging zone (150) outside the reaction chamber (10) into a work position within the reaction chamber, a device (300) for dispatching the wafer support (50) with wafers (70) into the charging zone (15), and a pure air space (1) for the reception of said components of the installation. Also a pipe for carrying circulation and reaction gases from the gas mixer (100) through the reaction chamber (10) when the wafer supports (50) are in the work position, and for carrying pure air gases and inert gases to the pure air space (1) between the charging zone (150) and the work position within the reaction chamber (10), when the wafer supports are in the charging zone, ensuring that particles carried with the gases and created during the epitaxial process are kept away from the surface of the wafer support (50).

3. 发明申请

WO02056907A3 MOLECULAR ANTIGEN ARRAY PRESENTING AMYLOID BETA 审中-公开
标题翻译：分子抗原阵列呈现AMYLOID BETA
公开(公告)号：WO02056907A3
公开(公告)日：2002-12-27
申请号：PCT/IB0200168
申请日：2002-01-21
申请人： CYTOS BIOTECHNOLOGY AG , NOVARTIS PHARMA AG , RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE , ORTMANN RAINER , LUEOEND RAINER , STAUFENBIEL MATTHIAS , FREY PETER
发明人： RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE , ORTMANN RAINER , LUEOEND RAINER , STAUFENBIEL MATTHIAS , FREY PETER
IPC分类号： A61K39/00 , A61K35/76 , A61K38/00 , A61K38/11 , A61K39/02 , A61K39/12 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/00 , C07K14/005 , C07K14/02 , C07K14/08 , C07K14/245 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N15/40
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序的和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病的疫苗，用于预防或治愈癌症以及有效地诱导自身特异性免疫应答（特别是抗体应答）的过敏症药物和药物。

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