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1. 发明申请

WO2022043558A1 METHOD OF TREATING PSMA-EXPRESSING CANCERS 审中-公开
公开(公告)号：WO2022043558A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073900
申请日：2021-08-30
申请人： ADVANCED ACCELERATOR APPLICATIONS INTERNATIONAL SA , ADVANCED ACCELERATOR APPLICATIONS USA, INC. , NOVARTIS PHARMA AG
发明人： GERICKE, Germo , GIMENEZ ARNAU, Jose-Maria , DALAL, Darshan
IPC分类号： A61K51/04 , A61K103/30 , A61K103/40 , A61P35/00
摘要： The present invention relates to combinations for use and methods of treating cancers that express prostate specific membrane antigen (PSMA). In particular, the invention provides novel therapies based on the combination of a PSMA therapeutic agent, such as radiolabeled Compound I, and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR agonists, TGF-β inhibitors, IL15/IL-15RA, PD-1 inhibitors, PD-L1 inhibitors, and CTLA-4 inhibitors.

2. 发明申请

WO2022043557A1 METHOD OF TREATING PSMA-EXPRESSING CANCERS 审中-公开
公开(公告)号：WO2022043557A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073898
申请日：2021-08-30
申请人： ADVANCED ACCELERATOR APPLICATIONS INTERNATIONAL SA , ADVANCED ACCELERATOR APPLICATIONS USA, INC. , NOVARTIS PHARMA AG
发明人： GERICKE, Germo , GIMENEZ ARNAU, Jose-Maria , DALAL, Darshan
IPC分类号： A61K51/04 , A61K45/06 , A61K103/30 , A61K103/40 , A61P35/00
摘要： The present invention relates to combinations for use and methods of treating cancers that express prostate specific membrane antigen (PSMA). In particular, the invention provides novel therapies based on the combination of a PSMA therapeutic agent, such as radiolabeled Compound of the Formula I, and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR agonists, TGF-β inhibitors, IL15/IL-15RA complex, PD-1 inhibitors, PD-L1 inhibitors, and CTLA-4 inhibitors.

3. 发明申请

WO2014130682A3 METHOD OF ANALYSIS USING ARRAY SENSOR 审中-公开
标题翻译：使用阵列传感器的分析方法
公开(公告)号：WO2014130682A3
公开(公告)日：2016-07-21
申请号：PCT/US2014017413
申请日：2014-02-20
申请人： NOVARTIS PHARMA AG , MASSACHUSETTS INST TECHNOLOGY
发明人： REUEL NIGEL F , STRANO MICHEAL S , WAHL RAMON , HELK BERNHARD
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54346
摘要： Arrays can be used to assay binding heterogeneity and other characteristics of biomanufactured products.
摘要翻译：数组可用于测定生物制造产品的结合异质性和其他特征。

4. 发明申请

WO2014186692A8 COMPUTER-IMPLEMENTED METHODS OF DETERMINING PROTEIN VISCOSITY 审中-公开
标题翻译：计算机实现蛋白质粘度测定方法
公开(公告)号：WO2014186692A8
公开(公告)日：2014-12-31
申请号：PCT/US2014038368
申请日：2014-05-16
申请人： MASSACHUSETTS INST TECHNOLOGY , NOVARTIS PHARMA AG
发明人： TROUT BERNHARDT LEVY , HELK BERNHARD , AGRAWAL NEERAJ JAGDISH
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G06F19/16 , G01N11/00 , G01N33/6803 , G01N33/6854 , G01N2011/006
摘要： The invention provides computer-implemented methods for screening proteins such as antibodies based on viscosity properties. The methods involve making a spatial charge map (SCM) of the three- dimensional structure of the antibody or protein and determine a SCM score depending on a condition such as e.g. pH, which score correlates with the viscosity. Thus a quantitative measure of the viscosity is obtained.
摘要翻译：本发明提供用于基于粘度性质筛选蛋白质如抗体的计算机实现的方法。所述方法包括制备抗体或蛋白质的三维结构的空间电荷图（SCM），并根据诸如例如， pH，该分数与粘度相关。因此获得粘度的定量测量。

5. 发明申请

WO2014186692A1 COMPUTER-IMPLEMENTED METHODS OF DETERMINING PROTEIN VISCOSITY 审中-公开
标题翻译：计算机实施的测定蛋白质粘度的方法
公开(公告)号：WO2014186692A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/038368
申请日：2014-05-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NOVARTIS PHARMA AG
发明人： TROUT, Bernhardt, Levy , HELK, Bernard , AGRAWAL, Neerah, Jagdish
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G06F19/16 , G01N11/00 , G01N33/6803 , G01N33/6854 , G01N2011/006
摘要： The invention provides computer-implemented methods for screening proteins such as antibodies based on viscosity properties. The methods involve making a spatial charge map (SCM) of the three- dimensional structure of the antibody or protein and determine a SCM score depending on a condition such as e.g. pH, which score correlates with the viscosity. Thus a quantitative measure of the viscosity is obtained.
摘要翻译：本发明提供了用于基于粘度特性筛选诸如抗体的蛋白质的计算机实施的方法。该方法涉及制作抗体或蛋白质的三维结构的空间电荷图（SCM），并根据诸如例如血管生成的状况确定SCM分数。 pH值，该评分与粘度相关。因此可以获得粘度的定量测量值。

6. 发明申请

WO2014130682A2 METHOD OF ANALYSIS USING ARRAY SENSOR 审中-公开
标题翻译：使用阵列传感器的分析方法
公开(公告)号：WO2014130682A2
公开(公告)日：2014-08-28
申请号：PCT/US2014/017413
申请日：2014-02-20
申请人： NOVARTIS PHARMA AG , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： REUEL, Nigel, F. , STRANO, Micheal, S. , WAHL, Ramon , HELK, Bernhard
IPC分类号： G01N33/53
CPC分类号： G01N33/54346
摘要： Arrays can be used to assay binding heterogeneity and other characteristics of biomanufactured products.
摘要翻译：数组可用于测定生物制造产品的结合异质性和其他特征。

7. 发明申请

WO2007100741A2 SYSTEM FOR DELIVERING NEBULIZED CYCLOSPORINE AND METHODS OF TREATMENT 审中-公开
标题翻译：递送环磷酰胺系统和治疗方法
公开(公告)号：WO2007100741A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004861
申请日：2007-02-22
申请人： NOVARTIS PHARMA AG , LAI, Johnny
发明人： LAI, Johnny
IPC分类号： A61M16/10
CPC分类号： A61M16/105 , A61M16/0093 , A61M16/1065
摘要： Systems comprising a pressurized delivery device and a formulation of cyclosporine coupled to an exhalation filter or trap that is capable of preventing cyclosporine from escaping into the local environment are provided. An apparatus for use in the system comprises either an exhalation filter and a pressurized delivery device, wherein the exhalation filter is capable of providing high filter efficiency and maintaining low filter resistance after usage with the formulation, or a trap which provides a means for expired gas to be released into a solvent chamber containing a solvent with a high affinity for cyclosporine. These systems may be used to treat patients with pulmonary disorders, organ transplant patients such as lung transplant patients, and other immune-related disorders.
摘要翻译：提供了包括加压输送装置和联合到呼出过滤器或捕集器的环孢菌素制剂的系统，其能够防止环孢菌素逃逸到局部环境中。用于该系统的装置包括呼气过滤器和加压输送装置，其中呼气过滤器能够在配制剂使用后提供高过滤效率和维持低过滤阻力，或提供呼出气体的装置被释放到含有对环孢菌素具有高亲和力的溶剂的溶剂室中。这些系统可用于治疗肺部疾病患者，器官移植患者如肺移植患者和其他免疫相关疾病。

8. 发明申请

WO2005063766A3 BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS 审中-公开
标题翻译： Bicyclic杂环P-38激酶抑制剂
公开(公告)号：WO2005063766A3
公开(公告)日：2005-09-09
申请号：PCT/US2004043682
申请日：2004-12-23
申请人： NOVARTIS PHARMA AG , DONG QING , WANG JIANQIANG , LAN JIONG , LANG HENGYUAN
发明人： DONG QING , WANG JIANQIANG , LAN JIONG , LANG HENGYUAN
IPC分类号： C07D473/00 , C07D487/04 , A61K31/437 , A61P29/00
CPC分类号： C07D473/00 , C07D473/28 , C07D473/30 , C07D473/34 , C07D487/04
摘要： Provided are bicyclic heterocycle-based p38 kinase, including p38alpha and p38beta kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amehoration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
摘要翻译：提供了基于双环杂环的p38激酶，包括p38α和p38β激酶抑制剂。还提供了含有这些化合物的药物组合物。还提供了使用所述化合物和组合物的方法，包括治疗，预防，或p38激酶介导的疾病和病症，包括的一种或多种症状的amehoration方法，但不限于，炎性疾病和病症。

9. 发明申请

WO2004016282A1 VACCINE COMPOSITIONS CONTAINING AMYLOID BETA1-6 ANTIGEN ARRAYS 审中-公开
标题翻译：含有AMYLOID BETA1-6抗原阵列的疫苗组合物
公开(公告)号：WO2004016282A1
公开(公告)日：2004-02-26
申请号：PCT/EP2003/007864
申请日：2003-07-18
申请人： CYTOS BIOTECHNOLOGY AG , NOVARTIS PHARMA AG , BACHMANN, Martin, F. , TISSOT, Alain , ORTMANN, Rainer , LÜÖND, Rainer , STAUFENBIEL, Matthias , FREY, Peter
发明人： BACHMANN, Martin, F. , TISSOT, Alain , ORTMANN, Rainer , LÜÖND, Rainer , STAUFENBIEL, Matthias , FREY, Peter
IPC分类号： A61K39/385
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ 1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是Abeta1-6肽-VLP组合物的组合物。更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

10. 发明申请

WO2014015280A1 COMBINATION THERAPY OF INHIBITORS FOR IGF1 R AND PI3K 审中-公开
标题翻译： IGF1 R和PI3K抑制剂的组合治疗
公开(公告)号：WO2014015280A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/051345
申请日：2013-07-19
申请人： NOVARTIS PHARMA AG , AMGEN INC. , HUANG, Xizhong , PETERS, Malte , SCHUMACHER, Karl Maria , CAO, Zhu Alexander , GANSERT, Jennifer Lorraine , CHANG, David Dong Eun
发明人： HUANG, Xizhong , PETERS, Malte , SCHUMACHER, Karl Maria , CAO, Zhu Alexander , GANSERT, Jennifer Lorraine , CHANG, David Dong Eun
IPC分类号： C07K16/28 , A61P35/00 , A61K31/4439 , C07D417/14
CPC分类号： A61K31/4439 , A61K39/3955 , A61K2039/505 , C07K16/2863 , C07K2316/96 , C07K2317/565 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination comprising an alpha- isoform specific phosphatidylinositol 3-kinase inhibitor compound, such as (S)-Pyrrolidine- 1,2-dicarboxylic acid 2-amide l-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin- 4-yl]-thiazol-2-yl}-amide), or pharmaceutically acceptable salt thereof, and an IGF1R inhibitor (e.g., the IGF1R inhibitor ANTIBODY A, or a variant or derivative thereof), a pharmaceutical composition comprising such combination, methods for treating cancer comprising administration of therapeutically effective amounts of such inhibitors to a subject in need thereof, and uses of such combination for the treatment of cancer.
摘要翻译：本发明涉及包含α-同种型特异性磷脂酰肌醇3-激酶抑制剂化合物的药物组合，例如（S） - 吡咯烷-1,2-二羧酸2-酰胺1 - （{4-甲基-5- [2 - （2,2,2-三氟-1,1-二甲基 - 乙基） - 吡啶-4-基] - 噻唑-2-基} - 酰胺）或其药学上可接受的盐和IGF1R抑制剂（例如， IGF1R抑制剂抗体A或其变体或衍生物），包含这种组合的药物组合物，用于治疗癌症的方法，包括向有需要的受试者施用治疗有效量的此类抑制剂，以及这种组合用于治疗癌症的用途。

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