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1. 发明申请

WO2010125202A1 INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：流感嗜血红蛋白组合物及其用途
公开(公告)号：WO2010125202A1
公开(公告)日：2010-11-04
申请号：PCT/EP2010/055944
申请日：2010-04-30
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , JEGERLEHNER, Andrea , SAUDAN, Philippe
发明人： BACHMANN, Martin , JEGERLEHNER, Andrea , SAUDAN, Philippe
IPC分类号： A61K47/48 , A61P39/00
CPC分类号： A61K47/6901 , A61K47/646
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and / or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and / or preventing influenza virus infection.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供用于治疗，改善和/或预防流感的组合物，疫苗组合物和药物组合物。本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是流感病毒血凝素蛋白的胞外域或所述胞外域的片段流感病毒血凝素蛋白。当施用于动物，优选给人时，所述组合物，疫苗组合物和药物组合物有效诱导免疫应答，特别是抗体应答，其中通常且优选地，所述抗体应答针对流感病毒。因此，本发明还提供了治疗，改善和/或预防流感病毒感染的方法。

2. 发明申请

WO2009068335A1 HUMAN MONOCLONAL NICOTINE SPECIFIC ANTIBODIES 审中-公开
标题翻译：人类单克隆抗体特异性抗体
公开(公告)号：WO2009068335A1
公开(公告)日：2009-06-04
申请号：PCT/EP2008/062104
申请日：2008-09-11
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , BAUER, Monika , BEERLI, Roger
发明人： BACHMANN, Martin , BAUER, Monika , BEERLI, Roger
IPC分类号： C07K16/16 , A61K39/395 , C07K16/44 , A61P25/34
CPC分类号： C07K16/16 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to recombinantly produced human monoclonalantibodies which are specifically binding nicotine and to nucleic acids encoding the same.The invention further relates to the use of such antibodies in the treatment of nicotine addiction.
摘要翻译：本发明涉及重组产生的特异性结合尼古丁的人单克隆抗体和编码该烟碱的核酸。本发明还涉及这种抗体在治疗尼古丁成瘾中的用途。

3. 发明申请

WO2008129020A1 VACCINATION REGIMEN FOR B-CELL VACCINES 审中-公开
标题翻译： B细胞疫苗的疫苗接种
公开(公告)号：WO2008129020A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054775
申请日：2008-04-18
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , MAURER, Patrik , MÜLLER, Philipp , PFISTER, Thomas , RENNER, Wolfgang
发明人： BACHMANN, Martin , MAURER, Patrik , MÜLLER, Philipp , PFISTER, Thomas , RENNER, Wolfgang
IPC分类号： A61K39/385 , A61K47/48 , A61P25/30
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/55505
摘要： This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibodyresponses in a vaccinated subject. The invention further provides a method forprevention or treatment of a disease by inducing hapten-specific antibodiesin asubject comprising administering into said subject acomposition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.
摘要翻译：本发明涉及疫苗接种和治疗或预防疾病领域。特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。本发明进一步提供了一种预防或治疗疾病的方法，通过诱导半抗原特异性抗体作为对象，包括向所述受试者的复合物施用，其包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原。

4. 发明申请

WO2008071774A1 PURIFICATION PROCESS FOR COAT PROTEIN OF RNA BACTERIOPHAGES 审中-公开
标题翻译： RNA特异性蛋白的蛋白质蛋白的纯化过程
公开(公告)号：WO2008071774A1
公开(公告)日：2008-06-19
申请号：PCT/EP2007/063907
申请日：2007-12-13
申请人： CYTOS BIOTECHNOLOGY AG , GÜNTHER, Constanze , PROBA, Karl , RICHTER, Susanne , TOPELL, Simon
发明人： GÜNTHER, Constanze , PROBA, Karl , RICHTER, Susanne , TOPELL, Simon
IPC分类号： C07K14/08 , C12N7/02 , C12N7/04
CPC分类号： C07K14/005 , C12N2795/18122
摘要： The invention relates to aprocess for purifying coat protein of an RNA bacteriophage, wherein said process comprises the steps of disassembling a virus-like particle of an RNA bacteriophage and subsequently purifying said coat protein. The process described herein is designed to be scaled up to produce up to 100 g coat protein and more per batch, and it allows the efficientremoval of RNA and host cell derived impurities, typically below the quantification level. The invention further relates to purified coat protein of RNA bacteriophages, wherein said purified coat protein typically comprises less than 0.5 µg RNA, less than 0.4 IU of endotoxin, less than 5 ng host cell protein, and less than 1.5 ng of host cell DNA per 100 µg of said coat protein.
摘要翻译：本发明涉及用于纯化RNA噬菌体外壳蛋白的方法，其中所述方法包括分解RNA噬菌体的病毒样颗粒并随后纯化所述外壳蛋白的步骤。本文描述的方法被设计为按比例增加以产生高达100μg外壳蛋白质和每批次更多的量，并且其允许有效地去除RNA和宿主细胞来源的杂质，通常低于定量水平。本发明还涉及RNA噬菌体的纯化外壳蛋白，其中所述纯化的外壳蛋白通常包含少于0.5μgRNA，小于0.4IU的内毒素，小于5ng的宿主细胞蛋白，以及小于1.5ng的宿主细胞DNA 100μg所述外壳蛋白。

5. 发明申请

WO2007131972A1 NICOTINE-CARRIER VACCINE FORMULATION 审中-公开
标题翻译： NICOTINE-CARRIER VACCINE配方
公开(公告)号：WO2007131972A1
公开(公告)日：2007-11-22
申请号：PCT/EP2007/054604
申请日：2007-05-11
申请人： CYTOS BIOTECHNOLOGY AG , LUDWIG MAXIMILIANS UNIVERSITÄT MÜNCHEN , LANG, Rainer , WINTER, Gerhard , VOGT, Lorenz
发明人： LANG, Rainer , WINTER, Gerhard , VOGT, Lorenz
IPC分类号： A61K39/385 , A61K47/06
CPC分类号： A61K39/0013 , A61K9/19 , A61K2039/5258
摘要： The present invention is in the fields of medicine, public health, vaccine and drug formulation. The invention provides composition formulat ions comprising a nicotine- carrier conjugate and a stabilizer, wherein said stabilizer comprises a non-reducing disaccharide and a non-ionic surfactant. The composition formulations are stable after a long time of storage at room temperature.
摘要翻译：本发明在医药，公共卫生，疫苗和药物制剂领域。本发明提供了包含尼古丁 - 载体缀合物和稳定剂的组合物制剂，其中所述稳定剂包含非还原性二糖和非离子表面活性剂。组合物制剂在室温下长时间储存后是稳定的。

6. 发明申请

WO2007039458A2 HIV PEPTIDE CONJUGATES AND USES THEREOF 审中-公开
标题翻译： HIV肽缀合物及其用途
公开(公告)号：WO2007039458A2
公开(公告)日：2007-04-12
申请号：PCT/EP2006/066526
申请日：2006-09-20
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SAUDAN, Philippe , JEGERLEHNER, Andrea , RÖHN, Till Alexander , JENNINGS, Gary
发明人： BACHMANN, Martin , SAUDAN, Philippe , JEGERLEHNER, Andrea , RÖHN, Till Alexander , JENNINGS, Gary
IPC分类号： A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , C12N2740/16122 , C12N2740/16134 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is HIV gpl60 peptide. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and treatment of diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译：本发明属于医学，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供了包含与至少一种抗原连接的病毒样颗粒（VLP）的组合物，其中所述抗原是HIV gp160肽。本发明还提供了一种生产该组合物的方法。本发明的组合物可用于生产疫苗，特别是用于预防和治疗疾病。而且，本发明的组合物诱导有效的免疫应答，特别是抗体应答。

7. 发明申请

WO2006097530A3 CAT ALLERGEN FUSION PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2006097530A3
公开(公告)日：2006-09-21
申请号：PCT/EP2006/060845
申请日：2006-03-17
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , BAUER, Monika , DIETMEIER, Klaus , SCHMITZ, Nicole , UTZINGER, Stephan
发明人： BACHMANN, Martin , BAUER, Monika , DIETMEIER, Klaus , SCHMITZ, Nicole , UTZINGER, Stephan
IPC分类号： A61K39/35 , A61P37/08
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

8. 发明申请

WO2006063974A3 IL-15 ANTIGEN ARRAYS AND USES THEREOF 审中-公开
公开(公告)号：WO2006063974A3
公开(公告)日：2006-06-22
申请号：PCT/EP2005/056680
申请日：2005-12-12
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , ZOU, Yu , TISSOT, Alain , MAURER, Patrik
发明人： BACHMANN, Martin , ZOU, Yu , TISSOT, Alain , MAURER, Patrik
IPC分类号： A61K39/00 , A61K39/385 , A61P11/06 , A61P19/02 , A61P9/10
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

9. 发明申请

WO2005068639A3 PARTICLE-INDUCED GHRELIN IMMUNE RESPONSE 审中-公开
公开(公告)号：WO2005068639A3
公开(公告)日：2005-07-28
申请号：PCT/EP2005/000497
申请日：2005-01-19
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin, F. , FULURIJA, Alma
发明人： BACHMANN, Martin, F. , FULURIJA, Alma
IPC分类号： A61K47/48
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and particular peptides derived from ghrelin linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of obesity and other disease associated with increased food-uptake or increased body weight and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

10. 发明申请

WO2004106532A8 MODIFIED POLYPEPTIDES FOR TARGETING CELL-ENTRY OF THE ADENOVIRUSES OF SUBTYPE B 审中-公开
标题翻译：用于靶向B型腺病毒细胞进入的改性多聚体
公开(公告)号：WO2004106532A8
公开(公告)日：2005-03-31
申请号：PCT/EP2004005762
申请日：2004-05-27
申请人： CYTOS BIOTECHNOLOGY AG , BEERLI ROGER R , BACHMANN MARTIN F
发明人： BEERLI ROGER R , BACHMANN MARTIN F
IPC分类号： A61K38/17 , C07K14/705 , C07K16/46 , C12N15/62 , C12N15/86 , A61K35/76 , C07K16/28 , C07K19/00
CPC分类号： C07K14/705 , A61K38/00 , C07K16/46 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/43 , C12N15/62
摘要： This invention relates to modified polypeptides comprising two functional components: first, a polypeptide derived from the extracellular region of CD46 as a specific binding site for adenoviruses of the subgroup B, and second, a component capable of binding to a cell surface molecule. Such modified polypeptides are able to direct adenovirusinfection specifically to cells having said cell surface molecule on their surface. The invention relates to nucleic acid sequences encoding fusion proteins comprising a) a polypeptide derived from the extracellular domain of CD46 and b) a heterologous polypeptide, methods for the production of the modified polypeptides and suitable recombinant expression vectors and host cells. Pharmaceutical compositions comprising the modified polypeptide of the invention are useful together with recombinant, genetically engineered adenovirus of subtype B for the treatment and prophylaxis of disorders and diseases, like cancer.
摘要翻译：本发明涉及包含两个功能组分的修饰的多肽：首先，衍生自CD46细胞外区域的多肽作为亚组B的腺病毒的特异性结合位点，其次是能够结合细胞表面分子的组分。这种修饰的多肽能够将腺病毒感染特异性地引导到其表面上具有所述细胞表面分子的细胞。本发明涉及编码融合蛋白的核酸序列，其包含a）源自CD46细胞外结构域的多肽和b）异源多肽，产生修饰多肽的方法和合适的重组表达载体和宿主细胞。包含本发明修饰多肽的药物组合物与B型重组基因工程改造的腺病毒一起可用于治疗和预防疾病和疾病如癌症。

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