专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016110453A8 A CRISPR-CAS SYSTEM FOR A FILAMENTOUS FUNGAL HOST CELL 审中-公开
标题翻译：用于FILAMENTOUS FUNGAL HOST细胞的CRISPR-CAS系统
公开(公告)号：WO2016110453A8
公开(公告)日：2016-12-22
申请号：PCT/EP2016000029
申请日：2016-01-06
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： MEIJRINK BERNARD , VERWAAL RENÉ , GIELESEN BIANCA ELISABETH MARIA , ROUBOS JOHANNES ANDRIES , NYGÅRD YVONNE IRENE , BOVENBERG ROELOF ARIJ LANS , DRIESSEN ARNOLD JACOB MATHIEU , POHL CARSTEN
IPC分类号： C12N15/90
CPC分类号： C12N15/902 , C12N15/102 , C12N15/111 , C12N15/905 , C12N2310/10 , C12N2310/20
摘要： The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a filamentous fungal host cell.
摘要翻译：本发明涉及分子生物学和细胞生物学领域。更具体地，本发明涉及用于丝状真菌宿主细胞的CRISPR-CAS系统。

2. 发明申请

WO2015181312A3 RECOMBINANT CELLS PRODUCING ITACONIC ACID AND METHYL ESTERS THEREOF 审中-公开
标题翻译：生产乙酸和甲基酯的重组细胞
公开(公告)号：WO2015181312A3
公开(公告)日：2016-01-21
申请号：PCT/EP2015061884
申请日：2015-05-28
申请人： DSM IP ASSETS BV
发明人： ZHAO ZHENG , MEIJRINK BERNARD , HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT , WU LIANG , ROUBOS JOHANNES ANDRIES , GELDER VAN MARINA
IPC分类号： C12N15/52 , C12P7/46 , C12P7/62
CPC分类号： C12P7/62 , C12N15/52 , C12P7/46
摘要： The present invention relates to a recombinant cell which is capable of producing one or more of itaconic acid,4-methyl itaconate or 1-methyl itaconate, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. A recombinant yeast cell which is capable of producing itaconic acid and which over expresses: -a nucleic 1 acid encoding a polypeptide having cis-aconitate decarboxylase activity; and-one or more nucleic acids encoding polypeptides which separately or together catalyze a reaction towards acetyl CoA,wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans- aconitate methyltransferase. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
摘要翻译：本发明涉及能够产生衣康酸，衣康酸4-甲酯或衣康酸1-甲酯中的一种或多种的重组细胞，其中所述重组微生物已经在其基因组中被修饰，从而导致其中的缺陷产生反式乌头碱甲基转移酶。能够产生衣康酸的重组酵母细胞，其过表达： - 编码具有顺式乌头酸脱羧酶活性的多肽的核酸1; 一种或多种编码分别或一起催化乙酰CoA的反应的多肽的核酸，其中所述重组微生物已经在其基因组中被修饰，从而导致转基因甲基转移酶的产生缺陷。这些重组酵母细胞可用于生产衣康酸，衣康酸4-甲酯或衣康酸1-甲酯的方法。

3. 发明申请

WO2017037304A3 AN ASSEMBLY SYSTEM FOR A EUKARYOTIC CELL 审中-公开
标题翻译：真核细胞组装系统
公开(公告)号：WO2017037304A3
公开(公告)日：2017-06-01
申请号：PCT/EP2016081240
申请日：2016-12-15
申请人： DSM IP ASSETS BV
发明人： ROUBOS JOHANNES ANDRIES , VERWAAL RENÉ , GIELESEN BIANCA ELISABETH MARIA , VONK BRENDA
IPC分类号： C12N15/10 , C12N15/113
CPC分类号： C12N15/102 , C12N15/111 , C12N2310/20 , C12Q2521/301
摘要： The present invention is based on the adavantageous use of single-stranded oligonucleotides in the in vivo (within a cell) assembly of double-stranded oligonucleotides into a single double-stranded nucleic acid construct. The present invention relates to the use of at least a first and a second single-stranded oligonucleotide in the assembly within a cell of at least two double-stranded nucleic acid molecules into a single double-stranded nucleic acid construct of pre-determined sequence, wherein the first and second single-stranded oligonucleotide are essentially complementary to each other.
摘要翻译：本发明基于单链寡核苷酸在双链寡核苷酸体内（在细胞内）装配成单个双链核酸构建体的有利应用。本发明涉及至少第一和第二单链寡核苷酸在细胞内在至少两个双链核酸分子的装配中用于预定序列的单个双链核酸构建体的用途，其中所述第一和第二单链寡核苷酸彼此基本互补。

4. 发明申请

WO2015181310A3 ITACONIC ACID AND ITACONATE METHYLESTER AND DIMETHYLESTER PRODUCTION 审中-公开
标题翻译：异柠檬酸和甲基丙烯酸甲酯和二甲醚生产
公开(公告)号：WO2015181310A3
公开(公告)日：2016-02-18
申请号：PCT/EP2015061882
申请日：2015-05-28
申请人： DSM IP ASSETS BV
发明人： ZHAO ZHENG , MEIJRINK BERNARD , HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT , WU LIANG , ROUBOS JOHANNES ANDRIES
IPC分类号： C12N15/63 , C12P1/00
CPC分类号： C12P7/44 , C07K14/395 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1217 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/62 , C12Y203/03001 , C12Y401/01006 , C12Y401/01031 , C12Y401/01032 , C12Y604/01001
摘要： The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate, 1-methyl itaconate or 1,4-dimethyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: - a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and - a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate, 1-methyl itaconate or 1,4-dimethyl itaconate.
摘要翻译：本发明涉及能够产生衣康酸4-甲酯，衣康酸1-甲酯或衣康酸1,4-二甲酯中的一种或多种的重组酵母细胞。本发明还涉及能够产生衣康酸并且过表达的重组酵母细胞： - 编码具有顺 - 乌头酸脱羧酶活性的多肽的核酸; 以及 - 编码催化向乙酰辅酶A反应的多肽的核酸。这些重组酵母细胞可用于生产衣康酸，衣康酸4-甲酯，衣康酸1-甲酯或衣康酸1,4-二甲酯的方法。

5. 发明申请

WO2014080024A3 ITACONIC ACID AND ITACONATE METHYLESTER PRODUCTION 审中-公开
标题翻译： ITACONIC ACID和ITACONATE METHYLESTER生产
公开(公告)号：WO2014080024A3
公开(公告)日：2014-09-18
申请号：PCT/EP2013074658
申请日：2013-11-25
申请人： DSM IP ASSETS BV
发明人： ZHAO ZHENG , MEIJRINK BERNARD , HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT , WU LIANG , ROUBOS JOHANNES ANDRIES
IPC分类号： C12N15/10 , C12N15/52 , C12P7/46 , C40B40/06 , C40B40/08
CPC分类号： C12P7/46 , C12N9/88 , C12N15/81 , C12P7/62 , C12Y401/01006
摘要： The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate or 1-methyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
摘要翻译：本发明涉及能够产生衣康酸4-甲酯或衣康酸1-甲酯中的一种或多种的重组酵母细胞。本发明还涉及能够产生衣康酸并且过表达的重组酵母细胞：编码具有顺式乌头酸脱羧酶活性的多肽的核酸; 以及编码催化向乙酰辅酶A反应的多肽的核酸。这些重组酵母细胞可用于生产衣康酸，衣康酸4-甲酯或衣康酸1-甲酯的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式