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    • 2. 发明申请
    • RECOMBINANT CELLS PRODUCING ITACONIC ACID AND METHYL ESTERS THEREOF
    • 生产乙酸和甲基酯的重组细胞
    • WO2015181312A3
    • 2016-01-21
    • PCT/EP2015061884
    • 2015-05-28
    • DSM IP ASSETS BV
    • ZHAO ZHENGMEIJRINK BERNARDHOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERTWU LIANGROUBOS JOHANNES ANDRIESGELDER VAN MARINA
    • C12N15/52C12P7/46C12P7/62
    • C12P7/62C12N15/52C12P7/46
    • The present invention relates to a recombinant cell which is capable of producing one or more of itaconic acid,4-methyl itaconate or 1-methyl itaconate, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. A recombinant yeast cell which is capable of producing itaconic acid and which over expresses: -a nucleic 1 acid encoding a polypeptide having cis-aconitate decarboxylase activity; and-one or more nucleic acids encoding polypeptides which separately or together catalyze a reaction towards acetyl CoA,wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans- aconitate methyltransferase. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
    • 本发明涉及能够产生衣康酸,衣康酸4-甲酯或衣康酸1-甲酯中的一种或多种的重组细胞,其中所述重组微生物已经在其基因组中被修饰,从而导致其中的缺陷 产生反式乌头碱甲基转移酶。 能够产生衣康酸的重组酵母细胞,其过表达: - 编码具有顺式乌头酸脱羧酶活性的多肽的核酸1; 一种或多种编码分别或一起催化乙酰CoA的反应的多肽的核酸,其中所述重组微生物已经在其基因组中被修饰,从而导致转基因甲基转移酶的产生缺陷。 这些重组酵母细胞可用于生产衣康酸,衣康酸4-甲酯或衣康酸1-甲酯的方法。