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1. 发明申请

WO2015086839A9 FUMARATE REDUCTASES 审中-公开
标题翻译：减少脂肪
公开(公告)号：WO2015086839A9
公开(公告)日：2016-09-09
申请号：PCT/EP2014077638
申请日：2014-12-12
申请人： DSM IP ASSETS BV
发明人： JONG DE RENÉ MARCEL , ZHAO ZHENG , DULK DEN BEN , WINTER REMKO TSJIBBE
IPC分类号： C12N9/02
CPC分类号： C12N9/001 , C12P7/46 , C12Y103/01006
摘要： The present invention relates to a variant polypeptide having fumarate reductase activity, which has modified NADP(H)-dependent and/or NAD(H)-dependent activity as compared with a reference polypeptide having fumarate reductase activity. Such a variant may be overexpressed in a host cell in order to improve production of a dicarboxylic acid.
摘要翻译：本发明涉及具有富马酸盐还原酶活性的变体多肽，其与具有富马酸盐还原酶活性的参照多肽相比具有修饰的NADP（H） - 依赖和/或NAD（H） - 依赖性活性。这种变体可以在宿主细胞中过表达，以改善二羧酸的产生。

2. 发明申请

WO2015181312A3 RECOMBINANT CELLS PRODUCING ITACONIC ACID AND METHYL ESTERS THEREOF 审中-公开
标题翻译：生产乙酸和甲基酯的重组细胞
公开(公告)号：WO2015181312A3
公开(公告)日：2016-01-21
申请号：PCT/EP2015061884
申请日：2015-05-28
申请人： DSM IP ASSETS BV
发明人： ZHAO ZHENG , MEIJRINK BERNARD , HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT , WU LIANG , ROUBOS JOHANNES ANDRIES , GELDER VAN MARINA
IPC分类号： C12N15/52 , C12P7/46 , C12P7/62
CPC分类号： C12P7/62 , C12N15/52 , C12P7/46
摘要： The present invention relates to a recombinant cell which is capable of producing one or more of itaconic acid,4-methyl itaconate or 1-methyl itaconate, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. A recombinant yeast cell which is capable of producing itaconic acid and which over expresses: -a nucleic 1 acid encoding a polypeptide having cis-aconitate decarboxylase activity; and-one or more nucleic acids encoding polypeptides which separately or together catalyze a reaction towards acetyl CoA,wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans- aconitate methyltransferase. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
摘要翻译：本发明涉及能够产生衣康酸，衣康酸4-甲酯或衣康酸1-甲酯中的一种或多种的重组细胞，其中所述重组微生物已经在其基因组中被修饰，从而导致其中的缺陷产生反式乌头碱甲基转移酶。能够产生衣康酸的重组酵母细胞，其过表达： - 编码具有顺式乌头酸脱羧酶活性的多肽的核酸1; 一种或多种编码分别或一起催化乙酰CoA的反应的多肽的核酸，其中所述重组微生物已经在其基因组中被修饰，从而导致转基因甲基转移酶的产生缺陷。这些重组酵母细胞可用于生产衣康酸，衣康酸4-甲酯或衣康酸1-甲酯的方法。

3. 发明申请

WO2015181310A3 ITACONIC ACID AND ITACONATE METHYLESTER AND DIMETHYLESTER PRODUCTION 审中-公开
标题翻译：异柠檬酸和甲基丙烯酸甲酯和二甲醚生产
公开(公告)号：WO2015181310A3
公开(公告)日：2016-02-18
申请号：PCT/EP2015061882
申请日：2015-05-28
申请人： DSM IP ASSETS BV
发明人： ZHAO ZHENG , MEIJRINK BERNARD , HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT , WU LIANG , ROUBOS JOHANNES ANDRIES
IPC分类号： C12N15/63 , C12P1/00
CPC分类号： C12P7/44 , C07K14/395 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1217 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/62 , C12Y203/03001 , C12Y401/01006 , C12Y401/01031 , C12Y401/01032 , C12Y604/01001
摘要： The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate, 1-methyl itaconate or 1,4-dimethyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: - a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and - a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate, 1-methyl itaconate or 1,4-dimethyl itaconate.
摘要翻译：本发明涉及能够产生衣康酸4-甲酯，衣康酸1-甲酯或衣康酸1,4-二甲酯中的一种或多种的重组酵母细胞。本发明还涉及能够产生衣康酸并且过表达的重组酵母细胞： - 编码具有顺 - 乌头酸脱羧酶活性的多肽的核酸; 以及 - 编码催化向乙酰辅酶A反应的多肽的核酸。这些重组酵母细胞可用于生产衣康酸，衣康酸4-甲酯，衣康酸1-甲酯或衣康酸1,4-二甲酯的方法。

4. 发明申请

WO2014080024A3 ITACONIC ACID AND ITACONATE METHYLESTER PRODUCTION 审中-公开
标题翻译： ITACONIC ACID和ITACONATE METHYLESTER生产
公开(公告)号：WO2014080024A3
公开(公告)日：2014-09-18
申请号：PCT/EP2013074658
申请日：2013-11-25
申请人： DSM IP ASSETS BV
发明人： ZHAO ZHENG , MEIJRINK BERNARD , HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT , WU LIANG , ROUBOS JOHANNES ANDRIES
IPC分类号： C12N15/10 , C12N15/52 , C12P7/46 , C40B40/06 , C40B40/08
CPC分类号： C12P7/46 , C12N9/88 , C12N15/81 , C12P7/62 , C12Y401/01006
摘要： The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate or 1-methyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.
摘要翻译：本发明涉及能够产生衣康酸4-甲酯或衣康酸1-甲酯中的一种或多种的重组酵母细胞。本发明还涉及能够产生衣康酸并且过表达的重组酵母细胞：编码具有顺式乌头酸脱羧酶活性的多肽的核酸; 以及编码催化向乙酰辅酶A反应的多肽的核酸。这些重组酵母细胞可用于生产衣康酸，衣康酸4-甲酯或衣康酸1-甲酯的方法。

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