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1. 发明申请

WO2010128859A2 GLUCO-OLIGOSACCHARIDES COMPRISING (a1?4) AND (a1?6) GLYCOSIDIC BONDS, USE THEREOF, AND METHODS FOR PROVIDING THEM 审中-公开
标题翻译：包含（a1〜4）和（a1-6）GLYCOSIDIC BONDS的GLUCO-OLIGOSACCHARIDES及其用途及其提供方法
公开(公告)号：WO2010128859A2
公开(公告)日：2010-11-11
申请号：PCT/NL2010050269
申请日：2010-05-10
申请人： UNIV GRONINGEN , DIJKHUIZEN LUBBERT , VAN DER MAAREL MARC JOS ELISE CORNELIS , KAMERLING JOHANNIS PAULUS , LEEMHUIS REINDER JOHANNES , KRALJ SLAVKO , DOBRUCHOWSKA JUSTYNA MALGORZATA
发明人： DIJKHUIZEN LUBBERT , VAN DER MAAREL MARC JOS ELISE CORNELIS , KAMERLING JOHANNIS PAULUS , LEEMHUIS REINDER JOHANNES , KRALJ SLAVKO , DOBRUCHOWSKA JUSTYNA MALGORZATA
IPC分类号： C12P19/00 , C12P19/04
CPC分类号： C12P19/00 , C12N9/1051 , C12P19/04 , C12Y204/01005
摘要： The invention relates to the field of poly- and oligosaccharides and their nutritional effects. In particular, it relates to the application of a-glucanotransferases in methods for preparing dietary fibers, including prebiotic oligosaccharides, and to novel oligosaccharides obtainable thereby. Provided is a method for producing a mixture of gluco-oligosaccharides having one or more consecutive (a1?6) glucosidic linkages and one or more consecutive (a1?4) glucosidic linkages, comprising contacting a poly- and/or oligosaccharide substrate comprising at least two (a1?4) linked D-glucose units with an ?-glucanotransferase capable of cleaving (a1?4) glucosidic linkages and making new (a1?4) and (a1?6) glucosidic linkages. Also provided are (isolated) gluco-oligosaccharides obtainable thereby, and their application in nutritional and cosmetic compositions.
摘要翻译：本发明涉及多糖和寡糖的领域及其营养效果。特别涉及α-葡聚糖转移酶在制备膳食纤维，包括益生元寡糖的方法中的应用，以及由此得到的新型寡糖。提供了一种制备具有一个或多个连续（a1→6）糖苷键和一个或多个连续（a1→4）糖苷键的葡萄糖寡糖的混合物的方法，包括使包含至少包含两个（a1→4）连接的D-葡萄糖单元与能够切割（a1→4）糖苷键的β-葡聚糖转移酶并产生新的（a1→4）和（a1→6）糖苷键。还提供了可由此获得的（分离的）葡糖寡糖，以及它们在营养和美容组合物中的应用。

2. 发明申请

WO2008044149A3 SHIGELLA IPAD PROTEIN AND ITS USE AS A VACCINE AGAINST SHIGELLA INFECTION 审中-公开
标题翻译： SHIGELLA IPAD蛋白及其作为疫苗感染的疫苗使用
公开(公告)号：WO2008044149A3
公开(公告)日：2008-08-07
申请号：PCT/IB2007004192
申请日：2007-10-12
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , UNIV BRUXELLES , UNIV GRONINGEN , ALLAOUI ADBELMOUNAAIM , SANSONETTI PHILIPPE , SANI MUSA , BOTTEAUX ANNE , PARSOT CLAUDE , BOEKEMA EGBERT J
发明人： ALLAOUI ADBELMOUNAAIM , SANSONETTI PHILIPPE , SANI MUSA , BOTTEAUX ANNE , PARSOT CLAUDE , BOEKEMA EGBERT J
IPC分类号： A61K39/00
CPC分类号： A61K39/0283
摘要： The present invention relates to compositions and methods for blocking entry of Shigella into a cell of an animal, to therefore providing protection against, or reduce the severity of Shigella infections. More particularly it relates to the use of the IpaD protein obtained from natural sources and/or through synthesis or recombinant technology, and conjugates thereof to induce neutralizing antibodies having protective activity against several serotypes of Shigella, in particular S. flexneri. The composition of the invention is useful to prevent and/or treat shigellosis caused by a bacterium of the Shigella family.
摘要翻译：本发明涉及用于阻止志贺氏菌进入动物细胞的组合物和方法，从而提供抗或降低志贺氏菌感染的严重性。更具体地说，本发明涉及从天然来源和/或通过合成或重组技术获得的IpaD蛋白质的用途，以及它们的共轭物诱导对志贺氏菌，特别是灵芝菌的几种血清型具有保护活性的中和抗体。本发明的组合物可用于预防和/或治疗由志贺氏菌家族细菌引起的志贺氏菌病。

3. 发明申请

WO2007013807A9 TARGETING-ENHANCED ACTIVATION OF GALECTINS 审中-公开
标题翻译：加强对策的强化活动
公开(公告)号：WO2007013807A9
公开(公告)日：2008-06-26
申请号：PCT/NL2006000394
申请日：2006-07-28
申请人： UNIV GRONINGEN , BREMER EDWIN , HELFRICH WIJNAND
发明人： BREMER EDWIN , HELFRICH WIJNAND
IPC分类号： C07K14/47 , A61K38/17 , C12N15/62
CPC分类号： C07K14/4726 , A61K38/00 , C07K2319/01
摘要： The invention relates to lectin-binding proteins and their therapeutic use, inter alia in the field of immunology and oncology. In particular, it relates to the targeting and targeting-enhanced multimerization and activation of galectins. Provided is a galectin-conjugate comprising at least one galectin molecule conjugated to a non-galectin cell targeting means. Exemplary targeting means include targeting means capable of binding to EGP2, a pancarcinoma associated cell surface target antigen, CD antigen, such as CD7 or CD38, or a TNF family member, such as TRAIL-R. The targeting means may comprise an antibody or a functional fragment thereof, preferably a single chain variable antibody fragment (scFv). Also provided is the use of a galectin-conjugate for the treatment of a disease, like cancer or an immune disorder, such as auto-immune disease, allergic disorder, autoimmune encephalomyelitis, arthritis, colitis, hepatitis, asthma, multiple sclerosis, transplant rejection, Graft-versus-host disease (GVHD) and inflammatory bowel disease.
摘要翻译：本发明涉及凝集素结合蛋白及其治疗用途，特别是在免疫学和肿瘤学领域。特别地，它涉及靶向和靶向增强的聚合酶的多聚化和活化。提供了包含至少一个与非半乳凝素细胞靶向手段缀合的半乳凝素分子的半乳凝素缀合物。示例性靶向装置包括能够结合EGP2的靶向装置，与癌细胞相关的细胞表面靶抗原，CD抗原如CD7或CD38或TNF家族成员如TRAIL-R。靶向装置可以包含抗体或其功能片段，优选单链可变抗体片段（scFv）。还提供了半乳凝素缀合物用于治疗疾病如癌症或免疫疾病如自身免疫疾病，过敏性疾病，自身免疫性脑脊髓炎，关节炎，结肠炎，肝炎，哮喘，多发性硬化，移植排斥，移植物抗宿主病（GVHD）和炎症性肠病。

4. 发明申请

WO0133605A3 ATMOSPHERIC PRESSURE PHOTOIONIZATION (APPI): A NEW IONIZATION METHOD FOR LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY 审中-公开
标题翻译：大气压力光电离（APPI）：一种液体色谱 - 质谱分析的新型电离方法
公开(公告)号：WO0133605A3
公开(公告)日：2002-01-03
申请号：PCT/CA0001270
申请日：2000-10-26
申请人： UNIV GRONINGEN , ROBB DAMON B , BRUINS ANDRIES PIETER
发明人： ROBB DAMON B , BRUINS ANDRIES PIETER
IPC分类号： G01N27/62 , G01N27/64 , G01N30/72 , H01J49/04 , H01J49/10 , H01J49/16
CPC分类号： H01J49/162 , H01J49/045 , H01J49/049
摘要： There is provided a method of, and apparatus for, analyzing a sample of an analyte provided as a sample solution comprising a solvent and an analyte. A dopant is provided, either separately or as the solvent of the sample solution. The sample solution is formed into a spray, for example in a nebulizer, and the solvent evaporated. The sample stream is irradiated in a region at atmospheric pressure, either in the liquid state prior to formation of a spray, or in the liquid state after formation of a droplet spray, or in the vapour state after evaporation of the sprayed droplets, to ionize the dopant. Then, subsequent collisions between the ionized dopant and the analyte, either directly or indirectly, result in ionization of the analyte. Analyte ions are passed from the atmospheric pressure ionization region into a mass analyzer for mass analysis. This technique has been found to give much enchanced inonization for some substances, as compared to atmospheric pressure chemical ionization.
摘要翻译：提供了分析作为包含溶剂和分析物的样品溶液的分析物样品的方法和设备。提供掺杂剂，分开或作为样品溶液的溶剂。样品溶液例如在喷雾器中形成喷雾，并且蒸发溶剂。将样品流在大气压下的区域中进行照射，或者在形成喷雾之前处于液体状态，或者在形成液滴喷雾之后处于液体状态，或者在喷雾液滴蒸发之后处于蒸气状态，以电离掺杂剂。然后，电离掺杂剂与分析物之间的后续碰撞直接或间接导致分析物的电离。分析物离子从大气压电离区域传递到质量分析器进行质量分析。与大气压化学电离相比，这种技术已经被发现对某些物质提供了更加紧迫的化学反应。

5. 发明申请

WO2016060564A8 BODY SCULPTING 审中-公开
标题翻译：身体扫描
公开(公告)号：WO2016060564A8
公开(公告)日：2017-06-15
申请号：PCT/NL2015050722
申请日：2015-10-14
申请人： BRAINS ONLINE HOLDING B V , UNIV GRONINGEN
发明人： CREMERS THOMAS , FLIK GUNNAR , FRIJLINK HENDERIK WILLEM , WOERDENBAG HERMAN JOHAN
IPC分类号： A61K31/23 , A61K9/00 , A61K9/06 , A61P3/04 , C07C219/30
CPC分类号： A61K8/37 , A61K8/41 , A61K9/0014 , A61K9/06 , A61K31/00 , A61K31/23 , A61K47/32 , A61K2800/74 , A61Q19/06 , C07C219/30
摘要： The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue. The invention further pertains to cosmetic and therapeutic application of such prodrugs, such as their use in methods of shaping a mammalian body by locally modulating subcutaneous fat tissue. The invention also pertains to the prodrugs themselves, as well as to methods of making these prodrugs.
摘要翻译：本发明涉及用于局部给药的药物组合物，其包含用于肾上腺素能受体的激动剂和/或拮抗剂的前药，其中所述前药的辛醇/水分配系数至少为0，用于使哺乳动物身体通过调节皮下脂肪组织。本发明还涉及这种前药的美容和治疗应用，例如它们在通过局部调节皮下脂肪组织来成形哺乳动物体的方法中的应用。本发明还涉及前体药物本身以及制备这些前体药物的方法。

6. 发明申请

WO2017009257A3 PECTIN COMPOSITIONS FOR PREVENTING AND TREATING INFLAMMATORY DISEASES 审中-公开
标题翻译：用于预防和治疗炎症疾病的PECTIN组合物
公开(公告)号：WO2017009257A3
公开(公告)日：2017-02-23
申请号：PCT/EP2016066351
申请日：2016-07-08
申请人： NUTRITION SCIENCES N V , ROYAL AGRIFIRM GROUP B V , UNIV GRONINGEN , ACAD ZIEKENHUIS GRONINGEN , UNIV WAGENINGEN
发明人： BRUGGEMAN GEERT , BRUININX ERIK , VAN DEN BERG MARCO , DE VOS PAULUS , SAHASRABUDHE NEHA MOHAN , SCHEURINK ANTONIUS JOHANNES WILLIBRORDUS , SCHOLS HENDRIK ARIE , SCHOLTE JAN , TIAN LINGMIN
IPC分类号： A61K31/732 , A23K10/30 , A23K10/37 , A23K20/163 , A23K50/30 , A23K50/60 , A23L5/00 , A23L29/231 , A23L33/10 , A61P1/04 , A61P11/06 , A61P29/00 , A61P37/06
CPC分类号： A61K31/732 , A23K20/163 , A23L29/231 , A23L33/125 , A23L33/21
摘要： This invention relates generally to compositions and methods for combating inflammatory disease and particularly to the use of feed or food compositions for preventing, reducing and/or treating inflammatory disorders, diseases, or discomforts, wherein the compositions comprising at least one specific pectin.
摘要翻译：本发明一般涉及抗炎症疾病的组合物和方法，特别涉及用于预防，减少和/或治疗炎性疾病，疾病或不适的饲料或食物组合物的用途，其中所述组合物包含至少一种特定的果胶。

7. 发明申请

WO2016110453A8 A CRISPR-CAS SYSTEM FOR A FILAMENTOUS FUNGAL HOST CELL 审中-公开
标题翻译：用于FILAMENTOUS FUNGAL HOST细胞的CRISPR-CAS系统
公开(公告)号：WO2016110453A8
公开(公告)日：2016-12-22
申请号：PCT/EP2016000029
申请日：2016-01-06
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： MEIJRINK BERNARD , VERWAAL RENÉ , GIELESEN BIANCA ELISABETH MARIA , ROUBOS JOHANNES ANDRIES , NYGÅRD YVONNE IRENE , BOVENBERG ROELOF ARIJ LANS , DRIESSEN ARNOLD JACOB MATHIEU , POHL CARSTEN
IPC分类号： C12N15/90
CPC分类号： C12N15/902 , C12N15/102 , C12N15/111 , C12N15/905 , C12N2310/10 , C12N2310/20
摘要： The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a filamentous fungal host cell.
摘要翻译：本发明涉及分子生物学和细胞生物学领域。更具体地，本发明涉及用于丝状真菌宿主细胞的CRISPR-CAS系统。

8. 发明申请

WO2014195521A3 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195521A3
公开(公告)日：2015-02-19
申请号：PCT/EP2014063069
申请日：2014-06-20
申请人： DSM IP ASSETS BV , UNIV GRONINGEN
发明人： KLAASSEN PAUL , DE WAAL PAULUS PETRUS , DE JONG RENÉ MARCEL , DRIESSEN ARNOLD JACOB MATTIEU , NIJLAND JEROEN GERBEN , SHIN HYUN YONG
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 &Dgr;tR.
摘要翻译：本发明涉及在对应于SEQ ID NO：59的位置339或376的位置具有一个或多个取代的多肽，其中多肽是主要促进剂超家族（MFS）的成员。在一个实施方案中，取代位于对应于376的位置，并且其中该位置处的氨基酸被具有范德华体积为80至138埃的氨基酸和10至100重量％的侧链疏水性。

9. 发明申请

WO2014155395A3 GLUCAN BRANCHING ENZYMES AND THEIR METHODS OF USE 审中-公开
标题翻译：葡聚糖支链酶及其使用方法
公开(公告)号：WO2014155395A3
公开(公告)日：2014-11-06
申请号：PCT/IS2014050003
申请日：2014-03-26
申请人： MATIS OHF , UNIV GRONINGEN
发明人： JONSSON WHEAT JON OSKAR , HREGGVIDSSON GUDMUNDUR OLI , FRIDJONSSON OLAFUR HEDINN , DOBRUCHOWSKA JUSTYNA M , KAMERLING JOHANNES P
IPC分类号： C12N9/10
CPC分类号： C12P19/18 , C08B37/0024 , C12N9/1051 , C12P19/04
摘要： The present invention relates to the use of &bgr;-glucan branching enzymes in transglycosylation reactions.
摘要翻译：本发明涉及β-葡聚糖分支酶在转糖基反应中的用途。

10. 发明申请

WO2013081461A3 METHODS AND KITS FOR DETERMINING PROTEIN-BOUND BIOMARKERS 审中-公开
标题翻译：用于测定蛋白质结合生物标记物的方法和试剂盒
公开(公告)号：WO2013081461A3
公开(公告)日：2013-08-22
申请号：PCT/NL2012050849
申请日：2012-11-29
申请人： UNIV GRONINGEN , GRONINGEN ACAD ZIEKENHUIS
发明人： KEMA IDO PETER , VAN FAASSEN HERMANNUS JOHANNES ROELOF , MANZ BERNHARD
IPC分类号： G01N33/538 , G01N33/74
CPC分类号： G01N33/538 , G01N33/6848 , G01N33/743 , G01N33/82 , G01N2333/575 , G01N2560/00
摘要： The invention relates to the field of diagnostic methods, in particular to detection of biological molecules using mass spectroscopy (MS). Provided is an automated high-throughput method for quantitating a low molecular weight protein-bound biomarker directly in an isolated biological sample, comprising the steps of: (a) automated prepurification of the sample using an effective amount of an acid protease under conditions that allow for digestion of one or more binding proteins; (b) applying said protease-digested sample onto an on-line SPE column to capture at least part of said biomarker, followed by sequential washing of the solid phase; (c) eluting a fraction comprising said biomarker directly onto a liquid chromatography (LC) column comprising an apolar stationary phase and subjecting it to LC-MS or LC-MS-MS measurements to determine the amount of at least one biomarker; and (d) quantitating the biomarker(s). Also provided are kits for use in such method, for instance in the determination of vitamin D derivatives, testosterone and/or or melatonin.
摘要翻译：本发明涉及诊断方法领域，特别涉及使用质谱（MS）检测生物分子。提供了一种用于在分离的生物样品中直接定量低分子量蛋白质结合的生物标志物的自动化高通量方法，其包括以下步骤：（a）在允许的条件下使用有效量的酸性蛋白酶自动预纯化样品用于消化一种或多种结合蛋白; （b）将所述蛋白酶消化的样品施加到在线SPE柱上以捕获至少部分所述生物标志物，然后连续洗涤固相; （c）将包含所述生物标记物的级分直接洗脱到包含非极性固定相的液相色谱（LC）柱上，并使其进行LC-MS或LC-MS-MS测量以确定至少一种生物标志物的量; 和（d）定量生物标志物。还提供了用于这种方法的试剂盒，例如在维生素D衍生物，睾酮和/或褪黑激素的测定中。

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