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1. 发明申请

WO2010147779A3 PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：用于医疗应用的基于磷酰胆碱的AMPHIPILILIC硅
公开(公告)号：WO2010147779A3
公开(公告)日：2011-02-17
申请号：PCT/US2010037576
申请日：2010-06-07
申请人： DSM IP ASSETS BV , PARAKKA JAMES , IYER ANANTH V , WANG ANFENG , JIANG XUWEI , TIAN YUAN , WARD ROBERT
发明人： PARAKKA JAMES , IYER ANANTH V , WANG ANFENG , JIANG XUWEI , TIAN YUAN , WARD ROBERT
IPC分类号： C08G77/395 , A61L15/26 , A61L31/06 , C08F230/08 , C08L83/08 , C08L83/10 , G02B1/04
CPC分类号： C08G77/395 , A61F13/00017 , A61L15/26 , A61L26/0019 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , C07F9/091 , C07F9/092 , C07F9/65742 , C07F9/65746 , C08F230/02 , C08F230/08 , C08L83/08 , C08L83/10 , G02B1/043 , C08L83/04
摘要： Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.
摘要翻译：用于局部和内部应用的两亲仿生磷酰胆碱的硅氧烷化合物作为生物医学装置的组件。包含两性离子磷酰胆碱基团的硅氧烷化合物可以是可聚合的或不可聚合的。应用的具体实例包括用作眼科镜片中的活性功能组分，眼用晶状体护理溶液，液体绷带，伤口敷料以及润滑和抗血栓形成的涂层。

2. 发明申请

WO2009148880A2 ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
标题翻译：抗微生物聚合物及其用途
公开(公告)号：WO2009148880A2
公开(公告)日：2009-12-10
申请号：PCT/US2009045140
申请日：2009-05-26
申请人： DSM IP ASSETS BV , WANG SHANGER , WARD ROBERT S , TIAN YUAN , LI LI , MCCREA KEITH , PARAKKA JAMES , JONES ROBERT L JR
发明人： WANG SHANGER , WARD ROBERT S , TIAN YUAN , LI LI , MCCREA KEITH , PARAKKA JAMES , JONES ROBERT L JR
IPC分类号： A01N33/12 , A01N25/10
CPC分类号： A01N33/12 , A01N47/44 , A01N25/10 , A01N2300/00
摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
摘要翻译：具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管，和其他可植入装置）。在需要控制生物膜形成的环境中，例如海产品，这样的材料也可以用作与微生物接触的结构上的抗微生物和防污涂料。

3. 发明申请

WO2009073401A4 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
标题翻译：有机硅水凝胶用于组织粘合剂和组织敷料应用
公开(公告)号：WO2009073401A4
公开(公告)日：2009-12-03
申请号：PCT/US2008084306
申请日：2008-11-21
申请人： DSM IP ASSETS BV , MCCREA KEITH , WARD ROBERT S , TIAN YUAN
发明人： MCCREA KEITH , WARD ROBERT S , TIAN YUAN
IPC分类号： A61L26/00
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethylacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
摘要翻译：硅酮水凝胶制剂可含有无规和/或嵌段共聚物或低聚物或大分子单体。硅氧烷共聚物与其他聚合物或单体或大分子单体共聚或共混以获得最终配方。硅酮水凝胶可以含有交联基团以提供完全或部分交联的最终结构。硅酮水凝胶制剂可以预先形成为膜或其他结构，或者可以在施用期间如在粘合剂制剂的情况下那样聚合。 1.一种创伤敷料，其包含作为膜形成的硅酮水凝胶，所述硅酮水凝胶在应用于伤口之前或原位置于伤口上，所述膜具有气体渗透性，透湿性和高含水量，其中所述硅酮水凝胶由可聚合硅酮如双官能聚二甲基硅氧烷甲基丙烯酸酯和交联剂如N，N-二甲基丙烯酰胺（DMA），甲基丙烯酸2-羟乙酯（HEMA）和三甲基甲硅烷氧基硅烷（TRIS）。

4. 发明申请

WO2007142683A3 SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS 审中-公开
标题翻译：自组装单体和低聚物作为表面修饰聚合物的终端
公开(公告)号：WO2007142683A3
公开(公告)日：2008-10-30
申请号：PCT/US2006046586
申请日：2006-12-07
申请人： POLYMER TECHNOLOGY GROUP INC , WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
发明人： WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
IPC分类号： A61K47/00
CPC分类号： A61K31/785 , C08G18/0895 , C08G18/2875 , C08G18/288 , C08G18/44 , C08G18/6266
摘要： Polymers having the formula R(LE) x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE) x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
摘要翻译：具有式R（LE）x X的聚合物其中R是数均分子量为5000-7,000,000道尔顿并具有x个端基的聚合物芯，E是通过共价键与聚合物芯R共价连接的端基连接L，L是具有至少5个相同重复单元的二价低聚链，其能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x < 可以彼此相同或不同。单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面修饰该聚合物的端基。使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

5. 发明申请

WO2006102050A2 PROCESS FOR THE PRODUCTION OF MONODISPERSE AND NARROW DISPERSE MONOFUNCTIONAL SILICONES 审中-公开
标题翻译：单分散和单分散单功能硅生产工艺
公开(公告)号：WO2006102050A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009666
申请日：2006-03-16
申请人： JOHNSON & JOHNSON VISION CARE , PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
发明人： PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
CPC分类号： C08G77/045 , C07F7/0874 , C08G77/06 , C08G77/08 , C08G77/20 , C08G77/36 , C08G77/38 , G02B1/043 , C08L83/06
摘要： Synthesis and purification of mono and narrow disperse monofunctional polydimethylsiloxane methacrylate derivatives with different molecular weights are disclosed.
摘要翻译：公开了具有不同分子量的单分散和单分散单官能聚二甲基硅氧烷甲基丙烯酸酯衍生物的合成和纯化。

6. 发明申请

WO2007121180A3 BIOSENSOR MEMBRANE MATERIAL 审中-公开
标题翻译：生物传感器膜材料
公开(公告)号：WO2007121180A3
公开(公告)日：2008-10-30
申请号：PCT/US2007066332
申请日：2007-04-10
申请人： ISENSE CORP , WARD ROBERT S , TIAN YUAN , WARD WILLIAM KENNETH , ANDERSON ELLEN M , HOUSE JODY
发明人： WARD ROBERT S , TIAN YUAN , WARD WILLIAM KENNETH , ANDERSON ELLEN M , HOUSE JODY
IPC分类号： C08G77/42 , C08F283/02 , C08G77/448
CPC分类号： C08G64/18 , C08G77/448 , C08G77/458
摘要： Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
摘要翻译：本发明的实施方案提供了用于生物传感器和其它可植入医疗装置和假体的各种多聚体和选择渗透膜。本发明的实施方案可以提供结构强度和完整性，并且还可以控制葡萄糖，氧气和/或水的流入。例如，本发明的实施方案可以通过使亲水链段的百分比最小化来最小化或减少葡萄糖的流入，从而使吸水的百分比和葡萄糖转运的程度最小化。

7. 发明申请

WO2009073401A3 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
公开(公告)号：WO2009073401A3
公开(公告)日：2009-10-15
申请号：PCT/US2008084306
申请日：2008-11-21
申请人： POLYMER TECHNOLOGY GROUP INC , MCCREA KEITH , WARD ROBERT S , TIAN YUAN
发明人： MCCREA KEITH , WARD ROBERT S , TIAN YUAN
IPC分类号： A61L26/00
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethylacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).

8. 发明申请

WO2013120974A3 POLYSILOXANE BASED BLOCK COPOLYMERS 审中-公开
标题翻译：聚硅氧烷基嵌段共聚物
公开(公告)号：WO2013120974A3
公开(公告)日：2013-10-10
申请号：PCT/EP2013053027
申请日：2013-02-14
申请人： DSM IP ASSETS BV
发明人： TIAN YUAN , CURTIN SCOTT , IYER ANANTH , WANG ANFENG , OUYANG MENG
IPC分类号： C08F299/00 , C08F230/08 , C08F299/08 , C08G77/46 , C08L43/04 , G02B1/04
CPC分类号： C08F283/008 , C08F230/08 , C08F299/08 , C08G77/388 , C08G77/46 , G02B1/043 , C08L83/12 , C08L101/14
摘要： The invention is directed to polysiloxane based block copolymers that comprise siloxane untis and units derived from diol compounds comprising at least one pendant oligomeric or polymeric group. The block copolymers according to the invention surprisingly allows any glassware used during its preparation to be washed cleaned with water. The block copolymer can be used in ophthalmic lenses, and may be useful in providing contact lens formulations which are water processable.
摘要翻译：本发明涉及包含硅氧烷基团的聚硅氧烷基嵌段共聚物和衍生自包含至少一个侧链低聚或聚合基团的二醇化合物的单元。根据本发明的嵌段共聚物令人惊讶地允许在其制备期间使用的任何玻璃器皿用水清洗。该嵌段共聚物可用于眼科镜片，并可用于提供可水处理的隐形眼镜配方。

9. 发明申请

WO2010041122A3 METHOD OF USING ACKNOWLEDGMENT TONES FOR DATA CONSISTENCY IN INTRA-VEHICULAR WIRELESS NETWORKS 审中-公开
标题翻译：在车内无线网络中使用确认音调数据一致性的方法
公开(公告)号：WO2010041122A3
公开(公告)日：2010-06-10
申请号：PCT/IB2009007058
申请日：2009-10-06
申请人： BOSCH GMBH ROBERT , HOGENMUELLER THOMAS ALFONS , JAIN VIVEK , VENKATRAMAN LAKSHMI , KESHAVARZIAN ABTIN , CHINTALAPUDI KRISHNA , TOZLU SERBULENT , TIAN YUAN
发明人： HOGENMUELLER THOMAS ALFONS , JAIN VIVEK , VENKATRAMAN LAKSHMI , KESHAVARZIAN ABTIN , CHINTALAPUDI KRISHNA , TOZLU SERBULENT , TIAN YUAN
IPC分类号： H04L1/16
CPC分类号： H04L1/1692 , H04L2001/0097
摘要： A method for providing electronic communications between wireless nodes includes wirelessly transmitting data from a transmitting one of the nodes to a plurality of receiving ones of the nodes. A respective first acknowledgment tone is wirelessly transmitted from each of the receiving nodes to the transmitting node and to each other one of the receiving nodes. Each first acknowledgment tone is transmitted in response to the respective receiving node receiving the transmitted data. Each of the first acknowledgment tones is transmitted in a respective, unique time slot. At least one second acknowledgment tone is wirelessly transmitted from at least one of the nodes to each other one of the nodes. The second acknowledgment tone is transmitted dependent upon whether a group of received first acknowledgment tones matches a group of expected-to-be-received first acknowledgment tones.
摘要翻译：一种用于提供无线节点之间的电子通信的方法包括：将数据从节点中的发送节点无线发送到节点中的多个接收节点。相应的第一确认音调从每个接收节点无线地发送到发送节点和每个接收节点中的每个接收节点。响应于各个接收节点接收发送的数据来发送每个第一确认音。每个第一确认音调在相应的唯一时隙中传输。至少一个第二确认音调从节点中的至少一个无线地发送到节点中的彼此之一。根据接收到的第一确认音的组是否与一组期望接收的第一确认音相匹配来发送第二确认音。

10. 发明申请

WO2006081589A3 TUNGSTEN ELECTROPROCESSING 审中-公开
标题翻译：钨电镀
公开(公告)号：WO2006081589A3
公开(公告)日：2006-11-23
申请号：PCT/US2006004873
申请日：2006-01-27
申请人： APPLIED MATERIALS INC , JIA RENHE , WANG ZHIHONG , TIAN YUAN , TRAN HUYEN KAREN , MAO DAXIN , TSAI STAN D , KARUPPIAH LAKSH , CHEN LIANG-YUH
发明人： JIA RENHE , WANG ZHIHONG , TIAN YUAN , TRAN HUYEN KAREN , MAO DAXIN , TSAI STAN D , KARUPPIAH LAKSH , CHEN LIANG-YUH
IPC分类号： B24B37/04
CPC分类号： B23H5/08 , B24B37/042 , C25F3/08
摘要： Methods for polishing tungsten are provided. During ECMP, increasing the voltage to the pad is not always enough to increase the polishing rate. When polishing tungsten, simply increasing the applied voltage will, in some cases, actually decrease the removal rate. By increasing the down force pressure between the polishing pad and the substrate, the applied voltage, and the rotation speed of the substrate and the polishing pad, the tungsten removal rate will also increase.
摘要翻译：提供了抛光钨的方法。在ECMP期间，增加到焊盘的电压并不总是足以提高抛光速率。抛光钨时，仅仅增加施加的电压在某些情况下会实际降低去除速率。通过增加抛光垫与基底之间的向下的压力，施加的电压以及基底和抛光垫的旋转速度，钨的移除速率也将增加。

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