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1. 发明申请

WO2006094161A3 NEW SOURCES FOR, AND TYPES OF, INSECTICIDALLY ACTIVE PROTEINS, AND POLYNUCLEOTIDES THAT ENCODE THE PROTEINS 审中-公开
标题翻译：新的来源和类型的杀虫活性蛋白质和编码蛋白质的多核苷酸
公开(公告)号：WO2006094161A3
公开(公告)日：2007-03-08
申请号：PCT/US2006007524
申请日：2006-03-02
申请人： DOW AGROSCIENCES LLC , LARRINUA IGNACIO M , MERLO DONALD J , WOOSLEY AARON TODD , HEY TIMOTHY D , MEADE THOMAS , BURTON STEPHANIE LOVE
发明人： LARRINUA IGNACIO M , MERLO DONALD J , WOOSLEY AARON TODD , HEY TIMOTHY D , MEADE THOMAS , BURTON STEPHANIE LOVE
IPC分类号： A01N65/00 , C12N15/82 , C07K14/195 , C07K14/37
CPC分类号： C07K14/195 , A01N63/00 , A01N63/04 , C07K14/20 , C07K14/21 , C07K14/37 , C07K16/14 , C07K2319/00 , Y10S530/858
摘要： The subject invention provides exciting new sources for surprising, new types of toxin complex ("TC") proteins. The subject invention includes these new classes and types of TC proteins. The subject invention also includes polynucleotides that encode the subject proteins. The subject invention further provides vectors and cells comprising these polynucleotides. The subject invention also provides novel methods of controlling insects. The subject invention relates in part to the surprising discovery that new types of TC proteins can be obtained from a widely diverse phylogenetic spectrum of organisms including, most notably and surprisingly, eukaryotic fungus.
摘要翻译：本发明为令人惊奇的新型毒素复合物（“TC”）蛋白质提供令人兴奋的新来源。本发明包括这些新类型和TC蛋白。本发明还包括编码受试蛋白的多核苷酸。本发明进一步提供了包含这些多核苷酸的载体和细胞。本发明还提供了控制昆虫的新方法。本发明部分地涉及令人惊奇的发现，即可以从广泛多样的生物学系统发育谱获得新型TC蛋白质，包括最引人注目和令人惊讶的真核真菌。

2. 发明申请

WO2004067727A8 MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL 审中-公开
标题翻译：混合和匹配TC蛋白进行病虫害防治
公开(公告)号：WO2004067727A8
公开(公告)日：2005-08-18
申请号：PCT/US2004000394
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC , HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C , MEADE THOMAS
发明人： HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C , MEADE THOMAS
IPC分类号： A01N37/46 , A01N63/02 , C07K14/195 , C07K14/24 , C12N15/82 , A01H5/00 , C12N5/10
CPC分类号： C07K14/195 , A01N37/46 , A01N63/02 , C07K14/24 , C12N15/8286 , Y02A40/162
摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibacillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a "stand-alone" TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein "potentiators" derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand-alone Photorhabdus protein toxin. This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterologous TC proteins are also disclosed herein.
摘要翻译：本发明涉及令人惊讶的发现，即可从Xenorhabdus，光杆状芽孢杆菌和类芽孢杆菌中获得的毒素复合物（TC）蛋白可彼此互换使用。在本发明的特别优选的实施方案中，“独立的”TC蛋白（例如来自光杆状病毒，Xenorhabdus或类芽孢杆菌属）的毒性通过一种或多种衍生自一种或多种来源于源生物的TC蛋白“增效剂” 毒素来自的不同属。如本领域技术人员将认识到本公开的益处，这具有广泛的含义并扩大了各种类型的TC蛋白现在将被识别具有的效用范围。其中最重要的优点是本领域技术人员现在将能够使用单组增效剂来增强独立的致病杆菌蛋白毒素以及独立的光杆状菌蛋白毒素的活性。这减少了转基因植物需要表达的基因数量和转化事件，以实现对更广谱目标害虫的有效控制。本文还公开了异源TC蛋白的某些优选组合。

3. 发明申请

WO2005084355A3 INSECTICIDAL TOXIN COMPLEX FUSION PROTEINS 审中-公开
标题翻译：杀虫毒素复合融合蛋白
公开(公告)号：WO2005084355A3
公开(公告)日：2006-08-31
申请号：PCT/US2005006851
申请日：2005-03-02
申请人： DOW AGROSCIENCES LLC , HEY TIMOTHY D , CAI QIHUA , MEADE THOMAS , MOON HALEY , BURTON STEPHANIE , SHEETS JOEL J , MERLO DONALD J , WOOSLEY AARON T
发明人： HEY TIMOTHY D , CAI QIHUA , MEADE THOMAS , MOON HALEY , BURTON STEPHANIE , SHEETS JOEL J , MERLO DONALD J , WOOSLEY AARON T
IPC分类号： C07K14/195 , A01H5/00 , A01H5/10 , A01N63/02 , C07K14/32 , C12N15/62 , C12N15/82
CPC分类号： C12N15/8286 , C07K14/195 , C07K14/24 , C07K14/32 , C07K2319/00 , C07K2319/55 , C12N15/62 , Y02A40/162
摘要： The subject invention relates to insecticidal toxin complex ("TC") fusion proteins and to polynucleotides that encode these fusion proteins. The subject invention also includes polynucleotides that encode the subject TC fusion proteins, and vectors comprising said polynucleotides. In some embodiments, the invention provides a fusion protein comprising a Class A protein, a Class B protein, and a Class C TC protein fused together to form a single protein. In some other embodiments, the invention provides a fusion protein comprising a Class B and a Class C TC proteins fused together. In the latter embodiments, the BC or CB fusion protein can be used to enhance or potentiate the anti-insect activity of a "Toxin A" or Class A protein. Heretofore, there was no expectation that such fusion proteins would properly function and retain their activity when fused together. The subject invention advantageously reduces the number of genes needed to transform plants. Thus, the subject invention also includes plants, cells (bacterial and plant cells for example), and seeds that comprise said polynucleotides. Said plants can produce fusion proteins of the subject invention, which convey insect resistance to said plants. The subject invention also includes methods of controlling pests (preferably insects and other plant pests) with fusion proteins of the subject invention.
摘要翻译：本发明涉及杀虫毒素复合物（“TC”）融合蛋白和编码这些融合蛋白的多核苷酸。本发明还包括编码受试者TC融合蛋白的多核苷酸和包含所述多核苷酸的载体。在一些实施方案中，本发明提供了融合蛋白，其包含融合在一起形成单一蛋白质的A类蛋白质，B类蛋白质和C类TC蛋白质。在一些其它实施方案中，本发明提供了融合蛋白，其包含融合在一起的B类和C类TC蛋白。在后一个实施方案中，BC或CB融合蛋白可用于增强或增强“毒素A”或A类蛋白的抗昆虫活性。迄今为止，没有任何期望，当融合在一起时，这种融合蛋白将适当地起作用并保持其活性。本发明有利地减少转化植物所需的基因数量。因此，本发明还包括植物，细胞（例如细菌和植物细胞）和包含所述多核苷酸的种子。所述植物可以产生本发明的融合蛋白，其向所述植物传递昆虫抗性。本发明还包括用本发明的融合蛋白控制害虫（优选昆虫和其它植物害虫）的方法。

4. 发明申请

WO2004067727A2 MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL 审中-公开
标题翻译：混合和匹配TC蛋白进行病虫害防治
公开(公告)号：WO2004067727A2
公开(公告)日：2004-08-12
申请号：PCT/US2004000394
申请日：2004-01-07
申请人： DOW AGROSCIENCES LLC , HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C
发明人： HEY TIMOTHY D , SCHLEPER AMANDA D , BEVAN SCOTT A , BINTRIM SCOTT B , MITCHELL JON C , LI ZE SHENG , NI WEITING , ZHU BAOLONG , MERLO DONALD J , APEL-BIRKHOLD PATRICIA C , MEADE THOMAS
IPC分类号： A01N37/46 , A01N63/02 , C07K14/195 , C07K14/24 , C12N15/82 , C12N
CPC分类号： C07K14/195 , A01N37/46 , A01N63/02 , C07K14/24 , C12N15/8286 , Y02A40/162
摘要： The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdus, and Paenibucillus, can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a "stand-alone" TC protein (from Photorhabdus, Xenorhabdus, or Paenibacillus, for example) is enhanced by one or more TC protein "potentiators" derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will new be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone Xenorhabdus protein toxin as well as a stand alone Photorlzabdus protein toxin. (As one skilled in the art knows, Xenorhabdus toxin proteins tend to be more desirable for controlling lepidopterans while Photorhabdus toxin proteins tend to be more desirable for controlling coleopterans.) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests. Certain preferred combinations of heterolugous TC proteins are also disclosed herein. Other objects, advantages, and features of the subject invention will be apparent to cue skilled in the art having the benefit of the subject disclosure.
摘要翻译：本发明涉及令人惊奇的发现，可以从Xenorhabdus，Photorhabdus和Paenibucillus获得的毒素复合物（TC）蛋白质彼此互换使用。在本发明的特别优选的实施方案中，“独立”TC蛋白（例如，来自Photorhabdus，Xenorhabdus或Paenibacillus的例如）的毒性由一种或多种衍生自以下的源生物体的TC蛋白“增强剂”增强来源于毒素的不同属。本领域技术人员将会认识到本公开的益处，这具有广泛的含义，并且扩展了新认证的各种类型的TC蛋白质具有的效用范围。最重要的优点之一是，本领域技术人员现在将能够使用单组增效剂来增强独立的Xenorhabdus蛋白毒素的活性以及独立的Photorlzabdus蛋白毒素。（如本领域技术人员所知，Xenorhabdus毒素蛋白质倾向于更有利于控制鳞翅目，而Photorhabdus毒素蛋白质倾向于更有利于控制鞘翅目）。这减少了需要表达的基因数量和转化事件一个转基因植物，以实现更广泛的目标害虫的有效控制。杂种TC蛋白的某些优选组合也在本文中公开。本发明的其它目的，优点和特征对本领域的技术人员而言是显而易见的。

5. 发明申请

WO2005067491A3 TOXIN COMPLEX PROTEINS AND GENES FROM XENORHABDUS BOVIENII 审中-公开
标题翻译：毒素复合蛋白和XENORHABDUS BOVIENII的基因
公开(公告)号：WO2005067491A3
公开(公告)日：2006-05-18
申请号：PCT/US2004043000
申请日：2004-12-23
申请人： DOW AGROSCIENCES LLC , APEL-BIRKHOLD PATRICIA C , HEY TIMOTHY D , SHEETS JOEL J , MEADE THOMAS , LI ZE SHENG , LIRA JUSTIN M , RUSSELL SEAN M , THOMPSON ROBIN L , MITCHELL JON C , FENCIL KRISTIN
发明人： APEL-BIRKHOLD PATRICIA C , HEY TIMOTHY D , SHEETS JOEL J , MEADE THOMAS , LI ZE SHENG , LIRA JUSTIN M , RUSSELL SEAN M , THOMPSON ROBIN L , MITCHELL JON C , FENCIL KRISTIN
IPC分类号： C12N15/31 , A01H1/00 , A01H5/00 , A01N63/00 , A01N63/02 , C07H21/04 , C07K14/24 , C12N5/04 , C12N15/00 , C12N15/03 , C12N15/05 , C12N15/08 , C12N15/10 , C12N15/32 , C12N15/82 , C12P21/02
CPC分类号： C12N15/8286 , A01N63/00 , A01N63/02 , C07H21/04 , C07K14/24 , C12N15/8279 , Y02A40/162 , Y10S530/825
摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus bovienii strain ILM104.
摘要翻译：本发明涉及新型异戊酰梭菌毒素复合物（TC）蛋白质和编码这些蛋白质的基因。更具体地，本发明涉及从Xenorhabdus bovienii菌株ILM104获得的TC基因和蛋白质。

6. 发明申请

WO2011084627A2 MODIFIED CRY1CA INSECTICIDAL CRY PROTEINS 审中-公开
标题翻译：修饰的CRY1CA杀虫活性蛋白
公开(公告)号：WO2011084627A2
公开(公告)日：2011-07-14
申请号：PCT/US2010060826
申请日：2010-12-16
申请人： DOW AGROSCIENCES LLC , MEADE THOMAS , NARVA KENNETH , HEY TIMOTHY , LARRINUA IGNACIO , WOOSLEY AARON T , BURTON STEPHANIE L
发明人： MEADE THOMAS , NARVA KENNETH , HEY TIMOTHY , LARRINUA IGNACIO , WOOSLEY AARON T , BURTON STEPHANIE L
IPC分类号： A01H5/00
CPC分类号： C12N15/8286 , C07K14/325 , Y02A40/162
摘要： The present invention includes modified, insecticidal B.t. Cry1Ca proteins, including the proteins designated herein as DIG-109 and DIG-152, as well as variants of DIG-109 and DIG-152, nucleic acids encoding these proteins, methods of controlling pests using the proteins, methods of producing the proteins in transgenic host cells, and transgenic plants that produce the proteins. The DIG-109 and DIG-152 proteins comprise chimeric peptides composed of a core toxin segment of B.t. Cry1Ca and a Cry1Ab protoxin segment. Insecticidally active variants of the DIG-109 and DIG-152 proteins are also described.
摘要翻译：本发明包括修饰的杀虫剂B.t. 包括本文中命名为DIG-109和DIG-152的蛋白质的Cry1Ca蛋白质，以及DIG-109和DIG-152的变体，编码这些蛋白质的核酸，使用该蛋白质控制害虫的方法，转基因宿主细胞和产生蛋白质的转基因植物。 DIG-109和DIG-152蛋白包含由B.t.的核心毒素片段组成的嵌合肽。 Cry1Ca和Cry1Ab原毒素片段。还描述了DIG-109和DIG-152蛋白的杀虫活性变体。

7. 发明申请

WO9638184A2 MAGNETIC RESONANCE IMAGING AGENTS FOR THE DETECTION OF PHYSIOLOGICAL AGENTS 审中-公开
标题翻译：用于检测生理代理的磁共振成像剂
公开(公告)号：WO9638184A2
公开(公告)日：1996-12-05
申请号：PCT/US9608548
申请日：1996-06-03
申请人： CALIFORNIA INST OF TECHN , MEADE THOMAS , FRASER SCOTT , JACOBS RUSSELL
发明人： MEADE THOMAS , FRASER SCOTT , JACOBS RUSSELL
IPC分类号： A61K49/00 , A61K49/06 , A61K49/08
CPC分类号： A61K49/10 , A61K49/085 , A61K49/103 , A61K49/106
摘要： The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
摘要翻译：本发明涉及新型磁共振成像造影剂和检测生理信号或物质的方法。

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