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1. 发明申请

WO03023044A2 PROCESS FOR THE PRODUCTION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA 审中-公开
标题翻译：使用CORYNEFORM BACTERIA生产L-氨基酸的方法
公开(公告)号：WO03023044A2
公开(公告)日：2003-03-20
申请号：PCT/EP0209043
申请日：2002-08-13
申请人： DEGUSSA , BATHE BRIGITTE , PFEFFERLE WALTER , HUTHMACHER KLAUS
发明人： BATHE BRIGITTE , PFEFFERLE WALTER , HUTHMACHER KLAUS
IPC分类号： C12N1/21 , C12P13/12 , C12P13/04
CPC分类号： C12P13/12
摘要： The invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which at least the gene coding for S-adenosylmethionine synthetase and/or the gene coding for a transporter for branched-chain amino acids is/are attenuated, b) enrichment of the desired L-amino acid in the medium or in the bacterial cells, and c) isolation of the L-amino acid, and optionally bacteria are used in which in addition further genes of the biosynthesis pathway of the desired L-amino acid are enhanced, or bacteria are used in which the metabolic pathways that reduce the formation of the desired L-amino acid are at least partially switched off.
摘要翻译：本发明涉及生产L-氨基酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中至少编码S-腺苷甲硫氨酸的基因合成酶和/或编码支链氨基酸转运蛋白的基因被减毒，b）在培养基或细菌细胞中富集所需的L-氨基酸，和c）分离L-氨基酸，并且任选地使用细菌，其中另外还需要增加所需L-氨基酸的生物合成途径的其它基因，或使用细菌，其中减少所需L-氨基酸形成的代谢途径至少部分地关闭

2. 发明申请

WO02100530A8 METHOD FOR CONTROLLING FERMENTATION 审中-公开
标题翻译：法发酵控制的
公开(公告)号：WO02100530A8
公开(公告)日：2005-03-17
申请号：PCT/EP0206525
申请日：2002-06-13
申请人： DEGUSSA , FARWICK MIKE , BATHE BRIGITTE , MOECKEL BETTINA , HUTHMACHER KLAUS , PFEFFERLE WALTER
发明人： FARWICK MIKE , BATHE BRIGITTE , MOECKEL BETTINA , HUTHMACHER KLAUS , PFEFFERLE WALTER
IPC分类号： C12N1/21 , C12N15/12 , C12N15/31 , C12N15/67 , C12P1/00 , C12P13/08 , C12Q1/68 , C12R1/15
CPC分类号： C12R1/15 , C12N15/67 , C12P1/00
摘要： The invention relates to genes and polypeptides, which are coded thereby and which originate from Corynebacterium glutamicum. These genes and polypeptides can be used for analyzing or diagnosing and, in particular, for monitoring fermentation processes while using Corynebacterium glutamicum.
摘要翻译：本发明涉及谷氨酸棒杆菌编码的基因和多肽，其可以被用于分析或诊断，特别是用于使用谷氨酸棒杆菌发酵过程的监测。

3. 发明申请

WO2005090589A3 PROCESS FOR THE PRODUCTION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA 审中-公开
标题翻译：使用厌氧菌生产L-氨基酸的方法
公开(公告)号：WO2005090589A3
公开(公告)日：2005-12-01
申请号：PCT/EP2005002652
申请日：2005-03-11
申请人： DEGUSSA , BATHE BRIGITTE , SCHISCHKA NATALIE , PFEFFERLE WALTER
发明人： BATHE BRIGITTE , SCHISCHKA NATALIE , PFEFFERLE WALTER
IPC分类号： C07K14/34 , C12N1/20 , C12P13/08 , C12P13/12 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34 , C12P13/12
摘要： The invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which bacteria at least one or more genes belonging to the group of the transcription regulators, selected from the group smtB, cgl1, hspR, cgl2, cebR, cgl3, gatR, glcR, tcmR, smtB2, dtxR, degA, galR, tipA2, malI, cgl4, arsR, merR, hrcA, glpR2, lexA, ccpA3 and degA2, has (have) been attenuated, especially excluded or expressed at a low level, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and optionally there are used bacteria in which further genes of the biosynthesis pathway of the desired L-amino acid are additionally enhanced, or there are used bacteria in which the metabolic pathways that reduce the formation of the desired L-amino acid are at least partially excluded.
摘要翻译：本发明涉及生产L-氨基酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中细菌中至少一种或多种属于选自组smtB，cgl1，hspR，cgl2，cebR，cgl3，gatR，glcR，tcmR，smtB2，dtxR，degA，galR，tipA2，malI，cgl4，arsR，merR，hrcA，glpR2 ，lexA，ccpA3和degA2已被减毒，尤其是被排除或以低水平表达，b）期望的L-氨基酸在细菌培养基或细胞中的浓度，以及c）分离 L-氨基酸，并且任选地使用其中额外增强所需L-氨基酸的生物合成途径的其他基因的细菌，或使用细菌，其中减少所需L-氨基酸形成的代谢途径酸至少部分被排除在外。

4. 发明申请

WO0222799A3 METHOD FOR THE MICROBIAL PRODUCTION OF METABOLIC PRODUCTS, POLYNUCLEOTIDES FROM CORYNEFORM BACTERIA AND USE THEREOF 审中-公开
标题翻译：用于生产微生物代谢产物，从杆状菌及其用途多核苷酸
公开(公告)号：WO0222799A3
公开(公告)日：2003-03-13
申请号：PCT/DE0103485
申请日：2001-09-08
申请人： FORSCHUNGSZENTRUM JUELICH GMBH , DEGUSSA , BOTT MICHAEL , NIEBISCH AXEL , BATHE BRIGITTE , MARX ACHIM , HERMANN THOMAS
发明人： BOTT MICHAEL , NIEBISCH AXEL , BATHE BRIGITTE , MARX ACHIM , HERMANN THOMAS
IPC分类号： C07K14/34 , C12N1/21 , C12N9/02 , C12N15/31 , C12N15/52 , C12N15/53 , C12P1/04 , C12P7/04 , C12P7/40 , C12P13/04 , C12P19/38 , C12Q1/68
CPC分类号： C12N9/0036 , C07K14/34 , C12N9/0038 , C12N9/0053 , C12N15/52 , C12P1/04
摘要： The invention relates to a method for the microbial production ofmetabolic products, polynucleotides from coryneform bacteria and use thereof. According to the invention, by means of said method and polynucleotides it is possible to influence the synthesis of ATP in a controlled manner and also to control the synthesis of metabolic products. The invention relates to genes from Corynebacterium glutamicum coding for cytochrome aa3 oxidase and the cytochrome bcl complex. The monocistronic ctaD gene codes for a 65 kDa protein, the primary structure of which displays all the typical properties of the sub-unit I of cytochrome aa3 oxidase. The genes which code for the sub-unit III of the cytochrome aa3 (ctaE) and the three characteristic sub-units of the cytochrome bc1 complex (qcrABC) are arranged in a group with the sequence ctaE-qcrCAB.
摘要翻译：本发明涉及一种用于从棒状细菌和它们的使用的微生物生产的代谢产物，多核苷酸的方法。本发明的方法和多核苷酸，它是现在可以影响ATP的合成目标，从而控制代谢产物的合成。本发明涉及一种细胞色素氧化酶AA3和谷氨酸棒杆菌细胞色素BC1复杂的编码基因。单顺反子基因编码CTAD大的蛋白质，其主要结构具有细胞色素氧化酶AA3的亚基我为65 kDa的所有的典型特征。编码细胞色素BC1络合物（qcrABC）被布置的顺序ctaE-qcrCAB一组中的特性编码细胞色素AA3（ctaE）的亚基III的基因和三个亚基。

5. 发明申请

WO2008046810A3 ALLELES OF THE REL GENE OF CORYNEFORM BACTERIA 审中-公开
标题翻译：细菌细菌的所有释放
公开(公告)号：WO2008046810A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007060967
申请日：2007-10-15
申请人： EVONIK DEGUSSA GMBH , BATHE BRIGITTE , KREUTZER CAROLINE , THIERBACH GEORG
发明人： BATHE BRIGITTE , KREUTZER CAROLINE , THIERBACH GEORG
IPC分类号： C12N9/12 , A23L1/227 , C12N1/21 , C12N15/54 , C12N15/63 , C12N15/69 , C12P13/04 , C12P13/08 , C12R1/15
CPC分类号： C12P13/08 , A23L33/135 , A23L33/175 , C12N9/1235 , C12P13/04
摘要： The invention relates to mutants and alleles of the rel gene of coryneform bacteria coding for variants of GTP pyrophosphate kinase (EC No. 2.7.6.5) as well as methods for producing amino acids by means of bacteria containing said alleles.
摘要翻译：本发明涉及编码GTP焦磷酸激酶变体（EC No.2.7.6.5）的棒状杆菌型细菌的rel基因的突变体和等位基因，并涉及使用含有这些等位基因的细菌生产氨基酸的方法。

6. 发明申请

WO2008006680A8 METHOD FOR PRODUCING L-AMINO ACIDS BY MEANS OF MUTANTS OF THE GLTA GENE CODING FOR CITRATE SYNTHASE 审中-公开
标题翻译：工艺生产L-氨基酸BY GLTA突变体的基因编码的柠檬酸合成酶
公开(公告)号：WO2008006680A8
公开(公告)日：2008-09-25
申请号：PCT/EP2007056153
申请日：2007-06-20
申请人： EVONIK DEGUSSA GMBH , BATHE BRIGITTE , CLAES WILFRIED
发明人： BATHE BRIGITTE , CLAES WILFRIED
IPC分类号： C12N9/12 , C12N9/88 , C12P13/06 , C12P13/08
CPC分类号： C12N9/88 , C12N9/1217 , C12P13/06 , C12P13/08 , C12Y203/03001 , C12Y207/02004
摘要： The invention relates to novel polynucleotides, coding for a polypeptide with citrate synthase activity, bacteria comprising the same, preferably of the species Corynebacterium and Escherichia, and methods for producing amino acids using said bacteria. The invention particularly relates to an isolated polynucleotide, coding for a polypeptide with the amino acid sequence SEQ ID NO:2, wherein the L-aspartic acid in position 5 of the amino acid sequence is replaced by another proteinogenic amino acid and the polypeptide has citrate synthase activity.
摘要翻译：本发明涉及新的，编码具有柠檬酸合酶活性的多肽，含有多核苷酸的细菌它们，优选棒杆菌属和埃希氏菌属，以及使用所述细菌的氨基酸的方法。本发明在特定的编码包含SEQ ID NO：2的氨基酸序列的多肽的分离的多核苷酸：2，其中所述的L-天冬氨酸，在位置5由另外的蛋白质的氨基酸置换的氨基酸序列取代，并且其中所述多肽具有柠檬酸合酶活性有。

7. 发明申请

WO2006125714A3 ALLELES OF THE OPCA GENE FROM CORYNEFORM BACTERIA 审中-公开
标题翻译：从杆状菌基因OPCA等位基因
公开(公告)号：WO2006125714A3
公开(公告)日：2007-05-03
申请号：PCT/EP2006062010
申请日：2006-05-03
申请人： DEGUSSA , SCHISCHKA NATALIE , BATHE BRIGITTE , THIERBACH GEORG
发明人： SCHISCHKA NATALIE , BATHE BRIGITTE , THIERBACH GEORG
IPC分类号： C07K14/34
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria coding for variants of the OpcA subunit of glucose-6-phosphate dehydrogenase (EC: 1.1.1.49) as well as methods for producing amino acids, especially L-lysine and L-tryptophan, using bacterial that contain said alleles.
摘要翻译：本发明涉及棒状细菌的编码葡萄糖-6-磷酸脱氢酶的OPCA亚基的变体的基因OPCA的突变体和等位基因（EC：1.1.1.49），及其制造方法的氨基酸，特别是L-赖氨酸和L-色氨酸使用含有这些等位基因的细菌。

8. 发明申请

WO2005021771A3 PROCESS FOR THE PRODUCTION OF L-LYSINE 审中-公开
标题翻译：生产L-赖氨酸的方法
公开(公告)号：WO2005021771A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004009385
申请日：2004-08-23
申请人： DEGUSSA , PETERSEN SOEREN , GERIGK MARC , HERMANN THOMAS , BATHE BRIGITTE
发明人： PETERSEN SOEREN , GERIGK MARC , HERMANN THOMAS , BATHE BRIGITTE
IPC分类号： C12P13/08
CPC分类号： C12P13/08
摘要： The invention relates to an improved process for the production of L-lysine by fermentation using L-lysine-producing coryneform bacteria.
摘要翻译：本发明涉及通过使用L-赖氨酸生产的棒状细菌发酵生产L-赖氨酸的改进方法。

9. 发明申请

WO03040373A2 CORYNEFORM BACTERIA WHICH PRODUCE CHEMICAL COMPOUNDS I 审中-公开
标题翻译：生产化学化合物的CORYNEFORM BACTERIA I
公开(公告)号：WO03040373A2
公开(公告)日：2003-05-15
申请号：PCT/EP0208464
申请日：2002-07-30
申请人： DEGUSSA , BATHE BRIGITTE , KREUTZER CAROLINE , MOECKEL BETTINA , THIERBACH GEORG
发明人： BATHE BRIGITTE , KREUTZER CAROLINE , MOECKEL BETTINA , THIERBACH GEORG
IPC分类号： C12N1/21 , C12N15/52 , C12N15/53 , C12N15/54 , C12N15/60 , C12N15/77 , C12P13/08
CPC分类号： C12R1/15 , C12N15/52 , C12N15/77 , C12P13/08
摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
摘要翻译：本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌，在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物通过这些细菌的发酵。

10. 发明申请

WO2006077004A3 ALLELES OF THE MQO-GENE FROM CORYNEFORM BACTERIA 审中-公开
标题翻译：从杆状菌基因MQO等位基因
公开(公告)号：WO2006077004A3
公开(公告)日：2007-03-15
申请号：PCT/EP2005057216
申请日：2005-12-29
申请人： DEGUSSA , BATHE BRIGITTE , HANS STEPHAN , SCHISCHKA NATALIE , THIERBACH GEORG
发明人： BATHE BRIGITTE , HANS STEPHAN , SCHISCHKA NATALIE , THIERBACH GEORG
IPC分类号： C12N9/02 , C12N1/20 , C12P13/08
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the mqo-gene from coryneform bacteria which codes for malate-quinone oxidoreductases, which contain the L-serine which is received for each amino acid on position 111 or a comparable position of the amino acid sequence. The invention also relates to a method for the fermative production of amino acids, preferably L-lysine, L-tryptophane and L-proline, using bacteria which contain said alleles.
摘要翻译：本发明涉及突变体和从棒状细菌的编码苹果酸 - 醌氧化还原酶的MQO基因的等位基因，包含除了在111位或每个氨基酸L-丝氨酸和处理用于发酵生产氨基酸，优选L-赖氨酸的氨基酸序列的相当的位置，L-色氨酸和L-脯氨酸，使用含有这些等位基因的细菌。

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