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1. 发明申请

WO2008046810A3 ALLELES OF THE REL GENE OF CORYNEFORM BACTERIA 审中-公开
标题翻译：细菌细菌的所有释放
公开(公告)号：WO2008046810A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007060967
申请日：2007-10-15
申请人： EVONIK DEGUSSA GMBH , BATHE BRIGITTE , KREUTZER CAROLINE , THIERBACH GEORG
发明人： BATHE BRIGITTE , KREUTZER CAROLINE , THIERBACH GEORG
IPC分类号： C12N9/12 , A23L1/227 , C12N1/21 , C12N15/54 , C12N15/63 , C12N15/69 , C12P13/04 , C12P13/08 , C12R1/15
CPC分类号： C12P13/08 , A23L33/135 , A23L33/175 , C12N9/1235 , C12P13/04
摘要： The invention relates to mutants and alleles of the rel gene of coryneform bacteria coding for variants of GTP pyrophosphate kinase (EC No. 2.7.6.5) as well as methods for producing amino acids by means of bacteria containing said alleles.
摘要翻译：本发明涉及编码GTP焦磷酸激酶变体（EC No.2.7.6.5）的棒状杆菌型细菌的rel基因的突变体和等位基因，并涉及使用含有这些等位基因的细菌生产氨基酸的方法。

2. 发明申请

WO2007141111A3 PROCESS FOR PRODUCTION OF A L-LYSINE CONTAINING FEED ADDITIVE 审中-公开
标题翻译：工艺生产L-赖氨酸含饲料添加剂
公开(公告)号：WO2007141111A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007054566
申请日：2007-05-11
申请人： EVONIK DEGUSSA GMBH , BATHE BRIGITTE , HANS STEPHAN , KREUTZER CAROLINE , LOTTER HERMANN , THIERBACH GEORG
发明人： BATHE BRIGITTE , HANS STEPHAN , KREUTZER CAROLINE , LOTTER HERMANN , THIERBACH GEORG
IPC分类号： A23K1/00 , A23K1/16 , A23K1/165 , C07C229/26 , C12N1/20 , C12N9/02 , C12N9/04 , C12N9/12 , C12N15/54 , C12P13/08
CPC分类号： C12P13/08 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1217
摘要： The invention relates to a process for producing animal feed additives based on fermentation broth having a high content of L-lysine and to lower-loss processes for producing broths obtained by fermentation using coryneforme bacteria which contains selected mutations, and to these feed additives themselves.
摘要翻译：本发明涉及一种用于制造基于发酵肉汤与L-赖氨酸和低损失的过程用于从使用棒状细菌发酵液制备高含量的动物饲料添加剂的方法，包括在所选择的突变和这些饲料添加剂本身。

3. 发明申请

WO03040373A2 CORYNEFORM BACTERIA WHICH PRODUCE CHEMICAL COMPOUNDS I 审中-公开
标题翻译：生产化学化合物的CORYNEFORM BACTERIA I
公开(公告)号：WO03040373A2
公开(公告)日：2003-05-15
申请号：PCT/EP0208464
申请日：2002-07-30
申请人： DEGUSSA , BATHE BRIGITTE , KREUTZER CAROLINE , MOECKEL BETTINA , THIERBACH GEORG
发明人： BATHE BRIGITTE , KREUTZER CAROLINE , MOECKEL BETTINA , THIERBACH GEORG
IPC分类号： C12N1/21 , C12N15/52 , C12N15/53 , C12N15/54 , C12N15/60 , C12N15/77 , C12P13/08
CPC分类号： C12R1/15 , C12N15/52 , C12N15/77 , C12P13/08
摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
摘要翻译：本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌，在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物通过这些细菌的发酵。

4. 发明申请

WO2007039532A3 METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS WITH THE AID OF CORYNEFORM BACTERIA CAPABLE OF USING GLYCERIN AS THE ONLY CARBON SOURCE 审中-公开
标题翻译： PROCEDURE用于发酵生产的使用棒状细菌的L-氨基酸，其ABLE，甘油作为唯一碳源的使用方法
公开(公告)号：WO2007039532A3
公开(公告)日：2007-08-02
申请号：PCT/EP2006066813
申请日：2006-09-27
申请人： DEGUSSA , FORSCHUNGSZENTRUM JUELICH GMBH , WENDISCH VOLKER F , RITTMANN DORIS , SAHM HERMANN , KREUTZER CAROLINE
发明人： WENDISCH VOLKER F , RITTMANN DORIS , SAHM HERMANN , KREUTZER CAROLINE
IPC分类号： C12P1/04 , C12N1/20 , C12P13/04
CPC分类号： C12N1/20 , C12P13/04 , C12P13/08 , C12P13/227
摘要： The invention relates to a method for producing L-amino acids in which the following steps are carried out: a) the recombinant coryneform bacteria which produce the desired L-amino acid and in which at least one or several of the heterologous polynucleotides of the glycerol metabolism, selected among the group comprising glpA, glpB, glpC, glpD, glpE, glpF, glpG, glpK, glpQ, glpT, glpX, gldA, dhaK, dhaL, dhaM, dhaR, fsa, and talC, is/are expressed are cultivated in a medium containing glycerol or one or several other optional C sources in conditions in which the desired L-amino acid is enriched in the medium or the cells; and, optionally, b) the desired L-amino acid is isolated, all or fractions (> 0 to 100 percent) of the components of the fermentation broth and/or biomass optionally remaining in the final product. In said method, bacteria are used in which other genes of the biosynthesis pathway of the desired L-amino acid are additionally reinforced or in which the metabolism pathways reducing the formation of the desired L-amino acid are eliminated at least in part.
摘要翻译：本发明涉及一种用于生产L- L-氨基酸，该方法包括进行下列步骤：a）所需的L-氨基酸生产重组棒状细菌的培养中，至少一个或多个所述甘油的异源多核苷酸STOF fwechsels的（甘油代谢）选自glpA，glpB，glpC，glpD，glpE，glpF中，glpG，GLPK，glpQ，glpT，glpX，GLDA，DHAK，木豆，DHAM，达尔，FSA和滑石选择，来表示（）在甘油或任选地加入一种或条件下含有培养基更多额外的C源，其中在培养基中或在细胞中的所需L-氨基酸富集，和任选地b）分离所需的L-氨基酸，其中所述发酵液的任选成分和/或（> 0至100％）以其整体或在最终产物水平保持生物质。并且其中除了所需的L-氨基酸的生物合成途径进一步扩增基因的细菌，或者其中代谢途径至少部分地消除，这减少所需的L-氨基酸的形成，被使用。

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