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1. 发明申请

WO03023044A2 PROCESS FOR THE PRODUCTION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA 审中-公开
标题翻译：使用CORYNEFORM BACTERIA生产L-氨基酸的方法
公开(公告)号：WO03023044A2
公开(公告)日：2003-03-20
申请号：PCT/EP0209043
申请日：2002-08-13
申请人： DEGUSSA , BATHE BRIGITTE , PFEFFERLE WALTER , HUTHMACHER KLAUS
发明人： BATHE BRIGITTE , PFEFFERLE WALTER , HUTHMACHER KLAUS
IPC分类号： C12N1/21 , C12P13/12 , C12P13/04
CPC分类号： C12P13/12
摘要： The invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which at least the gene coding for S-adenosylmethionine synthetase and/or the gene coding for a transporter for branched-chain amino acids is/are attenuated, b) enrichment of the desired L-amino acid in the medium or in the bacterial cells, and c) isolation of the L-amino acid, and optionally bacteria are used in which in addition further genes of the biosynthesis pathway of the desired L-amino acid are enhanced, or bacteria are used in which the metabolic pathways that reduce the formation of the desired L-amino acid are at least partially switched off.
摘要翻译：本发明涉及生产L-氨基酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中至少编码S-腺苷甲硫氨酸的基因合成酶和/或编码支链氨基酸转运蛋白的基因被减毒，b）在培养基或细菌细胞中富集所需的L-氨基酸，和c）分离L-氨基酸，并且任选地使用细菌，其中另外还需要增加所需L-氨基酸的生物合成途径的其它基因，或使用细菌，其中减少所需L-氨基酸形成的代谢途径至少部分地关闭

2. 发明申请

WO02100530A8 METHOD FOR CONTROLLING FERMENTATION 审中-公开
标题翻译：法发酵控制的
公开(公告)号：WO02100530A8
公开(公告)日：2005-03-17
申请号：PCT/EP0206525
申请日：2002-06-13
申请人： DEGUSSA , FARWICK MIKE , BATHE BRIGITTE , MOECKEL BETTINA , HUTHMACHER KLAUS , PFEFFERLE WALTER
发明人： FARWICK MIKE , BATHE BRIGITTE , MOECKEL BETTINA , HUTHMACHER KLAUS , PFEFFERLE WALTER
IPC分类号： C12N1/21 , C12N15/12 , C12N15/31 , C12N15/67 , C12P1/00 , C12P13/08 , C12Q1/68 , C12R1/15
CPC分类号： C12R1/15 , C12N15/67 , C12P1/00
摘要： The invention relates to genes and polypeptides, which are coded thereby and which originate from Corynebacterium glutamicum. These genes and polypeptides can be used for analyzing or diagnosing and, in particular, for monitoring fermentation processes while using Corynebacterium glutamicum.
摘要翻译：本发明涉及谷氨酸棒杆菌编码的基因和多肽，其可以被用于分析或诊断，特别是用于使用谷氨酸棒杆菌发酵过程的监测。

3. 发明申请

WO2005090589A3 PROCESS FOR THE PRODUCTION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA 审中-公开
标题翻译：使用厌氧菌生产L-氨基酸的方法
公开(公告)号：WO2005090589A3
公开(公告)日：2005-12-01
申请号：PCT/EP2005002652
申请日：2005-03-11
申请人： DEGUSSA , BATHE BRIGITTE , SCHISCHKA NATALIE , PFEFFERLE WALTER
发明人： BATHE BRIGITTE , SCHISCHKA NATALIE , PFEFFERLE WALTER
IPC分类号： C07K14/34 , C12N1/20 , C12P13/08 , C12P13/12 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34 , C12P13/12
摘要： The invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which bacteria at least one or more genes belonging to the group of the transcription regulators, selected from the group smtB, cgl1, hspR, cgl2, cebR, cgl3, gatR, glcR, tcmR, smtB2, dtxR, degA, galR, tipA2, malI, cgl4, arsR, merR, hrcA, glpR2, lexA, ccpA3 and degA2, has (have) been attenuated, especially excluded or expressed at a low level, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and optionally there are used bacteria in which further genes of the biosynthesis pathway of the desired L-amino acid are additionally enhanced, or there are used bacteria in which the metabolic pathways that reduce the formation of the desired L-amino acid are at least partially excluded.
摘要翻译：本发明涉及生产L-氨基酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中细菌中至少一种或多种属于选自组smtB，cgl1，hspR，cgl2，cebR，cgl3，gatR，glcR，tcmR，smtB2，dtxR，degA，galR，tipA2，malI，cgl4，arsR，merR，hrcA，glpR2 ，lexA，ccpA3和degA2已被减毒，尤其是被排除或以低水平表达，b）期望的L-氨基酸在细菌培养基或细胞中的浓度，以及c）分离 L-氨基酸，并且任选地使用其中额外增强所需L-氨基酸的生物合成途径的其他基因的细菌，或使用细菌，其中减少所需L-氨基酸形成的代谢途径酸至少部分被排除在外。

4. 发明申请

WO0185948A3 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE CORYNEFORM ACYL CARRIER PROTEIN GENE 审中-公开
标题翻译： CORYNEFORM ACYL载体蛋白基因的核苷酸序列
公开(公告)号：WO0185948A3
公开(公告)日：2002-12-05
申请号：PCT/EP0104793
申请日：2001-04-27
申请人： DEGUSSA , FORSCHUNGSZENTRUM JUELICH GMBH
发明人： MOECKEL BETTINA , WEISSENBORN ANKE , PFEFFERLE WALTER , SAHM HERMANN , EGGELING LOTHAR , NAMPOOTHIRI MADHAVAN
IPC分类号： C07K14/34 , C12N1/21 , C12N15/31 , C12P13/08 , C12N15/52 , C12Q1/68
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of: a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2; b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No.2; c) polynucleotide which is complementary to the polynucleotides of a) or b); and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of (a, b or c), a process for the fermentative preparation of L-amino acids with enhancement of the acp gene and the use of the polynucleotide as a primer or hybridization probe.
摘要翻译：本发明涉及包含多核苷酸序列的分离的多核苷酸，所述多核苷酸序列选自：a）多核苷酸，其与编码多肽的多核苷酸的程度相同，所述多核苷酸包含SEQ ID NO的氨基酸序列 2; b）编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％的程度相同的氨基酸序列; c）与a）或b）的多核苷酸互补的多核苷酸; 和d）包含（a，b或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，具有增强acp基因的L-氨基酸的发酵制备方法和多核苷酸作为引物的用途杂交探针。

5. 发明申请

WO02066651A2 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE RPSL GENE 审中-公开
标题翻译：核苷酸序列，其编码RPSL基因
公开(公告)号：WO02066651A2
公开(公告)日：2002-08-29
申请号：PCT/EP0200573
申请日：2002-01-22
申请人： DEGUSSA
发明人： MOECKEL BETTINA , BATHE BRIGITTE , HANS STEPHAN , KREUTZER CAROLINE , HERMANN THOMAS , PFEFFERLE WALTER , BINDER MICHAEL
IPC分类号： C07K14/34 , C12N15/31
CPC分类号： C07K14/34
摘要： The invention relates to an isolated polynucleotide coding for the ribosomal protein S12 from Corynebacterium glutamicum and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及编码来自谷氨酸棒杆菌的核糖体蛋白S12的分离的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少rpsL基因以增强形式存在，以及使用多核苷酸包括根据本发明的序列作为杂交探针。

6. 发明申请

WO0218589A3 NUCLEOTIDE SEQUENCE CODING FOR THE SIGC GENE OF CORYNEBACTERIUM GLUTAMICUM 审中-公开
标题翻译：核苷酸序列的序列编码
公开(公告)号：WO0218589A3
公开(公告)日：2002-08-15
申请号：PCT/EP0109163
申请日：2001-08-08
申请人： DEGUSSA
发明人： BATHE BRIGITTE , HANS STEPHAN , FARWICK MIKE , HERMANN THOMAS , PFEFFERLE WALTER
IPC分类号： C07K14/34 , C12P13/08 , C12N1/14 , C12N15/77 , C12P13/04 , C12Q1/68
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical to a polynucleotide coding for a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide coding for a polypeptide that contains an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the enzymatic production of L-amino acids using coryneform bacteria in which at least the sigC gene is present in enhanced form, and the use of polynucleotides that contain the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及含有多核苷酸序列的分离的多核苷酸，所述多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的至少15个连续核苷酸，以及使用棒状细菌酶促生产L-氨基酸的方法，其中至少sigC基因以增强形式存在，以及使用的含有根据本发明的序列的多核苷酸作为杂交探针。

7. 发明申请

WO0222666A3 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE GORA GENE 审中-公开
标题翻译：核苷酸序列，其代码为GORA基因
公开(公告)号：WO0222666A3
公开(公告)日：2002-07-25
申请号：PCT/EP0109314
申请日：2001-08-11
申请人： DEGUSSA
发明人： FARWICK MIKE , HUTHMACHER KLAUS , PFEFFERLE WALTER , MARX ACHIM
IPC分类号： C12N9/02 , C12P13/08 , C12N15/53 , C12N5/10 , C12P13/04 , C12Q1/68 , C12R1/15
CPC分类号： C12N9/0036 , C12P13/08
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the gorA gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码多肽的多核苷酸的程度相同，所述多核苷酸包含SEQ ID No的氨基酸序列 2，b）编码多肽的多核苷酸，其包含与至少70％与SEQ ID No.2的氨基酸序列相同程度的氨基酸序列，c）多核苷酸，其与）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少gorA 基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

8. 发明申请

WO0224915A8 DCTA (C4-DICARBOXYLATE TRANSPORTER) FROM CORYNEBACTERIUM GLUTAMICUM 审中-公开
标题翻译：来自谷氨酸棒杆菌的DCTA（C4-二羧酸酯转运蛋白）
公开(公告)号：WO0224915A8
公开(公告)日：2002-06-13
申请号：PCT/EP0109099
申请日：2001-08-07
申请人： DEGUSSA
发明人： FARWICK MIKE , HUTHMACHER KLAUS , BATHE BRIGITTE , HERMANN THOMAS , PFEFFERLE WALTER
IPC分类号： C07K14/34 , C12N15/31 , C12N15/77 , C12P13/08 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34 , C12N15/77
摘要： The invention provides nucleotide sequences from coryne bacteria coding for the dctA gene and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the dctA gene present is enhanced, and the use of polynucleotides which contain sequences according to the invention as hybridization probes.
摘要翻译：本发明提供了编码dctA基因的棒杆菌的核苷酸序列以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少存在dctA基因存在，并且使用含有根据发明作为杂交探针。

9. 发明申请

WO0242466A3 NUCLEOTIDE SEQUENCES CODING FOR THE CYSQ GENE 审中-公开
标题翻译： CYSQ基因的核苷酸序列编码
公开(公告)号：WO0242466A3
公开(公告)日：2003-03-13
申请号：PCT/EP0112294
申请日：2001-10-24
申请人： DEGUSSA
发明人： FARWICK MIKE , HUTHMACHER KLAUS , BATHE BRIGITTE , PFEFFERLE WALTER
IPC分类号： C07K14/34 , C12N1/21 , C12N15/31 , C12P13/04 , C12N9/00 , C12N9/10 , C12N15/63 , C12Q1/68
CPC分类号： C12P13/04 , C07K14/34
摘要： The invention relates to polynucleotide sequences from coryneform bacteria coding for the cysQ gene and a process for the fermentative preparation of amino acids using bacteria in which the endogenous cysQ gene is enhanced, as well as to the use of polynucleotides containing the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及编码cysQ基因的棒状细菌的多核苷酸序列和使用其中内源性cysQ基因增强的细菌发酵制备氨基酸的方法，以及使用含有本发明序列的多核苷酸作为杂交探针。

10. 发明申请

WO0218430A3 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE METR AND METZ GENES 审中-公开
标题翻译： METR和METZ基因编码的核苷酸序列
公开(公告)号：WO0218430A3
公开(公告)日：2002-07-04
申请号：PCT/EP0108221
申请日：2001-07-17
申请人： DEGUSSA
发明人： BATHE BRIGITTE , PFEFFERLE WALTER , HUTHMACHER KLAUS , RUECKERT CHRISTIAN , KALINOWSKI JOERN , PUEHLER ALFRED , BINDER MICHAEL , GREISSINGER DIETER , THIERBACH GEORG
IPC分类号： C07K14/34 , C12N9/88 , C12P13/08 , C12P13/12
CPC分类号： C12P13/12 , C07K14/34 , C12N9/88 , C12P13/08
摘要： The invention relates to polynucleotides from coryneform bacteria which code for the metR and/or metZ genes and comprise polynucleotide sequences, chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 3, c) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 2, d) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 3, e) polynucleotide which is complementary to the polynucleotides of a) b), c) or d), and f) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequences of a), b), c), d) or e) and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metR gene and/or the metZ gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及编码metR和/或metZ基因的来自棒状细菌的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码多核苷酸的多核苷酸至少70％相同的多核苷酸，包含SEQ ID No.2的氨基酸序列的多肽，b）与编码包含SEQ ID No.3的氨基酸序列的多肽的多核苷酸的至少70％同一性的多核苷酸，c ）多核苷酸，其编码包含与SEQ ID No.2的氨基酸序列的至少70％的同一性的氨基酸序列的多肽，d）编码包含氨基酸序列的多肽的多核苷酸其与SEQ ID No.3的氨基酸序列的至少70％的同一性程度相同，e）与a）b），c）或d）和f）多核苷酸的多核苷酸互补的多核苷酸其包含a），b），c），d）或e）的多核苷酸序列的至少15个连续核苷酸以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少该metR基因和/或 metZ基因以减毒形式存在，并且使用包含根据本发明的序列作为杂交探针的多核苷酸。

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