专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013113501A1 PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPIDE ANTIGEN 审中-公开
标题翻译：包含聚合物载体复合物和至少一种蛋白质或抗原抗原的药物组合物
公开(公告)号：WO2013113501A1
公开(公告)日：2013-08-08
申请号：PCT/EP2013/000291
申请日：2013-01-31
申请人： CUREVAC GMBH , BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
发明人： BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
IPC分类号： A61K47/48 , A61K39/39 , A61P35/00 , A61P37/00 , A61P31/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/29 , A61K39/35 , A61K47/64 , A61K47/645 , A61K47/646 , A61K48/0041 , A61K2039/5252 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , A61K2039/6093 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , C12N2730/10134 , C12N2730/10171 , C12N2760/16134 , C12N2760/16171 , C12N2760/20134 , C12N2760/20171 , Y02A50/416
摘要： The present invention is directed to a pharmaceutical composition including (e.g. for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease; an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits, as well as the use of the pharmaceutical composition or the kit as a vaccine, particularly in the treatment of infectious diseases, allergies, autoimmune diseases and tumour or cancer diseases.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫化物交联的阳离子组分形成的聚合物载体; 以及作为货物至少一种核酸分子和至少一种选自与感染性疾病相关的病原体的抗原的抗原; 与过敏或过敏性疾病相关的抗原; 与自身免疫性疾病相关的抗原; 或与癌症或肿瘤疾病相关的抗原，或在每种情况下都是所述抗原的片段，变体和/或衍生物。药物组合物允许有效诱导针对所述抗原的适应性免疫应答。本发明还提供试剂盒，以及药物组合物或试剂盒作为疫苗的用途，特别是用于治疗感染性疾病，过敏反应，自身免疫性疾病和肿瘤或癌症疾病。

2. 发明申请

WO2013113326A1 PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPTIDE ANTIGEN 审中-公开
标题翻译：包含聚合物载体复合物和至少一种蛋白质或肽抗原的药物组合物
公开(公告)号：WO2013113326A1
公开(公告)日：2013-08-08
申请号：PCT/EP2012/000420
申请日：2012-01-31
申请人： CUREVAC GMBH , BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
发明人： BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
IPC分类号： A61K47/48 , A61K39/39 , A61P35/00 , A61P37/00 , A61P31/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/29 , A61K39/35 , A61K47/64 , A61K47/645 , A61K47/646 , A61K48/0041 , A61K2039/5252 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , A61K2039/6093 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , C12N2730/10134 , C12N2730/10171 , C12N2760/16134 , C12N2760/16171 , C12N2760/20134 , C12N2760/20171 , Y02A50/416
摘要： The present invention is directed to a pharmaceutical composition including (eg for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease;_an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits, as well as the use of the pharmaceutical composition or the kit as a vaccine, particularly in the treatment of infectious diseases, allergies, autoimmune diseases and tumour or cancer diseases.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫化物交联的阳离子组分形成的聚合物载体; 以及至少一种核酸分子和至少一种选自与感染性疾病相关的病原体的抗原的抗原; - 与过敏或过敏性疾病相关的抗原; 与自身免疫性疾病相关的抗原; 或与癌症或肿瘤疾病相关的抗原，或在每种情况下都是所述抗原的片段，变体和/或衍生物。药物组合物允许有效诱导针对所述抗原的适应性免疫应答。本发明还提供试剂盒，以及药物组合物或试剂盒作为疫苗的用途，特别是用于治疗感染性疾病，过敏反应，自身免疫性疾病和肿瘤或癌症疾病。

3. 发明申请

WO2012013326A1 COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION 审中-公开
标题翻译：用转移和免疫接种的交联中和组分的核酸复合物
公开(公告)号：WO2012013326A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/003719
申请日：2011-07-25
申请人： CUREVAC GMBH , BAUMHOF, Patrick , VOSS, Söhnke , KRAMPS, Thomas , KALLEN, Karl-Josef
发明人： BAUMHOF, Patrick , VOSS, Söhnke , KRAMPS, Thomas , KALLEN, Karl-Josef
IPC分类号： C12N15/87 , A61K48/00 , A61K47/34 , A61K47/48
CPC分类号： A61K48/0041 , A61K39/00 , A61K39/385 , A61K39/39 , A61K47/645 , A61K2039/51 , A61K2039/55516 , A61K2039/55561 , C12N15/87 , Y02A50/412 , Y02A50/472
摘要： The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably non-toxic and non-immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an (innate and/or adaptive) immune response, preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides, pharmaceutical compositions, particularly vaccines and adjuvants, comprising the inventive polymeric carrier cargo complex and optionally an antigen, as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell, a tissue or an organism, for (gene-)therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition, adjuvant or vaccine in one or more parts of the kit.
摘要翻译：本发明涉及一种聚合物载体货物复合物，其包含至少一种核酸（分子）和作为（优选无毒的和非免疫原性的）聚合物载体的二硫键交联的阳离子组分。本发明的聚合物载体货物复合物允许在体内和体外有效地将核酸转染到细胞中和/或诱导（先天和/或自适应）免疫应答，优选依赖于作为货物运输的核酸。本发明还提供药物组合物，特别是疫苗和佐剂，其包含本发明的聚合物载体货物复合物和任选的抗原，以及使用本发明的本发明的聚合物载体货物复合物和任选的抗原用于转染细胞，组织或用于本文公开的（基因 - ）治疗目的的生物体，和/或作为免疫刺激剂或佐剂，例如，用于引发用于治疗或预防上述疾病的免疫应答。最后，本发明涉及在试剂盒的一个或多个部分中含有本发明的聚合物载体货物复合物和/或本发明的药物组合物，佐剂或疫苗的试剂盒。

4. 发明申请

WO2009095226A3 NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS 审中-公开
公开(公告)号：WO2009095226A3
公开(公告)日：2009-08-06
申请号：PCT/EP2009/000546
申请日：2009-01-28
申请人： CUREVAC GMBH , KRAMPS, Thomas , VOSS, Söhnke , PROBST, Jochen , HOERR, Ingmar
发明人： KRAMPS, Thomas , VOSS, Söhnke , PROBST, Jochen , HOERR, Ingmar
IPC分类号： C12N15/09 , C12N15/11 , A61K39/39
摘要： The present invention relates to nucleic acids of the general formula (I): (N u G l X m G n N v ) a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (N u G l X m G n N v ) a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.

5. 发明申请

WO2010037408A1 COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF 审中-公开
标题翻译：包含用于在哺乳动物中提供或增强免疫刺激反应的复合（M）RNA和未结合MRNA的组合物及其用途
公开(公告)号：WO2010037408A1
公开(公告)日：2010-04-08
申请号：PCT/EP2008/008304
申请日：2008-09-30
申请人： CUREVAC GMBH , FOTIN-MLECZEK, Mariola , VOSS, Söhnke
发明人： FOTIN-MLECZEK, Mariola , VOSS, Söhnke
IPC分类号： A61K39/39 , A61P35/00 , A61K47/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/53 , A61K2039/55511 , Y02A50/491
摘要： The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.
摘要翻译：本发明涉及免疫刺激组合物，其包含a）佐剂组分，其包含至少一种（m）RNA，与阳离子或聚阳离子化合物复合，或b）至少一种游离编码至少一种治疗活性蛋白，抗原，变应原和/或抗体的mRNA，其中免疫刺激组合物能够引发或增强哺乳动物中的先天性和任选的适应性免疫应答。本发明的免疫刺激性组合物可以是药物组合物或疫苗。本发明还涉及制备本发明免疫刺激组合物的方法。本发明还涉及本发明免疫刺激组合物或其组分（用于制备药物组合物或疫苗）用于治疗各种疾病的用途。最后，本发明涉及包含本发明的免疫刺激性组合物，其组分和/或药物组合物或疫苗的试剂盒。

6. 发明申请

WO2010037539A1 COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF 审中-公开
标题翻译：包含复合（M）RNA的组合物和用于提供或增强哺乳动物的免疫应答的NANA MRNA及其用途
公开(公告)号：WO2010037539A1
公开(公告)日：2010-04-08
申请号：PCT/EP2009/007032
申请日：2009-09-30
申请人： CUREVAC GMBH , FOTIN-MLECZEK, Mariola , VOSS, Söhnke
发明人： FOTIN-MLECZEK, Mariola , VOSS, Söhnke
IPC分类号： A61K39/39 , A61P35/00 , A61K47/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/53 , A61K2039/55511 , Y02A50/491
摘要： The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.
摘要翻译：本发明涉及免疫刺激组合物，其包含a）佐剂组分，其包含或与由阳离子或多阳离子化合物络合的至少一种（m）RNA组成，和b）至少一种游离mRNA，其编码至少一种治疗活性蛋白质，抗原，变应原和/或抗体，其中所述免疫刺激组合物能够引发或增强哺乳动物中的先天和任选的适应性免疫应答。本发明的免疫刺激组合物可以是药物组合物或疫苗。本发明还涉及本发明的免疫刺激组合物的制备方法。本发明还涉及本发明的免疫刺激组合物或其组分（用于制备药物组合物或疫苗）用于治疗各种疾病的用途。最后，本发明涉及包含本发明的免疫刺激组合物，其组分和/或药物组合物或疫苗的试剂盒。

7. 发明申请

WO2011012240A3 LIPOPEPTIDE ZUR THERAPIE UND PROPHYLAXE ALLERGISCHER ERKRANKUNGEN 审中-公开
公开(公告)号：WO2011012240A3
公开(公告)日：2011-02-03
申请号：PCT/EP2010/004418
申请日：2010-07-20
申请人： EMC MICROCOLLECTIONS GMBH , WIESMÜLLER, Karl-Heinz , VOSS, Söhnke , BUFE, Albrecht , PETERS, Marcus
发明人： WIESMÜLLER, Karl-Heinz , VOSS, Söhnke , BUFE, Albrecht , PETERS, Marcus
IPC分类号： A61P37/08 , A61P11/06
摘要： Die vorliegende Erfindung betrifft neue, von einem Sporen-Keimungs-Protein der Spezies Bacillus cereus abgeleitete Lipopeptide, Verfahren zur Herstellung von synthetischen Analoga, die Nutzung ihrer immunstimulatorischen Wirkung zum Zweck der Reifung des Immunsystems und darauf aufbauend deren Verwendung als Wirkstoffe zur Therapie und Prophylaxe zahlreicher allergischer Erkrankungen bei Mensch und Tier, vorzugsweise von allergischem Asthma, sowie Formulierungen von entsprechenden pharmazeutischen Mitteln. Die beschriebenen Lipopeptide tragen durch die Aktivierung der TLR-Rezeptoren 1, 2 und 6 zur Reifung des angeborenen Immunsystems und damit zur Senkung des Allergierisikos bei. Im Tiermodell konnte eine deutliche Reduzierung der Empfindlichkeit gegenüber allergenen Substanzen bei gleichzeitig guter Verträglichkeit nachgewiesen werden. Erstmals wird eine TLR-1, -2, -6 vermittelte Stimulation des angeborenen Immunsystems durch Lipopeptide aus Bakterien-Sporen sowie durch synthetische Analoga derselben auf molekularer Ebene nachgewiesen (Formula (A)).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式