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1. 发明申请

WO2009095226A3 NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENTS /ADJUVANTS 审中-公开
公开(公告)号：WO2009095226A3
公开(公告)日：2009-08-06
申请号：PCT/EP2009/000546
申请日：2009-01-28
申请人： CUREVAC GMBH , KRAMPS, Thomas , VOSS, Söhnke , PROBST, Jochen , HOERR, Ingmar
发明人： KRAMPS, Thomas , VOSS, Söhnke , PROBST, Jochen , HOERR, Ingmar
IPC分类号： C12N15/09 , C12N15/11 , A61K39/39
摘要： The present invention relates to nucleic acids of the general formula (I): (N u G l X m G n N v ) a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (N u G l X m G n N v ) a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.

2. 发明申请

WO2009046975A1 COMPOSITION FOR TREATING PROSTATE CANCER (PCa) 审中-公开
标题翻译：治疗前列腺癌（PCa）的组合物
公开(公告)号：WO2009046975A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/008504
申请日：2008-10-08
申请人： CUREVAC GMBH , PROBST, Jochen , HOERR, Ingmar , LANDER, Thomas
发明人： PROBST, Jochen , HOERR, Ingmar , LANDER, Thomas
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K39/00 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/572 , A61K2039/575 , A61K2039/70
摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate- Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.
摘要翻译：本发明涉及包含至少一种RNA（优选mRNA）的活性（免疫刺激性）组合物，其编码至少两种（优选不同的）能够在哺乳动物中引发（适应性）免疫应答的抗原，其中所述抗原选自组由PSA（前列腺特异性抗原），PSMA（前列腺特异性膜抗原），PSCA（前列腺干细胞抗原）和STEAP（前列腺的六跨膜上皮抗原）组成。本发明还涉及包含所述活性（免疫刺激）组合物的疫苗，以及所述活性（免疫刺激性）组合物（用于制备疫苗）和/或用于引发（适应性）免疫应答的疫苗的用途治疗前列腺癌（PCa），优选新辅助和/或激素难治性前列腺癌，以及与之相关的疾病或病症。最后，本发明涉及试剂盒，特别是涉及包含活性（免疫刺激）组合物的试剂盒， /或疫苗。

3. 发明申请

WO2008014979A2 NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT 审中-公开
标题翻译：制剂的核酸（I）：GIXmGn，或（II）：CIXmCn，特别是作为免疫刺激剂/ ADJUVANT
公开(公告)号：WO2008014979A2
公开(公告)日：2008-02-07
申请号：PCT/EP2007/006772
申请日：2007-07-31
申请人： CUREVAC GMBH , HOERR, Ingmar , PROBST, Jochen , KETTERER, Thomas , SCHEEEL, Birgit
发明人： HOERR, Ingmar , PROBST, Jochen , KETTERER, Thomas , SCHEEEL, Birgit
IPC分类号： C12N15/11 , C07H21/02
CPC分类号： A61K39/39 , A61K2039/55561 , C07H21/02 , C12N15/117 , C12N2310/17 , C12N2310/3515 , Y02A50/491
摘要： The present invention relates to a nucleic acid of the general formula (I): G l X m G n , or (II): C l X m C n , which may be modified by a lipid. The nucleic acid of the invention acts as an immune-stimulating agent inducing the innate immune response. The invention relates further to a pharmaceutical composition (in a first embodiment), each containing an immune-stimulating agent according to the invention in combination with a pharmaceutically active carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). In another embodiment, the inventive nucleic acid is combined with at least one pharmaceutically active component, a pharmaceutically acceptable carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). Accordingly, the presemt invention is directed to a vaccine, which corresponds to a pharmaceutical composition of the invention (second embodiment), wherein the pharmaceutically active component induces a specific immune response (e.g. an antigen). The present invention relates likewise to the use of a nucleic acid of the invention or a pharmaceutical composition according to the invention for the treatment of infectious diseases, autoimmune diseases, allergies or cancer diseases.
摘要翻译：本发明涉及通式（I）的核酸：或（II）：C 其可以被脂质修饰。本发明的核酸作为诱导先天免疫应答的免疫刺激剂起作用。本发明进一步涉及药物组合物（在第一个实施方案中），每个药物组合物含有根据本发明的免疫刺激剂与药物活性载体/载体（以及任选的其它辅助物质，添加剂和/或其它佐剂）的组合）。在另一个实施方案中，将本发明的核酸与至少一种药学活性成分，药学上可接受的载体/载体（和任选的其它辅助物质，添加剂和/或其它佐剂）组合。因此，本发明涉及对应于本发明的药物组合物（第二实施方案）的疫苗，其中药物活性成分诱导特异性免疫应答（例如抗原）。本发明同样涉及本发明的核酸或根据本发明的药物组合物用于治疗感染性疾病，自身免疫性疾病，过敏或癌症疾病的用途。

4. 发明申请

WO2009127230A1 MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION 审中-公开
标题翻译：改良（m）RNA用于抑制或避免免疫应答和免疫抑制组合物
公开(公告)号：WO2009127230A1
公开(公告)日：2009-10-22
申请号：PCT/EP2008/003033
申请日：2008-04-16
申请人： CUREVAC GMBH , THEß, Andreas , PROBST, Jochen , HOERR, Ingmar
发明人： THEß, Andreas , PROBST, Jochen , HOERR, Ingmar
IPC分类号： C12N15/85
CPC分类号： C12N15/111 , C12N15/67 , C12N2310/17 , C12N2310/321 , C12N2310/33 , C12N2320/53 , C12N2310/3521
摘要： The present invention relates to a modified (m)RNA suitable for suppressing and/or avoiding an innate immunostimulatory response in a mammal typically exhibited when administering the corresponding unmodified (m)RNA and an immunosuppressive composition comprising this RNA. The invention furthermore relates to a pharmaceutical composition containing said modified (m)RNA. The invention also relates to the use of said modified (m)RNA or immunosuppressive composition (for the preparation of a medicament, e.g. a pharmaceutical composition) and/or the use of the pharmaceutical composition for suppressing and/or avoiding an immune response in a mammal when administering said pharmaceutical composition for the treatment of various diseases. Finally, the invention relates to kits containing the immunosuppressive composition and/or the pharmaceutical composition.
摘要翻译：本发明涉及适用于抑制和/或避免在施用相应的未修饰的（m）RNA时通常显示的哺乳动物和包含该RNA的免疫抑制组合物中的先天免疫刺激反应的修饰的（m）RNA。本发明还涉及含有所述修饰的（m）RNA的药物组合物。本发明还涉及所述修饰的（m）RNA或免疫抑制组合物（用于制备药物，例如药物组合物）和/或在药物组合物中用于抑制和/或避免免疫应答的用途哺乳动物在施用用于治疗各种疾病的药物组合物时。最后，本发明涉及含有免疫抑制组合物和/或药物组合物的试剂盒。

5. 发明申请

WO2008083949A2 RNA-CODED ANTIBODY 审中-公开
标题翻译： RNA编码的抗体
公开(公告)号：WO2008083949A2
公开(公告)日：2008-07-17
申请号：PCT/EP2008/000081
申请日：2008-01-08
申请人： CUREVAC GMBH , HOERR, Ingmar , PROBST, Jochen
发明人： HOERR, Ingmar , PROBST, Jochen
IPC分类号： A61K48/00 , C12N15/13 , C12N15/85 , C07K16/28 , C07K16/32 , A61K39/395
CPC分类号： C07K16/1027 , A61K9/0019 , A61K39/395 , A61K39/39558 , A61K39/40 , A61K39/42 , A61K48/00 , A61K48/005 , A61K48/0066 , A61K48/0075 , A61K2039/505 , A61K2039/51 , A61K2039/53 , C07K16/1018 , C07K16/2803 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/3046 , C07K16/3061 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , Y02A50/388 , Y02A50/41 , Y02A50/412
摘要： The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of a pharmaceutical composition, in particular a passive vaccine, for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, auto-immune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention furthermore describes an in vitro transcription method, in vitro methods for expression of this antibody using the RNA according to the invention and an in vivo method.
摘要翻译：本申请描述了抗体编码，未修饰或修饰的RNA及其用于表达该抗体的用途，用于制备药物组合物，特别是被动疫苗，用于治疗肿瘤和癌症疾病，心血管疾病，传染病，自身免疫疾病，病毒病和单基因疾病，例如也用于基因治疗。本发明还描述了体外转录方法，使用根据本发明的RNA和体内方法表达该抗体的体外方法。

6. 发明申请

WO2009046974A3 COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG CANCERS (NSCLC) 审中-公开
公开(公告)号：WO2009046974A3
公开(公告)日：2009-04-16
申请号：PCT/EP2008/008503
申请日：2008-10-08
申请人： CUREVAC GMBH , BARNER, Marijke , PROBST, Jochen , LANDER, Thomas , HOERR, Ingmar
发明人： BARNER, Marijke , PROBST, Jochen , LANDER, Thomas , HOERR, Ingmar
IPC分类号： A61K39/00
摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.

7. 发明申请

WO2009046739A1 COMPOSITION FOR TREATING PROSTATE CANCER (PCA) 审中-公开
标题翻译：用于治疗前列腺癌（PCA）的组合物
公开(公告)号：WO2009046739A1
公开(公告)日：2009-04-16
申请号：PCT/EP2007/008771
申请日：2007-10-09
申请人： CUREVAC GMBH , PROBST, Jochen , HOERR, Ingmar , LANDER, Thomas
发明人： PROBST, Jochen , HOERR, Ingmar , LANDER, Thomas
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K39/00 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/572 , A61K2039/575 , A61K2039/70
摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate-Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.
摘要翻译：本发明涉及包含至少一种RNA（优选mRNA）的活性（免疫刺激性）组合物，其编码至少两种（优选不同的）能够在哺乳动物中引发（适应性）免疫应答的抗原，其中所述抗原选自组由PSA（前列腺特异性抗原），PSMA（前列腺特异性膜抗原），PSCA（前列腺干细胞抗原）和STEAP（前列腺的六跨膜上皮抗原）组成。本发明还涉及包含所述活性（免疫刺激）组合物的疫苗，以及所述活性（免疫刺激性）组合物（用于制备疫苗）和/或用于引发（适应性）免疫应答的疫苗的用途治疗前列腺癌（PCa），优选新辅助和/或激素难治性前列腺癌，以及与之相关的疾病或病症。最后，本发明涉及试剂盒，特别是涉及包含活性（免疫刺激）组合物的试剂盒， /或疫苗。

8. 发明申请

WO2009046738A1 COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG CANCERS (NSCLC) 审中-公开
标题翻译：用于治疗肺癌的组合物，特别是非小细胞肺癌（NSCLC）
公开(公告)号：WO2009046738A1
公开(公告)日：2009-04-16
申请号：PCT/EP2007/008770
申请日：2007-10-09
申请人： CUREVAC GMBH , BARNER, Marijke , PROBST, Jochen , LANDER, Thomas , HOERR, Ingmar
发明人： BARNER, Marijke , PROBST, Jochen , LANDER, Thomas , HOERR, Ingmar
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/70
摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.
摘要翻译：本发明涉及包含至少一种编码至少两种（优选不同的）能够在哺乳动物中产生（适应性的）免疫应答的抗原的RNA，优选mRNA的活性（免疫刺激）组合物。本发明还涉及包含所述活性（免疫刺激）组合物的疫苗，以及所述活性（免疫刺激性）组合物（用于制备疫苗）和/或用于引发（适应性）免疫应答的疫苗的用途治疗肺癌，特别是非小细胞肺癌（NSCLC），优选选自三种主要亚型鳞状细胞肺癌，腺癌和大细胞肺癌，或与其相关的疾病。最后，本发明涉及试剂盒，特别涉及含有活性（免疫刺激）组合物和/或疫苗的试剂盒。

9. 发明申请

WO2006024518A1 KOMBINATIONSTHERAPIE ZUR IMMUNSTIMULATION 审中-公开
标题翻译：联合治疗的免疫刺激
公开(公告)号：WO2006024518A1
公开(公告)日：2006-03-09
申请号：PCT/EP2005/009383
申请日：2005-08-31
申请人： CUREVAC GMBH , HOERR, Ingmar , PASCOLO, Steve
发明人： HOERR, Ingmar , PASCOLO, Steve
IPC分类号： A61K39/39 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/1841 , A61K38/19 , A61K38/20 , A61K38/21 , A61K39/39 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/55561 , A61K2039/572 , A61K2039/6031 , A61K2039/70 , A61K2300/00
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Immunstimulation in einem Säugetier, welches a. das Verabreichen mindestens einer mRNA enthaltend einen für mindestens ein Antigen eines Pathogens oder mindestens ein Tumorantigen kodierenden Bereich und b. das Verabreichen mindestens eines Cytokins, mindestens einer Cytokin-mRNA, mindestens einer CpG DNA oder mindestens einer adjuvanten RNA umfasst. Ebenfalls betrifft die Erfindung ein Erzeugnis sowie ein Kit, enthaltend die/das mRNA und Cytokin bzw. Cytokin-mRNA, bzw. CpG DNA bzw. adjuvante RNA der Erfindung enthält.
摘要翻译：本发明涉及一种用于在哺乳动物中免疫刺激的方法。施用至少一种mRNA，其包括一个编码的病原体的至少一种抗原或至少一种肿瘤抗原和区域b。包括施用至少一种细胞因子，至少一种细胞因子mRNA，至少一个的CpG DNA或至少一种佐剂RNA。本发明还涉及一种产品以及含有试剂盒/包括mRNA和细胞因子或细胞因子的mRNA，或CpG DNA或本发明的RNA佐剂。

10. 发明申请

WO2008052770A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN 审中-公开
标题翻译：（BASE-）修饰的RNA用于增加蛋白质的表达
公开(公告)号：WO2008052770A2
公开(公告)日：2008-05-08
申请号：PCT/EP2007/009469
申请日：2007-10-31
申请人： CUREVAC GMBH , HOERR, Ingmar , VON DER MÜLBE, Florian
发明人： HOERR, Ingmar , VON DER MÜLBE, Florian
IPC分类号： A61K39/00
CPC分类号： C12N15/67 , A61K39/00 , A61K48/00 , C12N15/85 , C12N2830/50 , Y02A50/487 , Y02A50/491
摘要： The present application describes a base-modified RNA and the use thereof for increasing the expression of a protein and for the preparation of a pharmaceutical composition, especially a vaccine, for the treatment of tumours and cancer diseases, heart and circulatory diseases, infectious diseases, autoimmune diseases or monogenetic diseases, for example in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the base-modified RNA, and an in vivo method.
摘要翻译：本申请描述了碱基修饰的RNA及其用于增加蛋白质表达和用于制备用于治疗肿瘤和癌症疾病，心脏和循环系统疾病，感染性疾病的药物组合物，特别是疫苗的用途，自身免疫性疾病或单因素疾病，例如基因治疗。本发明进一步描述体外转录方法，使用碱修饰RNA增加蛋白质表达的体外方法和体内方法。

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