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1. 发明申请

WO2009052432A3 MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDANGE AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于修改左心室附件的医疗装置及相关系统及方法
公开(公告)号：WO2009052432A3
公开(公告)日：2009-07-30
申请号：PCT/US2008080374
申请日：2008-10-17
申请人： COHEREX MEDICAL INC , MILES SCOTT D , LINDER RICHARD J , DAVIS CLARK C , WHISENANT BRIAN K , EDMISTON DARYL R , FOX DEWAYNE C
发明人： MILES SCOTT D , LINDER RICHARD J , DAVIS CLARK C , WHISENANT BRIAN K , EDMISTON DARYL R , FOX DEWAYNE C
IPC分类号： A61B17/12
CPC分类号： A61B17/12122 , A61B17/00491 , A61B17/12022 , A61B17/1214 , A61B17/1215 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/00898 , A61B2017/0412 , A61B2017/0427 , A61B2017/0649 , A61B2017/1205
摘要： Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a device includes a body (300, 320) that is collapsible and self -expanding. The body includes a textured surface with protruding portions (304, 322) and recessed portions (306,326). The body may be formed of a reticulated foam material and may exhibit a substantially spherical geometry or a truncated spherical geometry. The body may be substantially hollow. In one embodiment, portions of the textured surface may be metalized or have a coating placed thereon to enhance frictional engagement of the body with the atrial appendage wall. In another embodiment (360), a mesh bag (362) is disposed within an LAA and one or more self- expanding bodies (364) are disposed within the mesh bag. The mesh bag is then secured to retain the self -expanding bodies within the bag and the LAA.
摘要翻译：阐述用于修改诸如左心耳（LAA）的心房附件的装置，系统和方法的几个实施例。在一个实施例中，装置包括可折叠和自展开的主体（300,320）。主体包括具有突出部分（304,322）和凹陷部分（306,326）的织纹表面。主体可以由网状泡沫材料形成，并且可以呈现基本上球形的几何形状或截顶的球形几何形状。身体可以是基本上中空的。在一个实施例中，纹理表面的部分可以被金属化或者具有放置在其上的涂层，以增强身体与心耳壁的摩擦接合。在另一实施例（360）中，网袋（362）设置在LAA内，并且一个或多个自扩张体（364）设置在网袋内。然后将网袋固定，以将自发展体保持在袋和LAA内。

2. 发明申请

WO2007140419A3 METHODS AND SYSTEMS FOR CLOSURE OF A PATENT FORAMEN OVALE 审中-公开
标题翻译：用于封闭玻璃瓶的方法和系统
公开(公告)号：WO2007140419A3
公开(公告)日：2008-09-25
申请号：PCT/US2007069994
申请日：2007-05-30
申请人： COHEREX MEDICAL INC , FOX DEWAYNE C , EDMISTON DARYL R , MILES SCOTT D , DAVIS CLARK C , WHISENANT BRIAN K
发明人： FOX DEWAYNE C , EDMISTON DARYL R , MILES SCOTT D , DAVIS CLARK C , WHISENANT BRIAN K
IPC分类号： A61B18/18
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00026 , A61B2017/00084 , A61B2017/00575 , A61B2017/00623 , A61B2017/00867 , A61B2018/00791 , A61B2018/00875 , A61B2090/378
摘要： A medical device for reducing the size of a Patent Foramen Ovale is disclosed. The medical device can include a first electrode (116a), a second electrode (111a), and at least one sensor mounted to at least one of the first electrode or the second electrode, the at least one sensor adapted to sense at least one operating parameter of the medical device or the patient to facilitate closure of the Patent Foramen Ovale. The medical device can also include a delivery shaft (120c) coupled to the first electrode, wherein the delivery shaft includes an indicia for determining the position of the first electrode relative to the second electrode. A method for determining a characteristic of an internal tissue opening is also disclosed. The method can include the steps of introducing a detectable fluid in the right atrium of a heart and then detecting the location of the detectable fluid in the heart.
摘要翻译：公开了一种用于减小专利孔径的医疗装置。医疗装置可以包括第一电极（116a），第二电极（111a）和安装到第一电极或第二电极中的至少一个的至少一个传感器，所述至少一个传感器适于感测至少一个操作医疗设备或患者的参数，以便于关闭专利孔洞。医疗装置还可以包括联接到第一电极的输送轴（120c），其中输送轴包括用于确定第一电极相对于第二电极的位置的标记。还公开了一种用于确定内部组织开口的特性的方法。该方法可以包括在心脏的右心房中引入可检测流体，然后检测心脏中可检测流体的位置的步骤。

3. 发明申请

WO2007140420A3 METHODS, SYSTEMS, AND DEVICES FOR CLOSING A PATENT FORAMEN OVALE USING MECHANICAL STRUCTURES 审中-公开
标题翻译：使用机械结构封闭专利的瓦楞纸的方法，系统和装置
公开(公告)号：WO2007140420A3
公开(公告)日：2008-09-25
申请号：PCT/US2007069995
申请日：2007-05-30
申请人： COHEREX MEDICAL INC , DAVIS CLARK C , MILES SCOTT D , EDMISTON DARYL R , WHISENANT BRIAN K , LINDER RICHARD J , FOX DEWAYNE C
发明人： DAVIS CLARK C , MILES SCOTT D , EDMISTON DARYL R , WHISENANT BRIAN K , LINDER RICHARD J , FOX DEWAYNE C
IPC分类号： A61B18/18
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00557 , A61B2017/00575 , A61B2017/00623 , A61B2018/1435
摘要： A medical device is disclosed that can include a first atrial anchor, a first delivery shaft linked to the first atrial anchor, wherein the first delivery shaft is adapted to move the first atrial anchor, a second atrial anchor, a second delivery shaft linked to the second atrial anchor, wherein the second delivery shaft is adapted to move the second atrial anchor, and a biasing member linking either (i) the first atrial anchor to the first delivery shaft or (ii) the second atrial anchor to the second delivery shaft. The medical device can include an insulation material coupled to one or more of the first or second atrial anchors, or the first or second delivery shaft. A method for treating an internal tissue opening is also disclosed wherein a first and second electrode can be operated between unipolar and bipolar modes to initiate tissue damage, thereby inducing tissue regrowth.
摘要翻译：公开了一种医疗装置，其可以包括第一心房锚，连接到第一心房锚的第一输送轴，其中第一输送轴适于移动第一心房锚，第二心房锚，第二输送轴第二心房锚，其中第二输送轴适于移动第二心房锚，以及将（i）第一心房锚与第一输送轴连接的偏压构件，或（ii）第二心房锚固件连接到第二输送轴。医疗装置可以包括耦合到第一或第二心房锚或第一或第二输送轴中的一个或多个的绝缘材料。还公开了一种用于治疗内部组织开口的方法，其中第一和第二电极可以在单极和双极模式之间操作以引发组织损伤，从而诱导组织再生长。

4. 发明申请

WO2007092860A3 PATENT FORAMEN OVALE CLOSURE DEVICE AND METHODS FOR DETERMINING RF DOSE FOR PATENT FORAMEN OVALE CLOSURE 审中-公开
标题翻译：用于确定射频剂量的专利封闭式封闭装置和方法专利封闭式封闭装置
公开(公告)号：WO2007092860A3
公开(公告)日：2007-12-27
申请号：PCT/US2007061713
申请日：2007-02-06
申请人： COHEREX MEDICAL INC , WHISENANT BRIAN K , DAVIS CLARK C , MILES SCOTT D , LINDER RICHARD J , EDMISTON DARYL R
发明人： WHISENANT BRIAN K , DAVIS CLARK C , MILES SCOTT D , LINDER RICHARD J , EDMISTON DARYL R
IPC分类号： A61B5/04 , A61F2/00
CPC分类号： A61B5/053
摘要： A medical system and device for use in delivering RF energy to a tissue opening and a method for determining an RP dose is disclosed. In one embodiment, the medical device includes an electrode or anchor and one or more devices, such as an impedance electrode, RF electrode and/or thermocouple. The electrode or anchor can be deployed from a delivery shaft inside the left atrium, for example, of a heart and substantially conform to the tissue proximate the tissue opening. Tissue characteristics, such as temperature and/or impedance, can be measured, before, during and after application of RF energy to the tissue, by one or more devices to determine an RF dose. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.
摘要翻译：公开了用于将RF能量递送至组织开口的医疗系统和装置以及用于确定RP剂量的方法。在一个实施例中，医疗装置包括电极或锚以及一个或多个装置，例如阻抗电极，RF电极和/或热电偶。电极或锚可以从例如心脏的左心房内的输送轴部署并且基本上贴合组织开口附近的组织。可以在通过一个或多个装置将RF能量施加到组织之前，期间和之后测量组织特性，例如温度和/或阻抗，以确定RF剂量。在向左右电极之间的组织施加能量之后，左电极可以通过被接收回到输送轴中而从左心房移除，并且随后从开口移除递送轴。

5. 发明申请

WO2007038609A3 COMPLIANT ELECTRODE FOR PATENT FORAMEN OVALE CLOSURE DEVICE 审中-公开
标题翻译：专用型烤箱封闭装置的合适电极
公开(公告)号：WO2007038609A3
公开(公告)日：2007-09-20
申请号：PCT/US2006037691
申请日：2006-09-26
申请人： COHEREX MEDICAL INC , WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL R
发明人： WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL R
IPC分类号： A61B17/08
CPC分类号： A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2018/00214 , A61B2018/00351 , A61B2018/0063 , A61B2018/1435 , A61B2018/1467 , A61B2018/1475 , A61B2090/3966 , C08L2201/12
摘要： A medical device for use in delivering RF energy to a tissue opening is disclosed. In one embodiment, the medical device comprises a compliant electrode. The compliant electrode can include a shape memory material, such as NITINOL, to facilitate the electrode having at least one relaxed orientation. The electrode can be deployed from a delivery shaft inside the left atrium, for example, of a heart through the delivery shaft. The electrode can be configured to substantially conform to the tissue proximate the tissue opening. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.
摘要翻译：公开了一种用于向组织开口输送RF能量的医疗装置。在一个实施例中，医疗装置包括顺应性电极。柔性电极可以包括诸如NITINOL的形状记忆材料，以便于具有至少一个松弛取向的电极。电极可以从左心房内的输送轴，例如通过输送轴的心脏部署。电极可以构造成基本上符合组织开口附近的组织。在将能量施加到左右电极之间的组织之后，左电极可以通过被收回到输送轴中而从左心房移除，此后从开口排出输送轴。

6. 发明申请

WO2007038608A3 DELIVERY SYSTEM FOR PATENT FORAMEN OVALE CLOSURE DEVICE 审中-公开
标题翻译：专利废物封闭装置的输送系统
公开(公告)号：WO2007038608A3
公开(公告)日：2009-04-30
申请号：PCT/US2006037690
申请日：2006-09-26
申请人： COHEREX MEDICAL INC , WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL R
发明人： WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL R
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623
摘要： A medical system for use in reducing the size of an internal tissue opening is disclosed. The medical system can include a patent foramen ovale or PFO closure device and a delivery device therefore. The PFO closure device can include left and right anchors connected by a stem. The delivery device is configured to selectively deploy at least one of the right or left anchors of PFO closure device so as to enable a practitioner to adjust PFO closure device during the positioning procedure. In one embodiment, the delivery device includes a filament operating shaft linked to the right anchor by one or more filaments. A practitioner can move the filament operating shaft to selectively deploy and retract the right anchor during positioning of the PFO closure device. Furthermore, the delivery device comprises a tether shaft for coupling delivery device to PFO closure device.
摘要翻译：公开了一种用于减小内部组织开口尺寸的医疗系统。因此，医疗系统可以包括卵孔或PFO封闭装置和输送装置。 PFO闭合装置可以包括由杆连接的左和右锚定器。输送装置被配置为选择性地展开PFO闭合装置的右侧或左侧锚固件中的至少一个，以使得从业者能够在定位过程期间调节PFO闭合装置。在一个实施例中，输送装置包括通过一个或多个细丝连接到右锚的细丝操作轴。在定位PFO闭合装置期间，从业者可以移动细丝操作轴以选择性地展开和缩回右锚。此外，输送装置包括用于将输送装置耦合到PFO闭合装置的系绳轴。

7. 发明申请

WO2006110147A3 PATENT FORAMEN OVALE CLOSURE DEVICES, DELIVERY APPARATUS AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：专利文件OVALE封闭装置，传送装置及相关方法和系统
公开(公告)号：WO2006110147A3
公开(公告)日：2007-12-21
申请号：PCT/US2005012591
申请日：2005-04-13
申请人： PROXIMARE INC , WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL R
发明人： WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL R
IPC分类号： A61F2/02 , A61B20060101 , A61B17/00 , A61B17/08 , A61D1/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867 , A61B2017/00893
摘要： The present invention includes systems, methods, and apparatus configured to close an internal tissue opening, such as an internal tissue opening cased by an atrial septal defect including a patent foramen ovale defect, ventricular septal defect, patent ductus arterosus defect, or the like. For example, a closure device includes a right anchor cooperatively coupled with a left anchor, where the right anchor and left anchor are configured to be positioned about the internal tissue opening. The left and/or right anchor are configured to close the internal tissue opening in one instance, and to provide tissue stimulating or growth-encouraging substances at the tissue opening. Additional aspects of the invention relate to shape, formation, positioning, and detachment of the closure device about the internal tissue opening.
摘要翻译：本发明包括用于封闭内部组织开口的系统，方法和装置，所述内部组织开口例如由包括卵孔缺失专利，心室间隔缺损，动脉导管未闭合缺损等的房间隔缺损引起的内部组织开口。例如，闭合装置包括与左锚配合地联接的右锚，其中右锚和左锚配置成围绕内组织开口定位。左和/或右锚固件被构造成在一个实例中关闭内部组织开口，并且在组织开口处提供组织刺激或促进生长的物质。本发明的另外的方面涉及封闭装置围绕内部组织开口的形状，形成，定位和分离。

8. 发明申请

WO2009137530A3 VENTRICULAR ASSIST DEVICE AND RELATED METHODS 审中-公开
标题翻译：静脉辅助装置及相关方法
公开(公告)号：WO2009137530A3
公开(公告)日：2010-04-22
申请号：PCT/US2009042910
申请日：2009-05-05
申请人： COHEREX MEDICAL INC , WHISENANT BRIAN K , MILES SCOTT D
发明人： WHISENANT BRIAN K , MILES SCOTT D
IPC分类号： A61M1/36
CPC分类号： A61F2/06 , A61B2017/00243 , A61B2017/00252 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/064 , A61M27/002
摘要： A method and system are provided for percutaneously gaining access to oxygenated blood with an anastomosis device and pumping such oxygenated blood to other arterial regions of the vascular system via an LVAD system. In one embodiment, a system may include an anastomosis device extending through an opening of the atrial septum. A filament may be coupled to the anastomosis device. A snare device may access the right atrium through the superior vena cava, grasp the filament, and withdraw the filament through the superior vena cava. The filament may then be used as a guide to direct a catheter, a conduit or some other structure into the right atrium of the heart via the superior vena cava. A flow path may be defined between the anastomosis device and an arterial location, such as in the aorta, such that at least some oxygenated blood may by-pass the left ventricle and be discharged into the aorta.
摘要翻译：提供了一种方法和系统，用于通过吻合装置经皮获得含氧血液，并经由LVAD系统将这种氧合血液泵送到血管系统的其他动脉区域。在一个实施例中，系统可以包括延伸穿过心房隔膜的开口的吻合装置。丝可以连接到吻合装置。圈套装置可以通过上腔静脉进入右心房，抓住细丝，并通过上腔静脉取出细丝。然后可以将细丝用作引导件，以将导管，导管或一些其它结构经由上腔静脉引导到心脏的右心房。可以在吻合装置和动脉位置（例如主动脉）之间限定流动路径，使得至少一些氧合血液可以绕过左心室并排出到主动脉。

9. 发明申请

WO2011056823A3 VENTRICULAR ASSIST DEVICE AND RELATED METHODS 审中-公开
标题翻译：静脉辅助装置及相关方法
公开(公告)号：WO2011056823A3
公开(公告)日：2011-09-09
申请号：PCT/US2010055216
申请日：2010-11-03
申请人： COHEREX MEDICAL INC , WHISENANT BRIAN K , LINDER RICHARD J , MILES SCOTT D , STOTT DAVID L , JONES RANDALL K
发明人： WHISENANT BRIAN K , LINDER RICHARD J , MILES SCOTT D , STOTT DAVID L , JONES RANDALL K
IPC分类号： A61M1/12
CPC分类号： A61M1/10 , A61B17/11 , A61B2017/00358 , A61B2017/1107 , A61B2017/1135 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/122 , A61M1/125
摘要： A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery.
摘要翻译：提供了一种方法和系统，用于通过一个或多个吻合装置经皮地获得进入氧合血液，并且经由VAD系统将这些氧合血液直接泵送到邻近右心房或左心房的主动脉。在一个实施例中，可以用开放手术植入VAD系统。

10. 发明申请

WO2005034738A3 PATENT FORAMEN OVALE (PFO) CLOSURE DEVICES, DELIVERY APPARATUS AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：专利文献（PFO）封闭装置，输送装置及相关方法和系统
公开(公告)号：WO2005034738A3
公开(公告)日：2006-01-26
申请号：PCT/US2004033701
申请日：2004-10-12
申请人： PROXIMARE INC , WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL
发明人： WHISENANT BRIAN K , DAVIS CLARK C , EDMISTON DARYL
IPC分类号： A61B20060101 , A61B17/00 , A61B17/08 , A61D1/00 , A61B17/04
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/00893
摘要： The present invention includes systems, methods and apparatus configured to close an internal tissue opening, such as an internal tissue opening cased by an atrial septal defect including a patent foramen ovale defect, ventricular septal defect, patent ductus arterosus defect, or the like. A closure device includes a right anchor (170) cooperatively coupled with a left anchor (130), where the right anchor and left anchor are configured to be positioned about the internal tissue opening (58). The left and/or right anchor are configured to close the internal tissue opening in one instance, and to provide tissue stimulating or growth-encouraging substances at the tissue opening. Additional aspects of the invention relate to shape, formation, positioning, and detachment of the closure device about the internal tissue opening.
摘要翻译：本发明包括被构造为闭合内部组织开口的系统，方法和装置，所述内部组织开口例如由包括卵圆孔缺损专利，心室间隔缺损，导管未闭导管缺损等的房间隔缺损引起的内部组织开口。闭合装置包括与左锚固件（130）协作地联接的右锚固件（170），其中所述右锚固件和左锚固件构造成围绕内部组织开口（58）定位。左和/或右锚固件被构造成在一个实例中关闭内部组织开口，并且在组织开口处提供组织刺激或促进生长的物质。本发明的另外的方面涉及封闭装置围绕内部组织开口的形状，形成，定位和分离。

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