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1. 发明申请

WO1996018739A1 PLANT ADENYLOSUCCINATE LYASE AND DNA CODING THEREFOR 审中-公开
标题翻译：植物腺苷酸和其编码的DNA
公开(公告)号：WO1996018739A1
公开(公告)日：1996-06-20
申请号：PCT/EP1995004796
申请日：1995-12-06
申请人： CIBA-GEIGY AG , GUYER, Charles, David , WARD, Eric, Russell
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/60
CPC分类号： C12N9/88 , C12N15/8274
摘要： The present invention provides novel plant DNA sequences coding for native adenylosuccinate lyase (ADSL). Methods for using the complete or partial ADSL coding sequence as a probe for diagnostic, mapping and other purposes are taught. Generation of transformed host cells capable of expressing ADSL is also taught. Methods of using the transformed host cells are taught, including methods for recombinant production of ADSL enzymes. A method for using the plant ADSL enzyme to screen for inhibitors of ADSL activity is also provided.
摘要翻译：本发明提供编码天然腺淀粉琥珀酸裂合酶（ADSL）的新型植物DNA序列。教导了使用完整或部分ADSL编码序列作为诊断，绘图和其他目的探针的方法。还教导了能够表达ADSL的转化的宿主细胞的产生。教导使用转化的宿主细胞的方法，包括重组生产ADSL酶的方法。还提供了使用植物ADSL酶筛选ADSL活性抑制剂的方法。

2. 发明申请

WO1995034659A1 MANIPULATION OF PROTOPORPHYRINOGEN OXIDASE ENZYME ACTIVITY IN EUKARYOTIC ORGANISMS 审中-公开
标题翻译：原核生物有机体中原生质体氧化酶酶活性的操作
公开(公告)号：WO1995034659A1
公开(公告)日：1995-12-21
申请号：PCT/IB1995000452
申请日：1995-06-08
申请人： CIBA-GEIGY AG , WARD, Eric, Russell , VOLRATH, Sandra
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/53
CPC分类号： C12Y103/03004 , C12N5/04 , C12N9/001 , C12N15/8274 , C12Q1/6895
摘要： The present invention provides novel eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant. Plants having altered protox activity which confers tolerance to herbicides are also provided. These plants may be bred or engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or through increased levels of expression of the native protox gene, or they may be transformed with modified eukaryotic or prokaryotic protox coding sequences or wild type prokaryotic protox sequences which are herbicide tolerant. Diagnostic and other uses for the novel eukaryotic protox sequence are also described. Plant genes encoding wild-type and altered protox, purified plant protox, methods of isolating protox from plants, and methods of using protox-encoding genes are also disclosed.
摘要翻译：本发明提供编码天然原卟啉原氧化酶（protox）或耐除草剂的酶的修饰形式的新型真核DNA序列。还提供了赋予除草剂耐受性的具有改变的排毒活性的植物。这些植物可以通过将天然protox基因突变为抗性形式或通过增加天然protox基因的表达水平培育或设计用于抵抗前毒素抑制剂，或者可以用经修饰的真核或原核protox编码序列或野生型类型的原核生殖毒素序列是耐除草剂。还描述了用于新型真核毒素序列的诊断和其它用途。还公开了编码野生型和改变的protox的植物基因，纯化的植物protox，从植物中分离protox的方法，以及使用protox编码基因的方法。

3. 发明申请

WO1997011067A1 POLYMER-BOUND FLUOROPHORES AS OPTICAL ION SENSORS 审中-公开
标题翻译：聚对苯二甲酸乙二醇酯作为光离子传感器
公开(公告)号：WO1997011067A1
公开(公告)日：1997-03-27
申请号：PCT/EP1996003954
申请日：1996-09-10
申请人： CIBA-GEIGY AG , ALDER, Alex , BARNARD, Steven, Mark , BECKELMANN, Dirk , BERGER, Joseph , WALDNER, Adrian
发明人： CIBA-GEIGY AG
IPC分类号： C07D311/82
CPC分类号： C07D493/10 , C07D219/08 , C07D311/82 , G01N33/533
摘要： The invention relates to compounds of formula (I), (IIa) or (IIb), wherein R1, R2, R5 and R6 are each independently of one another hydrogen, -SO2-(C1-C6)alkylphenyl, C1-C30alkyl, C1-C30alkyl-CO- or a radical of formula -(CnH2n-O-)m-R10; R3 is hydrogen or -SO2-(C1-C6)alkylphenyl; R4 and R7 are C1-C30 alkylene or a radical of formula -(CnH2n-O-)m-R10; Z is a functional group which is selected from the group consisting of -OH, -SH, -NH2, -COOH, -NCO, -CO-NR8YR9Y, -NH-CO-CH=CH2, -NH-CO-C(CH3)=CH2; R8 and R9 are each independently of the other C1-C30alkylene; R10 is a direct bond or C1-C12alkylene; n is a number from 2 to 6, and m is a number from 1 to 10, with the proviso that the total number of carbon atoms is at most 30; and Y is -OH or -SH. The compounds are used as comonomers for the preparation of copolymer membranes for plasticiser-free ion sensors.
摘要翻译：本发明涉及式（I），（IIa）或（IIb）的化合物，其中R 1，R 2，R 5和R 6各自独立地为氢，-SO 2 - （C 1 -C 6）烷基苯基，C 1 -C 30烷基， -C 30烷基-CO-或式 - （C n H 2n -O-）m -R 10的基团; R3是氢或-SO2-（C1-C6）烷基苯基; R4和R7是C1-C30亚烷基或式 - （CnH2n-O-）m -R10的基团; Z是选自-OH，-SH，-NH2，-COOH，-NCO，-CO-NR8YR9Y，-NH-CO-CH = CH2，-NH-CO-C（CH3 ）= CH 2; R8和R9各自独立地为C 1 -C 30亚烷基; R10是直接键或C1-C12亚烷基; n为2〜6的数，m为1〜10的数，条件是碳原子数为30以下。 Y为-OH或-SH。该化合物用作制备用于不含增塑剂的离子传感器的共聚物膜的共聚单体。

4. 发明申请

WO1997008193A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY 审中-公开
标题翻译：具有细胞信号抑制活性的酰化寡核苷酸衍生物
公开(公告)号：WO1997008193A1
公开(公告)日：1997-03-06
申请号：PCT/EP1996003473
申请日：1996-08-06
申请人： CIBA-GEIGY AG , GARCIA-ECHEVERRIA, Carlos , GAY, Brigitte , FURET, Pascal , RAHUEL, Joseph , CARAVATTI, Giorgio , FRETZ, Heinz , SCHOEPFER, Joseph
发明人： CIBA-GEIGY AG
IPC分类号： C07K05/065
CPC分类号： C07K5/1027 , A61K38/00 , C07K5/0202 , C07K5/0207 , C07K5/06191 , C07K5/0827 , C07K14/71 , Y02P20/55
摘要： The invention relates to an acylated peptide, namely a compound of formula (I), wherein n is 0 to 15, X is arylcarbonyl, cycloalkylcarbonyl, tricycloalkylcarbonyl, arylsulfonyl, heterocyclylcarbonyl, heterocyclylsulfonyl, carbamoyl-lower alkanoyl, aryl-lower alkylcarbonyl, cycloalkyl-lower alkylcarbonyl, aryl-lower alkylsulfonyl, heterocyclyl-lower alkylcarbonyl, heterocyclyl-lower alkylsulfonyl with the proviso that in any of the lower alkyl radicals mentioned a methylene group may be replaced with oxa, aza or thia; heterocyclyl-lower alkenylcarbonyl or aryl-lower alkenylcarbonyl; or, if Y is a secondary or tertiary amino group, is one of the moieties X mentioned above or lower alkanoyl, halo-lower alkanoyl, lower-alkoxycarbonyl, aryl-lower alkoxycarbonyl or cycloalkyl-lower alkoxycarbonyl; PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimic, AA stands for a bivalent radical of a natural or unnatural amino acid, and Y is hydroxy, a C-terminal protecting group or a primary, secondary or tertiary amino group, or a salt thereof, said compound being useful for the treatment of diseases that respond to inhibition of the interaction of (a) protein(s) comprising (an) SH2 domain(s) and a protein tyrosine kinase or a modified version thereof.
摘要翻译：本发明涉及酰化肽，即式（I）化合物，其中n为0至15，X为芳基羰基，环烷基羰基，三环烷基羰基，芳基磺酰基，杂环基羰基，杂环基磺酰基，氨基甲酰基 - 低级烷酰基，芳基 - 低级烷基羰基，环烷基 - 低级烷基羰基，芳基 - 低级烷基磺酰基，杂环基 - 低级烷基羰基，杂环基 - 低级烷基磺酰基，条件是在所提及的任何低级烷基中亚甲基可以被氧杂，氮杂或硫代替代; 杂环基低级烯基羰基或芳基 - 低级烯基羰基; 或者如果Y是仲或叔氨基，则是上述部分X或低级烷酰基，卤代低级烷酰基，低级烷氧基羰基，芳基 - 低级烷氧基羰基或环烷基 - 低级烷氧基羰基之一; PTI是酪氨酸或（优选）磷酸酪氨酸或磷酸酪氨酸模拟物的二价基团的二价基团，AA代表天然或非天然氨基酸的二价基团，Y是羟基，C-末端保护基或伯，仲或叔氨基或其盐，所述化合物可用于治疗响应于（a）包含（a）SH2结构域和蛋白质酪氨酸激酶的蛋白质的相互作用的抑制的疾病，或其修改版本。

5. 发明申请

WO1997005095A1 PROCESS FOR THE HYDROGENATION OF IMINES 审中-公开
标题翻译：加氢方法
公开(公告)号：WO1997005095A1
公开(公告)日：1997-02-13
申请号：PCT/EP1996003143
申请日：1996-07-17
申请人： CIBA-GEIGY AG , JALETT, Hans-Peter , SIEBENHAAR, Bernd
发明人： CIBA-GEIGY AG
IPC分类号： C07C213/02
CPC分类号： C07D333/36 , C07C213/02 , C07C217/08 , C07C209/52 , C07C211/48
摘要： A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers. Improved optical yields and high chemical conversion rates are achieved while the catalyst is easily separable.
摘要翻译：在含有二膦配体的铱催化剂存在下，在升高的压力下氢化亚胺的方法，在有或者没有惰性溶剂的情况下，含有可溶性氯化铵，溴化物或碘化物的反应混合物或可溶性金属氯化物，溴化物或碘化物，其中所述反应混合物另外含有除离子交换剂之外的至少一种固体酸。在催化剂容易分离的同时，获得了提高的光学收率和高化学转化率。

6. 发明申请

WO1997001087A1 FLOW CELL 审中-公开
标题翻译：流通池
公开(公告)号：WO1997001087A1
公开(公告)日：1997-01-09
申请号：PCT/EP1996002519
申请日：1996-06-10
申请人： CIBA-GEIGY AG , OROSZLAN, Peter , ERBACHER, Christoph , DUVENECK, Gert, Ludwig , VERPOORTE, Elisabeth
发明人： CIBA-GEIGY AG
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N2021/0346
摘要： A flow cell (1) has in its interior a flow channel (2) and is provided with an inlet opening (3) for the sample and with an outlet opening (4). Also provided are means for producing a sample-free blocked volume located in the flow channel (2). Those means comprise, for example, a further inlet opening (5) for a reference fluid, that inlet opening (5) being so positioned that the reference fluid flows counter to the sample in the flow channel (2). The flow cell (1) is suitable for a sensor apparatus in which one of the boundary surfaces of the flow channel (2) comprises a detection layer that contains selectively sensitive recognition elements for an analyte. The flow cell (1) is also suitable for an optical detection device which preferably utilises luminescence excitation in the evanescent field of an optical waveguide.
摘要翻译：流动池（1）在其内部具有流动通道（2），并且设置有用于样品的入口开口（3）和出口开口（4）。还提供了用于产生位于流动通道（2）中的无样品阻塞体积的装置。这些装置包括例如用于参考流体的另一个入口开口（5），该入口开口（5）被定位成使得参考流体与流动通道（2）中的样品相反。流动池（1）适用于传感器装置，其中流动通道（2）的边界表面之一包括检测层，该检测层包含用于分析物的选择性敏感的识别元件。流动池（1）还适用于光学检测装置，其优选地在光波导的消逝场中利用发光激发。

7. 发明申请

WO1997000859A1 THIOAMIDES S-OXIDES FOR USE AS PESTICIDES 审中-公开
标题翻译：用作杀虫剂的硫氧化物S-氧化物
公开(公告)号：WO1997000859A1
公开(公告)日：1997-01-09
申请号：PCT/EP1996002520
申请日：1996-06-10
申请人： CIBA-GEIGY AG , ZURFLÜH, René
发明人： CIBA-GEIGY AG
IPC分类号： C07C327/60
CPC分类号： A01N43/80 , A01N41/02 , C07C327/60 , C07D261/20
摘要： Thioamide S-oxides of formula (I) are suitable as fungicidally, insecticidally and acaricidally active ingredients in crop protection, in which R1 is hydrogen or C1-C4alkyl, and R2 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl or C3-C6cycloalkyl, and in which R3 and R4 independently of one another are hydrogen, cyano, C1-C4alkyl, halo-C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, cyclopropylmethyl, C1-C4alkoxy, C2-C5alkoxyalkyl, C1-C4alkoxycarbonyl, C1-C4alkylthio, C2-C5alkylthioalkyl; an unsubstituted or up to trisubstituted ring which has not more than 15 ring carbon atoms, which can be polycyclic and which contains 0-3 hetero atoms N, O or S, it being possible for this ring to be bonded via an aliphatic bridge having not more than 4 carbon atoms and/or via either CO, oxygen or sulfur; or in which R3 and R4 together with the joint carbon atom form an unsubstituted or up to trisubstituted ring which has not more than 15 ring carbon atoms, which can be polycyclic and which contains 0-3 hereto atoms N, O or S. They can be used on their own or as formulated compositions, preferably for controlling or preventing infestation with microorganisms.
摘要翻译：式（I）的硫酰胺S-氧化物在作物保护中适合作为杀真菌，杀虫和杀螨活性成分，其中R1是氢或C1-C4烷基，R2是氢，C1-C4烷基，C2-C4链烯基，C2-C4炔基或 C 3 -C 6环烷基，其中R 3和R 4彼此独立地是氢，氰基，C 1 -C 4烷基，卤代-C 1 -C 4烷基，C 2 -C 4烯基，C 2 -C 4炔基，C 3 -C 6环烷基，环丙基甲基，C 1 -C 4烷氧基，C 2 -C 5烷氧基烷基，C 1 -C 4烷氧基羰基，C 1 -C 4烷硫基，C 2 -C 5烷硫基烷基; 具有不多于15个环碳原子的未被取代或最多三取代的环，其可以是多环的并且含有0-3个杂原子N，O或S，该环可能通过没有多于4个碳原子和/或经由CO，氧或硫; 或其中R 3和R 4与连接碳原子一起形成具有不多于15个环碳原子的未取代或至多三取代的环，其可以是多环的并且含有0-3个原子N ，O或S.它们可以单独使用或作为配制的组合物使用，优选用于控制或预防用微生物侵染。

8. 发明申请

WO1997000669A1 COMPOSITIONS AND METHODS FOR STABILIZING POLYMERS 审中-公开
标题翻译：用于稳定聚合物的组合物和方法
公开(公告)号：WO1997000669A1
公开(公告)日：1997-01-09
申请号：PCT/EP1996002539
申请日：1996-06-12
申请人： CIBA-GEIGY AG , TSAO, Fu-Pao
发明人： CIBA-GEIGY AG
IPC分类号： A61K09/00
CPC分类号： A61K9/0048 , C08K5/5317 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915 , C08L33/02
摘要： Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.
摘要翻译：用于降低聚合物生物粘合剂和粘度增强剂（例如聚（丙烯酸））的分解速率的组合物和方法。组合物包括至少一种强稳定的螯合剂，优选有机亚磷化合物，例如二亚乙基三胺五（亚甲基膦酸）。这些生物相容性组合物特别适用于眼科领域。

9. 发明申请

WO1996030392A1 PROCESS FOR THE PRODUCTION OF COMBINATORIAL COMPOUND LIBRARIES 审中-公开
标题翻译：生产组合复合图书馆的过程
公开(公告)号：WO1996030392A1
公开(公告)日：1996-10-03
申请号：PCT/EP1996001154
申请日：1996-03-18
申请人： CIBA-GEIGY AG , RINK, Hans , VETTER, Dirk , GERCKEN, Bertold , FELDER, Eduard
发明人： CIBA-GEIGY AG
IPC分类号： C07K01/04
CPC分类号： C07K1/047 , A61K38/00 , B01J2219/005 , B01J2219/00572 , B01J2219/00596 , B01J2219/00725 , C40B40/10 , C40B70/00
摘要： Described is a process for the production of a library from a plurality of different units consisting of a solid or semisolid carrier (bead), a synthetic ligand and a binary information structure (tag), by means of which the building blocks of the ligand are coded, and the use of that library for searching for novel classes of active ingredient and individual active ingredients. Also described are compounds found using that process. The process is characterized by the use of element atoms or ions as binary tags which are bound non covalently to the beads. Their unique combination which can be measured by e.g. mass spectrometry codes for the specific ligand.
摘要翻译：描述了从由固体或半固体载体（珠粒），合成配体和二元信息结构（标签）组成的多个不同单元生产文库的方法，通过该文库，配体的结构单元编码，以及使用该库搜索新类别的活性成分和各种活性成分。还描述了使用该方法发现的化合物。该方法的特征在于使用元素原子或离子作为与珠不共价结合的二进制标记。它们独特的组合可以通过例如用于特定配体的质谱法编码。

10. 发明申请

WO1996029870A1 HERBICIDAL COMPOSITIONS 审中-公开
标题翻译：除草剂组合物
公开(公告)号：WO1996029870A1
公开(公告)日：1996-10-03
申请号：PCT/EP1996001086
申请日：1996-03-14
申请人： CIBA-GEIGY AG , GLOCK, Jutta , HUDETZ, Manfred , KERBER, Elmar
发明人： CIBA-GEIGY AG
IPC分类号： A01N43/54
CPC分类号： A01N43/54 , A01N43/66 , A01N25/32 , A01N2300/00
摘要： A selective herbicidal composition comprising, in addition to conventional formulation assistants, a mixture of a) a herbicidally effective amount of a herbicide of formula (I), or a salt or a stereoisomer of the compounds of formula (I), and b) to antagonise the herbicide, an antidotally effective amount of a safener of formula (IIa) of a compound of formula (IIb1), of a compound of formula (IIb2), of a compound of formula (IIc), of a compound of formula (IId), of a compound of formula (IIe), of a compound of formula (IIf), of a compound of formula (IIg), or of a compound of formula (IIh), wherein the substituents have the meanings claimed in claim 1.
摘要翻译：一种选择性除草组合物，除了常规制剂助剂外还包含a）除草有效量的式（I）除草剂或式（I）化合物的盐或立体异构体的混合物，和b）至拮抗除草剂，式（IIb1）化合物，式（IIb2）化合物，式（IIc）化合物，式（IId）化合物的式（IIa）化合物的安定剂）式（IIe）化合物，式（IIf）化合物，式（IIg）化合物或式（IIh）化合物，其中取代基具有权利要求1所述的含义。

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